The era of anti-vascular endothelial growth factor (VEGF) drugs in ophthalmology, VEGF and anti-VEGF therapy

Central European Journal of Immunology

Volumn 41, Issue 3, 2016, Pages 311-316

  Pozarowska, Dorota ^a   Pozarowski, Piotr ^a  

^a MEDICAL UNIVERSITY OF LUBLIN   (Poland)

Author keywords

AMD; Anti VEGF therapy; Macular oedema; Safety; VEGF

Indexed keywords

AFLIBERCEPT; BEVACIZUMAB; BEVASIRANIB; PAZOPANIB; PEGAPTANIB; RANIBIZUMAB; SIRNA 027; VASCULOTROPIN; VASCULOTROPIN ANTIBODY; VASCULOTROPIN RECEPTOR;

ADVERSE DRUG REACTION; AGE RELATED MACULAR DEGENERATION; CEREBROVASCULAR ACCIDENT; COLORECTAL CARCINOMA; DIABETIC MACULAR EDEMA; DIABETIC RETINOPATHY; DRUG EFFICACY; DRUG INDICATION; DRUG SAFETY; ENDOPHTHALMITIS; HEART INFARCTION; HUMAN; HYPERTENSION; INTESTINE PERFORATION; INTRAOCULAR PRESSURE ABNORMALITY; IRIS DISEASE; MACULAR EDEMA; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; OPHTHALMOLOGY; PROLIFERATIVE RETINOPATHY; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEINURIA; RETINA DETACHMENT; RETINA DISEASE; RETINA MACULA HOLE; RETINA TEAR; REVIEW; STOMACH PERFORATION; SYSTEMIC DISEASE; THROMBOEMBOLISM; TREATMENT RESPONSE; UVEITIS; VITREOUS HEMORRHAGE;

EID: 84992562529     PISSN: 14263912     EISSN: 16444124     Source Type: Journal    
DOI: 10.5114/ceji.2016.63132     Document Type: Review

References (66)

