Docosahexaenoic acid improves vascular function via up-regulation of SIRT1 expression in endothelial cells

Biochemical and Biophysical Research Communications

Volumn 437, Issue 1, 2013, Pages 114-119

  Jung, Saet Byel ^a   Kwon, Sun Kwan ^b   Kwon, Mina ^c   Nagar, Harsha ^b   Jeon, Byeong Hwa ^b   Irani, Kaikobad ^d   Yoon, Seok Hwa ^a   Kim, Cuk Seong ^b  

^a Chungnam National University College of Medicine   (South Korea)

^b Chungnam National University   (South Korea)

^c Dankook University   (South Korea)

^d UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Docosahexaenoic acid; ENOS; Nitric oxide; SIRT1

Indexed keywords

DOCOSAHEXAENOIC ACID; ENDOTHELIAL NITRIC OXIDE SYNTHASE; LYSINE; NITRIC OXIDE SYNTHASE; SIRTUIN 1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR FUNCTION; CELL VIABILITY; CONTROLLED STUDY; DEACETYLATION; DIET SUPPLEMENTATION; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR UPREGULATION; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULAR ENDOTHELIUM; VASCULAR RING;

DOCOSAHEXAENOIC ACID; ENOS; NITRIC OXIDE; SIRT1;

ACETYLATION; ANIMALS; BIOLOGICAL AVAILABILITY; CELL SURVIVAL; DOCOSAHEXAENOIC ACIDS; ENDOTHELIUM, VASCULAR; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MICE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; RATS; SIRTUIN 1; UP-REGULATION;

RATTUS;

EID: 84880506407     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.06.049     Document Type: Article

References (28)

