Schlemm's canal: More than meets the eye, lymphatics in disguise

Journal of Clinical Investigation

Volumn 124, Issue 9, 2014, Pages 3701-3703

  Karpinich, Natalie O ^a   Caron, Kathleen M ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HOMEODOMAIN PROTEIN; PARVOVIRUS VECTOR; PROX1 PROTEIN; RECOMBINANT GROWTH FACTOR; RECOMBINANT VASCULAR ENDOTHELIAL GROWTH FACTOR C; UNCLASSIFIED DRUG; VASCULOTROPIN A; VASCULOTROPIN C;

ADENO ASSOCIATED VIRUS; AGING; AQUEOUS HUMOR; BIOSENSOR; ENDOTHELIUM CELL; EYE; EYE DISEASE; GLAUCOMA; HUMAN; INTRAOCULAR PRESSURE; LYMPH; LYMPH VESSEL; LYMPHATIC SYSTEM DISEASE; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; REVIEW; SCHLEMM CANAL; STUDY; VIRAL GENE DELIVERY SYSTEM;

EID: 84907013875     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI77507     Document Type: Review

References (21)

1. Tamm ER. The trabecular meshwork outflow pathways: structural and functional aspects. Exp Eye Res. 2009;88(4):648-655.
2. Alm A, Nilsson SF. Uveoscleral outflow - a review. Exp Eye Res. 2009;88(4):760-768.
3. Bill A. Formation and drainage of aqueous humour in cats. Exp Eye Res. 1966;5:185-190.
4. Bill A. The routes for bulk drainage of aqueous humour in rabbits with and without cyclodialysis. Documenta Ophthal. 1966;20:157-169.
5. Ramos RF, Hoying JB, Witte MH, Daniel Stamer W. Schlemm's canal endothelia, lymphatic, or blood vasculature? J Glaucoma. 2007;16(4):391-405.
6. Dickinson AJ, Gausas RE. Orbital lymphatics: do they exist? Eye (Lond). 2006;20(10):1145-1148.
7. Alitalo K. The lymphatic vasculature in disease. Nat Med. 2011;17(11):1371-1380.
8. Nakao S, Hafezi-Moghadam A, Ishibashi T. Lymphatics and lymphangiogenesis in the eye. J Ophthalmol. 2012;2012:783163.
9. Birke K, Lutjen-Drecoll E, Kerjaschki D, Birke MT. Expression of podoplanin and other lymphatic markers in the human anterior eye segment. Invest Ophthalmol Vis Sci. 2010;51(1):344-354.
10. Yucel YH, et al. Identification of lymphatics in the ciliary body of the human eye: a novel "uveolymphatic" outflow pathway. Exp Eye Res. 2009;89(5):810-819.
11. Cao R, et al. Mouse corneal lymphangiogenesis model. Nat Protoc. 2011;6(6):817-826.
12. Hoopes SL, Willcockson HH, Caron KM. Characteristics of multi-organ lymphangiectasia resulting from temporal deletion of calcitonin receptor-like receptor in adult mice. PLoS One. 2012;7(9):e45261.
13. Truong TN, Li H, Hong YK, Chen L. Novel characterization and live imaging of Schlemm's canal expressing Prox-1. PLoS One. 2014;9(5):e98245.
14. Park D-Y, et al. Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity. J Clin Invest. 2014;124(9):3960-3974.
15. Aspelund A, et al. The Schlemm's canal is a VEGF-C/VEGFR-3-responsive lymphatic-like vessel. J Clin Invest. 2014;124(9):3975-3986.
16. Sabin FR. On the origin of the lymphatic system from the veins and the development of the lymph hearts and thoracic duct in the pig. Am J Anat. 1902;1(3):367-389.
17. Yang Y, Oliver G. Development of the mammalian lymphatic vasculature. J Clin Invest. 2014;124(3):888-897.
18. Oliver G, Srinivasan RS. Endothelial cell plasticity: how to become and remain a lymphatic endothelial cell. Development. 2010;137(3):363-372.
19. Wigle JT, Oliver G. Prox1 function is required for the development of the murine lymphatic system. Cell. 1999;98(6):769-778.
20. Shields JD, Fleury ME, Yong C, Tomei AA, Randolph GJ, Swartz M.A. Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling. Cancer Cell. 2007;11(6):526-538.
21. Aihara M, Lindsey JD, Weinreb RN. Aqueous humor dynamics in mice. Invest Ophthalmol Vis Sci. 2003;44(12):5168-5173.