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Volumn 23, Issue 10, 2016, Pages 783-796

Brachyury, a vaccine target, is overexpressed in triple-negative breast cancer

Author keywords

Brachyury; TNBC; Tumor antigen; Vaccine target

Indexed keywords

CANCER VACCINE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; KI 67 ANTIGEN; MESSENGER RNA; NUCLEAR PROTEIN; PROTEIN P53; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR BRACHYURY; UNCLASSIFIED DRUG; BRACHYURY PROTEIN; FETOPROTEIN; T BOX TRANSCRIPTION FACTOR;

EID: 84993939994     PISSN: 13510088     EISSN: 14796821     Source Type: Journal    
DOI: 10.1530/ERC-16-0037     Document Type: Article
Times cited : (28)

References (46)
  • 1
    • 84907033478 scopus 로고    scopus 로고
    • PhenoNet: Identification of key networks associated with disease phenotype
    • Ben-Hamo R, Gidoni M & Efroni S 2014 PhenoNet: identification of key networks associated with disease phenotype. Bioinformatics 30 2399-2405. (doi:10.1093/bioinformatics/btu199)
    • (2014) Bioinformatics , vol.30 , pp. 2399-2405
    • Ben-Hamo, R.1    Gidoni, M.2    Efroni, S.3
  • 3
    • 84877028141 scopus 로고    scopus 로고
    • Comprehensive molecular portraits of human breast tumours
    • Cancer Genome Atlas Network 2012 Comprehensive molecular portraits of human breast tumours. Nature 490 61-70. (doi:10.1038/nature11412)
    • (2012) Nature , vol.490 , pp. 61-70
    • Cancer Genome Atlas Network1
  • 6
    • 84962850014 scopus 로고    scopus 로고
    • MUC1 upregulation promotes immune resistance in tumor cells undergoing brachyury-mediated epithelial-mesenchymal transition
    • David JM, Hamilton DH & Palena C 2016 MUC1 upregulation promotes immune resistance in tumor cells undergoing brachyury-mediated epithelial-mesenchymal transition. Oncoimmunology 5 e1117738. (doi:10.1080/2162402X.2015.1117738)
    • (2016) Oncoimmunology , vol.5 , pp. e1117738
    • David, J.M.1    Hamilton, D.H.2    Palena, C.3
  • 8
    • 84924175796 scopus 로고    scopus 로고
    • Overexpression of brachyury contributes to tumor metastasis by inducing epithelialmesenchymal transition in hepatocellular carcinoma
    • Du R, Wu S, Lv X, Fang H, Wu S & Kang J 2014 Overexpression of brachyury contributes to tumor metastasis by inducing epithelialmesenchymal transition in hepatocellular carcinoma. Journal of Experimental and Clinical Cancer Research 33 105. (doi:10.1186/s13046-014-0105-6)
    • (2014) Journal of Experimental and Clinical Cancer Research , vol.33 , pp. 105
    • Du, R.1    Wu, S.2    Lv, X.3    Fang, H.4    Wu, S.5    Kang, J.6
  • 10
    • 79960952144 scopus 로고    scopus 로고
    • IL-8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cells
    • Fernando RI, Castillo MD, Litzinger M, Hamilton DH & Palena C 2011 IL-8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cells. Cancer Research 71 5296-5306. (doi:10.1158/0008-5472.CAN-11-0156)
    • (2011) Cancer Research , vol.71 , pp. 5296-5306
    • Fernando, R.I.1    Castillo, M.D.2    Litzinger, M.3    Hamilton, D.H.4    Palena, C.5
  • 12
    • 84945542492 scopus 로고    scopus 로고
    • The generation and analyses of a novel combination of recombinant adenovirus vaccines targeting three tumor antigens as an immunotherapeutic
    • Gabitzsch ES, Tsang KY, Palena C, David JM, Fantini M, Kwilas A, Rice AE, Latchman Y, Hodge JW, Gulley JL, et al. 2015 The generation and analyses of a novel combination of recombinant adenovirus vaccines targeting three tumor antigens as an immunotherapeutic. Oncotarget 6 31344-31359. (doi:10.18632/oncotarget.5181)
    • (2015) Oncotarget , vol.6 , pp. 31344-31359
    • Gabitzsch, E.S.1    Tsang, K.Y.2    Palena, C.3    David, J.M.4    Fantini, M.5    Kwilas, A.6    Rice, A.E.7    Latchman, Y.8    Hodge, J.W.9    Gulley, J.L.10
  • 14
    • 33751252276 scopus 로고    scopus 로고
    • Cancer metastasis: Building a framework
    • Gupta GP & Massague J 2006 Cancer metastasis: building a framework. Cell 127 679-695. (doi:10.1016/j.cell.2006.11.001)
