A Cannabinoid Receptor 2 Agonist Prevents Thrombin-Induced Blood–Brain Barrier Damage via the Inhibition of Microglial Activation and Matrix Metalloproteinase Expression in Rats

Translational Stroke Research

Volumn 6, Issue 6, 2015, Pages 467-477

  Li, Lin ^a   Tao, Yihao ^a   Tang, Jun ^a   Chen, Qianwei ^a   Yang, Yang ^a   Feng, Zhou ^a   Chen, Yujie ^a   Yang, Liming ^a   Yang, Yunfeng ^b   Zhu, Gang ^a   Feng, Hua ^a   Chen, Zhi ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b Chinese People's Armed Police Forces   (China)

Author keywords

Blood brain barrier; Cannabinoid receptor; Matrix metalloproteinase; p44 42 MAPK; Thrombin

Indexed keywords

1 DEOXY 3 (1,1 DIMETHYLBUTYL) DELTA8 TETRAHYDROCANNABINOL; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; EVANS BLUE; GELATINASE B; MACROPHAGE ELASTASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN ZO1; THROMBIN; VON WILLEBRAND FACTOR; 1,1-DIMETHYLBUTYL-1-DEOXY-DELTA(9)-THC; CANNABINOID; CANNABINOID 2 RECEPTOR; MATRIX METALLOPROTEINASE; TJP1 PROTEIN, RAT;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASAL GANGLION; BLOOD BRAIN BARRIER; BRAIN EDEMA; BRAIN WATER; CELL ACTIVATION; CELL COUNT; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; IMMUNOFLUORESCENCE; IMMUNOREACTIVITY; MALE; MICROGLIA; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; WESTERN BLOTTING; AGONISTS; ANIMAL; BRAIN INJURY; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; METABOLISM; PATHOLOGY; PERMEABILITY; PHOSPHORYLATION; SPRAGUE DAWLEY RAT;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN EDEMA; BRAIN INJURIES; CANNABINOIDS; DISEASE MODELS, ANIMAL; MALE; MATRIX METALLOPROTEINASES; MICROGLIA; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PERMEABILITY; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, CANNABINOID, CB2; THROMBIN; ZONULA OCCLUDENS-1 PROTEIN;

EID: 84946481526     PISSN: 18684483     EISSN: 1868601X     Source Type: Journal    
DOI: 10.1007/s12975-015-0425-7     Document Type: Article

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