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Volumn 77, Issue 7, 2016, Pages 346-356

S-Adenosyl Methionine in the Therapy of Depression and Other Psychiatric Disorders

Author keywords

Alzheimer's disease; bipolar disorder; depression; S adenosyl methionine; schizophrenia

Indexed keywords

CATECHOL METHYLTRANSFERASE; PHOSPHOLIPID; S ADENOSYLMETHIONINE; HOMOCYSTEINE;

EID: 84992505867     PISSN: 02724391     EISSN: 10982299     Source Type: Journal    
DOI: 10.1002/ddr.21345     Document Type: Article
Times cited : (26)

References (71)
  • 1
    • 0017184017 scopus 로고
    • Effect of s-adenosyl-l-methionine (SAMe) upon depressive symptoms
    • Agnoli A, Andreoli V, Casacchia M, Cerbo R. 1976. Effect of s-adenosyl-l-methionine (SAMe) upon depressive symptoms. J Psychiatr Res 13:43–54.
    • (1976) J Psychiatr Res , vol.13 , pp. 43-54
    • Agnoli, A.1    Andreoli, V.2    Casacchia, M.3    Cerbo, R.4
  • 2
    • 0142043253 scopus 로고    scopus 로고
    • (Agency for Healthcare Research and Quality) USDfhahs. AHFQ Evidenc 64., Retrieved June 1 2016.
    • AHRQ (Agency for Healthcare Research and Quality) USDfhahs. 2002. S-Adenosyl-L-Methionine for tratment of depression, osteoarthritis, and liver disease. AHFQ Evidence Report 64. http://archive.ahrq.gov/clinic/epcsums/samesum.htm. Retrieved June 1 2016.
    • (2002) S-Adenosyl-L-Methionine for tratment of depression, osteoarthritisliver disease.
  • 3
    • 0018220146 scopus 로고
    • Sugli effetti clinici della s-adenosil-metionina (SAMe) nelle sindromi depressive
    • Barberi A, Pusateri C. 1978. Sugli effetti clinici della s-adenosil-metionina (SAMe) nelle sindromi depressive. Minerva Psichiatr 19:235–244.
    • (1978) Minerva Psichiatr , vol.19 , pp. 235-244
    • Barberi, A.1    Pusateri, C.2
  • 4
    • 0023688477 scopus 로고
    • S-adenosylmethionine treatment of depression: a controlled clinical trial
    • Bell KM, Plon L, Bunney WE Jr., Potkin SG. 1988. S-adenosylmethionine treatment of depression: a controlled clinical trial. Am J Psychiatry 145:1110–1114.
    • (1988) Am J Psychiatry , vol.145 , pp. 1110-1114
    • Bell, K.M.1    Plon, L.2    Bunney, W.E.3    Potkin, S.G.4
  • 5
    • 85001705657 scopus 로고
    • Oral s-adenosylmethionine in the treatment of depression: a double-blind comparison with desipramine
    • BioResearch File
    • Bell MB, Carreon D, Plon L, Bunney WE, Potkin SG. 1990. Oral s-adenosylmethionine in the treatment of depression: a double-blind comparison with desipramine. Study Report. BioResearch File.
    • (1990) Study Report.
    • Bell, M.B.1    Carreon, D.2    Plon, L.3    Bunney, W.E.4    Potkin, S.G.5
  • 9
    • 0025606597 scopus 로고
    • Cerebrospinal fluid S-adenosylmethionine in depression and dementia: effects of treatment with parenteral and oral S-adenosylmethionine
    • Bottiglieri T, Godfrey P, Flynn T, Carney MW, Toone BK, Reynolds EH. 1990. Cerebrospinal fluid S-adenosylmethionine in depression and dementia: effects of treatment with parenteral and oral S-adenosylmethionine. J Neurol Neurosurg Psychiatry 53:1096–1098.