    • (2006) Cell , vol.127 , pp. 679-695
    • Gupta, G.P.1    Massague, J.2
  • 17
    • 84900021817 scopus 로고    scopus 로고
    • WEE1 inhibition alleviates resistance to immune attack of tumor cells undergoing epithelial-mesenchymal transition
    • Hamilton DH, Huang B, Fernando RI, Tsang KY & Palena C 2014 WEE1 inhibition alleviates resistance to immune attack of tumor cells undergoing epithelial-mesenchymal transition. Cancer Research 74 2510-2519. (doi:10.1158/0008-5472.CAN-13-1894)
    • (2014) Cancer Research , vol.74 , pp. 2510-2519
    • Hamilton, D.H.1    Huang, B.2    Fernando, R.I.3    Tsang, K.Y.4    Palena, C.5
  • 18
    • 84924955938 scopus 로고    scopus 로고
    • Aberrant expression of the embryonic transcription factor brachyury in human tumors detected with a novel rabbit monoclonal antibody
    • Hamilton DH, Fernando RI, Schlom J & Palena C 2015 Aberrant expression of the embryonic transcription factor brachyury in human tumors detected with a novel rabbit monoclonal antibody. Oncotarget 6 4853-4862. (doi:10.18632/oncotarget.3086)
    • (2015) Oncotarget , vol.6 , pp. 4853-4862
    • Hamilton, D.H.1    Fernando, R.I.2    Schlom, J.3    Palena, C.4
  • 22
    • 84879680963 scopus 로고    scopus 로고
    • The embryonic transcription factor Brachyury blocks cell cycle progression and mediates tumor resistance to conventional antitumor therapies
    • Huang B, Cohen JR, Fernando RI, Hamilton DH, Litzinger MT, Hodge JW & Palena C 2013 The embryonic transcription factor Brachyury blocks cell cycle progression and mediates tumor resistance to conventional antitumor therapies. Cell Death Disease 4 e682. (doi:10.1038/cddis.2013.208)
    • (2013) Cell Death Disease , vol.4 , pp. e682
    • Huang, B.1    Cohen, J.R.2    Fernando, R.I.3    Hamilton, D.H.4    Litzinger, M.T.5    Hodge, J.W.6    Palena, C.7
  • 23
    • 84862820130 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in breast cancer correlates with high histological grade and triple-negative phenotype
    • Jeong H, Ryu YJ, An J, Lee Y & Kim A 2012 Epithelial-mesenchymal transition in breast cancer correlates with high histological grade and triple-negative phenotype. Histopathology 60 E87-95. (doi:10.1111/j.1365-2559.2012.04195.x)
    • (2012) Histopathology , vol.60 , pp. E87-95
    • Jeong, H.1    Ryu, Y.J.2    An, J.3    Lee, Y.4    Kim, A.5
  • 24
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • Kalluri R & Weinberg RA 2009 The basics of epithelial-mesenchymal transition. Journal of Clinical Investigation 119 1420-1428. (doi:10.1172/JCI39104)
    • (2009) Journal of Clinical Investigation , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 26
    • 0029165111 scopus 로고
    • The T protein encoded by Brachyury is a tissue-specific transcription factor
    • Kispert A, Koschorz B & Herrmann BG 1995 The T protein encoded by Brachyury is a tissue-specific transcription factor. EMBO Journal 14 4763-4772.
    • (1995) EMBO Journal , vol.14 , pp. 4763-4772
    • Kispert, A.1    Koschorz, B.2    Herrmann, B.G.3
  • 27
    • 84884524473 scopus 로고    scopus 로고
    • An autocrine loop between TGF-beta1 and the transcription factor brachyury controls the transition of human carcinoma cells into a mesenchymal phenotype
    • Larocca C, Cohen JR, Fernando RI, Huang B, Hamilton DH & Palena C 2013 An autocrine loop between TGF-beta1 and the transcription factor brachyury controls the transition of human carcinoma cells into a mesenchymal phenotype. Molecular Cancer Therapy 12 1805-1815. (doi:10.1158/1535-7163.MCT-12-1007)
    • (2013) Molecular Cancer Therapy , vol.12 , pp. 1805-1815
    • Larocca, C.1    Cohen, J.R.2    Fernando, R.I.3    Huang, B.4    Hamilton, D.H.5    Palena, C.6
  • 29
    • 84941765467 scopus 로고    scopus 로고
    • Nuclear brachyury expression is consistent in chordoma, common in germ cell tumors and small cell carcinomas, and rare in other carcinomas and sarcomas: An immunohistochemical study of 5229 Cases
