메뉴 건너뛰기




Volumn 15, Issue 5, 2009, Pages 523-529

Dietary supplement s-adenosyl-l-methionine (AdoMet) effects on plasma homocysteine levels in healthy human subjects: A double-blind, placebo-controlled, randomized clinical trial

Author keywords

[No Author keywords available]

Indexed keywords

ADOMET; ALANINE AMINOTRANSFERASE; C REACTIVE PROTEIN; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN; HOMOCYSTEINE; PLACEBO; S ADENOSYLMETHIONINE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 67149105905     PISSN: 10755535     EISSN: None     Source Type: Journal    
DOI: 10.1089/acm.2008.0402     Document Type: Article
Times cited : (19)

References (36)
  • 1
    • 0033826139 scopus 로고    scopus 로고
    • Balluz LS, Kieszak SM, Philen RM, Mulinare J. Vitamin and mineral supplement use in the United States: Results from the third National Health and Nutrition Examination Survey. Arch Fam Med 2000;9:258-262. Erratum in Arch Fam Med 2000;9:652.
    • Balluz LS, Kieszak SM, Philen RM, Mulinare J. Vitamin and mineral supplement use in the United States: Results from the third National Health and Nutrition Examination Survey. Arch Fam Med 2000;9:258-262. Erratum in Arch Fam Med 2000;9:652.
  • 3
    • 3042576191 scopus 로고    scopus 로고
    • Complementary and alternative medicine use among adults: United States, 2002
    • Barnes PM, Powell-Griner E, McFann K, Nahin RL. Complementary and alternative medicine use among adults: United States, 2002. Adv Data 2004;343:1-19.
    • (2004) Adv Data , vol.343 , pp. 1-19
    • Barnes, P.M.1    Powell-Griner, E.2    McFann, K.3    Nahin, R.L.4
  • 4
    • 0025784237 scopus 로고
    • Oral S-adenosylmethionine in primary fibromyalgia: Double-blind clinical evaluation
    • Jacobsen S, Danneskiold-Samsøe B, Andersen RB. Oral S-adenosylmethionine in primary fibromyalgia: Double-blind clinical evaluation. Scand J Rheumatol 1991;20:294-302.
    • (1991) Scand J Rheumatol , vol.20 , pp. 294-302
    • Jacobsen, S.1    Danneskiold-Samsøe, B.2    Andersen, R.B.3
  • 5
    • 67149134590 scopus 로고    scopus 로고
    • S-Adenosyl-l-Methionine for Treatment of Depression, Osteoarthritis, and Liver Disease. Summary, Evidence Report/Technology Assessment: Number 64. Publication No. 02-E033. Rockville, MD: Agency for Healthcare Research and Quality, 2002.
    • S-Adenosyl-l-Methionine for Treatment of Depression, Osteoarthritis, and Liver Disease. Summary, Evidence Report/Technology Assessment: Number 64. Publication No. 02-E033. Rockville, MD: Agency for Healthcare Research and Quality, 2002.
  • 6
    • 0036828353 scopus 로고    scopus 로고
    • Bottiglieri T. S-Adenosyl-l-methionine (SAMe): From the bench to the bedside: molecular basis of a pleiotrophic molecule. Am J Clin Nutr 2002;76:1151S-1157S.
    • Bottiglieri T. S-Adenosyl-l-methionine (SAMe): From the bench to the bedside: molecular basis of a pleiotrophic molecule. Am J Clin Nutr 2002;76:1151S-1157S.
  • 8
    • 0030857453 scopus 로고    scopus 로고
    • Influence of oral S-adenosylmethionine on plasma 5-methyltetrahydrofolate, S-adenosylhomocysteine, homocysteine and methionine in healthy humans
    • Loehrer FM, Schwab R, Angst CP, Haefeli WE, Fowler B. Influence of oral S-adenosylmethionine on plasma 5-methyltetrahydrofolate, S-adenosylhomocysteine, homocysteine and methionine in healthy humans. J Pharmacol Exp Ther 1997;282:845-850.
    • (1997) J Pharmacol Exp Ther , vol.282 , pp. 845-850
    • Loehrer, F.M.1    Schwab, R.2    Angst, C.P.3    Haefeli, W.E.4    Fowler, B.5
  • 9
    • 0034758285 scopus 로고    scopus 로고