    • (1990) J Neurol Neurosurg Psychiatry , vol.53 , pp. 1096-1098
    • Bottiglieri, T.1    Godfrey, P.2    Flynn, T.3    Carney, M.W.4    Toone, B.K.5    Reynolds, E.H.6
  • 10
    • 0028189416 scopus 로고
    • S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies
    • Bressa GM. 1994. S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies. Acta Neurol Scand Suppl 154:7–14.
    • (1994) Acta Neurol Scand Suppl , vol.154 , pp. 7-14
    • Bressa, G.M.1
  • 12
    • 0023629703 scopus 로고
    • Treatment of depression in rheumatoid arthritic patients. A comaprison of S-adenosylmethionine (Samyr) and placebo in a double-blind study
    • Caruso I, Fumagalli M, Boccazzini L. 1987. Treatment of depression in rheumatoid arthritic patients. A comaprison of S-adenosylmethionine (Samyr) and placebo in a double-blind study. Clin Trials J 24:305–311.
    • (1987) Clin Trials J , vol.24 , pp. 305-311
    • Caruso, I.1    Fumagalli, M.2    Boccazzini, L.3
  • 14
    • 77955576741 scopus 로고    scopus 로고
    • A vitamin/nutriceutical formulation improves memory and cognitive performance in community-dwelling adults without dementia
    • Chan A, Remington R, Kotyla E, Lepore A, Zemianek J, Shea TB. 2010. A vitamin/nutriceutical formulation improves memory and cognitive performance in community-dwelling adults without dementia. J Nutr Health Aging 14:224–230.
    • (2010) J Nutr Health Aging , vol.14 , pp. 224-230
    • Chan, A.1    Remington, R.2    Kotyla, E.3    Lepore, A.4    Zemianek, J.5    Shea, T.B.6
  • 15
    • 84855319030 scopus 로고    scopus 로고
    • Suicide attempt by self-burning associated with ingestion of S-adenosylmethionine: a review of the literature and case report
    • Chitiva H, Audivert F, Alvarez C. 2012. Suicide attempt by self-burning associated with ingestion of S-adenosylmethionine: a review of the literature and case report. J Nerv Ment Dis 200:99–101.
    • (2012) J Nerv Ment Dis , vol.200 , pp. 99-101
    • Chitiva, H.1    Audivert, F.2    Alvarez, C.3
  • 17
    • 0023833543 scopus 로고
    • Outcome from carotid endarterectomy. Neuropsychological performances, depressive symptoms and quality of life: 8-month follow-up
    • De Leo D, Serraiotto L, Pellegrini C, Magni G, Franceschi L, Deriu GP. 1987. Outcome from carotid endarterectomy. Neuropsychological performances, depressive symptoms and quality of life: 8-month follow-up. Int J Psychiatry Med 17:317–325.
    • (1987) Int J Psychiatry Med , vol.17 , pp. 317-325
    • De Leo, D.1    Serraiotto, L.2    Pellegrini, C.3    Magni, G.4    Franceschi, L.5    Deriu, G.P.6
  • 18
    • 0026795129 scopus 로고
    • Oral S-adenosyl-L-Methionine in depression
    • De Vanna M, Rigamonti R. 1992. Oral S-adenosyl-L-Methionine in depression. Curr Ther Res Clin Exp 52:478–486.
    • (1992) Curr Ther Res Clin Exp , vol.52 , pp. 478-486
    • De Vanna, M.1    Rigamonti, R.2
  • 19
    • 84891630466 scopus 로고    scopus 로고
    • Complementary and alternative medicine therapies for perinatal depression
    • Deligiannidis KM, Freeman MP. 2014. Complementary and alternative medicine therapies for perinatal depression. Best Pract Res Clin Obstet Gynaecol 28:85–95.
