-
1
-
-
0035943594
-
Sphingosine 1-phosphate may be a major component of plasma lipoproteins responsible for the cytoprotective actions in human umbilical vein endothelial cells
-
Kimura T, Sato K, Kuwabara A, et al. Sphingosine 1-phosphate may be a major component of plasma lipoproteins responsible for the cytoprotective actions in human umbilical vein endothelial cells. J Biol Chem. 2001;276:31780-31785
-
(2001)
J Biol Chem
, vol.276
, pp. 31780-31785
-
-
Kimura, T.1
Sato, K.2
Kuwabara, A.3
-
2
-
-
36148982619
-
Signals from type 1 sphingosine 1-phosphate receptors enhance adult mouse cardiac myocyte survival during hypoxia
-
Zhang J, Honbo N, Goetzl EJ, et al. Signals from type 1 sphingosine 1-phosphate receptors enhance adult mouse cardiac myocyte survival during hypoxia. Am J Physiol Heart Circ Physiol. 2007;293:H3150-H3158
-
(2007)
Am J Physiol Heart Circ Physiol
, vol.293
-
-
Zhang, J.1
Honbo, N.2
Goetzl, E.J.3
-
3
-
-
21844457949
-
Sphingosine 1-phosphate and its receptors: An autocrine and paracrine network
-
Rosen H, Goetzl EJ. Sphingosine 1-phosphate and its receptors: An autocrine and paracrine network. Nat Rev Immunol. 2005;5:560-570
-
(2005)
Nat Rev Immunol
, vol.5
, pp. 560-570
-
-
Rosen, H.1
Goetzl, E.J.2
-
4
-
-
34250809874
-
Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury
-
Means CK, Xiao CY, Li Z, et al. Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2007; 292:H2944-H2951
-
(2007)
Am J Physiol Heart Circ Physiol
, vol.292
-
-
Means, C.K.1
Xiao, C.Y.2
Li, Z.3
-
5
-
-
45849147642
-
Ischaemic postconditioning protects isolated mouse hearts against ischaemia/reperfusion injury via sphingosine kinase isoform-1 activation
-
Jin ZQ, Karliner JS, Vessey DA. Ischaemic postconditioning protects isolated mouse hearts against ischaemia/reperfusion injury via sphingosine kinase isoform-1 activation. Cardiovasc Res. 2008;79:134-140
-
(2008)
Cardiovasc Res
, vol.79
, pp. 134-140
-
-
Jin, Z.Q.1
Karliner, J.S.2
Vessey, D.A.3
-
6
-
-
34548411384
-
A sphingosine kinase 1 mutation sensitizes the myocardium to ischemia/reperfusion injury
-
Jin ZQ, Zhang J, Huang Y, et al. A sphingosine kinase 1 mutation sensitizes the myocardium to ischemia/reperfusion injury. Cardiovasc Res. 2007;76:41-50
-
(2007)
Cardiovasc Res
, vol.76
, pp. 41-50
-
-
Jin, Z.Q.1
Zhang, J.2
Huang, Y.3
-
7
-
-
67449164535
-
Sphingosine-1-phosphate as a mediator of highdensity lipoprotein effects in cardiovascular protection
-
Sattler K, Levkau B. Sphingosine-1-phosphate as a mediator of highdensity lipoprotein effects in cardiovascular protection. Cardiovasc Res. 2009;82:201-211
-
(2009)
Cardiovasc Res
, vol.82
, pp. 201-211
-
-
Sattler, K.1
Levkau, B.2
-
8
-
-
33749673952
-
Role of sphingosine kinase activity in protection of heart against ischemia reperfusion injury
-
Vessey DA, Kelley M, Li L, et al. Role of sphingosine kinase activity in protection of heart against ischemia reperfusion injury. Med Sci Monit. 2006;12:BR318-BR324
-
(2006)
Med Sci Monit
, vol.12
-
-
Vessey, D.A.1
Kelley, M.2
Li, L.3
-
9
-
-
34250832664
-
Sphingosine 1-phosphate receptors in health and disease: Mechanistic insights from gene deletion studies and reverse pharmacology
-
Brinkmann V. Sphingosine 1-phosphate receptors in health and disease: Mechanistic insights from gene deletion studies and reverse pharmacology. Pharmacol Ther. 2007;115:84-105
