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Volumn 4, Issue 1, 2013, Pages 59-72

Factor VIII inhibitors in hemophilia A: Rationale and latest evidence

Author keywords

FVIII; FVIII alloantibodies; hemophilia A; immune tolerance; inhibitors; risk factors

Indexed keywords

ACTIVATED PROTHROMBIN COMPLEX; BLOOD CLOTTING FACTOR 8 INHIBITOR; BLOOD CLOTTING FACTOR 8 PLUS VON WILLEBRAND FACTOR; CYTOKINE; IMMUNOLOGIC FACTOR; INTERLEUKIN DERIVATIVE; RECOMBINANT BLOOD CLOTTING FACTOR 7A; RECOMBINANT BLOOD CLOTTING FACTOR 8; RITUXIMAB; TUMOR NECROSIS FACTOR ALPHA;

EID: 84993661361     PISSN: 20406207     EISSN: 20406215     Source Type: Journal    
DOI: 10.1177/2040620712464509     Document Type: Article
Times cited : (175)

References (119)
  • 1
    • 0027257566 scopus 로고
    • Frequency of inhibitor development in haemophiliacs treated with low-purity factor VIII
    • Addiego J. Kasper C. Abildgaard C. Hilgartner M. Lusher J. Glader B. et al. (1993) Frequency of inhibitor development in haemophiliacs treated with low-purity factor VIII. Lancet 342: 462–464.
    • (1993) Lancet , vol.342 , pp. 462-464
    • Addiego, J.1    Kasper, C.2    Abildgaard, C.3    Hilgartner, M.4    Lusher, J.5    Glader, B.6
  • 2
    • 0031598278 scopus 로고    scopus 로고
    • Inhibitors occur more frequently in African-American and Latino haemophiliacs
    • Aledort L. Dimichele D. (1998) Inhibitors occur more frequently in African-American and Latino haemophiliacs. Haemophilia 4: 68.
    • (1998) Haemophilia , vol.4 , pp. 68
    • Aledort, L.1    Dimichele, D.2
  • 3
    • 33646140127 scopus 로고    scopus 로고
    • Why do inhibitors develop? Principles of and factors influencing the risk for inhibitor development in haemophilia
    • Astermark J. (2006) Why do inhibitors develop? Principles of and factors influencing the risk for inhibitor development in haemophilia. Haemophilia 12(Suppl. 3): 52–60.
    • (2006) Haemophilia , vol.12 , pp. 52-60
    • Astermark, J.1
  • 4
    • 6644227418 scopus 로고    scopus 로고
    • The Malmo International Brother Study (MIBS): further support for genetic predisposition to inhibitor development in hemophilia patients
    • Astermark J. Berntorp E. White G. Kroner B. (2001) The Malmo International Brother Study (MIBS): further support for genetic predisposition to inhibitor development in hemophilia patients. Haemophilia 7: 267–272.
    • (2001) Haemophilia , vol.7 , pp. 267-272
    • Astermark, J.1    Berntorp, E.2    White, G.3    Kroner, B.4
  • 5
    • 33846185403 scopus 로고    scopus 로고
    • A randomized comparison of bypassing agents in hemophilia complicated by an inhibitor: the FEIBA NovoSeven Comparative (FENOC) Study
    • Astermark J. Donfield S. Di Michele D. Gringeri A. Gilbert S. Waters J. et al. (2007) A randomized comparison of bypassing agents in hemophilia complicated by an inhibitor: the FEIBA NovoSeven Comparative (FENOC) Study. Blood 109: 546–551.
    • (2007) Blood , vol.109 , pp. 546-551
    • Astermark, J.1    Donfield, S.2    Di Michele, D.3    Gringeri, A.4    Gilbert, S.5    Waters, J.6
  • 6
    • 33845239946 scopus 로고    scopus 로고
    • Polymorphisms in the TNFA gene and the risk of inhibitor development in patients with hemophilia A
    • Astermark J. Oldenburg J. Carlson J. Pavlova A. Kavakli K. Berntorp E. et al. (2006 a) Polymorphisms in the TNFA gene and the risk of inhibitor development in patients with hemophilia A. Blood 108: 3739–3745.
    • (2006) Blood , vol.108 , pp. 3739-3745
    • Astermark, J.1    Oldenburg, J.2    Carlson, J.3    Pavlova, A.4    Kavakli, K.5    Berntorp, E.6
  • 7
    • 33645751563 scopus 로고    scopus 로고
    • Polymorphisms in the IL 10 but not in the IL 1 beta and IL 4 genes are associated with inhibitor development in patients with hemophilia A
    • Astermark J. Oldenburg J. Pavlova A. Berntorp E. Lefvert A. (2006 b) Polymorphisms in the IL 10 but not in the IL 1 beta and IL 4 genes are associated with inhibitor development in patients with hemophilia A. Blood 107: 3167–3172.
    • (2006) Blood , vol.107 , pp. 3167-3172
    • Astermark, J.1    Oldenburg, J.2    Pavlova, A.3    Berntorp, E.4    Lefvert, A.5
  • 8
    • 77953557014 scopus 로고    scopus 로고
    • Polymorphisms in genes involved in autoimmune disease and the risk of FVIII inhibitor development in Italian patients with haemophilia A
    • Bafunno V. Santacroce R. Chetta M. D'Andrea G. Pisanelli D. Sessa F. et al. (2010) Polymorphisms in genes involved in autoimmune disease and the risk of FVIII inhibitor development in Italian patients with haemophilia A. Haemophilia 16: 469–473.
    • (2010) Haemophilia , vol.16 , pp. 469-473
    • Bafunno, V.1    Santacroce, R.2    Chetta, M.3    D'Andrea, G.4    Pisanelli, D.5    Sessa, F.6
  • 9
    • 0033678464 scopus 로고    scopus 로고
    • Immune tolerance induction and the treatment of hemophilia. Malmo protocol update
    • discussion 50-51.
    • Berntorp E. Astermark J. Carlborg E. (2000) Immune tolerance induction and the treatment of hemophilia. Malmo protocol update. Haematologica 85(10 Suppl.): 48–50; discussion 50-51.
    • (2000) Haematologica , vol.85 , Issue.10 Suppl. , pp. 48-50
    • Berntorp, E.1    Astermark, J.2    Carlborg, E.3
  • 10
    • 0028266130 scopus 로고
    • A multicenter study of recombinant factor VIII (recombinate): safety, efficacy, and inhibitor risk in previously untreated patients with hemophilia A. The Recombinate Study Group
    • Bray G. Gomperts E. Courter S. Gruppo R. Gordon E. Manco-Johnson M. et al. (1994) A multicenter study of recombinant factor VIII (recombinate): safety, efficacy, and inhibitor risk in previously untreated patients with hemophilia A. The Recombinate Study Group. Blood 83: 2428–2435.
    • (1994) Blood , vol.83 , pp. 2428-2435
    • Bray, G.1    Gomperts, E.2    Courter, S.3    Gruppo, R.4    Gordon, E.5    Manco-Johnson, M.6
  • 11
    • 4844221200 scopus 로고    scopus 로고
    • HLA class II genotype and factor VIII inhibitors in mild haemophilia A patients with an Arg 593 to Cys mutation
    • Bril W. MacLean P. Kaijen P. van den Brink E. Lardy N. Fijnvandraat K. et al. (2004) HLA class II genotype and factor VIII inhibitors in mild haemophilia A patients with an Arg 593 to Cys mutation. Haemophilia 10: 509–514.
    • (2004) Haemophilia , vol.10 , pp. 509-514
    • Bril, W.1    MacLean, P.2    Kaijen, P.3    van den Brink, E.4    Lardy, N.5    Fijnvandraat, K.6
  • 12
    • 67649884757 scopus 로고    scopus 로고
    • Health-related quality of life and productivity impact in haemophilia patients with inhibitors
    • Brown T. Lee W. Joshi A. Pashos C. (2009) Health-related quality of life and productivity impact in haemophilia patients with inhibitors. Haemophilia 15: 911–917.