    • (2014) Best Pract Res Clin Obstet Gynaecol , vol.28 , pp. 85-95
    • Deligiannidis, K.M.1    Freeman, M.P.2
  • 20
    • 0036828360 scopus 로고    scopus 로고
    • Efficacy and tolerability of oral and intramuscular S-adenosyl-L-methionine 1,4-butanedisulfonate (SAMe) in the treatment of major depression: comparison with imipramine in 2 multicenter studies
    • Delle Chiaie R, Pancheri P, Scapicchio P. 2002. Efficacy and tolerability of oral and intramuscular S-adenosyl-L-methionine 1,4-butanedisulfonate (SAMe) in the treatment of major depression: comparison with imipramine in 2 multicenter studies. Am J Clin Nutr 76:1172S–1176S.
    • (2002) Am J Clin Nutr , vol.76 , pp. 1172S-1176S
    • Delle Chiaie, R.1    Pancheri, P.2    Scapicchio, P.3
  • 21
    • 84921769185 scopus 로고    scopus 로고
    • Role of betaine in improving the antidepressant effect of S-adenosyl-methionine in patients with mild-to-moderate depression
    • Di Pierro F, Orsi R, Settembre R. 2015. Role of betaine in improving the antidepressant effect of S-adenosyl-methionine in patients with mild-to-moderate depression. J Multidiscip Healthc 8:39–45.
    • (2015) J Multidiscip Healthc , vol.8 , pp. 39-45
    • Di Pierro, F.1    Orsi, R.2    Settembre, R.3
  • 23
    • 0026778237 scopus 로고
    • The thyrotropin response to thyrotropin-releasing hormone as a predictor of response to treatment in depressed outpatients
    • Fava M, Rosenbaum JF, Birnbaum R, Kelly K, Otto MW, MacLaughlin R. 1992. The thyrotropin response to thyrotropin-releasing hormone as a predictor of response to treatment in depressed outpatients. Acta Psychiatr Scand 86:42–45.
    • (1992) Acta Psychiatr Scand , vol.86 , pp. 42-45
    • Fava, M.1    Rosenbaum, J.F.2    Birnbaum, R.3    Kelly, K.4    Otto, M.W.5    MacLaughlin, R.6
  • 24
    • 34548289315 scopus 로고    scopus 로고
    • Dramatic reduction in self-injury in Lesch-Nyhan disease following S-adenosylmethionine administration
    • Glick N. 2006. Dramatic reduction in self-injury in Lesch-Nyhan disease following S-adenosylmethionine administration. J Inherit Metab Dis 29:687.
    • (2006) J Inherit Metab Dis , vol.29 , pp. 687
    • Glick, N.1
  • 26
    • 7044250875 scopus 로고    scopus 로고
    • Bioavailability and lack of toxicity of S-adenosyl-L-methionine (SAMe) in humans
    • Goren JL, Stoll AL, Damico KE, Sarmiento IA, Cohen BM. 2004. Bioavailability and lack of toxicity of S-adenosyl-L-methionine (SAMe) in humans. Pharmacotherapy 24:1501–1507.
    • (2004) Pharmacotherapy , vol.24 , pp. 1501-1507
    • Goren, J.L.1    Stoll, A.L.2    Damico, K.E.3    Sarmiento, I.A.4    Cohen, B.M.5
  • 27
    • 84869495800 scopus 로고    scopus 로고
    • The feasibility and safety of S-adenosyl-L-methionine (SAMe) for the treatment of neuropsychiatric symptoms in 22q11.2 deletion syndrome: a double-blind placebo-controlled trial
    • Green T, Steingart L, Frisch A, Zarchi O, Weizman A, Gothelf D. 2012. The feasibility and safety of S-adenosyl-L-methionine (SAMe) for the treatment of neuropsychiatric symptoms in 22q11.2 deletion syndrome: a double-blind placebo-controlled trial. J Neural Transm (Vienna) 119:1417–1423.