-
(2007)
Pharmacol Ther
, vol.115
, pp. 84-105
-
-
Brinkmann, V.1
-
10
-
-
68249121132
-
Cardiomyocyte S1P1 receptormediated extracellular signal-related kinase signaling and desensitization
-
Tao R, Hoover HE, Zhang J, et al. Cardiomyocyte S1P1 receptormediated extracellular signal-related kinase signaling and desensitization. J Cardiovasc Pharmacol. 2009;53:486-494
-
(2009)
J Cardiovasc Pharmacol
, vol.53
, pp. 486-494
-
-
Tao, R.1
Hoover, H.E.2
Zhang, J.3
-
11
-
-
1142309743
-
New directions for protecting the heart against ischaemia-reperfusion injury: Targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway
-
Hausenloy DJ, Yellon DM. New directions for protecting the heart against ischaemia-reperfusion injury: Targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway. Cardiovasc Res. 2004;61:448-460
-
(2004)
Cardiovasc Res
, vol.61
, pp. 448-460
-
-
Hausenloy, D.J.1
Yellon, D.M.2
-
12
-
-
71549129836
-
Ischaemic postconditioning protects against reperfusion injury via the SAFE pathway
-
Lacerda L, Somers S, Opie LH, et al. Ischaemic postconditioning protects against reperfusion injury via the SAFE pathway. Cardiovasc Res. 2009; 84:201-208
-
(2009)
Cardiovasc Res
, vol.84
, pp. 201-208
-
-
Lacerda, L.1
Somers, S.2
Opie, L.H.3
-
13
-
-
70349629000
-
Sphingosine 1-phosphate is an important endogenous cardioprotectant released by ischemic pre- and postconditioning
-
Vessey DA, Li L, Honbo N, et al. Sphingosine 1-phosphate is an important endogenous cardioprotectant released by ischemic pre- and postconditioning. Am J Physiol Heart Circ Physiol. 2009;297:H1429-H1435
-
(2009)
Am J Physiol Heart Circ Physiol
, vol.297
-
-
Vessey, D.A.1
Li, L.2
Honbo, N.3
-
14
-
-
74149086892
-
FTY720 prevents ischemia/reperfusion injury-Associated arrhythmias in an ex vivo rat heart model via activation of Pak1/Akt signaling
-
Egom EE, Ke Y, Musa H, et al. FTY720 prevents ischemia/reperfusion injury-Associated arrhythmias in an ex vivo rat heart model via activation of Pak1/Akt signaling. J Mol Cell Cardiol. 2010;48:406-414
-
(2010)
J Mol Cell Cardiol
, vol.48
, pp. 406-414
-
-
Egom, E.E.1
Ke, Y.2
Musa, H.3
-
15
-
-
67650263679
-
Protective effects of sphingosine-1-phosphate receptor agonist treatment after myocardial ischaemia-reperfusion
-
Hofmann U, Burkard N, Vogt C, et al. Protective effects of sphingosine-1-phosphate receptor agonist treatment after myocardial ischaemia-reperfusion. Cardiovasc Res. 2009;83:285-293
-
(2009)
Cardiovasc Res
, vol.83
, pp. 285-293
-
-
Hofmann, U.1
Burkard, N.2
Vogt, C.3
-
16
-
-
79952027563
-
Sphingosine 1-phosphate (S1P): Physiology and the effects of S1P receptor modulation
-
Hla T, Brinkmann V. Sphingosine 1-phosphate (S1P): Physiology and the effects of S1P receptor modulation. Neurology. 2011;76:S3-S8
-
(2011)
Neurology
, vol.76
-
-
Hla, T.1
Brinkmann, V.2
-
17
-
-
28044462458
-
FTY720, a new class of immunomodulator, inhibits lymphocyte egress from secondary lymphoid tissues and thymus by agonistic activity at sphingosine 1-phosphate receptors
-
Chiba K. FTY720, a new class of immunomodulator, inhibits lymphocyte egress from secondary lymphoid tissues and thymus by agonistic activity at sphingosine 1-phosphate receptors. Pharmacol Ther. 2005; 108:308-319