1. Shibuya M (2014): VEGF-VEGFR signals in health and disease. Biomol Ther (Seoul) 22: 1-9.
2. Van Bergen T, Vandewalle E, Van de Veire S, et al. (2011): The role of different VEGF isoforms in scar formation after glaucoma filtration surgery. Exp Eye Res 93: 689-699.
3. Shibuya M (2013): Vascular endothelial growth factor and its receptor system: physiological functions in angiogenesis and pathological roles in various diseases. J Biochem 153: 13-19.
4. Shibuya M (2011): Vascular endothelial growth factor (VEGF) and its receptor (VEGFR) signaling in angiogenesis: a crucial target for anti- and pro-angiogenic therapies. Genes Cancer 2: 1097-1105.
5. Tolentino M (2011): Systemic and ocular safety of intravitreal anti-VEGF therapies for ocular neovascular disease. Surv Ophthalmol 56: 95-113.
6. Chalam KV, Brar VS, Murthy RK (2014): Human ciliary epithelium as a source of synthesis and secretion of vascular endothelial growth factor in neovascular glaucoma. JAMA Ophthalmol 132: 1350-1354.
7. Kaur C, Foulds WS, Ling EA (2008): Hypoxia-ischemia and retinal ganglion cell damage. Clin Ophthalmol 2: 879-889.
8. Kaur C, Sivakumar V, Foulds WS (2006): Early response of neurons and glial cells to hypoxia in the retina. Invest Ophthalmol Vis Sci 47: 1126-1141.
9. Kim M, Lee C, Payne R, et al. (2015): Angiogenesis in glaucoma filtration surgery and neovascular glaucoma: A review. Surv Ophthalmol 60: 524-535.
10. Andreoli CM, Miller JW (2007): Anti-vascular endothelial growth factor therapy for ocular neovascular disease. Curr Opin Ophthalmol 18: 502-508.
11. Al-Latayfeh M, Silva PS, Sun JK, Aiello LP (2012): Antiangiogenic therapy for ischemic retinopathies. Cold Spring Harb Perspect Med 2: a006411.
12. Popescu V, Pricopie S, Totir M, et al. (2015): Clinical use of Bevacizumab in treating refractory glaucoma. J Med Life 8: 8-12.
13. Osaadon P, Fagan XJ, Lifshitz T, Levy J (2014): A review of anti-VEGF agents for proliferative diabetic retinopathy. Eye (Lond) 28: 510-520.
14. Foxton RH, Finkelstein A, Vijay S, et al. (2013): VEGF-A is necessary and sufficient for retinal neuroprotection in models of experimental glaucoma. Am J Pathol 182: 1379-1390.
15. Noma H, Mimura T, Yasuda K, Shimura M (2014): Vascular endothelial growth factor and its soluble receptors-1 and -2 in iris neovascularization and neovascular glaucoma. Ophthalmologica 232: 102-109.
16. Chang JH, Garg NK, Lunde E, et al. (2012): Corneal neovascularization: an anti-VEGF therapy review. Surv Ophthalmol 57: 415-429.
17. Zheng W, Aspelund A, Alitalo K (2014): Lymphangiogenic factors, mechanisms, and applications. J Clin Invest 124: 878-887.
18. Daneshvar R (2013): Anti-VEGF agents and glaucoma filtering surgery. J Ophthalmic Vis Res 8: 182-186.
19. Chen S, Zhou M, Wang W, et al. (2015): Levels of angiogenesis- related vascular endothelial growth factor family in neovascular glaucoma eyes. Acta Ophthalmol 93: e556-560.
20. Aspelund A, Tammela T, Antila S, et al. (2014): The Schlemm's canal is a VEGF-C/VEGFR-3-responsive lymphatic- like vessel. J Clin Invest 124: 3975-3986.
21. Karpinich NO, Caron KM (2014): Schlemm's canal: more than meets the eye, lymphatics in disguise. J Clin Invest 124: 3701-3703.
22. Klein A, Loewenstein A (2016): Therapeutic monoclonal antibodies and fragments: Bevacizumab. Dev Ophthalmol 55: 232-245.
23. Kimoto K, Kubota T (2012): Anti-VEGF agents for ocular angiogenesis and vascular permeability. J Ophthalmol 2012:852183.
24. Park SC, Su D, Tello C (2012): Anti-VEGF therapy for the treatment of glaucoma: a focus on ranibizumab and bevacizumab. Expert Opin Biol Ther 12: 1641-1647.
25. Horsley MB, Kahook MY (2010): Anti-VEGF therapy for glaucoma. Curr Opin Ophthalmol 21: 112-117.
26. http://www.ema.europa.eu/docs/pl-PL/document-library/ EPAR-Product-Information/human/000582/WC500029271. pdf-14.12.2015
27. SooHoo JR, Seibold LK, Kahook MY (2014): The link between intravitreal antivascular endothelial growth factor injections and glaucoma. Curr Opin Ophthalmol 25: 127-133.
28. Ryu CL, Elfersy A, Desai U, et al. (2014): The effect of antivascular endothelial growth factor therapy on the development of neovascular glaucoma after central retinal vein occlusion: a retrospective analysis. J Ophthalmol 2014:317694.
29. Cardarelli WJ, Smith RA (2013): Managed care implications of age-related ocular conditions. Am J Manag Care 19 (5 Suppl): S85-91.
30. http://www.ema.europa.eu/docs/pl-PL/document-library/ EPAR-Summary-for-the-public/human/002392/ WC500135745.pdf-14.12.2015
31. http://www.ema.europa.eu/docs/pl-PL/document-library/ EPAR-Product-Information/human/002532/WC500139484. pdf -14.12.2015
32. Simha A, Braganza A, Abraham L, et al. (2013) Anti-vascular endothelial growth factor for neovascular glaucoma. Review Cochrane Database Syst Rev 10: CD007920.
33. Akpek EK, Smith RA (2013): Current treatment strategies for age-related ocular conditions. Am J Manag Care 19 (5 Suppl): S76-84.
34. Singh RS, Kim JE (2012): Ocular hypertension following intravitreal anti-vascular endothelial growth factor agents. Drugs Aging 29: 949-956.
35. Bahar I, Yeung SN, Sella R, Slomovic A (2012): Anterior segment uses of bevacizumab. Curr Opin Ophthalmol 23: 303-316.
36. Xiong Q, Li Z, Li Z, et al. (2014): Anti-VEGF agents with or without antimetabolites in trabeculectomy for glaucoma: a meta-analysis. PLoS One 9: e88403.