    • (2009) Haemophilia , vol.15 , pp. 911-917
    • Brown, T.1    Lee, W.2    Joshi, A.3    Pashos, C.4
  • 13
    • 0018189532 scopus 로고
    • Use of prothrombin complex concentrates in hemophiliacs with inhibitors: clinical and laboratory studies
    • Buchanan G. Kevy S. (1978) Use of prothrombin complex concentrates in hemophiliacs with inhibitors: clinical and laboratory studies. Pediatrics 62: 767–774.
    • (1978) Pediatrics , vol.62 , pp. 767-774
    • Buchanan, G.1    Kevy, S.2
  • 14
    • 84860351786 scopus 로고    scopus 로고
    • Increased prevalence of inhibitors in Hispanic patients with severe haemophilia A enrolled in the Universal Data Collection database
    • Carpenter S. Michael Soucie J. Sterner S. Presley R. (2012) Increased prevalence of inhibitors in Hispanic patients with severe haemophilia A enrolled in the Universal Data Collection database. Haemophilia 18: e260–e265.
    • (2012) Haemophilia , vol.18 , pp. e260-e265
    • Carpenter, S.1    Michael Soucie, J.2    Sterner, S.3    Presley, R.4
  • 15
    • 33846922841 scopus 로고    scopus 로고
    • Early factor VIII exposure and subsequent inhibitor development in children with severe haemophilia A
    • Chalmers E. Brown S. Keeling D. Liesner R. Richards M. Stirling D. et al. (2007) Early factor VIII exposure and subsequent inhibitor development in children with severe haemophilia A. Haemophilia 13: 149–155.
    • (2007) Haemophilia , vol.13 , pp. 149-155
    • Chalmers, E.1    Brown, S.2    Keeling, D.3    Liesner, R.4    Richards, M.5    Stirling, D.6
  • 16
    • 70449416200 scopus 로고    scopus 로고
    • Factor VIII gene (F8) mutations as predictors of outcome in immune tolerance induction of hemophilia A patients with high-responding inhibitors
    • Coppola A. Margaglione M. Santagostino E. Rocino A. Grandone E. Mannucci P. et al. (2009) Factor VIII gene (F8) mutations as predictors of outcome in immune tolerance induction of hemophilia A patients with high-responding inhibitors. J Thromb Haemost 7: 1809–1815.
    • (2009) J Thromb Haemost , vol.7 , pp. 1809-1815
    • Coppola, A.1    Margaglione, M.2    Santagostino, E.3    Rocino, A.4    Grandone, E.5    Mannucci, P.6
  • 17
    • 9144271883 scopus 로고    scopus 로고
    • The incidence of factor VIII and factor IX inhibitors in the hemophilia population of the UK and their effect on subsequent mortality, 1977-99
    • Darby S. Keeling D. Spooner R. Wan Kan S. Giangrande P. Collins P. et al. (2004) The incidence of factor VIII and factor IX inhibitors in the hemophilia population of the UK and their effect on subsequent mortality, 1977-99. J Thromb Haemost 2: 1047–1054.
    • (2004) J Thromb Haemost , vol.2 , pp. 1047-1054
    • Darby, S.1    Keeling, D.2    Spooner, R.3    Wan Kan, S.4    Giangrande, P.5    Collins, P.6
  • 18
    • 33846244931 scopus 로고    scopus 로고
    • VWF protects FVIII from endocytosis by dendritic cells and subsequent presentation to immune effectors
    • Dasgupta S. Repesse Y. Bayry J. Navarrete A. Wootla B. Delignat S. et al. (2007) VWF protects FVIII from endocytosis by dendritic cells and subsequent presentation to immune effectors. Blood 109: 610–612.
    • (2007) Blood , vol.109 , pp. 610-612
    • Dasgupta, S.1    Repesse, Y.2    Bayry, J.3    Navarrete, A.4    Wootla, B.5    Delignat, S.6
  • 19
    • 0029887497 scopus 로고    scopus 로고
    • High incidence of anti-FVIII antibodies against non-coagulant epitopes in haemophilia A patients: a possible role for the half-life of transfused FVIII
    • Dazzi F. Tison T. Vianello F. Radossi P. Zerbinati P. Carraro P. et al. (1996) High incidence of anti-FVIII antibodies against non-coagulant epitopes in haemophilia A patients: a possible role for the half-life of transfused FVIII. Br J Haematol 93: 688–693.
    • (1996) Br J Haematol , vol.93 , pp. 688-693
    • Dazzi, F.1    Tison, T.2    Vianello, F.3    Radossi, P.4    Zerbinati, P.5    Carraro, P.6
  • 20
    • 63049130236 scopus 로고    scopus 로고
    • The North American Immune Tolerance Registry: contributions to the thirty-year experience with immune tolerance therapy
    • Dimichele D. (2009) The North American Immune Tolerance Registry: contributions to the thirty-year experience with immune tolerance therapy. Haemophilia 15: 320–328.
    • (2009) Haemophilia , vol.15 , pp. 320-328
    • Dimichele, D.1
  • 22
    • 67650886236 scopus 로고    scopus 로고
    • Inhibitors of factor VIII in hemophilia
    • author reply 310.
    • Eckhardt C. Kamphuisen P. Fijnvandraat K. (2009 a) Inhibitors of factor VIII in hemophilia. N Engl J Med 361: 309; author reply 310.
    • (2009) N Engl J Med , vol.361 , pp. 309
    • Eckhardt, C.1    Kamphuisen, P.2    Fijnvandraat, K.3
  • 23
    • 65849180700 scopus 로고    scopus 로고
    • Intensive peri-operative use of factor VIII and the Arg593-->Cys mutation are risk factors for inhibitor development in mild / moderate hemophilia A
    • Eckhardt C. Menke L. van Ommen C. van der Lee J. Geskus R. Kamphuisen P. et al. (2009 b) Intensive peri-operative use of factor VIII and the Arg593-->Cys mutation are risk factors for inhibitor development in mild / moderate hemophilia A. J Thromb Haemost 7: 930–937.
    • (2009) J Thromb Haemost , vol.7 , pp. 930-937
    • Eckhardt, C.1    Menke, L.2    van Ommen, C.3    van der Lee, J.4    Geskus, R.5    Kamphuisen, P.6
  • 24
    • 0026548917 scopus 로고
    • Incidence of development of factor VIII and factor IX inhibitors in haemophiliacs
    • Ehrenforth S. Kreuz W. Scharrer I. Linde R. Funk M. Gungor T. et al. (1992) Incidence of development of factor VIII and factor IX inhibitors in haemophiliacs. Lancet 339: 594–598.
    • (1992) Lancet , vol.339 , pp. 594-598
    • Ehrenforth, S.1    Kreuz, W.2    Scharrer, I.3    Linde, R.4    Funk, M.5    Gungor, T.6
  • 26
    • 82955162691 scopus 로고    scopus 로고
    • Immune tolerance induction for patients with severe hemophilia A: a critical literature review
    • Franchini M. Lippi G. (2011) Immune tolerance induction for patients with severe hemophilia A: a critical literature review. J Thromb Thrombolysis 32: 439–447.
    • (2011) J Thromb Thrombolysis , vol.32 , pp. 439-447
    • Franchini, M.1    Lippi, G.2
  • 27
    • 51249104017 scopus 로고    scopus 로고
    • Immune tolerance with rituximab in congenital haemophilia with inhibitors: a systematic literature review based on individual patients’ analysis
    • Franchini M. Mengoli C. Lippi G. Targher G. Montagnana M. Salvagno G. et al. (2008) Immune tolerance with rituximab in congenital haemophilia with inhibitors: a systematic literature review based on individual patients’ analysis. Haemophilia 14: 903–912.