    • (2012) J Neural Transm (Vienna) , vol.119 , pp. 1417-1423
    • Green, T.1    Steingart, L.2    Frisch, A.3    Zarchi, O.4    Weizman, A.5    Gothelf, D.6
  • 28
    • 84963756166 scopus 로고    scopus 로고
    • Epigenetic RELN dysfunction in schizophrenia and related neuropsychiatric disorders
    • Guidotti A, Grayson DR, Caruncho HJ. 2016. Epigenetic RELN dysfunction in schizophrenia and related neuropsychiatric disorders. Front Cell Neurosci 10:89.
    • (2016) Front Cell Neurosci , vol.10 , pp. 89
    • Guidotti, A.1    Grayson, D.R.2    Caruncho, H.J.3
  • 30
    • 84867003004 scopus 로고    scopus 로고
    • COMT Val158Met polymorphism interacts with stressful life events and parental warmth to influence decision making
    • He Q, Xue G, Chen C, Lu ZL, Lei X, Liu Y, Li J, Zhu B, Moyzis RK Dong Q, et al. 2012. COMT Val158Met polymorphism interacts with stressful life events and parental warmth to influence decision making. Sci Rep 2:677.
    • (2012) Sci Rep , vol.2 , pp. 677
    • He, Q.1    Xue, G.2    Chen, C.3    Lu, Z.L.4    Lei, X.5    Liu, Y.6    Li, J.7    Zhu, B.8    Moyzis, R.K.9    Dong, Q.10
  • 32
    • 0025312343 scopus 로고
    • Oral S-adenosylmethionine in depression: a randomized, double-blind, placebo-controlled trial
    • Kagan BL, Sultzer DL, Rosenlicht N, Gerner RH. 1990. Oral S-adenosylmethionine in depression: a randomized, double-blind, placebo-controlled trial. Am J Psychiatry 147:591–595.
    • (1990) Am J Psychiatry , vol.147 , pp. 591-595
    • Kagan, B.L.1    Sultzer, D.L.2    Rosenlicht, N.3    Gerner, R.H.4
  • 34
    • 84863012028 scopus 로고    scopus 로고
    • Dietary supplementation with S-adenosyl methionine delayed amyloid-beta and tau pathology in 3xTg-AD mice
    • Lee S, Lemere CA, Frost JL, Shea TB. 2012. Dietary supplementation with S-adenosyl methionine delayed amyloid-beta and tau pathology in 3xTg-AD mice. J Alzheimers Dis 28:423–431.
    • (2012) J Alzheimers Dis , vol.28 , pp. 423-431
    • Lee, S.1    Lemere, C.A.2    Frost, J.L.3    Shea, T.B.4
  • 35
    • 84857368903 scopus 로고    scopus 로고
    • Effects of S-adenosylmethionine augmentation of serotonin-reuptake inhibitor antidepressants on cognitive symptoms of major depressive disorder
    • Levkovitz Y, Alpert JE, Brintz CE, Mischoulon D, Papakostas GI. 2012. Effects of S-adenosylmethionine augmentation of serotonin-reuptake inhibitor antidepressants on cognitive symptoms of major depressive disorder. J Affect Disord 136:1174–1178.
    • (2012) J Affect Disord , vol.136 , pp. 1174-1178
    • Levkovitz, Y.1    Alpert, J.E.2    Brintz, C.E.3    Mischoulon, D.4    Papakostas, G.I.5
  • 36
    • 33645999355 scopus 로고    scopus 로고
    • S-adenosylmethionine: jack of all trades and master of everything?
    • Loenen WA. 2006. S-adenosylmethionine: jack of all trades and master of everything? Biochem Soc Trans 34:330–333.
    • (2006) Biochem Soc Trans , vol.34 , pp. 330-333
    • Loenen, W.A.1
  • 37
    • 0015527971 scopus 로고
    • Folate deficiency after anticonvulsant drugs: an effect of hepatic enzyme induction?