1. Dyerberg J., Bang H.O., Hjorne N. Fatty acid composition of the plasma lipids in Greenland Eskimos. Am. J. Clin. Nutr. 1975, 28:958-966.
2. Pradelli L., Mayer K., Muscaritoli M., Heller A.R. N-3 fatty acid-enriched parenteral nutrition regimens in elective surgical and ICU patients: a meta-analysis. Crit. Care 2012, 16:R184.
3. Mori T.A., Watts G.F., Burke V., Hilme E., Puddey I.B., Beilin L.J. Differential effects of eicosapentaenoic acid and docosahexaenoic acid on vascular reactivity of the forearm microcirculation in hyperlipidemic, overweight men. Circulation 2000, 102:1264-1269.
4. Breslow J.L. N-3 fatty acids and cardiovascular disease. Am. J. Clin. Nutr. 2006, 83:1477S-1482S.
5. Stebbins C.L., Stice J.P., Hart C.M., Mbai F.N., Knowlton A.A. Effects of dietary decosahexaenoic acid (DHA) on eNOS in human coronary artery endothelial cells. J. Cardiovasc. Pharmacol. Ther. 2008, 13:261-268.
6. Casino P.R., Kilcoyne C.M., Quyyumi A.A., Hoeg J.M., Panza J.A. The role of nitric oxide in endothelium-dependent vasodilation of hypercholesterolemic patients. Circulation 1993, 88:2541-2547.
7. Cohen G.A., Hobbs A.J., Fitch R.M., Zinner M.J., Chaudhuri G., Ignarro L.J. Nitric oxide regulates endothelium-dependent vasodilator responses in rabbit hindquarters vascular bed in vivo. Am. J. Physiol. 1996, 271:H133-H139.
8. Lele R.D. Causation, prevention and reversal of vascular endothelial dysfunction. J. Assoc. Phys. India 2007, 55:643-651.
9. Fleming I., Bauersachs J., Busse R. Calcium-dependent and calcium-independent activation of the endothelial NO synthase. J. Vasc. Res. 1997, 34:165-174.
10. McCabe T.J., Fulton D., Roman L.J., Sessa W.C. Enhanced electron flux and reduced calmodulin dissociation may explain "calcium-independent" eNOS activation by phosphorylation. J. Biol. Chem. 2000, 275:6123-6128.
11. Fulton D., Gratton J.P., McCabe T.J., Fontana J., Fujio Y., Walsh K., Franke T.F., Papapetropoulos A., Sessa W.C. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 1999, 399:597-601.
12. Canto C., Gerhart-Hines Z., Feige J.N., Lagouge M., Noriega L., Milne J.C., Elliott P.J., Puigserver P., Auwerx J. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature 2009, 458:1056-1060.
13. Mattagajasingh I., Kim C.S., Naqvi A., Yamamori T., Hoffman T.A., Jung S.B., DeRicco J., Kasuno K., Irani K. SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase. Proc. Natl. Acad. Sci. USA 2007, 104:14855-14860.
14. Ruderman N.B., Xu X.J., Nelson L., Cacicedo J.M., Saha A.K., Lan F., Ido Y. AMPK and SIRT1: a long-standing partnership?. Am. J. Physiol. Endocrinol. Metab. 2010, 298:E751-E760.
15. Chen Z., Peng I.C., Sun W., Su M.I., Hsu P.H., Fu Y., Zhu Y., DeFea K., Pan S., Tsai M.D., Shyy J.Y. AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633. Circ. Res. 2009, 104:496-505.
16. Zhang Y., Lee T.S., Kolb E.M., Sun K., Lu X., Sladek F.M., Kassab G.S., Garland T., Shyy J.Y. AMP-activated protein kinase is involved in endothelial NO synthase activation in response to shear stress. Arterioscler. Thromb. Vasc. Biol. 2006, 26:1281-1287.
17. Hou X., Xu S., Maitland-Toolan K.A., Sato K., Jiang B., Ido Y., Lan F., Walsh K., Wierzbicki M., Verbeuren T.J., Cohen R.A., Zang M. SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase. J. Biol. Chem. 2008, 283:20015-20026.
18. Chen Z., Peng I.C., Cui X., Li Y.S., Chien S., Shyy J.Y. Shear stress, SIRT1, and vascular homeostasis. Proc. Natl. Acad. Sci. USA 2010, 107:10268-10273.
19. He K., Song Y., Daviglus M.L., Liu K., Van Horn L., Dyer A.R., Greenland P. Accumulated evidence on fish consumption and coronary heart disease mortality: a meta-analysis of cohort studies. Circulation 2004, 109:2705-2711.
20. Wu A., Ying Z., Gomez-Pinilla F. Omega-3 fatty acids supplementation restores mechanisms that maintain brain homeostasis in traumatic brain injury. J. Neurotrauma 2007, 24:1587-1595.
21. Cicero A.F., Ertek S., Borghi C. Omega-3 polyunsaturated fatty acids: their potential role in blood pressure prevention and management. Curr. Vasc. Pharmacol. 2009, 7:330-337.
22. Raitakari M., Ilvonen T., Ahotupa M., Lehtimaki T., Harmoinen A., Suominen P., Elo J., Hartiala J., Raitakari O.T. Weight reduction with very-low-caloric diet and endothelial function in overweight adults: role of plasma glucose. Arterioscler. Thromb. Vasc. Biol. 2004, 24:124-128.
23. Allard J.S., Perez E., Zou S., de Cabo R. Dietary activators of Sirt1. Mol. Cell. Endocrinol. 2009, 299:58-63.
24. Yung L.M., Leung F.P., Yao X., Chen Z.Y., Huang Y. Reactive oxygen species in vascular wall. Cardiovasc. Hematol. Disord. Drug Targets 2006, 6:1-19.
25. Rupp H., Wagner D., Rupp T., Schulte L.M., Maisch B. Risk stratification by the "EPA+DHA level" and the "EPA/AA ratio" focus on anti-inflammatory and antiarrhythmogenic effects of long-chain omega-3 fatty acids. Herz 2004, 29:673-685.
26. Gousset-Dupont A., Robert V., Grynberg A., Lacour B., Tardivel S. The effect of n-3 PUFA on eNOS activity and expression in Ea hy 926 cells. Prostaglandins Leukot. Essent. Fatty Acids 2007, 76:131-139.
27. de Lima T.M., de Sa Lima L., Scavone C., Curi R. Fatty acid control of nitric oxide production by macrophages. FEBS Lett. 2006, 580:3287-3295.
28. Sadli N., Ackland M.L., De Mel D., Sinclair A.J., Suphioglu C. Effects of zinc and DHA on the epigenetic regulation of human neuronal cells. Cell. Physiol. Biochem. 2012, 29:87-98.