MyD88 signaling in T cells directs IgA-mediated control of the microbiota to promote health

Cell Host and Microbe

Volumn 17, Issue 2, 2015, Pages 153-163

  Kubinak, Jason L ^a   Petersen, Charisse ^a   Stephens, W Zac ^a   Soto, Ray ^a   Bake, Erin ^a   O'Connell, Ryan M ^a   Round, June L ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN A; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR AGONIST; MYD88 PROTEIN, HUMAN;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; B LYMPHOCYTE; BINDING AFFINITY; CELL INTERACTION; CELL MATURATION; CONTROLLED STUDY; GERMINAL CENTER; HELPER CELL; HOST SUSCEPTIBILITY; IMMUNE RESPONSE; IMMUNOGLOBULIN PRODUCTION; INNATE IMMUNITY; INTESTINE FLORA; MICROBIAL COMMUNITY; MICROBIOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; SIGNAL TRANSDUCTION; T FOLLICULAR HELPER CELL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; ANIMAL; HOMEOSTASIS; IMMUNOLOGY; INTESTINE MUCOSA; METABOLISM; MICROBIOLOGY;

BACTERIA (MICROORGANISMS); MUS;

ADAPTIVE IMMUNITY; ANIMALS; B-LYMPHOCYTES; GASTROINTESTINAL MICROBIOME; HOMEOSTASIS; IMMUNITY, INNATE; IMMUNOGLOBULIN A; INTESTINAL MUCOSA; MICE; MYELOID DIFFERENTIATION FACTOR 88; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 84922937083     PISSN: 19313128     EISSN: 19346069     Source Type: Journal    
DOI: 10.1016/j.chom.2014.12.009     Document Type: Article

References (40)