    • Maxwell JD, Hunter J, Stewart DA, Ardeman S, Williams R. 1972. Folate deficiency after anticonvulsant drugs: an effect of hepatic enzyme induction? Br Med J 1:297–299.
    • (1972) Br Med J , vol.1 , pp. 297-299
    • Maxwell, J.D.1    Hunter, J.2    Stewart, D.A.3    Ardeman, S.4    Williams, R.5
  • 38
    • 0036578544 scopus 로고    scopus 로고
    • Activation and induction of glycine N-methyltransferase by retinoids are tissue- and gender-specific
    • McMullen MH, Rowling MJ, Ozias MK, Schalinske KL. 2002. Activation and induction of glycine N-methyltransferase by retinoids are tissue- and gender-specific. Arch Biochem Biophys 401:73–80.
    • (2002) Arch Biochem Biophys , vol.401 , pp. 73-80
    • McMullen, M.H.1    Rowling, M.J.2    Ozias, M.K.3    Schalinske, K.L.4
  • 39
    • 0018134353 scopus 로고
    • Comparison between the antidepressant activity and of S-adenosylmethionine (SAMe) and that of some tricyclic drugs
    • Miccoli L, Porro V, Bertolino A. 1978. Comparison between the antidepressant activity and of S-adenosylmethionine (SAMe) and that of some tricyclic drugs. Acta Neurol (Napoli) 33:243–255.
    • (1978) Acta Neurol (Napoli) , vol.33 , pp. 243-255
    • Miccoli, L.1    Porro, V.2    Bertolino, A.3
  • 40
    • 84863557233 scopus 로고    scopus 로고
    • Bioavailability of S-adenosyl methionine and impact on response in a randomized, double-blind, placebo-controlled trial in major depressive disorder
    • Mischoulon D, Alpert JE, Arning E, Bottiglieri T, Fava M, Papakostas GI. 2012. Bioavailability of S-adenosyl methionine and impact on response in a randomized, double-blind, placebo-controlled trial in major depressive disorder. J Clin Psychiatry 73:843–848.
    • (2012) J Clin Psychiatry , vol.73 , pp. 843-848
    • Mischoulon, D.1    Alpert, J.E.2    Arning, E.3    Bottiglieri, T.4    Fava, M.5    Papakostas, G.I.6
  • 42
    • 0018613968 scopus 로고
    • [Study of the antidepressive effects of a biological transmethylating agent (S-adenosyl-methione or SAM)]
    • Monaco P, Quattrocchi F. 1979. [Study of the antidepressive effects of a biological transmethylating agent (S-adenosyl-methione or SAM)]. Riv Neurol 49:417–439.
    • (1979) Riv Neurol , vol.49 , pp. 417-439
    • Monaco, P.1    Quattrocchi, F.2
  • 43
    • 0029799427 scopus 로고    scopus 로고
    • Brain S-adenosylmethionine levels are severely decreased in Alzheimer's disease
    • Morrison LD, Smith DD, Kish SJ. 1996. Brain S-adenosylmethionine levels are severely decreased in Alzheimer's disease. J Neurochem 67:1328–1331.
    • (1996) J Neurochem , vol.67 , pp. 1328-1331
    • Morrison, L.D.1    Smith, D.D.2    Kish, S.J.3
  • 44
    • 84900521861 scopus 로고    scopus 로고
    • Oral SAMe in persistent treatment-refractory bipolar depression: a double-blind, randomized clinical trial
    • Murphy BL, Babb SM, Ravichandran C, Cohen BM. 2014. Oral SAMe in persistent treatment-refractory bipolar depression: a double-blind, randomized clinical trial. J Clin Psychopharmacol 34:413–416.