    • (2008) Haemophilia , vol.14 , pp. 903-912
    • Franchini, M.1    Mengoli, C.2    Lippi, G.3    Targher, G.4    Montagnana, M.5    Salvagno, G.6
  • 28
    • 84855912746 scopus 로고    scopus 로고
    • Cumulative inhibitor incidence in previously untreated patients with severe hemophilia A treated with plasma-derived versus recombinant factor VIII concentrates: a critical systematic review
    • Franchini M. Tagliaferri A. Mengoli C. Cruciani M. (2012) Cumulative inhibitor incidence in previously untreated patients with severe hemophilia A treated with plasma-derived versus recombinant factor VIII concentrates: a critical systematic review. Crit Rev Oncol Hematol 81: 82–93.
    • (2012) Crit Rev Oncol Hematol , vol.81 , pp. 82-93
    • Franchini, M.1    Tagliaferri, A.2    Mengoli, C.3    Cruciani, M.4
  • 30
    • 0023274159 scopus 로고
    • FVIII inhibitor IgG subclass and FVIII polypeptide specificity determined by immunoblotting
    • Fulcher C. de Graaf Mahoney S. Zimmerman T. (1987) FVIII inhibitor IgG subclass and FVIII polypeptide specificity determined by immunoblotting. Blood 69: 1475–1480.
    • (1987) Blood , vol.69 , pp. 1475-1480
    • Fulcher, C.1    de Graaf Mahoney, S.2    Zimmerman, T.3
  • 31
    • 0023685204 scopus 로고
    • Immunoblot analysis shows changes in factor VIII inhibitor chain specificity in factor VIII inhibitor patients over time
    • Fulcher C. Lechner K. de Graaf Mahoney S. (1988) Immunoblot analysis shows changes in factor VIII inhibitor chain specificity in factor VIII inhibitor patients over time. Blood 72: 1348–1356.
    • (1988) Blood , vol.72 , pp. 1348-1356
    • Fulcher, C.1    Lechner, K.2    de Graaf Mahoney, S.3
  • 32
    • 0035139983 scopus 로고    scopus 로고
    • Danger signals: SOS to the immune system
    • Gallucci S. Matzinger P. (2001) Danger signals: SOS to the immune system. Curr Opin Immunol 13: 114–119.
    • (2001) Curr Opin Immunol , vol.13 , pp. 114-119
    • Gallucci, S.1    Matzinger, P.2
  • 33
    • 18344405441 scopus 로고    scopus 로고
    • A detailed comparison of the performance of the standard versus the Nijmegen modification of the Bethesda assay in detecting factor VIII:C inhibitors in the haemophilia A population of Canada. Association of Hemophilia Centre Directors of Canada. Factor VIII / IX Subcommittee of Scientific and Standardization Committee of International Society on Thrombosis and Haemostasis
    • Giles A. Verbruggen B. Rivard G. Teitel J. Walker I. (1998) A detailed comparison of the performance of the standard versus the Nijmegen modification of the Bethesda assay in detecting factor VIII:C inhibitors in the haemophilia A population of Canada. Association of Hemophilia Centre Directors of Canada. Factor VIII / IX Subcommittee of Scientific and Standardization Committee of International Society on Thrombosis and Haemostasis. Thromb Haemost 79: 872–875.
    • (1998) Thromb Haemost , vol.79 , pp. 872-875
    • Giles, A.1    Verbruggen, B.2    Rivard, G.3    Teitel, J.4    Walker, I.5
  • 34
    • 0027488655 scopus 로고
    • Anti-factor VIII antibodies of hemophiliac patients are frequently directed towards nonfunctional determinants and do not exhibit isotypic restriction
    • Gilles J. Arnout J. Vermylen J. Saint-Remy J. (1993) Anti-factor VIII antibodies of hemophiliac patients are frequently directed towards nonfunctional determinants and do not exhibit isotypic restriction. Blood 82: 2452–2461.
    • (1993) Blood , vol.82 , pp. 2452-2461
    • Gilles, J.1    Arnout, J.2    Vermylen, J.3    Saint-Remy, J.4
  • 35
    • 34250708408 scopus 로고    scopus 로고
    • Treatment characteristics and the risk of inhibitor development: a multicenter cohort study among previously untreated patients with severe hemophilia A
    • Gouw S. van den Berg H. Le Cessie S. van der Bom J. (2007 a) Treatment characteristics and the risk of inhibitor development: a multicenter cohort study among previously untreated patients with severe hemophilia A. J Thromb Haemost 5: 1383–1390.
    • (2007) J Thromb Haemost , vol.5 , pp. 1383-1390
    • Gouw, S.1    van den Berg, H.2    Le Cessie, S.3    van der Bom, J.4
  • 36
    • 84863419863 scopus 로고    scopus 로고
    • F 8 gene mutation type and inhibitor development in patients with severe hemophilia A: systematic review and meta-analysis
    • Gouw S. van den Berg H. Oldenburg J. Astermark J. de Groot P. Margaglione M. et al. (2012) F 8 gene mutation type and inhibitor development in patients with severe hemophilia A: systematic review and meta-analysis. Blood 119: 2922–2934.
    • (2012) Blood , vol.119 , pp. 2922-2934
    • Gouw, S.1    van den Berg, H.2    Oldenburg, J.3    Astermark, J.4    de Groot, P.5    Margaglione, M.6
  • 37
    • 34249690732 scopus 로고    scopus 로고
    • Treatment-related risk factors of inhibitor development in previously untreated patients with hemophilia A: the CANAL cohort study
    • Gouw S. van der Bom J. Marijke van den Berg H. (2007 b) Treatment-related risk factors of inhibitor development in previously untreated patients with hemophilia A: the CANAL cohort study. Blood 109: 4648–4654.
    • (2007) Blood , vol.109 , pp. 4648-4654
    • Gouw, S.1    van der Bom, J.2    Marijke van den Berg, H.3
  • 39
    • 37149006720 scopus 로고    scopus 로고
    • VWF / FVIII concentrates in high-risk immunotolerance: the RESIST study
    • Gringeri A. (2007) VWF / FVIII concentrates in high-risk immunotolerance: the RESIST study. Haemophilia 13(Suppl. 5): 73–77.
    • (2007) Haemophilia , vol.13 , pp. 73-77
    • Gringeri, A.1
  • 40
    • 79959509081 scopus 로고    scopus 로고
    • Sequential combined bypassing therapy is safe and effective in the treatment of unresponsive bleeding in adults and children with haemophilia and inhibitors
    • Gringeri A. Fischer K. Karafoulidou A. Klamroth R. Lopez-Fernandez M. Mancuso E. (2011 a) Sequential combined bypassing therapy is safe and effective in the treatment of unresponsive bleeding in adults and children with haemophilia and inhibitors. Haemophilia 17: 630–635.
    • (2011) Haemophilia , vol.17 , pp. 630-635
    • Gringeri, A.1    Fischer, K.2    Karafoulidou, A.3    Klamroth, R.4    Lopez-Fernandez, M.5    Mancuso, E.6
  • 41
    • 79953306825 scopus 로고    scopus 로고
    • A randomized clinical trial of prophylaxis in children with hemophilia A (the ESPRIT Study)
    • Gringeri A. Lundin B. von Mackensen S. Mantovani L. Mannucci P. (2011 b) A randomized clinical trial of prophylaxis in children with hemophilia A (the ESPRIT Study). J Thromb Haemost 9: 700–710.