1. K. Atarashi, T. Tanoue, T. Shima, A. Imaoka, T. Kuwahara, Y. Momose, G. Cheng, S. Yamasaki, T. Saito, and Y. Ohba Induction of colonic regulatory T cells by indigenous Clostridium species Science 331 2011 337 341
2. Y. Belkaid, and T.W. Hand Role of the microbiota in immunity and inflammation Cell 157 2014 121 141
3. M. Bemark, P. Boysen, and N.Y. Lycke Induction of gut IgA production through T cell-dependent and T cell-independent pathways Ann. N Y Acad. Sci. 1247 2012 97 116
4. D. Berry, C. Schwab, G. Milinovich, J. Reichert, K. Ben Mahfoudh, T. Decker, M. Engel, B. Hai, E. Hainzl, and S. Heider Phylotype-level 16S rRNA analysis reveals new bacterial indicators of health state in acute murine colitis ISME J. 6 2012 2091 2106
5. P. Brandtzaeg Secretory IgA: Designed for Anti-Microbial Defense Front Immunol 4 2013 222
6. J.G. Caporaso, J. Kuczynski, J. Stombaugh, K. Bittinger, F.D. Bushman, E.K. Costello, N. Fierer, A.G. Peña, J.K. Goodrich, and J.I. Gordon QIIME allows analysis of high-throughput community sequencing data Nat. Methods 7 2010 335 336
7. I. Caramalho, T. Lopes-Carvalho, D. Ostler, S. Zelenay, M. Haury, and J. Demengeot Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide J. Exp. Med. 197 2003 403 411
8. A. Cerutti, M. Cols, M. Gentile, L. Cassis, C.M. Barra, B. He, I. Puga, and K. Chen Regulation of mucosal IgA responses: lessons from primary immunodeficiencies Ann. N Y Acad. Sci. 1238 2011 132 144
9. J. Chang, P.R. Burkett, C.M. Borges, V.K. Kuchroo, L.A. Turka, and C.H. Chang MyD88 is essential to sustain mTOR activation necessary to promote T helper 17 cell proliferation by linking IL-1 and IL-23 signaling Proc. Natl. Acad. Sci. USA 110 2013 2270 2275
10. S. Crotty Follicular helper CD4 T cells (TFH) Annu. Rev. Immunol. 29 2011 621 663
11. T.C. Cullender, B. Chassaing, A. Janzon, K. Kumar, C.E. Muller, J.J. Werner, L.T. Angenent, M.E. Bell, A.G. Hay, and D.A. Peterson Innate and adaptive immunity interact to quench microbiome flagellar motility in the gut Cell Host Microbe 14 2013 571 581
12. S. Fagarasan, M. Muramatsu, K. Suzuki, H. Nagaoka, H. Hiai, and T. Honjo Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora Science 298 2002 1424 1427
13. S.G. Hansen, M.N. Skov, and U.S. Justesen Two cases of Ruminococcus gnavus bacteremia associated with diverticulitis J. Clin. Microbiol. 51 2013 1334 1336
14. H.J. Harmsen, S.D. Pouwels, A. Funke, N.A. Bos, and G. Dijkstra Crohn's disease patients have more IgG-binding fecal bacteria than controls Clin. Vaccine Immunol. 19 2012 515 521
15. L.V. Hooper, D.R. Littman, and A.J. Macpherson Interactions between the microbiota and the immune system Science 336 2012 1268 1273
16. I.I. Ivanov, Rde.L. Frutos, N. Manel, K. Yoshinaga, D.B. Rifkin, R.B. Sartor, B.B. Finlay, and D.R. Littman Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine Cell Host Microbe 4 2008 337 349
17. N. Kamada, S.U. Seo, G.Y. Chen, and G. Núñez Role of the gut microbiota in immunity and inflammatory disease Nat. Rev. Immunol. 13 2013 321 335
18. S. Kawamoto, T.H. Tran, M. Maruya, K. Suzuki, Y. Doi, Y. Tsutsui, L.M. Kato, and S. Fagarasan The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut Science 336 2012 485 489
19. J.L. Kubinak, and J.L. Round Toll-like receptors promote mutually beneficial commensal-host interactions PLoS Pathog. 8 2012 e1002785
20. C. Lindner, B. Wahl, L. Föhse, S. Suerbaum, A.J. Macpherson, I. Prinz, and O. Pabst Age, microbiota, and T cells shape diverse individual IgA repertoires in the intestine J. Exp. Med. 209 2012 365 377
21. M.A. Linterman, A. Liston, and C.G. Vinuesa T-follicular helper cell differentiation and the co-option of this pathway by non-helper cells Immunol. Rev. 247 2012 143 159
22. N.Y. Lycke, and M. Bemark The role of Peyer's patches in synchronizing gut IgA responses Front Immunol 3 2012 329
23. N.J. Mantis, N. Rol, and B. Corthésy Secretory IgA's complex roles in immunity and mucosal homeostasis in the gut Mucosal Immunol. 4 2011 603 611
24. S.K. Mazmanian, C.H. Liu, A.O. Tzianabos, and D.L. Kasper An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system Cell 122 2005 107 118
25. M. McFall-Ngai, M.G. Hadfield, T.C. Bosch, H.V. Carey, T. Domazet-Lošo, A.E. Douglas, N. Dubilier, G. Eberl, T. Fukami, and S.F. Gilbert Animals in a bacterial world, a new imperative for the life sciences Proc. Natl. Acad. Sci. USA 110 2013 3229 3236
26. N.W. Palm, M.R. de Zoete, T.W. Cullen, N.A. Barry, J. Stefanowski, L. Hao, P.H. Degnan, J. Hu, I. Peter, and W. Zhang Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease Cell 158 2014 1000 1010
27. D.H. Parks, and R.G. Beiko Identifying biologically relevant differences between metagenomic communities Bioinformatics 26 2010 715 721
28. D.A. Peterson, N.P. McNulty, J.L. Guruge, and J.I. Gordon IgA response to symbiotic bacteria as a mediator of gut homeostasis Cell Host Microbe 2 2007 328 339
29. C.W. Png, S.K. Lindén, K.S. Gilshenan, E.G. Zoetendal, C.S. McSweeney, L.I. Sly, M.A. McGuckin, and T.H. Florin Mucolytic bacteria with increased prevalence in IBD mucosa augment in vitro utilization of mucin by other bacteria Am. J. Gastroenterol. 105 2010 2420 2428
30. M. Raetz, S.H. Hwang, C.L. Wilhelm, D. Kirkland, A. Benson, C.R. Sturge, J. Mirpuri, S. Vaishnava, B. Hou, and A.L. Defranco Parasite-induced TH1 cells and intestinal dysbiosis cooperate in IFN-γ-dependent elimination of Paneth cells Nat. Immunol. 14 2013 136 142
31. J.M. Reynolds, B.P. Pappu, J. Peng, G.J. Martinez, Y. Zhang, Y. Chung, L. Ma, X.O. Yang, R.I. Nurieva, Q. Tian, and C. Dong Toll-like receptor 2 signaling in CD4(+) T lymphocytes promotes T helper 17 responses and regulates the pathogenesis of autoimmune disease Immunity 32 2010 692 702
32. J.L. Round, and S.K. Mazmanian Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota Proc. Natl. Acad. Sci. USA 107 2010 12204 12209
33. J.L. Round, S.M. Lee, J. Li, G. Tran, B. Jabri, T.A. Chatila, and S.K. Mazmanian The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota Science 332 2011 974 977
34. D. Schenten, S.A. Nish, S. Yu, X. Yan, H.K. Lee, I. Brodsky, L. Pasman, B. Yordy, F.T. Wunderlich, and J.C. Brüning Signaling through the adaptor molecule MyD88 in CD4+ T cells is required to overcome suppression by regulatory T cells Immunity 40 2014 78 90
35. P.D. Schloss, S.L. Westcott, T. Ryabin, J.R. Hall, M. Hartmann, E.B. Hollister, R.A. Lesniewski, B.B. Oakley, D.H. Parks, and C.J. Robinson Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities Appl. Environ. Microbiol. 75 2009 7537 7541
36. Z. Shulman, A.D. Gitlin, S. Targ, M. Jankovic, G. Pasqual, M.C. Nussenzweig, and G.D. Victora T follicular helper cell dynamics in germinal centers Science 341 2013 673 677
37. E. Slack, S. Hapfelmeier, B. Stecher, Y. Velykoredko, M. Stoel, M.A. Lawson, M.B. Geuking, B. Beutler, T.F. Tedder, and W.D. Hardt Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism Science 325 2009 617 620
38. E. Slack, M.L. Balmer, J.H. Fritz, and S. Hapfelmeier Functional flexibility of intestinal IgA - broadening the fine line Front Immunol 3 2012 100
39. W.Z. Stephens, and J.L. Round IgA targets the troublemakers Cell Host Microbe 16 2014 265 267
40. L.A. van der Waaij, F.G. Kroese, A. Visser, G.F. Nelis, B.D. Westerveld, P.L. Jansen, and J.O. Hunter Immunoglobulin coating of faecal bacteria in inflammatory bowel disease Eur. J. Gastroenterol. Hepatol. 16 2004 669 674