    • Efficacy of the dietary supplement S-adenosyl-l-methionine
    • Fetrow CW, Avila JR. Efficacy of the dietary supplement S-adenosyl-l-methionine. Ann Pharmacother 2001;35:1414 - 1425.
    • (2001) Ann Pharmacother , vol.35 , pp. 1414-1425
    • Fetrow, C.W.1    Avila, J.R.2
  • 10
    • 0033527517 scopus 로고    scopus 로고
    • SAMe for depression. Med Lett Drugs Ther 1999;41:107-108.
    • SAMe for depression. Med Lett Drugs Ther 1999;41:107-108.
  • 11
    • 0036829068 scopus 로고    scopus 로고
    • Role of S-adenosyl-l-methionine in the treatment of depression: A review of the evidence
    • Mischoulon D, Fava M. Role of S-adenosyl-l-methionine in the treatment of depression: A review of the evidence. Am J Clin Nutr 2002;76:1158S-1161S.
    • (2002) Am J Clin Nutr , vol.76
    • Mischoulon, D.1    Fava, M.2
  • 12
    • 0024342257 scopus 로고
    • S-adenosyl-l-methionine: A review of its pharmacological properties and therapeutic potential in liver dysfunction and affective disorders in relation to its physiological role in cell metabolism
    • Friedel HA, Goa KL, Benfield P. S-adenosyl-l-methionine: A review of its pharmacological properties and therapeutic potential in liver dysfunction and affective disorders in relation to its physiological role in cell metabolism. Drugs 1989;38:389-416.
    • (1989) Drugs , vol.38 , pp. 389-416
    • Friedel, H.A.1    Goa, K.L.2    Benfield, P.3
  • 13
    • 0021342568 scopus 로고
    • Open trial of S-adenosylmethionine for treatment of depression
    • Lipinski JF, Cohen BM, Frankenburg FT, et al. Open trial of S-adenosylmethionine for treatment of depression. Am J Psychiatry 1984;141:448-450.
    • (1984) Am J Psychiatry , vol.141 , pp. 448-450
    • Lipinski, J.F.1    Cohen, B.M.2    Frankenburg, F.T.3
  • 14
    • 0032823860 scopus 로고    scopus 로고
    • Method for the determination of total homocysteine in plasma and urine by stable isotope dilution and electrospray tandem mass spectrometry
    • Magera MJ, Lacey JM, Casetta B, Rinaldo P. Method for the determination of total homocysteine in plasma and urine by stable isotope dilution and electrospray tandem mass spectrometry. Clin Chem 1999;45:1517-1522.
    • (1999) Clin Chem , vol.45 , pp. 1517-1522
    • Magera, M.J.1    Lacey, J.M.2    Casetta, B.3    Rinaldo, P.4
  • 17
    • 0025635927 scopus 로고
    • The role of SAMe in the treatment of liver disease
    • Williams R, Lieber CS. The role of SAMe in the treatment of liver disease. Drugs 1990;40(Suppl 3):S1-S2.
    • (1990) Drugs , vol.40 , Issue.SUPPL. 3
    • Williams, R.1    Lieber, C.S.2
  • 18
    • 0025668607 scopus 로고
    • Role of S-adenosyl-l-methionine in the treatment of intrahepatic cholestasis
    • Almasio P, Bortolini M, Pagliaro L, Coltorti M. Role of S-adenosyl-l-methionine in the treatment of intrahepatic cholestasis. Drugs 1990;40(Suppl 3):S111-S123.
    • (1990) Drugs , vol.40 , Issue.SUPPL. 3
    • Almasio, P.1    Bortolini, M.2    Pagliaro, L.3    Coltorti, M.4
  • 19
    • 0033024498 scopus 로고    scopus 로고
    • Tauroursodeoxycholate and S-adenosyl-l-methionine exert an additive ameliorating effect on taurolithocholate-induced cholestasis: A study in isolated rat hepatocyte couplets
    • Milkiewicz P, Mills CO, Roma MG, Ahmed-Choudhury J, Elias E, Coleman R. Tauroursodeoxycholate and S-adenosyl-l-methionine exert an additive ameliorating effect on taurolithocholate-induced cholestasis: A study in isolated rat hepatocyte couplets. Hepatology 1999;29:471-476.
    • (1999) Hepatology , vol.29 , pp. 471-476