    • Miettinen M, Wang Z, Lasota J, Heery C, Schlom J & Palena C 2015 Nuclear brachyury expression is consistent in chordoma, common in germ cell tumors and small cell carcinomas, and rare in other carcinomas and sarcomas: an immunohistochemical study of 5229 Cases. American Journal of Surgical Pathology 39 1305-1312. (doi:10.1097/PAS.0000000000000462)
    • (2015) American Journal of Surgical Pathology , vol.39 , pp. 1305-1312
    • Miettinen, M.1    Wang, Z.2    Lasota, J.3    Heery, C.4    Schlom, J.5    Palena, C.6
  • 31
    • 84952714993 scopus 로고    scopus 로고
    • Immune targeting of tumor epithelialmesenchymal transition via brachyury-based vaccines
    • Palena C & Hamilton DH 2015 Immune targeting of tumor epithelialmesenchymal transition via brachyury-based vaccines. Advances in Cancer Research 128 69-93. (doi:10.1016/bs.acr.2015.04.001)
    • (2015) Advances in Cancer Research , vol.128 , pp. 69-93
    • Palena, C.1    Hamilton, D.H.2
  • 33
    • 84863707423 scopus 로고    scopus 로고
    • Influence of IL-8 on the epithelial-mesenchymal transition and the tumor microenvironment
    • Palena C, Hamilton DH & Fernando RI 2012 Influence of IL-8 on the epithelial-mesenchymal transition and the tumor microenvironment. Future Oncology 8 713-722. (doi:10.2217/fon.12.59)
    • (2012) Future Oncology , vol.8 , pp. 713-722
    • Palena, C.1    Hamilton, D.H.2    Fernando, R.I.3
  • 34
    • 84899099742 scopus 로고    scopus 로고
    • An immunotherapeutic intervention against tumor progression: Targeting a driver of the epithelial-to-mesenchymal transition
    • Palena C, Fernando RI & Hamilton DH 2014a An immunotherapeutic intervention against tumor progression: targeting a driver of the epithelial-to-mesenchymal transition. Oncoimmunology 3 e27220. (doi:10.4161/onci.27220)
    • (2014) Oncoimmunology , vol.3 , pp. e27220
    • Palena, C.1    Fernando, R.I.2    Hamilton, D.H.3
  • 40
    • 84865125800 scopus 로고    scopus 로고
    • PAM50 assay and the threegene model for identifying the major and clinically relevant molecular subtypes of breast cancer
    • Prat A, Parker JS, Fan C & Perou CM 2012 PAM50 assay and the threegene model for identifying the major and clinically relevant molecular subtypes of breast cancer. Breast Cancer Research Treatment 135 301-306. (doi:10.1007/s10549-012-2143-0)
    • (2012) Breast Cancer Research Treatment , vol.135 , pp. 301-306
    • Prat, A.1    Parker, J.S.2    Fan, C.3    Perou, C.M.4
  • 41
    • 37248999372 scopus 로고    scopus 로고
    • Triple negative tumours: A critical review
    • Reis-Filho JS & Tutt AN 2008 Triple negative tumours: A critical review. Histopathology 52 108-118. (doi:10.1111/j.1365-2559.2007.02889.x)
    • (2008) Histopathology , vol.52 , pp. 108-118
    • Reis-Filho, J.S.1    Tutt, A.N.2
  • 45
    • 84946574127 scopus 로고    scopus 로고
    • The potential role of Brachyury in inducing epithelial-to-mesenchymal transition (EMT) and HIF-1alpha expression in breast cancer cells
    • Shao C, Zhang J, Fu J & Ling F 2015 The potential role of Brachyury in inducing epithelial-to-mesenchymal transition (EMT) and HIF-1alpha expression in breast cancer cells. Biochemical and Biophysical Research Communications 467 1083-1089. (doi:10.1016/j. bbrc.2015.09.076)
    • (2015) Biochemical and Biophysical Research Communications , vol.467 , pp. 1083-1089
    • Shao, C.1    Zhang, J.2    Fu, J.3    Ling, F.4
  • 46
    • 33244463813 scopus 로고    scopus 로고
    • Complex networks orchestrate epithelialmesenchymal transitions
    • Thiery JP & Sleeman JP 2006 Complex networks orchestrate epithelialmesenchymal transitions. Nature Review Molecular Cell Biology 7 131-142. (doi:10.1038/nrm1835)
    • (2006) Nature Review Molecular Cell Biology , vol.7 , pp. 131-142
    • Thiery, J.P.1    Sleeman, J.P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.