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A detailed review focusing on the conformational properties of Lewis blood-group related carbohydrates bound to antibodies and lectins. Also discussed, are the implications of these structural data for the design of improved antibodies and vaccines as targeted cancer immunotherapies.
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Examines the complex biological activities of tumor-targeting antibodies, particularly those recognizing carbohydrate antigens and details how structure–function studies are leading to new opportunities in vaccines for cancer.
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A focused mini-review on the complex biological activities of glycolipid-binding antibodies. Mechanisms of direct antibody action including oncosis are discussed.
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The first crystal structure of a ganglioside-binding antibody in complex with its target glycan headgroup. Structures of Fab-peptide complexes were also determined, but differences between carbohydrate and peptide recognition indicate functional and not structural mimicry by these peptides.
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A comprehensive review of all known structures of carbohydrate-antibodies. The text is conveniently divided into disease areas with a major emphasis on infection (e.g. HIV and bacteria) and cancer, but many useful details of other carbohydrate-binding antibodies and the target glycans are provided.
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