P66Shc-Induced MicroRNA-34a Causes Diabetic Endothelial Dysfunction by Downregulating Sirtuin1

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 36, Issue 12, 2016, Pages 2394-2403

  Li, Qiuxia ^a   Kim, Young Rae ^a   Vikram, Ajit ^a   Kumar, Santosh ^a   Kassan, Modar ^a   Gabani, Mohanad ^a   Lee, Sang Ki ^b   Jacobs, Julia S ^a   Irani, Kaikobad ^a  

^a UNIVERSITY OF IOWA   (United States)

^b Chungnam National University   (South Korea)

Author keywords

diabetes mellitus; endothelial dysfunction; microRNA 34a; p66Shc; sirtuin1

Indexed keywords

GLUCOSE; HYDROGEN PEROXIDE; MICRORNA 34A; PALMITIC ACID; PROTEIN; PROTEIN P66SHC; SIRTUIN 1; STREPTOZOCIN; UNCLASSIFIED DRUG; ANTIOXIDANT; MICRORNA; MIRN34 MICRORNA, HUMAN; MIRN34 MICRORNA, MOUSE; PROTEIN P53; SHC TRANSFORMING PROTEIN 1; SHC1 PROTEIN, HUMAN; SHC1 PROTEIN, MOUSE; SIRT1 PROTEIN, HUMAN; SIRT1 PROTEIN, MOUSE; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA ENDOTHELIUM; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; EX VIVO STUDY; GENE EXPRESSION; GENE INACTIVATION; GENE OVEREXPRESSION; IN VITRO STUDY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN TARGETING; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; UPREGULATION; VASODILATATION; ANIMAL; AORTA; C57BL MOUSE; CELL CULTURE; COMPLICATION; DEFICIENCY; DIABETIC ANGIOPATHY; DOSE RESPONSE; DRUG EFFECT; ENERGY METABOLISM; ENZYMOLOGY; EXPERIMENTAL DIABETES MELLITUS; GENETIC TRANSFECTION; GENETICS; GENOTYPE; HUMAN; KNOCKOUT MOUSE; METABOLISM; PATHOPHYSIOLOGY; PHENOTYPE; RNA INTERFERENCE; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULAR ENDOTHELIUM;

ANIMALS; ANTIOXIDANTS; AORTA; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC ANGIOPATHIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENDOTHELIUM, VASCULAR; ENERGY METABOLISM; GENOTYPE; GLUCOSE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MICE, INBRED C57BL; MICE, KNOCKOUT; MICRORNAS; OXIDATIVE STRESS; PALMITIC ACID; PHENOTYPE; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SIRTUIN 1; SRC HOMOLOGY 2 DOMAIN-CONTAINING, TRANSFORMING PROTEIN 1; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53; VASODILATION; VASODILATOR AGENTS;

EID: 84992730313     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.116.308321     Document Type: Article

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