Gestational Diabetes Mellitus Impairs Fetal Endothelial Cell Functions Through a Mechanism Involving MicroRNA-101 and Histone Methyltransferase Enhancer of Zester Homolog-2

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 35, Issue 3, 2015, Pages 664-674

  Floris, Ilaria ^a,b   Descamps, Betty ^a   Vardeu, Antonella ^a,b   Mitić, Tijana ^a   Posadino, Anna Maria ^b   Shantikumar, Saran ^a   Sala Newby, Graciela ^a   Capobianco, Gianpiero ^c   Mangialardi, Giuseppe ^a   Howard, Lynsey ^a   Dessole, Salvatore ^c   Urrutia, Raul ^d   Pintus, Gianfranco ^b   Emanueli, Costanza ^a,e  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b Lab Vasc Biol and Hum Immunol   (Italy)

^c UNIVERSITY OF SASSARI   (Italy)

^d MAYO CLINIC   (United States)

^e NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

diabetes, gestational; endothelial cells; epigenomics; EZH2 protein human; microRNAs; polycomb repressive complex 2

Indexed keywords

CD31 ANTIGEN; GLUCOSE; HISTONE H3; LYSINE DERIVATIVE; MICRORNA 101; TRANSCRIPTION FACTOR EZH2; TRANSCRIPTION FACTOR EZH2 ALPHA; TRANSCRIPTION FACTOR EZH2 BETA; UNCLASSIFIED DRUG; EZH2 PROTEIN, HUMAN; HISTONE; MICRORNA; MIRN101 MICRORNA, HUMAN; POLYCOMB REPRESSIVE COMPLEX 2;

AMINO ACID SEQUENCE; ANGIOGENESIS; APOPTOSIS; ARTICLE; CELL FUNCTION; CELL LEVEL; CELL MIGRATION; CELL PROLIFERATION; CELL STIMULATION; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; FETUS; GENE EXPRESSION REGULATION; GENE LOCUS; GENE OVEREXPRESSION; GENE SILENCING; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; PHENOTYPE; PREGNANCY DIABETES MELLITUS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN METHYLATION; REGULATORY SEQUENCE; RNA ANALYSIS; TRANSCRIPTION REGULATION; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION; BINDING SITE; CASE CONTROL STUDY; CELL CULTURE; CELL MOTION; ENZYMOLOGY; GENETICS; GESTATIONAL AGE; METABOLISM; METHYLATION; PATHOLOGY; PATHOPHYSIOLOGY; PREGNANCY; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTOR;

APOPTOSIS; BINDING SITES; CASE-CONTROL STUDIES; CELL MOVEMENT; CELL SURVIVAL; CELLS, CULTURED; DIABETES, GESTATIONAL; FEMALE; GESTATIONAL AGE; GLUCOSE; HISTONES; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; METHYLATION; MICRORNAS; NEOVASCULARIZATION, PHYSIOLOGIC; PHENOTYPE; POLYCOMB REPRESSIVE COMPLEX 2; PREGNANCY; PROMOTER REGIONS, GENETIC; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; UP-REGULATION;

EID: 84921875766     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.114.304730     Document Type: Article

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