Incomplete tyrosine 1680 sulphation in recombinant FVIII concentrates

Haemophilia

Volumn 17, Issue 4, 2011, Pages 709-710

  Grancha, S ^a   Navajas, R ^b   Maranon C ^a   Paradela, A ^b   Albar, J P ^b   Jorquera, J I ^a  

^a Instituto Grifols   (Spain)

^b CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDE; RECOMBINANT BLOOD CLOTTING FACTOR 8; RECOMBINANT BLOOD CLOTTING FACTOR 8 CONCENTRATE; TYROSINE; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR;

ACCURACY; CHO CELL; HEMOPHILIA A; HUMAN; ION EXCHANGE; LETTER; NONHUMAN; PRECIPITATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SULFATION;

FACTOR VIII; RECOMBINANT PROTEINS; REPRODUCIBILITY OF RESULTS; TYROSINE;

EID: 79959526652     PISSN: 13518216     EISSN: 13652516     Source Type: Journal    
DOI: 10.1111/j.1365-2516.2010.02454.x     Document Type: Letter

References (5)

1. Lenting PJ, VAN Schooten CJ, Denis CV. Clearance mechanisms of von Willebrand factor and factor VIII. J Thromb Haemost 2007; 5: 1353-60.
2. Michnick DA, Pittman DD, Wise RJ, Kaufman RJ. Identification of individual tyrosine sulfation sites within factor VIII required for optimal activity and efficient thrombin cleavage. J Biol Chem 1994; 269: 20095-102.
3. Leyte A, van Schijndel HB, Niehrs C et al. Sulfation of Tyr1680 of human blood coagulation factor VIII is essential for the interaction of factor VIII with von Willebrand factor. J Biol Chem 1991; 266: 740-6.
4. Lin Y, Yang X, Chevrier MC et al. Relationships between factor VIII:Ag and factor VIII in recombinant and plasma-derived factor VIII concentrates. Haemophilia 2004; 10: 459-69.
5. Severs JC, Carnine M, Eguizabal H, Mock KK. Characterization of tyrosine sulfate residues in antihemophilic recombinant factor VIII by liquid chromatography electrospray ionization tandem mass spectrometry and amino acid analysis. Rapid Commun Mass Spectrom 1999; 13: 1016-23.