Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions

Nature Immunology

Volumn 17, Issue 12, 2016, Pages 1361-1372

  Martins, Rui ^a,b   Maier, Julia ^a,b   Gorki, Anna Dorothea ^a,b   Huber, Kilian V M ^a   Sharif, Omar ^a,b   Starkl, Philipp ^a,b   Saluzzo, Simona ^a,b   Quattrone, Federica ^a,b   Gawish, Riem ^a,b,f   Lakovits, Karin ^b   Aichinger, Michael C ^c   Radic Sarikas, Branka ^a   Lardeau, Charles Hugues ^a   Hladik, Anastasiya ^a,b   Korosec, Ana ^a,b   Brown, Markus ^b   Vaahtomeri, Kari ^d   Duggan, Michelle ^d   Kerjaschki, Dontscho ^b   Esterbauer, Harald ^b   Colinge, Jacques ^a   Eisenbarth, Stephanie C ^e   Decker, Thomas ^c   Bennett, Keiryn L ^a   Kubicek, Stefan ^a   Sixt, Michael ^d   Superti Furga, Giulio ^a,b   Knapp, Sylvia ^a,b   more..

^a ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c UNIVERSITY OF VIENNA   (Austria)

^d INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA   (Austria)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF VETERINARY MEDICINE   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; HEME; PROTEIN CDC42; PROTEIN DOCK8; QUININE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; DOCK8 PROTEIN, MOUSE; HEME OXYGENASE 1; HMOX1 PROTEIN, MOUSE; MEMBRANE PROTEIN;

ACTIN FILAMENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL CLEARANCE; BACTERIAL LOAD; CELL MIGRATION; CELL PROLIFERATION; CELL SHAPE; CONTROLLED STUDY; FEMALE; GRAM NEGATIVE SEPSIS; HEMOLYSIS; HUMAN; HUMAN CELL; IN VIVO STUDY; INFECTION SENSITIVITY; MACROPHAGE; MOUSE; NONHUMAN; PATHOGENIC ESCHERICHIA COLI; PHAGOCYTE; PHAGOCYTOSIS; PRIORITY JOURNAL; SCREENING; SURVIVAL; ANIMAL; C57BL MOUSE; CYTOSKELETON; DRUG EFFECTS; GENETICS; GRAM-NEGATIVE BACTERIAL INFECTIONS; IMMUNE EVASION; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; MICROBIOLOGY; RAW 264.7 CELL LINE; SEPSIS;

ANIMALS; ANTI-BACTERIAL AGENTS; CDC42 GTP-BINDING PROTEIN; CYTOSKELETON; FEMALE; GRAM-NEGATIVE BACTERIAL INFECTIONS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HEME; HEME OXYGENASE-1; HEMOLYSIS; HUMANS; IMMUNE EVASION; MACROPHAGES; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHAGOCYTOSIS; QUININE; RAW 264.7 CELLS; SEPSIS;

EID: 84992723964     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.3590     Document Type: Article

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