37. Mansour AM, Shahin M, Kofoed PK, et al. (2012): Collaborative Anti-VEGF Ocular Vascular Complications Group. Insight into 144 patients with ocular vascular events during VEGF antagonist injections. Clin Ophthalmol 6: 343-363.
38. SooHoo JR, Seibold LK, Kahook MY (2013): Recent advances in the management of neovascular glaucoma. Semin Ophthalmol 28: 165-172.
39. Gismondi M, Salati C, Salvetat ML, et al. (2009): Short-term effect of intravitreal injection of Ranibizumab (Lucentis) on intraocular pressure. J Glaucoma 18: 658-661.
40. Kim JE, Mantravadi AV, Hur EY, Covert DJ (2008): Shortterm intraocular pressure changes immediately after intravitreal injections of anti-vascular endothelial growth factor agents. Am J Ophthalmol 146: 930-4.e1.
41. Hollands H, Wong J, Bruen R, et al. (2007): Short-term intraocular pressure changes after intravitreal injection of bevacizumab. Can J Ophthalmol 42: 807-811.
42. Aref AA (2012): Management of immediate and sustained intraocular pressure rise associated with intravitreal antivascular endothelial growth factor injection therapy. Curr Opin Ophthalmol 23: 105-110.
43. Kiddee W, Montriwet M (2015): Intraocular pressure changes in non-glaucomatous patients receiving intravitreal anti-vascular endothelial growth factor agents. PLoS One 10: e0137833.
44. Cacciamani A, Oddone F, Parravano M, et al. (2013): Intravitreal injection of bevacizumab: changes in intraocular pressure related to ocular axial length. Jpn J Ophthalmol 57: 63-67.
45. Choi DY, Ortube MC, McCannel CA, et al. (2011): Sustained elevated intraocular pressures after intravitreal injection of bevacizumab, ranibizumab, and pegaptanib. Retina 31: 1028-1035.
46. Good TJ, Kimura AE, Mandava N, Kahook MY (2011): Sustained elevation of intraocular pressure after intravitreal injections of anti-VEGF agents. Br J Ophthalmol 95: 1111-1114.
47. Dedania VS, Bakri SJ (2015): Sustained elevation of intraocular pressure after intravitreal anti-VEGF agents: what is the evidence? Retina 35: 841-858.
48. Bakri SJ, Ekdawi NS (2008) Intravitreal silicone oil droplets after intravitreal drug injections. Retina 28: 996-1001.
49. Kahook MY, Liu L, Ruzycki P, et al. (2010): High-molecular- weight aggregates in repackaged bevacizumab. Retina 30: 887-892.
50. Sniegowski M, Mandava N, Kahook MY (2010): Sustained intraocular pressure elevation after intravitreal injection of bevacizumab and ranibizumab associated with trabeculitis. Open Ophthalmol J 4: 28-29.
51. Bakri SJ, McCannel CA, Edwards AO, Moshfeghi DM (2008): Persistent ocular hypertension following intravitreal ranibizumab. Graefes Arch Clin Exp Ophthalmol 246: 955-958.
52. Kahook MY, Ammar DA (2010): In vitro effects of antivascular endothelial growth factors on cultured human trabecular meshwork cells. J Glaucoma 19: 437-441.
53. Bakri SJ, Moshfeghi DM, Francom S, et al. (2014): Intraocular pressure in eyes receiving monthly ranibizumab in 2 pivotal age-related macular degeneration clinical trials. Ophthalmology 121: 1102-1108.
54. Tseng JJ, Vance SK, Della Torre KE, et al. (2012): Sustained increased intraocular pressure related to intravitreal antivascular endothelial growth factor therapy for neovascular age-related macular degeneration. J Glaucoma 21: 241-247.
55. Hoang QV, Mendonca LS, Della Torre KE, et al. (2012): Effect on intraocular pressure in patients receiving unilateral intravitreal anti-vascular endothelial growth factor injections. Ophthalmology 119: 321-326.
56. Kim YJ, Sung KR, Lee KS, et al. (2014): Long-term effects of multiple intravitreal antivascular endothelial growth factor injections on intraocular pressure. Am J Ophthalmol 157: 1266-1271.
57. Kahook MY, Kimura AE, Wong LJ, et al. (2009): Sustained elevation in intraocular pressure associated with intravitreal bevacizumab injections. Ophthalmic Surg Lasers Imaging 40: 293-295.
58. Kim YJ, Sung KR, Lee KS, et al. (2014): Long-term effects of multiple intravitreal antivascular endothelial growth factor injections on intraocular pressure. Am J Ophthalmol 157: 1266-1271.
59. Skalicky SE, Ho I, Agar A, Bank A (2012): Glaucoma filtration surgery following sustained elevation of intraocular pressure secondary to intravitreal anti-VEGF injections. Ophthalmic Surg Lasers Imaging 43: 328-334.
60. Sampat KM, Garg SJ (2010): Complications of intravitreal injections. Curr Opin Ophthalmol 21: 178-183.
61. Bakri SJ, Larson TA, Edwards AO (2008): Intraocular inflammation following intravitreal injection of bevacizumab. Graefes Arch Clin Exp Ophthalmol 246: 779-781.
62. Higashide T, Murotani E, Saito Y, et al. (2012): Adverse events associated with intraocular injections of bevacizumab in eyes with neovascular glaucoma. Graefes Arch Clin Exp Ophthalmol 250: 603-610.
63. Wilhelm A, Sietmann R, Wilhelm U, Hammer T (2015 ): The influence of VEGF inhibitors on corneal endothelium after injection into the anterior chamber in a porcine eye model. Ophthalmologe 112: 346-352.
64. Rusovici R, Sakhalkar M, Chalam KV (2011): Evaluation of cytotoxicity of bevacizumab on VEGF-enriched corneal endothelial cells. Mol Vis 17: 3339-3346.
65. Wu L, Martínez-Castellanos MA, Quiroz-Mercado H, et al. (2008): Pan American Collaborative Retina Group (PACORES). Twelve-month safety of intravitreal injections of bevacizumab (Avastin): results of the Pan-American Collaborative Retina Study Group (PACORES). Graefes Arch Clin Exp Ophthalmol 246: 81-87.
66. Ueta T, Yanagi Y, Tamaki Y, Yamaguchi T (2009): Cerebrovascular accidents in ranibizumab. Ophthalmology 116: 362.