Design and synthesis of purine analogues as highly specific ligands for FcyB, a ubiquitous fungal nucleobase transporter

Bioorganic and Medicinal Chemistry

Volumn 24, Issue 22, 2016, Pages 5941-5952

  Lougiakis, Nikolaos ^a   Gavriil, Efthymios Spyridon ^a   Kairis, Markelos ^a   Sioupouli, Georgia ^a   Lambrinidis, George ^a   Benaki, Dimitra ^a   Krypotou, Emilia ^a   Mikros, Emmanuel ^a   Marakos, Panagiotis ^a   Pouli, Nicole ^a   Diallinas, George ^a  

^a UNIVERSITY OF ATHENS   (Greece)

Author keywords

Aspergillus nidulans; Combiglide; Deazaadenine; Imidazo 4,5 c pyridine; Purine transporters; Structure activity relationships

Indexed keywords

AZGA PROTEIN; FCYB PROTEIN; NUCLEOBASE TRANSPORTER; PURINE DERIVATIVE; UNCLASSIFIED DRUG; LIGAND; PURINE;

ARTICLE; CONTROLLED STUDY; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR DYNAMICS; MOLECULAR MODEL; MOLECULAR RECOGNITION; NONHUMAN; PHYSICAL CHEMISTRY; PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; THEORETICAL MODEL; TRANSPORT KINETICS; ANTAGONISTS AND INHIBITORS; ASPERGILLUS NIDULANS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG DESIGN; METABOLISM; MOLECULAR DOCKING; SYNTHESIS;

ASPERGILLUS NIDULANS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; LIGANDS; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; NUCLEOBASE TRANSPORT PROTEINS; PURINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84994045047     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2016.09.055     Document Type: Article

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