    • (2014) J Clin Psychopharmacol , vol.34 , pp. 413-416
    • Murphy, B.L.1    Babb, S.M.2    Ravichandran, C.3    Cohen, B.M.4
  • 45
    • 0020014717 scopus 로고
    • SAMe versus placebo: a double blind comparison in major depressive disorders
    • Muscettola G, Galzenati M, Balbi A. 1982. SAMe versus placebo: a double blind comparison in major depressive disorders. Adv Biochem Psychopharmacol 32:151–156.
    • (1982) Adv Biochem Psychopharmacol , vol.32 , pp. 151-156
    • Muscettola, G.1    Galzenati, M.2    Balbi, A.3
  • 46
    • 0035008473 scopus 로고    scopus 로고
    • Pulsatile growth hormone secretion decreases S-adenosylmethionine synthetase in rat liver
    • Oscarsson J, Gardmo C, Eden S, Mode A. 2001. Pulsatile growth hormone secretion decreases S-adenosylmethionine synthetase in rat liver. Am J Physiol Endocrinol Metab 280:E280–E286.
    • (2001) Am J Physiol Endocrinol Metab , vol.280 , pp. E280-E286
    • Oscarsson, J.1    Gardmo, C.2    Eden, S.3    Mode, A.4
  • 47
    • 70449376943 scopus 로고    scopus 로고
    • Cytokines and glucocorticoid receptor signaling. Relevance to major depression
    • Pace TW, Miller AH. 2009. Cytokines and glucocorticoid receptor signaling. Relevance to major depression. Ann N Y Acad Sci 1179:86–105.
    • (2009) Ann N Y Acad Sci , vol.1179 , pp. 86-105
    • Pace, T.W.1    Miller, A.H.2
  • 48
    • 2942673042 scopus 로고    scopus 로고
    • S-adenosyl-methionine in depression: a comprehensive review of the literature
    • Papakostas GI, Alpert JE, Fava M. 2003. S-adenosyl-methionine in depression: a comprehensive review of the literature. Curr Psychiatry Rep 5:460–466.
    • (2003) Curr Psychiatry Rep , vol.5 , pp. 460-466
    • Papakostas, G.I.1    Alpert, J.E.2    Fava, M.3
  • 49
    • 77955360283 scopus 로고    scopus 로고
    • S-adenosyl methionine (SAMe) augmentation of serotonin reuptake inhibitors for antidepressant nonresponders with major depressive disorder: a double-blind, randomized clinical trial
    • Papakostas GI, Mischoulon D, Shyu I, Alpert JE, Fava M. 2010. S-adenosyl methionine (SAMe) augmentation of serotonin reuptake inhibitors for antidepressant nonresponders with major depressive disorder: a double-blind, randomized clinical trial. Am J Psychiatry 167:942–948.
    • (2010) Am J Psychiatry , vol.167 , pp. 942-948
    • Papakostas, G.I.1    Mischoulon, D.2    Shyu, I.3    Alpert, J.E.4    Fava, M.5
  • 50
    • 84865862602 scopus 로고    scopus 로고
    • Role of epigenetics in pharmacotherapy, psychotherapy and nutritional management of mental disorders
    • Peedicayil J. 2012. Role of epigenetics in pharmacotherapy, psychotherapy and nutritional management of mental disorders. J Clin Pharm Ther 37:499–501.
    • (2012) J Clin Pharm Ther , vol.37 , pp. 499-501
    • Peedicayil, J.1
  • 55
    • 84899797176 scopus 로고    scopus 로고
    • S-adenosyl methionine (SAMe) versus escitalopram and placebo in major depression RCT: efficacy and effects of histamine and carnitine as moderators of response
    • Sarris J, Papakostas GI, Vitolo O, Fava M, Mischoulon D. 2014. S-adenosyl methionine (SAMe) versus escitalopram and placebo in major depression RCT: efficacy and effects of histamine and carnitine as moderators of response. J Affect Disord 164:76–81.