    • Milkiewicz, P.1    Mills, C.O.2    Roma, M.G.3    Ahmed-Choudhury, J.4    Elias, E.5    Coleman, R.6
  • 20
    • 0029066299 scopus 로고
    • A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: Probable benefits of increasing folic acid intakes
    • Boushey CJ, Beresford SA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: Probable benefits of increasing folic acid intakes. JAMA 1995;274:1049-1057.
    • (1995) JAMA , vol.274 , pp. 1049-1057
    • Boushey, C.J.1    Beresford, S.A.2    Omenn, G.S.3    Motulsky, A.G.4
  • 21
    • 0037164104 scopus 로고    scopus 로고
    • Homocysteine and risk of ischemic heart disease and stroke: A meta-analysis
    • Homocysteine Studies Collaboration
    • Homocysteine Studies Collaboration. Homocysteine and risk of ischemic heart disease and stroke: A meta-analysis. JAMA 2002;288:2015-2022.
    • (2002) JAMA , vol.288 , pp. 2015-2022
  • 22
    • 0030698745 scopus 로고    scopus 로고
    • Homocysteine, atherosclerosis and prevalent cardiovascular disease in the elderly: The Rotterdam Study
    • Bots ML, Launer LJ, Lindemans J, Hofman A, Grobbee DE. Homocysteine, atherosclerosis and prevalent cardiovascular disease in the elderly: The Rotterdam Study. J Intern Med 1997;242:339-347.
    • (1997) J Intern Med , vol.242 , pp. 339-347
    • Bots, M.L.1    Launer, L.J.2    Lindemans, J.3    Hofman, A.4    Grobbee, D.E.5
  • 23
    • 0033547813 scopus 로고    scopus 로고
    • Homocyst(e)ine, diet, and cardiovascular diseases: A statement for healthcare professionals from the Nutrition Committee, American Heart Association
    • Malinow MR, Bostom AG, Krauss RM. Homocyst(e)ine, diet, and cardiovascular diseases: a statement for healthcare professionals from the Nutrition Committee, American Heart Association. Circulation 1999;99:178-182.
    • (1999) Circulation , vol.99 , pp. 178-182
    • Malinow, M.R.1    Bostom, A.G.2    Krauss, R.M.3
  • 24
    • 0026684554 scopus 로고
    • A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians
    • Stampfer MJ, Malinow MR, Willett WC, et al. A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians. JAMA 1992;268:877-881.
    • (1992) JAMA , vol.268 , pp. 877-881
    • Stampfer, M.J.1    Malinow, M.R.2    Willett, W.C.3
  • 25
    • 0028966321 scopus 로고
    • Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis
    • Selhub J, Jacques PF, Bostom AG, et al. Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis. N Engl J Med 1995;332:286-291.
    • (1995) N Engl J Med , vol.332 , pp. 286-291
    • Selhub, J.1    Jacques, P.F.2    Bostom, A.G.3
  • 26
    • 0028845307 scopus 로고
    • Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men
    • Perry IJ, Refsum H, Morris RW, Ebrahim SB, Ueland PM, Shaper AG. Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men. Lancet 1995;346:1395-1398.
    • (1995) Lancet , vol.346 , pp. 1395-1398
    • Perry, I.J.1    Refsum, H.2    Morris, R.W.3    Ebrahim, S.B.4    Ueland, P.M.5    Shaper, A.G.6
  • 27
    • 0029921114 scopus 로고    scopus 로고
    • Hyperhomocysteinemia as a risk factor for deep-vein thrombosis
    • den Heijer M, Koster T, Blom HJ, et al. Hyperhomocysteinemia as a risk factor for deep-vein thrombosis. N Engl J Med 1996;334:759-762.
    • (1996) N Engl J Med , vol.334 , pp. 759-762
    • den Heijer, M.1    Koster, T.2    Blom, H.J.3
  • 28
    • 0035969545 scopus 로고    scopus 로고
    • Decreased rate of coronary restenosis after lowering of plasma homocysteine levels
    • Schnyder G, Roffi M, Pin R, et al. Decreased rate of coronary restenosis after lowering of plasma homocysteine levels. N Engl J Med 2001;345:1593-1600.
