Secretory IgA is concentrated in the outer layer of colonic mucus along with gut bacteria

Pathogens

Volumn 3, Issue 2, 2014, Pages 390-403

  Rogier, Eric W ^a,b   Frantz, Aubrey L ^a,c   Bruno, Maria E C ^a   Kaetzel, Charlotte S ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^c UNIVERSITY OF NORTH TEXAS   (United States)

Author keywords

Gut bacteria; Intestinal epithelium; Intestinal mucus; Mucin 2; Polymeric immunoglobulin receptor (pIgR); Secretory IgA

Indexed keywords

MUCIN 2; RNA 16S; SECRETORY COMPONENT; SECRETORY IMMUNOGLOBULIN;

ANIMAL TISSUE; ARTICLE; BACTERIAL COLONIZATION; COLON; COLON BIOPSY; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOHISTOCHEMISTRY; INTESTINE FLORA; MUCUS; NONHUMAN; NORMAL HUMAN; PROTEIN EXPRESSION;

EID: 84914094986     PISSN: None     EISSN: 20760817     Source Type: Journal    
DOI: 10.3390/pathogens3020390     Document Type: Article

References (36)

1. Hooper, L. V.; Littman, D. R.; Macpherson, A. J. Interactions between the microbiota and the immune system. Science 2012, 336, 1268-1273.
2. Geuking, M. B.; McCoy, K. D.; Macpherson, A. J. The function of secretory IgA in the context of the intestinal continuum of adaptive immune responses in host-microbial mutualism. Semin. Immunol. 2012, 24, 36-42.
3. Macpherson, A. J.; Geuking, M. B.; Slack, E.; Hapfelmeier, S.; McCoy, K. D. The habitat, double life, citizenship, and forgetfulness of IgA. Immunol. Rev. 2012, 245, 132-146.
4. Van der Waaij, L. A.; Limburg, P. C.; Mesander, G.; van der Waaij, D. In vivo IgA coating of anaerobic bacteria in human faeces. Gut 1996, 38, 348-354.
5. Mestecky, J.; Russell, M. W. Specific antibody activity, glycan heterogeneity and polyreactivity contribute to the protective activity of S-IgA at mucosal surfaces. Immunol. Lett. 2009, 124, 57-62.
6. Mathias, A.; Corthésy, B. N-Glycans on secretory component: Mediators of the interaction between secretory IgA and gram-positive commensals sustaining intestinal homeostasis. Gut Microbes 2011, 2, 287-293.
7. Johansen, F. E.; Kaetzel, C. S. Regulation of the polymeric immunoglobulin receptor and IgA transport: New advances in environmental factors that stimulate pIgR expression and its role in mucosal immunity. Mucosal Immunol. 2011, 4, 598-602.
8. Kaetzel, C. S. The polymeric immunoglobulin receptor. eLS 2013, doi: 10. 1002/9780470015902. a0024237.
9. Chintalacharuvu, K. R.; Morrison, S. L. Production of secretory immunoglobulin A by a single mammalian cell. Proc. Natl. Acad. Sci. USA 1997, 94, 6364-6368.
10. Crottet, P.; Corthesy, B. Secretory component delays the conversion of secretory IgA into antigen-binding competent F(ab')2: A possible implication for mucosal defense. J. Immunol. 1998, 161, 5445-5453.
11. Mantis, N. J.; Rol, N.; Corthésy, B. Secretory IgA's complex roles in immunity and mucosal homeostasis in the gut. Mucosal Immunol. 2011, 4, 603-611.
12. Corthésy, B. Role of secretory IgA in infection and maintenance of homeostasis. Autoimmun. Rev. 2012, 12, 661-665.
13. Reikvam, D. H.; Derrien, M.; Islam, R.; Erofeev, A.; Grcic, V.; Sandvik, A.; Gaustad, P.; Meza-Zepeda, L. A.; Jahnsen, F. L.; Smidt, H.; et al. Epithelial-microbial cross-talk in polymeric Ig receptor deficient mice. Eur. J. Immunol. 2012, 42, 2959-2970.
14. Anderson, C. A.; Boucher, G.; Lees, C. W.; Franke, A.; D'Amato, M.; Taylor, K. D.; Lee, J. C.; Goyette, P.; Imielinski, M.; Latiano, A.; et al. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat. Genet. 2011, 43, 246-252.
15. Jostins, L.; Ripke, S.; Weersma, R. K.; Duerr, R. H.; McGovern, D. P.; Hui, K. Y.; Lee, J. C.; Schumm, L. P.; Sharma, Y.; Anderson, C. A.; et al. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature 2012, 491, 119-124.
16. Phalipon, A.; Cardona, A.; Kraehenbuhl, J. P.; Edelman, L.; Sansonetti, P. J.; Corthesy, B. Secretory component: A new role in secretory IgA-mediated immune exclusion in vitro. Immunity 2002, 17, 107-115.