    • (2011) J Thromb Haemost , vol.9 , pp. 700-710
    • Gringeri, A.1    Lundin, B.2    von Mackensen, S.3    Mantovani, L.4    Mannucci, P.5
  • 42
    • 0141482007 scopus 로고    scopus 로고
    • Cost of care and quality of life for patients with hemophilia complicated by inhibitors: the COCIS Study Group
    • Gringeri A. Mantovani L. Scalone L. Mannucci P. (2003) Cost of care and quality of life for patients with hemophilia complicated by inhibitors: the COCIS Study Group. Blood 102: 2358–2363.
    • (2003) Blood , vol.102 , pp. 2358-2363
    • Gringeri, A.1    Mantovani, L.2    Scalone, L.3    Mannucci, P.4
  • 43
    • 84856866914 scopus 로고    scopus 로고
    • The principal results of the International Immune Tolerance Study: a randomized dose comparison
    • Hay C. Di Michele D. (2012) The principal results of the International Immune Tolerance Study: a randomized dose comparison. Blood 119: 1335–1344.
    • (2012) Blood , vol.119 , pp. 1335-1344
    • Hay, C.1    Di Michele, D.2
  • 44
    • 0031958313 scopus 로고    scopus 로고
    • Factor VIII inhibitors in mild and moderate-severity haemophilia A. UK Haemophilia Centre Directors Organisation
    • Hay C. Ludlam C. Colvin B. Hill F. Preston F. Wasseem N. et al. (1998) Factor VIII inhibitors in mild and moderate-severity haemophilia A. UK Haemophilia Centre Directors Organisation. Thromb Haemost 79: 762–766.
    • (1998) Thromb Haemost , vol.79 , pp. 762-766
    • Hay, C.1    Ludlam, C.2    Colvin, B.3    Hill, F.4    Preston, F.5    Wasseem, N.6
  • 45
    • 0031057651 scopus 로고    scopus 로고
    • HLA class II profile: a weak determinant of factor VIII inhibitor development in severe haemophilia A. UKHCDO Inhibitor Working Party
    • Hay C. Ollier W. Pepper L. Cumming A. Keeney S. Goodeve A. et al. (1997) HLA class II profile: a weak determinant of factor VIII inhibitor development in severe haemophilia A. UKHCDO Inhibitor Working Party. Thromb Haemost 77: 234–237.
    • (1997) Thromb Haemost , vol.77 , pp. 234-237
    • Hay, C.1    Ollier, W.2    Pepper, L.3    Cumming, A.4    Keeney, S.5    Goodeve, A.6
  • 46
    • 79959486802 scopus 로고    scopus 로고
    • Incidence of factor VIII inhibitors throughout life in severe hemophilia A in the United Kingdom
    • Hay C. Palmer B. Chalmers E. Liesner R. Maclean R. Rangarajan S. et al. (2011) Incidence of factor VIII inhibitors throughout life in severe hemophilia A in the United Kingdom. Blood 117: 6367–6370.
    • (2011) Blood , vol.117 , pp. 6367-6370
    • Hay, C.1    Palmer, B.2    Chalmers, E.3    Liesner, R.4    Maclean, R.5    Rangarajan, S.6
  • 47
    • 0035082871 scopus 로고    scopus 로고
    • Immune tolerance treatment in haemophilia patients with inhibitors: the Spanish Registry
    • Haya S. Lopez M. Aznar J. Batlle J. (2001) Immune tolerance treatment in haemophilia patients with inhibitors: the Spanish Registry. Haemophilia 7: 154–159.
    • (2001) Haemophilia , vol.7 , pp. 154-159
    • Haya, S.1    Lopez, M.2    Aznar, J.3    Batlle, J.4
  • 48
    • 0020662181 scopus 로고
    • The use of factor eight inhibitor by-passing activity (FEIBA immuno) product for treatment of bleeding episodes in hemophiliacs with inhibitors
    • Hilgartner M. Knatterud G. (1983) The use of factor eight inhibitor by-passing activity (FEIBA immuno) product for treatment of bleeding episodes in hemophiliacs with inhibitors. Blood 61: 36–40.
    • (1983) Blood , vol.61 , pp. 36-40
    • Hilgartner, M.1    Knatterud, G.2
  • 49
    • 0026733430 scopus 로고
    • Comparative study of the sugar chains of factor VIII purified from human plasma and from the culture media of recombinant baby hamster kidney cells
    • Hironaka T. Furukawa K. Esmon P. Fournel M. Sawada S. Kato M. et al. (1992) Comparative study of the sugar chains of factor VIII purified from human plasma and from the culture media of recombinant baby hamster kidney cells. J Biol Chem 267: 8012–8020.
    • (1992) J Biol Chem , vol.267 , pp. 8012-8020
    • Hironaka, T.1    Furukawa, K.2    Esmon, P.3    Fournel, M.4    Sawada, S.5    Kato, M.6
  • 50
    • 43149116111 scopus 로고    scopus 로고
    • Secondary prophylaxis with recombinant activated factor VII improves health-related quality of life of haemophilia patients with inhibitors
    • Hoots W. Ebbesen L. Konkle B. Auerswald G. Roberts H. Weatherall J. et al. (2008) Secondary prophylaxis with recombinant activated factor VII improves health-related quality of life of haemophilia patients with inhibitors. Haemophilia 14: 466–475.
    • (2008) Haemophilia , vol.14 , pp. 466-475
    • Hoots, W.1    Ebbesen, L.2    Konkle, B.3    Auerswald, G.4    Roberts, H.5    Weatherall, J.6
  • 51
    • 80053570793 scopus 로고    scopus 로고
    • Parallel use of by-passing agents in haemophilia with inhibitors: a critical review
    • Ingerslev J. Sorensen B. (2011) Parallel use of by-passing agents in haemophilia with inhibitors: a critical review. Br J Haematol 155: 256–262.
    • (2011) Br J Haematol , vol.155 , pp. 256-262
    • Ingerslev, J.1    Sorensen, B.2
  • 52
    • 77954506432 scopus 로고    scopus 로고
    • Rate of inhibitor development in previously untreated hemophilia A patients treated with plasma-derived or recombinant factor VIII concentrates: a systematic review
    • Iorio A. Halimeh S. Holzhauer S. Goldenberg N. Marchesini E. Marcucci M. et al. (2010) Rate of inhibitor development in previously untreated hemophilia A patients treated with plasma-derived or recombinant factor VIII concentrates: a systematic review. J Thromb Haemost 8: 1256–1265.
    • (2010) J Thromb Haemost , vol.8 , pp. 1256-1265
    • Iorio, A.1    Halimeh, S.2    Holzhauer, S.3    Goldenberg, N.4    Marchesini, E.5    Marcucci, M.6
  • 54
    • 84865571944 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of OBI-1, a recombinant B domain-deleted porcine factor VIII, in subjects with haemophilia A
    • Kempton C. Abshire T. Deveras R. Hoots W. Gill J. Kessler C. et al. (2012) Pharmacokinetics and safety of OBI-1, a recombinant B domain-deleted porcine factor VIII, in subjects with haemophilia A. Haemophilia 18: 798–804.
    • (2012) Haemophilia , vol.18 , pp. 798-804
    • Kempton, C.1    Abshire, T.2    Deveras, R.3    Hoots, W.4    Gill, J.5    Kessler, C.6
  • 55
    • 78649367398 scopus 로고    scopus 로고
    • In non-severe hemophilia A the risk of inhibitor after intensive factor treatment is greater in older patients: a case-control study
    • Kempton C. Soucie J. Miller C. Hooper C. Escobar M. Cohen A. et al. (2010) In non-severe hemophilia A the risk of inhibitor after intensive factor treatment is greater in older patients: a case-control study. J Thromb Haemost 8: 2224–2231.