    • (2014) J Affect Disord , vol.164 , pp. 76-81
    • Sarris, J.1    Papakostas, G.I.2    Vitolo, O.3    Fava, M.4    Mischoulon, D.5
  • 57
    • 0242287507 scopus 로고
    • Confronto clinico in doppio cieco della SAMe versus clorimipramina nelle sindromi depressive
    • Scarzella R, Appiotti A. 1978. Confronto clinico in doppio cieco della SAMe versus clorimipramina nelle sindromi depressive. Rivisita Sperimentale Di Feniatria 102:359–366.
    • (1978) Rivisita Sperimentale Di Feniatria , vol.102 , pp. 359-366
    • Scarzella, R.1    Appiotti, A.2
  • 59
    • 84869223239 scopus 로고    scopus 로고
    • The amyloid precursor protein (APP) family members are key players in S-adenosylmethionine formation by MAT2A and modify BACE1 and PSEN1 gene expression-relevance for Alzheimer's disease
    • Schrotter A, Pfeiffer K, El Magraoui F, Platta HW, Erdmann R, Meyer HE, Egensperger R, Marcus K, Muller T. 2012. The amyloid precursor protein (APP) family members are key players in S-adenosylmethionine formation by MAT2A and modify BACE1 and PSEN1 gene expression-relevance for Alzheimer's disease. Mol Cell Proteomics 11:1274–1288.
    • (2012) Mol Cell Proteomics , vol.11 , pp. 1274-1288
    • Schrotter, A.1    Pfeiffer, K.2    El Magraoui, F.3    Platta, H.W.4    Erdmann, R.5    Meyer, H.E.6    Egensperger, R.7    Marcus, K.8    Muller, T.9
  • 60
    • 35148824104 scopus 로고    scopus 로고
    • A metabolic link between S-adenosylhomocysteine and polyunsaturated fatty acid metabolism in Alzheimer's disease
    • Selley ML. 2007. A metabolic link between S-adenosylhomocysteine and polyunsaturated fatty acid metabolism in Alzheimer's disease. Neurobiol Aging 28:1834–1839.
    • (2007) Neurobiol Aging , vol.28 , pp. 1834-1839
    • Selley, M.L.1
  • 61
    • 40549097476 scopus 로고    scopus 로고
    • S-adenosyl methionine: a natural therapeutic agent effective against multiple hallmarks and risk factors associated with Alzheimer's disease
    • Shea TB, Chan A. 2008. S-adenosyl methionine: a natural therapeutic agent effective against multiple hallmarks and risk factors associated with Alzheimer's disease. J Alzheimers Dis 13:67–70.
    • (2008) J Alzheimers Dis , vol.13 , pp. 67-70
    • Shea, T.B.1    Chan, A.2
  • 62
    • 57049171917 scopus 로고    scopus 로고
    • Improvement of aggressive behavior and quality of life impairment following S-adenosyl-methionine (SAM-e) augmentation in schizophrenia
    • Strous RD, Ritsner MS, Adler S, Ratner Y, Maayan R, Kotler M, Lachman H, Weizman A. 2009. Improvement of aggressive behavior and quality of life impairment following S-adenosyl-methionine (SAM-e) augmentation in schizophrenia. Eur Neuropsychopharmacol 19:14–22.
    • (2009) Eur Neuropsychopharmacol , vol.19 , pp. 14-22
    • Strous, R.D.1    Ritsner, M.S.2    Adler, S.3    Ratner, Y.4    Maayan, R.5    Kotler, M.6    Lachman, H.7    Weizman, A.8
  • 64
    • 67149105905 scopus 로고    scopus 로고
    • Dietary supplement S-adenosyl-L-methionine (AdoMet) effects on plasma homocysteine levels in healthy human subjects: a double-blind, placebo-controlled, randomized clinical trial
    • Thompson MA, Bauer BA, Loehrer LL, Cha SS, Mandrekar JN, Sood A, Wahner-Roedler DL. 2009. Dietary supplement S-adenosyl-L-methionine (AdoMet) effects on plasma homocysteine levels in healthy human subjects: a double-blind, placebo-controlled, randomized clinical trial. J Altern Complement Med 15:523–529.
