Mucus properties and goblet cell quantification in mouse, rat and human ileal Peyer's patches

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Ermund, Anna ^a   Gustafsson, Jenny K ^a   Hansson, Gunnar C ^a   Keita, Åsa V ^b  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b LINKÖPING UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

MUCIN 2; MUCIN 2 ANTIBODY; PROTEIN ANTIBODY; UNCLASSIFIED DRUG;

AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ANTIGEN RECOGNITION; ARTICLE; CELL COUNT; CELL FUNCTION; CELL STIMULATION; CONTROLLED STUDY; FEMALE; GOBLET CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; ILEUM; INTESTINE CELL; INTESTINE VILLUS; MALE; MOUSE; MUCUS; NONHUMAN; PEYER PATCH; RAT; SMALL INTESTINE MUCOSA; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ANIMALS; FEMALE; GOBLET CELLS; HUMANS; ILEUM; INTESTINAL MUCOSA; MALE; MICE; MUCIN-2; MUCUS; PEYER'S PATCHES; RATS;

EID: 84892638554     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0083688     Document Type: Article

References (36)

1. Johansson MEV, Phillipson M, Petersson J, Velcich A, Holm L, et al. (2008) The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. Proc Natl Acad Sci U S A 105: 15064-15069.
2. Atuma C, Strugala V, Allen A, Holm L (2001) The adherent gastrointestinal mucus gel layer: thickness and physical state in vivo. AJP - Gastroint Liver Physiol 280: G922-G929.
3. Ermund A, Schütte A, Johansson MEV, Gustafsson JK, Hansson GC (2013) The gastrointestinal mucus layers have different properties depending on location within the tract - 1. Studies of mucus in mouse stomach, small intestine, Peyer's patches and colon. AJP - Gastroint Liver Physiol 305: G341-347.
4. Vaishnava S, Yamamoto M, Severson KM, Ruhn KA, Yu X, et al. (2011) The Antibacterial Lectin RegIIIγ Promotes the Spatial Segregation of Microbiota and Host in the Intestine. Science 334: 255-258.
5. Johansson MEV, Hansson GC (2011) Keeping Bacteria at a Distance. Science 334: 182-183.
6. Meyer T, Ullrich R, Zeitz M (2012) Oral tolerance induction in humans. Exp Mol Pathol 93: 449-454.
7. Neutra MR, Mantis NJ, Kraehenbuhl JP (2001) Collaboration of epithelial cells with organized mucosal lymphoid tissues. Nat Immunol 2: 1004-1009.
8. Kelsall BL, Strober W (1996) Distinct populations of dendritic cells are present in the subepithelial dome and T cell regions of the murine Peyer's patch. J Exp Med 183: 237-247.
9. Neutra MR, Pringault E, Kraehenbuhl JP (1996) Antigen Sampling Across Epithelial Barriers and Induction of Mucosal Immune Responses. Annu Rev Immunol 14: 275-300.
10. Owen RL (1999) Uptake and transport of intestinal macromolecules and microorganisms by M cells in Peyer's patches- a personal and historical perspective. Semin Immunol 11: 157-163.
11. Tyrer PC, Foxwell RA, Kyd JM, Otczyk DC, Cripps AW (2007) Receptor mediated targeting of M-cells. Vaccine 25: 3204-3209.
12. Schulz O, Pabst O (2012) Antigen sampling in the small intestine. Trends Immunol.
13. Liu C, Gelius E, Liu G, Steiner H, Dziarski R (2000) Mammalian Peptidoglycan Recognition Protein Binds Peptidoglycan with High Affinity, Is Expressed in Neutrophils, and Inhibits Bacterial Growth. J Biol Chem 275: 24490-24499.
14. Lo D, Tynan W, Dickerson J, Mendy J, Chang HW, et al. (2003) Peptidoglycan recognition protein expression in mouse Peyer's Patch follicle associated epithelium suggests functional specialization. Cell Immunol 224: 8-16.
15. Gebert A (1997) The role of M cells in the protection of mucosal membranes. Histochem Cell Biol 108: 455-470.
16. Keita AV, Gullberg E, Ericson AC, Salim SaY, Wallon C, et al. (2006) Characterization of antigen and bacterial transport in the follicle-associated epithelium of human ileum. Lab Invest 86: 504-516.