    • (2010) J Thromb Haemost , vol.8 , pp. 2224-2231
    • Kempton, C.1    Soucie, J.2    Miller, C.3    Hooper, C.4    Escobar, M.5    Cohen, A.6
  • 56
    • 59449097322 scopus 로고    scopus 로고
    • How we treat a hemophilia A patient with a factor VIII inhibitor
    • Kempton C. White G. (2009) How we treat a hemophilia A patient with a factor VIII inhibitor. Blood 113: 11–17.
    • (2009) Blood , vol.113 , pp. 11-17
    • Kempton, C.1    White, G.2
  • 57
    • 34548096392 scopus 로고    scopus 로고
    • Randomized, prospective clinical trial of recombinant factor VIIa for secondary prophylaxis in hemophilia patients with inhibitors
    • Konkle B. Ebbesen L. Erhardtsen E. Bianco R. Lissitchkov T. Rusen L. et al. (2007) Randomized, prospective clinical trial of recombinant factor VIIa for secondary prophylaxis in hemophilia patients with inhibitors. J Thromb Haemost 5: 1904–1913.
    • (2007) J Thromb Haemost , vol.5 , pp. 1904-1913
    • Konkle, B.1    Ebbesen, L.2    Erhardtsen, E.3    Bianco, R.4    Lissitchkov, T.5    Rusen, L.6
  • 58
    • 41149118513 scopus 로고    scopus 로고
    • How dying cells alert the immune system to danger
    • Kono H. Rock K. (2008) How dying cells alert the immune system to danger. Nat Rev Immunol 8: 279–289.
    • (2008) Nat Rev Immunol , vol.8 , pp. 279-289
    • Kono, H.1    Rock, K.2
  • 59
    • 0032882450 scopus 로고    scopus 로고
    • Comparison of the international immune tolerance registry and the North American immune tolerance registry
    • Kroner B. (1999) Comparison of the international immune tolerance registry and the North American immune tolerance registry. Vox Sang 77(Suppl. 1): 33–37.
    • (1999) Vox Sang , vol.77 , pp. 33-37
    • Kroner, B.1
  • 60
    • 0016213054 scopus 로고
    • Activated prothrombin concentrate for patients with factor VIII inhibitors
    • Kurczynski E. Penner J. (1974) Activated prothrombin concentrate for patients with factor VIII inhibitors. N Engl J Med 291: 164–167.
    • (1974) N Engl J Med , vol.291 , pp. 164-167
    • Kurczynski, E.1    Penner, J.2
  • 61
    • 77950211350 scopus 로고    scopus 로고
    • New early prophylaxis regimen that avoids immunological danger signals can reduce FVIII inhibitor development
    • Kurnik K. Bidlingmaier C. Engl W. Chehadeh H. Reipert B. Auerswald G. (2010) New early prophylaxis regimen that avoids immunological danger signals can reduce FVIII inhibitor development. Haemophilia 16: 256–262.
    • (2010) Haemophilia , vol.16 , pp. 256-262
    • Kurnik, K.1    Bidlingmaier, C.2    Engl, W.3    Chehadeh, H.4    Reipert, B.5    Auerswald, G.6
  • 62
    • 67650869938 scopus 로고    scopus 로고
    • Inhibitors of factor VIII in hemophilia
    • author reply 310.
    • Lacroix-Desmazes S. Dimitrov J. Repesse Y. (2009) Inhibitors of factor VIII in hemophilia. N Engl J Med 361: 308; author reply 310.
    • (2009) N Engl J Med , vol.361 , pp. 308
    • Lacroix-Desmazes, S.1    Dimitrov, J.2    Repesse, Y.3
  • 63
    • 34547279111 scopus 로고    scopus 로고
    • Textbook of Hemophilia
    • 1st edn Malden, MA: Blackwell Publishing
    • Lee C. Berntorp E. Hoots W. (2005) Textbook of Hemophilia. 1st edn. Malden, MA: Blackwell Publishing.
    • (2005)
    • Lee, C.1    Berntorp, E.2    Hoots, W.3
  • 66
    • 0033678959 scopus 로고    scopus 로고
    • The German Registry of immune tolerance treatment in hemophilia – 1999 update
    • Lenk H. (2000) The German Registry of immune tolerance treatment in hemophilia – 1999 update. Haematologica 85(10 Suppl.): 45–47.
    • (2000) Haematologica , vol.85 , Issue.10 Suppl. , pp. 45-47
    • Lenk, H.1
  • 67
    • 1542649949 scopus 로고    scopus 로고
    • Low detection rate of antibodies to non-functional epitopes on factor VIII in patients with hemophilia A and negative for inhibitors by Bethesda assay
    • Ling M. Duncan E. Rodgers S. Street A. Lloyd J. (2003) Low detection rate of antibodies to non-functional epitopes on factor VIII in patients with hemophilia A and negative for inhibitors by Bethesda assay. J Thromb Haemost 1: 2548–2553.
    • (2003) J Thromb Haemost , vol.1 , pp. 2548-2553
    • Ling, M.1    Duncan, E.2    Rodgers, S.3    Street, A.4    Lloyd, J.5
  • 68
    • 8844263239 scopus 로고    scopus 로고
    • Pathogenic antibodies to coagulation factors. Part one: factor VIII and factor IX
    • Lollar P. (2004) Pathogenic antibodies to coagulation factors. Part one: factor VIII and factor IX. J Thromb Haemost 2: 1082–1095.
    • (2004) J Thromb Haemost , vol.2 , pp. 1082-1095
    • Lollar, P.1
  • 69
    • 0034994489 scopus 로고    scopus 로고
    • Incidence of factor VIII inhibitors in severe haemophilia: the importance of patient age
    • Lorenzo J. Lopez A. Altisent C. Aznar J. (2001) Incidence of factor VIII inhibitors in severe haemophilia: the importance of patient age. Br J Haematol 113: 600–603.
    • (2001) Br J Haematol , vol.113 , pp. 600-603
    • Lorenzo, J.1    Lopez, A.2    Altisent, C.3    Aznar, J.4
  • 70
    • 79959494195 scopus 로고    scopus 로고
    • A case-control study reveals immunoregulatory gene haplotypes that influence inhibitor risk in severe haemophilia A
    • Lozier J. Rosenberg P. Goedert J. Menashe I. (2011) A case-control study reveals immunoregulatory gene haplotypes that influence inhibitor risk in severe haemophilia A. Haemophilia 17: 641–649.
    • (2011) Haemophilia , vol.17 , pp. 641-649
    • Lozier, J.1    Rosenberg, P.2    Goedert, J.3    Menashe, I.4
  • 71
    • 0027473752 scopus 로고
    • Recombinant factor VIII for the treatment of previously untreated patients with hemophilia A. Safety, efficacy, and development of inhibitors. Kogenate Previously Untreated Patient Study Group
    • Lusher J. Arkin S. Abildgaard C. Schwartz R. (1993) Recombinant factor VIII for the treatment of previously untreated patients with hemophilia A. Safety, efficacy, and development of inhibitors. Kogenate Previously Untreated Patient Study Group. N Engl J Med 328: 453–459.
    • (1993) N Engl J Med , vol.328 , pp. 453-459
    • Lusher, J.1    Arkin, S.2    Abildgaard, C.3    Schwartz, R.4
  • 72
    • 0031743928 scopus 로고    scopus 로고
    • A randomized, double-blind comparison of two dosage levels of recombinant factor VIIa in the treatment of joint, muscle and mucocutaneous haemorrhages in persons with haemophilia A and B., with and without inhibitors. rFVIIa Study Group
    • Lusher J. Roberts H. Davignon G. Joist J. Smith H. Shapiro A. et al. (1998) A randomized, double-blind comparison of two dosage levels of recombinant factor VIIa in the treatment of joint, muscle and mucocutaneous haemorrhages in persons with haemophilia A and B, with and without inhibitors. rFVIIa Study Group. Haemophilia 4: 790–798.