    • (2009) J Altern Complement Med , vol.15 , pp. 523-529
    • Thompson, M.A.1    Bauer, B.A.2    Loehrer, L.L.3    Cha, S.S.4    Mandrekar, J.N.5    Sood, A.6    Wahner-Roedler, D.L.7
  • 66
    • 84865125057 scopus 로고    scopus 로고
    • Role of a redox-based methylation switch in mRNA life cycle (pre- and post-transcriptional maturation) and protein turnover: implications in neurological disorders
    • Trivedi MS, Deth RC. 2012. Role of a redox-based methylation switch in mRNA life cycle (pre- and post-transcriptional maturation) and protein turnover: implications in neurological disorders. Front Neurosci 6:92.
    • (2012) Front Neurosci , vol.6 , pp. 92
    • Trivedi, M.S.1    Deth, R.C.2
  • 67
    • 80052339060 scopus 로고    scopus 로고
    • Structural mechanism of S-adenosyl methionine binding to catechol O-methyltransferase
    • Tsao D, Diatchenko L, Dokholyan NV. 2011. Structural mechanism of S-adenosyl methionine binding to catechol O-methyltransferase. PLoS One 6:e24287.
    • (2011) PLoS One , vol.6
    • Tsao, D.1    Diatchenko, L.2    Dokholyan, N.V.3
  • 69
    • 84892917722 scopus 로고    scopus 로고
    • A systematic review and meta-analysis of the evidence base for add-on treatment for patients with major depressive disorder who have not responded to antidepressant treatment: a European perspective
    • Turner P, Kantaria R, Young AH. 2014. A systematic review and meta-analysis of the evidence base for add-on treatment for patients with major depressive disorder who have not responded to antidepressant treatment: a European perspective. J Psychopharmacol 28:85–98.
    • (2014) J Psychopharmacol , vol.28 , pp. 85-98
    • Turner, P.1    Kantaria, R.2    Young, A.H.3
  • 70
    • 84952636859 scopus 로고    scopus 로고
    • Relationship between the catechol-O-methyl transferase Val108/158Met genotype and brain volume in treatment-naive major depressive disorder: voxel-based morphometry analysis
    • Watanabe K, Kakeda S, Yoshimura R, Abe O, Ide S, Hayashi K, Katsuki A, Umene-Nakano W, Watanabe R Nakamura J, et al. 2015. Relationship between the catechol-O-methyl transferase Val108/158Met genotype and brain volume in treatment-naive major depressive disorder: voxel-based morphometry analysis. Psychiatry Res 233:481–487.
    • (2015) Psychiatry Res , vol.233 , pp. 481-487
    • Watanabe, K.1    Kakeda, S.2    Yoshimura, R.3    Abe, O.4    Ide, S.5    Hayashi, K.6    Katsuki, A.7    Umene-Nakano, W.8    Watanabe, R.9    Nakamura, J.10
  • 71
    • 84864529944 scopus 로고    scopus 로고
    • Characterization of the neuropsychological phenotype of glycine N-methyltransferase-/- mice and evaluation of its responses to clozapine and sarcosine treatments
    • Yang CP, Wang HA, Tsai TH, Fan A, Hsu CL, Chen CJ, Hong CJ, Chen YM. 2012. Characterization of the neuropsychological phenotype of glycine N-methyltransferase-/- mice and evaluation of its responses to clozapine and sarcosine treatments. Eur Neuropsychopharmacol 22:596–606.
    • (2012) Eur Neuropsychopharmacol , vol.22 , pp. 596-606
    • Yang, C.P.1    Wang, H.A.2    Tsai, T.H.3    Fan, A.4    Hsu, C.L.5    Chen, C.J.6    Hong, C.J.7    Chen, Y.M.8


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