Sphingosine-1-phosphate receptor 1 regulates cardiac function by modulating Ca2+ sensitivity and Na+/H+ exchange and mediates protection by ischemic preconditioning

Journal of the American Heart Association

Volumn 5, Issue 5, 2016, Pages

  Keul, Petra ^a   van Borren, Marcel M G J ^b   Ghanem, Alexander ^c   Müller, Frank Ulrich ^d   Baartscheer, Antonius ^b   Verkerk, Arie O ^b   Stümpel, Frank ^d   Schulte, Jan Sebastian ^d   Hamdani, Nazha ^e   Linke, Wolfgang A ^e   van Loenen, Pieter ^b   Matus, Marek ^d,f   Schmitz, Wilhelm ^d   Stypmann, Jörg ^g   Tiemann, Klaus ^g   Ravesloot, Jan Hindrik ^b   Alewijnse, Astrid E ^b   Hermann, Sven ^h   Spijkers, Léon J A ^b   Hiller, Karl Heinz ⁱ   Herr, Deron ^j   Heusch, Gerd ^a   Schäfers, Michael ^h   Peters, Stephan L M ^b   Chun, Jerold ^j   Levkau, Bodo ^a   more..

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c UNIVERSITY HOSPITAL BONN   (Germany)

^d Institute for Pharmakology und Toxikology   (Germany)

^e RUHR UNIVERSITY BOCHUM   (Germany)

^f Physics and Informatics   (Slovakia)

^g UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^h European Institute for Molecular Imaging   (Germany)

ⁱ MRB Forschungszentrum Magnet Resonanz Bayern   (Germany)

^j SCRIPPS RESEARCH INSTITUTE   (United States)

more..

Author keywords

Calcium sensitization; Heart failure; Ischemia reperfusion injury; Na+ H+ exchanger; Preconditioning; Signal transduction; Sphingosine; Sphingosine 1 phosphate

Indexed keywords

ADENYLATE CYCLASE; CALCIUM ION; DOBUTAMINE; MYOSIN BINDING PROTEIN C; MYOSIN LIGHT CHAIN 2; PROTEIN KINASE B; SODIUM ION; SODIUM PROTON EXCHANGE PROTEIN 1; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR 1; SPHINGOSINE KINASE; TROPONIN I; UNCLASSIFIED DRUG; CALCIUM; CARDIAC MYOSIN; CARRIER PROTEIN; GROWTH FACTOR-ACTIVATABLE NA-H EXCHANGER NHE-1; MYOSIN LIGHT CHAIN; MYOSIN-BINDING PROTEIN C; S1PR1 PROTEIN, MOUSE; SODIUM PROTON EXCHANGE PROTEIN;

ADRENERGIC SYSTEM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIAC MUSCLE CELL; CARDIOMYOPATHY; CELL ISOLATION; CONTROLLED STUDY; DIASTOLE; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; HEART FUNCTION; HEART INFARCTION PREVENTION; HEART MUSCLE CONTRACTILITY; HEART MUSCLE FIBER MEMBRANE; HEART MUSCLE RELAXATION; MALE; MOUSE; NONHUMAN; PREMATURE MORTALITY; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTON SODIUM EXCHANGE; REGULATORY MECHANISM; REPRODUCIBILITY; SARCOMERE LENGTH; SODIUM CELL LEVEL; SYSTOLE; ACTION POTENTIAL; ANIMAL; ANTAGONISTS AND INHIBITORS; DIAGNOSTIC IMAGING; DRUG EFFECTS; ECHOCARDIOGRAPHY; GENETICS; KNOCKOUT MOUSE; METABOLISM; MYOCARDIAL ISCHEMIA REPERFUSION INJURY; NUCLEAR MAGNETIC RESONANCE IMAGING; PHOSPHORYLATION; POSITRON EMISSION TOMOGRAPHY; REAL TIME POLYMERASE CHAIN REACTION; SARCOMERE; WESTERN BLOTTING;

ACTION POTENTIALS; ADENYLYL CYCLASES; ANIMALS; BLOTTING, WESTERN; CALCIUM; CARDIAC MYOSINS; CARDIOMYOPATHIES; CARRIER PROTEINS; ECHOCARDIOGRAPHY; ISCHEMIC PRECONDITIONING, MYOCARDIAL; MAGNETIC RESONANCE IMAGING; MICE; MICE, KNOCKOUT; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; MYOSIN LIGHT CHAINS; PHOSPHORYLATION; POSITRON-EMISSION TOMOGRAPHY; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, LYSOSPHINGOLIPID; SARCOMERES; SODIUM-HYDROGEN EXCHANGERS; TROPONIN I;

EID: 84992168393     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.116.003393     Document Type: Article

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