    • (1998) Haemophilia , vol.4 , pp. 790-798
    • Lusher, J.1    Roberts, H.2    Davignon, G.3    Joist, J.4    Smith, H.5    Shapiro, A.6
  • 73
    • 79951778636 scopus 로고    scopus 로고
    • Treatment related factors and inhibitor development in children with severe haemophilia A
    • Maclean P. Richards M. Williams M. Collins P. Liesner R. Keeling D. et al. (2011) Treatment related factors and inhibitor development in children with severe haemophilia A. Haemophilia 17: 282–287.
    • (2011) Haemophilia , vol.17 , pp. 282-287
    • Maclean, P.1    Richards, M.2    Williams, M.3    Collins, P.4    Liesner, R.5    Keeling, D.6
  • 74
    • 34547757915 scopus 로고    scopus 로고
    • Prophylaxis versus episodic treatment to prevent joint disease in boys with severe hemophilia
    • Manco-Johnson M. Abshire T. Shapiro A. Riske B. Hacker M. Kilcoyne R. et al. (2007) Prophylaxis versus episodic treatment to prevent joint disease in boys with severe hemophilia. N Engl J Med 357: 535–544.
    • (2007) N Engl J Med , vol.357 , pp. 535-544
    • Manco-Johnson, M.1    Abshire, T.2    Shapiro, A.3    Riske, B.4    Hacker, M.5    Kilcoyne, R.6
  • 75
    • 37149022850 scopus 로고    scopus 로고
    • Factor VIII products and inhibitor development: the SIPPET study (survey of inhibitors in plasma-product exposed toddlers)
    • Mannucci P. Gringeri A. Peyvandi F. Santagostino E. (2007) Factor VIII products and inhibitor development: the SIPPET study (survey of inhibitors in plasma-product exposed toddlers). Haemophilia 13(Suppl. 5): 65–68.
    • (2007) Haemophilia , vol.13 , pp. 65-68
    • Mannucci, P.1    Gringeri, A.2    Peyvandi, F.3    Santagostino, E.4
  • 76
    • 84860767903 scopus 로고    scopus 로고
    • How we choose factor VIII to treat hemophilia
    • Mannucci P. Mancuso M. Santagostino E. (2012) How we choose factor VIII to treat hemophilia. Blood 119: 4108–4114.
    • (2012) Blood , vol.119 , pp. 4108-4114
    • Mannucci, P.1    Mancuso, M.2    Santagostino, E.3
  • 77
    • 0028411947 scopus 로고
    • Immunetolerance as treatment of alloantibodies to factor VIII in hemophilia. The International Registry of Immunetolerance Protocols
    • Mariani G. Scheibel E. Nogao T. Kasper C. Ewing N. Mauser-Bunschoten E. et al. (1994) Immunetolerance as treatment of alloantibodies to factor VIII in hemophilia. The International Registry of Immunetolerance Protocols. Semin Hematol 31(2 Suppl. 4): 62–64.
    • (1994) Semin Hematol , vol.31 , Issue.2 , pp. 62-64
    • Mariani, G.1    Scheibel, E.2    Nogao, T.3    Kasper, C.4    Ewing, N.5    Mauser-Bunschoten, E.6
  • 78
    • 0037066427 scopus 로고    scopus 로고
    • The danger model: a renewed sense of self
    • Matzinger P. (2002) The danger model: a renewed sense of self. Science 296: 301–305.
    • (2002) Science , vol.296 , pp. 301-305
    • Matzinger, P.1
  • 80
    • 77449096331 scopus 로고    scopus 로고
    • The between-laboratory variation of factor VIII inhibitor testing: the experience of the external quality assessment program of the ECAT foundation
    • Meijer P. Verbruggen B. (2009) The between-laboratory variation of factor VIII inhibitor testing: the experience of the external quality assessment program of the ECAT foundation. Semin Thromb Hemost 35: 786–793.
    • (2009) Semin Thromb Hemost , vol.35 , pp. 786-793
    • Meijer, P.1    Verbruggen, B.2
  • 81
    • 77955604541 scopus 로고    scopus 로고
    • Immunomodulation for inhibitors in hemophilia A: the important role of Treg cells
    • Miao C. (2010) Immunomodulation for inhibitors in hemophilia A: the important role of Treg cells. Expert Rev Hematol 3: 469–483.
    • (2010) Expert Rev Hematol , vol.3 , pp. 469-483
    • Miao, C.1
  • 82
    • 84860334450 scopus 로고    scopus 로고
    • F 8 and F 9 mutations in US haemophilia patients: correlation with history of inhibitor and race/ethnicity
    • Miller C. Benson J. Ellingsen D. Driggers J. Payne A. Kelly F. et al. (2012) F 8 and F 9 mutations in US haemophilia patients: correlation with history of inhibitor and race/ethnicity. Haemophilia 18: 375–382.
    • (2012) Haemophilia , vol.18 , pp. 375-382
    • Miller, C.1    Benson, J.2    Ellingsen, D.3    Driggers, J.4    Payne, A.5    Kelly, F.6
  • 84
    • 0023933922 scopus 로고
    • Induction of immune tolerance in patients with hemophilia and antibodies to factor VIII by combined treatment with intravenous IgG, cyclophosphamide, and factor VIII
    • Nilsson I. Berntorp E. Zettervall O. (1988) Induction of immune tolerance in patients with hemophilia and antibodies to factor VIII by combined treatment with intravenous IgG, cyclophosphamide, and factor VIII. N Engl J Med 318: 947–950.
    • (1988) N Engl J Med , vol.318 , pp. 947-950
    • Nilsson, I.1    Berntorp, E.2    Zettervall, O.3
  • 85
    • 0031045680 scopus 로고    scopus 로고
    • HLA genotype of patients with severe haemophilia A due to intron 22 inversion with and without inhibitors of factor VIII
    • Oldenburg J. Picard J. Schwaab R. Brackmann H. Tuddenham E. Simpson E. (1997) HLA genotype of patients with severe haemophilia A due to intron 22 inversion with and without inhibitors of factor VIII. Thromb Haemost 77: 238–242.
    • (1997) Thromb Haemost , vol.77 , pp. 238-242
    • Oldenburg, J.1    Picard, J.2    Schwaab, R.3    Brackmann, H.4    Tuddenham, E.5    Simpson, E.6
  • 87
    • 77449101167 scopus 로고    scopus 로고
    • Impact of polymorphisms of the major histocompatibility complex class II, interleukin-10, tumor necrosis factor-alpha and cytotoxic T-lymphocyte antigen-4 genes on inhibitor development in severe hemophilia A
    • Pavlova A. Delev D. Lacroix-Desmazes S. Schwaab R. Mende M. Fimmers R. et al. (2009) Impact of polymorphisms of the major histocompatibility complex class II, interleukin-10, tumor necrosis factor-alpha and cytotoxic T-lymphocyte antigen-4 genes on inhibitor development in severe hemophilia A. J Thromb Haemost 7: 2006–2015.
    • (2009) J Thromb Haemost , vol.7 , pp. 2006-2015
    • Pavlova, A.1    Delev, D.2    Lacroix-Desmazes, S.3    Schwaab, R.4    Mende, M.5    Fimmers, R.6
  • 88
    • 67650896030 scopus 로고    scopus 로고
    • Inhibitors of factor VIII in hemophilia
    • author reply 310.
    • Peyvandi F. Lotta L. Mannucci P. (2009) Inhibitors of factor VIII in hemophilia. N Engl J Med 361: 309; author reply 310.
    • (2009) N Engl J Med , vol.361 , pp. 309
    • Peyvandi, F.1    Lotta, L.2    Mannucci, P.3
  • 89
    • 56749158179 scopus 로고    scopus 로고
    • Reduction of the immune response to factor VIII mediated through tolerogenic factor VIII presentation by immature dendritic cells
    • Qadura M. Othman M. Waters B. Chegeni R. Walker K. Labelle A. et al. (2008) Reduction of the immune response to factor VIII mediated through tolerogenic factor VIII presentation by immature dendritic cells. J Thromb Haemost 6: 2095–2104.
