Crystal structure of an anti-ganglioside antibody, and modelling of the functional mimicry of its NeuGc-GM3 antigen by an anti-idiotypic antibody

Molecular Immunology

Volumn 46, Issue 16, 2009, Pages 3466-3475

  Talavera, Ariel ^a,b   Eriksson, Agneta ^b   Ökvist, Mats ^b   López Requena, Alejandro ^a   Fernández Marrero, Yuniel ^a   Pérez, Rolando ^a   Moreno, Ernesto ^a   Krengel, Ute ^b  

^a CENTER OF MOLECULAR IMMUNOLOGY   (Cuba)

^b UNIVERSITY OF OSLO   (Norway)

Author keywords

Anti idiotypic antibody; Anti tumor antibodies; Antigen mimicry; Cancer vaccine; Computer docking; Molecular modelling; NeuGc GM3 ganglioside; Protein carbohydrate interactions; Protein protein complex; X ray crystal structure

Indexed keywords

ANTIIDIOTYPIC ANTIBODY; ARGININE; CANCER VACCINE; GANGLIOSIDE ANTIBODY; GANGLIOSIDE GM3; IMMUNOGLOBULIN F(AB) FRAGMENT; RACOTUMOMAB; SIALIC ACID; TRISACCHARIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBODY STRUCTURE; ARTICLE; BINDING AFFINITY; CANCER IMMUNOTHERAPY; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; DRUG STRUCTURE; HEAVY CHAIN; IMMUNIZATION; MOLECULAR DOCKING; MOLECULAR INTERACTION; MOLECULAR MIMICRY; MOLECULAR MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CARBOHYDRATE INTERACTION; PROTEIN MODIFICATION;

ANIMALS; ANTIBODIES, ANTI-IDIOTYPIC; ANTIBODIES, MONOCLONAL; CANCER VACCINES; CRYSTALLOGRAPHY, X-RAY; G(M3) GANGLIOSIDE; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN HEAVY CHAINS; MODELS, MOLECULAR; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS;

EID: 70349464667     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2009.07.032     Document Type: Article

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