17. Jung C, Hugot JP, Barreau F (2010) Peyer's Patches: The Immune Sensors of the Intestine. Int J Inflam 823710.
18. Donaldson DS, Kobayashi A, Ohno H, Yagita H, Williams IR, et al. (2012) M cell-depletion blocks oral prion disease pathogenesis. Mucosal Immunol 5: 216-225.
19. Kujala P, Raymond CR, Romeijn M, Godsave SF, van Kasteren SI, et al. (2011) Prion Uptake in the Gut: Identification of the First Uptake and Replication Sites. PLoS Pathog 7: e1002449.
20. Castro-Sánchez P, Martín-Villa JM (2013) Gut immune system and oral tolerance. Br J Nutr 109: S3-S11.
21. Terahara K, Yoshida M, Igarashi O, Nochi T, Pontes GS, et al. (2008) Comprehensive Gene Expression Profiling of Peyer's Patch M Cells, Villous M-Like Cells, and Intestinal Epithelial Cells. The Journal of Immunology 180: 7840-7846.
22. Nochi T, Yuki Y, Matsumura A, Mejima M, Terahara K, et al. (2007) A novel M cell-specific carbohydrate-targeted mucosal vaccine effectively induces antigen-specific immune responses. J Exp Med 204: 2789-2796.
23. Jang MH, Kweon MN, Iwatani K, Yamamoto M, Terahara K, et al. (2004) Intestinal villous M cells: An antigen entry site in the mucosal epithelium. Proc Natl Acad Sci U S A 101: 6110-6115.
24. Hase K, Kawano K, Nochi T, Pontes GS, Fukuda S, et al. (2009) Uptake through glycoprotein 2 of FimH+ bacteria by M cells initiates mucosal immune response. Nature 462: 226-230.
25. Wang J, Gusti V, Saraswati A, Lo DD (2011) Convergent and Divergent Development among M Cell Lineages in Mouse Mucosal Epithelium. J Immunol 187: 5277-5285.
26. Khan J, Iiboshi Y, Cui L, Wasa M, Akira O (1999) Role of intestinal mucus on the uptake of latex beads by Peyer's patches and on their transport to mesenteric lymph nodes in rats. JPEN J Parenter Enteral Nutr 23: 19-23.
27. Onori P, Franchitto A, Sferra R, Vetuschi A, Gaudio E (2001) Peyer's Patches Epithelium in the Rat. Dig Dis Sci 46: 1095-1104.
28. McGuckin MA, Lindén SK, Sutton P, Florin TH (2011) Mucin dynamics and enteric pathogens. Nat Rev Micro 9: 265-278.
29. Sansonetti PJ, Phalipon A (1999) M cells as ports of entry for enteroinvasive pathogens: Mechanisms of interaction, consequences for the disease process. Semin Immunol 11: 193-203.
30. Gustafsson JK, Ermund A, Johansson MEV, Schütte A, Hansson GC, et al. (2012) An ex vivo method for studying mucus formation, properties, and thickness in human colonic biopsies and mouse small and large intestinal explants. AJP - Gastrointest Liver Physiol 302: G430-G438.
31. Henriksnäs J, Phillipson M, Petersson J, Engstrand L, Holm L (2005) An in vivo model for gastric physiological and pathophysiological studies in the mouse. Acta Physiol Scand 184: 151-159.
32. Gustafsson JK, Ermund A, Ambort D, Johansson MEV, Nilsson HE, et al. (2012) Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype. J Exp Med 209: 1263-1272.
33. Inamoto T, Kawata Y, Qi WM, Yamamoto K, Warita K, et al. (2008) Ultrastructural Study on the Epithelial Responses against Attachment of Indigenous Bacteria to Epithelial Membranes in Peyer's Patches of Rat Small Intestine. J Vet Med Sci 70: 235-241.
34. Lelouard H, Reggio H, Mangeat P, Neutra M, Montcourrier P (1999) Mucin-Related Epitopes Distinguish M Cells and Enterocytes in Rabbit Appendix and Peyer's Patches. Infect Immun 67: 357-367.
35. Beyaz F, Ergün E, Bayraktaroǧlu A, Ergün L (2010) Identification of intestinal M cells in isolated lymphoid follicles and Peyer's patches of the Angora rabbit. Cell Tissue Res 341: 417-427.
36. McDole JR, Wheeler LW, McDonald KG, Wang B, Konjufca V, et al. (2012) Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine. Nature 483: 345-349.