    • (2008) J Thromb Haemost , vol.6 , pp. 2095-2104
    • Qadura, M.1    Othman, M.2    Waters, B.3    Chegeni, R.4    Walker, K.5    Labelle, A.6
  • 90
    • 68249161283 scopus 로고    scopus 로고
    • Recombinant and plasma-derived factor VIII products induce distinct splenic cytokine microenvironments in hemophilia A mice
    • Qadura M. Waters B. Burnett E. Chegeni R. Bradshaw S. Hough C. et al. (2009) Recombinant and plasma-derived factor VIII products induce distinct splenic cytokine microenvironments in hemophilia A mice. Blood 114: 871–880.
    • (2009) Blood , vol.114 , pp. 871-880
    • Qadura, M.1    Waters, B.2    Burnett, E.3    Chegeni, R.4    Bradshaw, S.5    Hough, C.6
  • 91
    • 69949099131 scopus 로고    scopus 로고
    • Risk factors for inhibitor formation in haemophilia: a prevalent case-control study
    • Ragni M. Ojeifo O. Feng J. Yan J. Hill K. Sommer S. et al. (2009 a) Risk factors for inhibitor formation in haemophilia: a prevalent case-control study. Haemophilia 15: 1074–1082.
    • (2009) Haemophilia , vol.15 , pp. 1074-1082
    • Ragni, M.1    Ojeifo, O.2    Feng, J.3    Yan, J.4    Hill, K.5    Sommer, S.6
  • 92
    • 65549105424 scopus 로고    scopus 로고
    • Factor VIII-pulsed dendritic cells reduce anti-factor VIII antibody formation in the hemophilia A mouse model
    • Ragni M. Wu W. Liang X. Hsieh C. Cortese-Hassett A. Lu L. (2009 b) Factor VIII-pulsed dendritic cells reduce anti-factor VIII antibody formation in the hemophilia A mouse model. Exp Hematol 37: 744–754.
    • (2009) Exp Hematol , vol.37 , pp. 744-754
    • Ragni, M.1    Wu, W.2    Liang, X.3    Hsieh, C.4    Cortese-Hassett, A.5    Lu, L.6
  • 93
    • 33748745477 scopus 로고    scopus 로고
    • Induction of partial immune tolerance to factor VIII through prior mucosal exposure to the factor VIII C 2 domain
    • Rawle F. Pratt K. Labelle A. Weiner H. Hough C. Lillicrap D. (2006) Induction of partial immune tolerance to factor VIII through prior mucosal exposure to the factor VIII C 2 domain. J Thromb Haemost 4: 2172–2179.
    • (2006) J Thromb Haemost , vol.4 , pp. 2172-2179
    • Rawle, F.1    Pratt, K.2    Labelle, A.3    Weiner, H.4    Hough, C.5    Lillicrap, D.6
  • 94
    • 22744432117 scopus 로고    scopus 로고
    • Can activated recombinant factor VII be used to postpone the exposure of infants to factor VIII until after 2 years of age?
    • Rivard G. Lillicrap D. Poon M. Demers C. Lepine M. St-Louis J. et al. (2005) Can activated recombinant factor VII be used to postpone the exposure of infants to factor VIII until after 2 years of age? Haemophilia 11: 335–339.
    • (2005) Haemophilia , vol.11 , pp. 335-339
    • Rivard, G.1    Lillicrap, D.2    Poon, M.3    Demers, C.4    Lepine, M.5    St-Louis, J.6
  • 95
    • 0034770548 scopus 로고    scopus 로고
    • Successful treatment of high titer inhibitors in mild hemophilia A with avoidance of factor VIII and immunosuppressive therapy
    • Robbins D. Kulkarni R. Gera R. Scott-Emuakpor A. Bosma K. Penner J. (2001) Successful treatment of high titer inhibitors in mild hemophilia A with avoidance of factor VIII and immunosuppressive therapy. Am J Hematol 68: 184–188.
    • (2001) Am J Hematol , vol.68 , pp. 184-188
    • Robbins, D.1    Kulkarni, R.2    Gera, R.3    Scott-Emuakpor, A.4    Bosma, K.5    Penner, J.6
  • 97
    • 24944440876 scopus 로고    scopus 로고
    • Environmental risk factors for inhibitor development in children with haemophilia A: a case-control study
    • Santagostino E. Mancuso M. Rocino A. Mancuso G. Mazzucconi M. Tagliaferri A. et al. (2005) Environmental risk factors for inhibitor development in children with haemophilia A: a case-control study. Br J Haematol 130: 422–427.
    • (2005) Br J Haematol , vol.130 , pp. 422-427
    • Santagostino, E.1    Mancuso, M.2    Rocino, A.3    Mancuso, G.4    Mazzucconi, M.5    Tagliaferri, A.6
  • 98
    • 67650896030 scopus 로고    scopus 로고
    • Inhibitors of factor VIII in hemophilia
    • author reply 310.
    • Santos A. Annichino-Bizzacchi J. Ozelo M. (2009) Inhibitors of factor VIII in hemophilia. N Engl J Med 361: 309–310; author reply 310.
    • (2009) N Engl J Med , vol.361 , pp. 309-310
    • Santos, A.1    Annichino-Bizzacchi, J.2    Ozelo, M.3
  • 99
    • 0024451521 scopus 로고
    • Localization of epitopes for human factor VIII inhibitor antibodies by immunoblotting and antibody neutralization
    • Scandella D. Mattingly M. de Graaf S. Fulcher C. (1989) Localization of epitopes for human factor VIII inhibitor antibodies by immunoblotting and antibody neutralization. Blood 74: 1618–1626.
    • (1989) Blood , vol.74 , pp. 1618-1626
    • Scandella, D.1    Mattingly, M.2    de Graaf, S.3    Fulcher, C.4
  • 100
    • 0032787813 scopus 로고    scopus 로고
    • Incidence of inhibitors in haemophilia A patients – a review of recent studies of recombinant and plasma-derived factor VIII concentrates
    • Scharrer I. Bray G. Neutzling O. (1999) Incidence of inhibitors in haemophilia A patients – a review of recent studies of recombinant and plasma-derived factor VIII concentrates. Haemophilia 5: 145–154.
    • (1999) Haemophilia , vol.5 , pp. 145-154
    • Scharrer, I.1    Bray, G.2    Neutzling, O.3
  • 101
    • 4043155658 scopus 로고    scopus 로고
    • Sequential therapy with activated prothrombin complex concentrate and recombinant factor VIIa in patients with severe haemophilia and inhibitors
    • Schneiderman J. Nugent D. Young G. (2004) Sequential therapy with activated prothrombin complex concentrate and recombinant factor VIIa in patients with severe haemophilia and inhibitors. Haemophilia 10: 347–351.
    • (2004) Haemophilia , vol.10 , pp. 347-351
    • Schneiderman, J.1    Nugent, D.2    Young, G.3
  • 102
    • 0031743504 scopus 로고    scopus 로고
    • Prospective, randomised trial of two doses of rFVIIa (NovoSeven) in haemophilia patients with inhibitors undergoing surgery
    • Shapiro A. Gilchrist G. Hoots W. Cooper H. Gastineau D. (1998) Prospective, randomised trial of two doses of rFVIIa (NovoSeven) in haemophilia patients with inhibitors undergoing surgery. Thromb Haemost 80: 773–778.