17. Boullier, S.; Tanguy, M.; Kadaoui, K. A.; Caubet, C.; Sansonetti, P.; Corthesy, B.; Phalipon, A. Secretory IgA-mediated neutralization of Shigella flexneri prevents intestinal tissue destruction by down-regulating inflammatory circuits. J. Immunol. 2009, 183, 5879-5885.
18. Mestecky, J.; Russell, M. W.; Jackson, S.; Brown, T. A. The human IgA system: A reassessment. Clin. Immunol. Immunopathol. 1986, 40, 105-114.
19. Conley, M. E.; Delacroix, D. L. Intravascular and mucosal immunoglobulin A: Two separate but related systems of immune defense? Ann. Intern. Med. 1987, 106, 892-899.
20. Thomas, A. D.; Parker, W. Cultivation of epithelial-associated microbiota by the immune system. Future. Microbiol. 2010, 5, 1483-1492.
21. McGuckin, M. A.; Linden, S. K.; Sutton, P.; Florin, T. H. Mucin dynamics and enteric pathogens. Nat. Rev. Microbiol. 2011, 9, 265-278.
22. Johansson, M. E.; Phillipson, M.; Petersson, J.; Velcich, A.; Holm, L.; Hansson, G. C. The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. Proc. Natl. Acad. Sci. USA 2008, 105, 15064-15069.
23. Perez-Vilar, J. Mucin granule intraluminal organization. Am. J. Respir. Cell Mol. Biol. 2007, 36, 183-190.
24. Velcich, A.; Yang, W.; Heyer, J.; Fragale, A.; Nicholas, C.; Viani, S.; Kucherlapati, R.; Lipkin, M.; Yang, K.; Augenlicht, L. Colorectal cancer in mice genetically deficient in the mucin Muc2. Science 2002, 295, 1726-1729.
25. Mizoguchi, E.; Xavier, R. J.; Reinecker, H. C.; Uchino, H.; Bhan, A. K.; Podolsky, D. K.; Mizoguchi, A. Colonic epithelial functional phenotype varies with type and phase of experimental colitis. Gastroenterology 2003, 125, 148-161.
26. Van der Sluis, M.; de Koning, B. A.; de Bruijn, A. C.; Velcich, A.; Meijerink, J. P.; van Goudoever, J. B.; Buller, H. A.; Dekker, J.; van Seuningen, I; Renes, I. B.; et al. Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection. Gastroenterology 2006, 131, 117-129.
27. Velcich, A. Montefiore Cancer Center, Albert Einstein University, Bronx, New York, NY, USA, Personal communication, 2010.
28. Johansen, F. E.; Pekna, M.; Norderhaug, I. N.; Haneberg, B.; Hietala, M. A.; Krajci, P.; Betsholtz, C.; Brandtzaeg, P. Absence of epithelial immunoglobulin A transport, with increased mucosal leakiness, in polymeric immunoglobulin receptor/secretory component-deficient mice. J. Exp. Med. 1999, 190, 915-922.
29. Gloag, E. S.; Turnbull, L.; Huang, A.; Vallotton, P.; Wang, H.; Nolan, L. M.; Mililli, L.; Hunt, C.; Lu, J.; Osvath, S. R.; et al. Self-organization of bacterial biofilms is facilitated by extracellular DNA. Proc. Natl. Acad. Sci. USA 2013, 110, 11541-11546.
30. Macpherson, A. J.; McCoy, K. D.; Johansen, F. E.; Brandtzaeg, P. The immune geography of IgA induction and function. Mucosal Immunol. 2008, 1, 11-22.
31. Frantz, A. L.; Rogier, E. W.; Weber, C. R.; Shen, L.; Cohen, D. A.; Fenton, L. A.; Bruno, M. E.; Kaetzel, C. S. Targeted deletion of MyD88 in intestinal epithelial cells results in compromised antibacterial immunity associated with downregulation of polymeric immunoglobulin receptor, mucin-2, and antibacterial peptides. Mucosal Immunol. 2012, 5, 501-512.
32. Amann, R. I.; Binder, B. J.; Olson, R. J.; Chisholm, S. W.; Devereux, R.; Stahl, D. A. Combination of 16S rRNA-targeted oligonucleotide probes with flow cytometry for analyzing mixed microbial populations. Appl. Environ. Microbiol. 1990, 56, 1919-1925.
33. Bienenstock, J.; Gibson, G.; Klaenhammer, T. R.; Walker, W. A.; Neish, A. S. New insights into probiotic mechanisms: A harvest from functional and metagenomic studies. Gut Microbes 2013, 4, 94-100.
34. Gill, N.; Wlodarska, M.; Finlay, B. B. Roadblocks in the gut: Barriers to enteric infection. Cell Microbiol. 2011, 13, 660-669.
35. Andersson, M. L.; Karlsson-Sjoberg, J. M.; Putsep, K. L. CRS-peptides: Unique defense peptides of mouse Paneth cells. Mucosal Immunol. 2012, 5, 367-376.
36. Kunisawa, J.; Kiyono, H. Immune regulation and monitoring at the epithelial surface of the intestine. Drug Discov. Today 2013, 18, 87-92.