-
(2005)
Pharmacol Ther
, vol.108
, pp. 308-319
-
-
Chiba, K.1
-
18
-
-
1642580757
-
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
-
Matloubian M, Lo CG, Cinamon G, et al. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature. 2004;427:355-360
-
(2004)
Nature
, vol.427
, pp. 355-360
-
-
Matloubian, M.1
Lo, C.G.2
Cinamon, G.3
-
19
-
-
33847022657
-
The sphingosine-1-phosphate analogue FTY720 reduces atherosclerosis in apolipoprotein E-deficient mice
-
Keul P, Tolle M, Lucke S, et al. The sphingosine-1-phosphate analogue FTY720 reduces atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 2007;27:607-613
-
(2007)
Arterioscler Thromb Vasc Biol
, vol.27
, pp. 607-613
-
-
Keul, P.1
Tolle, M.2
Lucke, S.3
-
20
-
-
33846688688
-
FTY720, a synthetic sphingosine 1 phosphate analogue, inhibits development of atherosclerosis in low-density lipoprotein receptor-deficient mice
-
Nofer JR, Bot M, Brodde M, et al. FTY720, a synthetic sphingosine 1 phosphate analogue, inhibits development of atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation. 2007;115:501-508
-
(2007)
Circulation
, vol.115
, pp. 501-508
-
-
Nofer, J.R.1
Bot, M.2
Brodde, M.3
-
21
-
-
0037192774
-
Hypomorphic apolipoprotein e mice. A new model of conditional gene repair to examine apolipoprotein E-mediated metabolism
-
Raffaï RL, Weisgraber KH. Hypomorphic apolipoprotein E mice. A new model of conditional gene repair to examine apolipoprotein E-mediated metabolism. J Biol Chem. 2002;277:11064-11068
-
(2002)
J Biol Chem
, vol.277
, pp. 11064-11068
-
-
Raffaï, R.L.1
Weisgraber, K.H.2
-
22
-
-
13244290159
-
Apolipoprotein e promotes the regression of atherosclerosis independently of lowering plasma cholesterol levels
-
Raffai RL, Loeb SM, Weisgraber KH. Apolipoprotein E promotes the regression of atherosclerosis independently of lowering plasma cholesterol levels. Arterioscler Thromb Vasc Biol. 2005;25:436-441
-
(2005)
Arterioscler Thromb Vasc Biol
, vol.25
, pp. 436-441
-
-
Raffai, R.L.1
Loeb, S.M.2
Weisgraber, K.H.3
-
23
-
-
21544454386
-
Diet-induced occlusive coronary atherosclerosis, myocardial infarction, cardiac dysfunction, and premature death in Scavenger receptor class B type I-deficient, hypomorphic apolipoprotein ER61 mice
-
Zhang S, Picard MH, Vasile E, et al. Diet-induced occlusive coronary atherosclerosis, myocardial infarction, cardiac dysfunction, and premature death in Scavenger receptor class B type I-deficient, hypomorphic apolipoprotein ER61 mice. Circulation. 2005;111:3457-3464
-
(2005)
Circulation
, vol.111
, pp. 3457-3464
-
-
Zhang, S.1
Picard, M.H.2
Vasile, E.3
-
24
-
-
58849118839
-
Prognostic value of left ventricular end-systolic volume index as a predictor of heart failure hospitalization in stable coronary artery disease: Data from the Heart and Soul Study
-
McManus DD, Shah SJ, Fabi MR, et al. Prognostic value of left ventricular end-systolic volume index as a predictor of heart failure hospitalization in stable coronary artery disease: Data from the Heart and Soul Study. J Am Soc Echocardiogr. 2009;22:190-197
-
(2009)
J Am Soc Echocardiogr
, vol.22
, pp. 190-197
-
-
McManus, D.D.1
Shah, S.J.2
Fabi, M.R.3
-
25
-
-
16844369607
-
Natural regulatory T cells in infectious disease
-
Belkaid Y, Rouse BT. Natural regulatory T cells in infectious disease. Nat Immunol. 2005;6:353-360