    • (1998) Thromb Haemost , vol.80 , pp. 773-778
    • Shapiro, A.1    Gilchrist, G.2    Hoots, W.3    Cooper, H.4    Gastineau, D.5
  • 103
    • 0842333021 scopus 로고    scopus 로고
    • Intensive exposure to factor VIII is a risk factor for inhibitor development in mild hemophilia A
    • Sharathkumar A. Lillicrap D. Blanchette V. Kern M. Leggo J. Stain A. et al. (2003) Intensive exposure to factor VIII is a risk factor for inhibitor development in mild hemophilia A. J Thromb Haemost 1: 1228–1236.
    • (2003) J Thromb Haemost , vol.1 , pp. 1228-1236
    • Sharathkumar, A.1    Lillicrap, D.2    Blanchette, V.3    Kern, M.4    Leggo, J.5    Stain, A.6
  • 104
    • 0019426632 scopus 로고
    • The effect of activated prothrombin-complex concentrate (FEIBA) on joint and muscle bleeding in patients with hemophilia A and antibodies to factor VIII. A double-blind clinical trial
    • Sjamsoedin L. Heijnen L. Mauser-Bunschoten E. van Geijlswijk J. van Houwelingen H. van Asten P. et al. (1981) The effect of activated prothrombin-complex concentrate (FEIBA) on joint and muscle bleeding in patients with hemophilia A and antibodies to factor VIII. A double-blind clinical trial. N Engl J Med 305: 717–721.
    • (1981) N Engl J Med , vol.305 , pp. 717-721
    • Sjamsoedin, L.1    Heijnen, L.2    Mauser-Bunschoten, E.3    van Geijlswijk, J.4    van Houwelingen, H.5    van Asten, P.6
  • 105
    • 0031785486 scopus 로고    scopus 로고
    • Occurrence of hemophilia in the United States. The Hemophilia Surveillance System Project Investigators
    • Soucie J. Evatt B. Jackson D. (1998) Occurrence of hemophilia in the United States. The Hemophilia Surveillance System Project Investigators. Am J Hematol 59: 288–294.
    • (1998) Am J Hematol , vol.59 , pp. 288-294
    • Soucie, J.1    Evatt, B.2    Jackson, D.3
  • 106
    • 74149090117 scopus 로고    scopus 로고
    • Suppression of FVIII inhibitor formation in hemophilic mice by delivery of transgene modified apoptotic fibroblasts
    • Su R. Epp A. Latchman Y. Bolgiano D. Pipe S. Josephson N. (2010) Suppression of FVIII inhibitor formation in hemophilic mice by delivery of transgene modified apoptotic fibroblasts. Mol Ther 18: 214–222.
    • (2010) Mol Ther , vol.18 , pp. 214-222
    • Su, R.1    Epp, A.2    Latchman, Y.3    Bolgiano, D.4    Pipe, S.5    Josephson, N.6
  • 107
    • 0026622961 scopus 로고
    • Prevalence of inhibitors in a population of 3435 hemophilia patients in France. French Hemophilia Study Group
    • Sultan Y. (1992) Prevalence of inhibitors in a population of 3435 hemophilia patients in France. French Hemophilia Study Group. Thromb Haemost 67: 600–602.
    • (1992) Thromb Haemost , vol.67 , pp. 600-602
    • Sultan, Y.1
  • 108
    • 56749175272 scopus 로고    scopus 로고
    • Risk stratification for inhibitor development at first treatment for severe hemophilia A: a tool for clinical practice
    • ter Avest P. Fischer K. Mancuso M. Santagostino E. Yuste V. van den Berg H. et al. (2008) Risk stratification for inhibitor development at first treatment for severe hemophilia A: a tool for clinical practice. J Thromb Haemost 6: 2048–2054.
    • (2008) J Thromb Haemost , vol.6 , pp. 2048-2054
    • ter Avest, P.1    Fischer, K.2    Mancuso, M.3    Santagostino, E.4    Yuste, V.5    van den Berg, H.6
  • 110
  • 111
    • 64749096663 scopus 로고    scopus 로고
    • Inhibitors of factor VIII in black patients with hemophilia
    • Viel K. Ameri A. Abshire T. Iyer R. Watts R. Lutcher C. et al. (2009) Inhibitors of factor VIII in black patients with hemophilia. N Engl J Med 360: 1618–1627.
    • (2009) N Engl J Med , vol.360 , pp. 1618-1627
    • Viel, K.1    Ameri, A.2    Abshire, T.3    Iyer, R.4    Watts, R.5    Lutcher, C.6
  • 112
    • 0036227304 scopus 로고    scopus 로고
    • Factor VIII inhibitor in a patient with mild haemophilia A and an Asn618-->Ser mutation responsive to immune tolerance induction and cyclophosphamide
    • Vlot A. Wittebol S. Strengers P. Turenhout E. Voorberg J. van den Berg H. et al. (2002) Factor VIII inhibitor in a patient with mild haemophilia A and an Asn618-->Ser mutation responsive to immune tolerance induction and cyclophosphamide. Br J Haematol 117: 136–140.
    • (2002) Br J Haematol , vol.117 , pp. 136-140
    • Vlot, A.1    Wittebol, S.2    Strengers, P.3    Turenhout, E.4    Voorberg, J.5    van den Berg, H.6
  • 113
    • 69249206732 scopus 로고    scopus 로고
    • The molecular mechanisms of immunomodulation and tolerance induction to factor VIII
    • Waters B. Lillicrap D. (2009) The molecular mechanisms of immunomodulation and tolerance induction to factor VIII. J Thromb Haemost 7: 1446–1456.
    • (2009) J Thromb Haemost , vol.7 , pp. 1446-1456
    • Waters, B.1    Lillicrap, D.2
  • 114
    • 0035077234 scopus 로고    scopus 로고
    • Definitions in hemophilia. Recommendation of the scientific subcommittee on factor VIII and factor IX of the scientific and standardization committee of the International Society on Thrombosis and Haemostasis
    • White G. Rosendaal F. Aledort L. Lusher J. Rothschild C. Ingerslev J. (2001) Definitions in hemophilia. Recommendation of the scientific subcommittee on factor VIII and factor IX of the scientific and standardization committee of the International Society on Thrombosis and Haemostasis. Thromb Haemost 85: 560.
    • (2001) Thromb Haemost , vol.85 , pp. 560
    • White, G.1    Rosendaal, F.2    Aledort, L.3    Lusher, J.4    Rothschild, C.5    Ingerslev, J.6
  • 115
    • 0038383605 scopus 로고    scopus 로고
    • The epidemiology of inhibitors in haemophilia A: a systematic review
    • Wight J. Paisley S. (2003) The epidemiology of inhibitors in haemophilia A: a systematic review. Haemophilia 9: 418–435.
    • (2003) Haemophilia , vol.9 , pp. 418-435
    • Wight, J.1    Paisley, S.2
  • 116
    • 67650896030 scopus 로고    scopus 로고
    • Inhibitors of factor VIII in hemophilia
    • author reply 310.
    • Yang G. Yao L. Lu Z. (2009) Inhibitors of factor VIII in hemophilia. N Engl J Med 361: 309; author reply 310.
    • (2009) N Engl J Med , vol.361 , pp. 309
    • Yang, G.1    Yao, L.2    Lu, Z.3
  • 118
    • 0031017506 scopus 로고    scopus 로고
    • Partial correction of a severe molecular defect in hemophilia A., because of errors during expression of the factor VIII gene
    • Young M. Inaba H. Hoyer L. Higuchi M. Kazazian H. Antonarakis S. (1997) Partial correction of a severe molecular defect in hemophilia A, because of errors during expression of the factor VIII gene. Am J Hum Genet 60: 565–573.
    • (1997) Am J Hum Genet , vol.60 , pp. 565-573
    • Young, M.1    Inaba, H.2    Hoyer, L.3    Higuchi, M.4    Kazazian, H.5    Antonarakis, S.6


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