    • (2001) N Engl J Med , vol.345 , pp. 1593-1600
    • Schnyder, G.1    Roffi, M.2    Pin, R.3
  • 29
    • 0035499977 scopus 로고    scopus 로고
    • Association of plasma homocysteine with the number of major coronary arteries severely narrowed
    • Schnyder G, Pin R, Roffi M, Flammer Y, Hess OM. Association of plasma homocysteine with the number of major coronary arteries severely narrowed. Am J Cardiol 2001;88:1027-1030.
    • (2001) Am J Cardiol , vol.88 , pp. 1027-1030
    • Schnyder, G.1    Pin, R.2    Roffi, M.3    Flammer, Y.4    Hess, O.M.5
  • 30
    • 0036558642 scopus 로고    scopus 로고
    • Association of plasma homocysteine with restenosis after percutaneous coronary angioplasty
    • Schnyder G, Roffi M, Flammer Y, Pin R, Hess OM. Association of plasma homocysteine with restenosis after percutaneous coronary angioplasty. Eur Heart J 2002;23:726-733.
    • (2002) Eur Heart J , vol.23 , pp. 726-733
    • Schnyder, G.1    Roffi, M.2    Flammer, Y.3    Pin, R.4    Hess, O.M.5
  • 31
    • 0037190083 scopus 로고    scopus 로고
    • 6 on clinical outcome after percutaneous coronary intervention: The Swiss Heart study: A randomized controlled trial
    • 6 on clinical outcome after percutaneous coronary intervention: the Swiss Heart study: A randomized controlled trial. JAMA 2002;288:973-979.
    • (2002) JAMA , vol.288 , pp. 973-979
    • Schnyder, G.1    Roffi, M.2    Flammer, Y.3    Pin, R.4    Hess, O.M.5
  • 32
    • 0037650207 scopus 로고    scopus 로고
    • Effect of homocysteine-lowering therapy on restenosis after percutaneous coronary intervention for narrowings in small coronary arteries
    • Schnyder G, Roffi M, Flammer Y, et al. Effect of homocysteine-lowering therapy on restenosis after percutaneous coronary intervention for narrowings in small coronary arteries. Am J Cardiol 2003;91:1265-1269.
    • (2003) Am J Cardiol , vol.91 , pp. 1265-1269
    • Schnyder, G.1    Roffi, M.2    Flammer, Y.3
  • 33
    • 33645753544 scopus 로고    scopus 로고
    • Lonn E, Yusuf S, Arnold MJ, et al., Heart Outcomes Prevention Evaluation (HOPE) 2 Investigators. Homocysteine lowering with folic acid and B vitamins in vascular disease. N Engl J Med 2006;354:1567-1577. Erratum in N Engl J Med 2006;355:746.
    • Lonn E, Yusuf S, Arnold MJ, et al., Heart Outcomes Prevention Evaluation (HOPE) 2 Investigators. Homocysteine lowering with folic acid and B vitamins in vascular disease. N Engl J Med 2006;354:1567-1577. Erratum in N Engl J Med 2006;355:746.
  • 34
    • 33645796222 scopus 로고    scopus 로고
    • NORVIT Trial Investigators. Homocysteine lowering and cardiovascular events after acute myocardial infarction
    • Bønaa KH, Njølstad I, Ueland PM, et al., NORVIT Trial Investigators. Homocysteine lowering and cardiovascular events after acute myocardial infarction. N Engl J Med 2006;354:1578-1588.
    • (2006) N Engl J Med , vol.354 , pp. 1578-1588
    • Bønaa, K.H.1    Njølstad, I.2    Ueland, P.M.3
  • 36
    • 10644237168 scopus 로고    scopus 로고
    • Fuso A, Seminara L, Cavallaro RA, D'Anselmi F, Scarpa S. S-adenosylmethionine/homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production. Mol Cell Neurosci 2005;28:195-204. Erratum in Mol Cell Neurosci 2006;32:419.
    • Fuso A, Seminara L, Cavallaro RA, D'Anselmi F, Scarpa S. S-adenosylmethionine/homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production. Mol Cell Neurosci 2005;28:195-204. Erratum in Mol Cell Neurosci 2006;32:419.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.