-
(2005)
Nat Immunol
, vol.6
, pp. 353-360
-
-
Belkaid, Y.1
Rouse, B.T.2
-
26
-
-
77449106966
-
Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats
-
Hasegawa Y, Suzuki H, Sozen T, et al. Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats. Stroke. 2010;41:368-374
-
(2010)
Stroke
, vol.41
, pp. 368-374
-
-
Hasegawa, Y.1
Suzuki, H.2
Sozen, T.3
-
27
-
-
79551495392
-
Fingolimod provides long-Term protection in rodent models of cerebral ischemia
-
Wei Y, Yemisci M, Kim HH, et al. Fingolimod provides long-Term protection in rodent models of cerebral ischemia. Ann Neurol. 2011;69: 119-129
-
(2011)
Ann Neurol
, vol.69
, pp. 119-129
-
-
Wei, Y.1
Yemisci, M.2
Kim, H.H.3
-
28
-
-
11844305973
-
FTY720 attenuates hepatic ischemiareperfusion injury in normal and cirrhotic livers
-
Man K, Ng KT, Lee TK, et al. FTY720 attenuates hepatic ischemiareperfusion injury in normal and cirrhotic livers. Am J Transplant. 2005;5:40-49
-
(2005)
Am J Transplant
, vol.5
, pp. 40-49
-
-
Man, K.1
Ng, K.T.2
Lee, T.K.3
-
29
-
-
33646511394
-
Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney
-
Awad AS, Ye H, Huang L, et al. Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney. Am J Physiol Renal Physiol. 2006;290:F1516-F1524
-
(2006)
Am J Physiol Renal Physiol
, vol.290
-
-
Awad, A.S.1
Ye, H.2
Huang, L.3
-
30
-
-
80053266443
-
Activation of Pak1/Akt/ eNOS signaling following sphingosine-1-phosphate release as part of a mechanism protecting cardiomyocytes against ischemic cell injury
-
Egom EE, Mohamed TM, Mamas MA, et al. Activation of Pak1/Akt/ eNOS signaling following sphingosine-1-phosphate release as part of a mechanism protecting cardiomyocytes against ischemic cell injury. Am J Physiol Heart Circ Physiol. 2011;301:H1487-H1495
-
(2011)
Am J Physiol Heart Circ Physiol
, vol.301
-
-
Egom, E.E.1
Mohamed, T.M.2
Mamas, M.A.3
-
31
-
-
83455168963
-
Pak1 as a novel therapeutic target for antihypertrophic treatment in the heart
-
Liu W, Zi M, Naumann R, et al. Pak1 as a novel therapeutic target for antihypertrophic treatment in the heart. Circulation. 2011;124: 2702-2715
-
(2011)
Circulation
, vol.124
, pp. 2702-2715
-
-
Liu, W.1
Zi, M.2
Naumann, R.3
-
32
-
-
77953200332
-
Pharmacological pre- and postconditioning with the sphingosine-1- phosphate receptor modulator FTY720 after myocardial ischaemia-reperfusion
-
Hofmann U, Hu K, Walter F, et al. Pharmacological pre- and postconditioning with the sphingosine-1-phosphate receptor modulator FTY720 after myocardial ischaemia-reperfusion. Br J Pharmacol. 2010;160:1243-1251
-
(2010)
Br J Pharmacol
, vol.160
, pp. 1243-1251
-
-
Hofmann, U.1
Hu, K.2
Walter, F.3
-
33
-
-
77949394551
-
FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages
-
Blom T, Back N, Mutka AL, et al. FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages. Circ Res. 2010;106:720-729
-
(2010)
Circ Res
, vol.106
, pp. 720-729
-
-
Blom, T.1
Back, N.2
Mutka, A.L.3
-
34
-
-
0035949490
-
Introduction of human apolipoprotein E4 domain interaction into mouse apolipoprotein e
-
Raffaï RL, Dong L-M, Farese RV Jr, et al. Introduction of human apolipoprotein E4 domain interaction into mouse apolipoprotein E. Proc Natl Acad Sci USA. 2001;98:11587-11591
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 11587-11591
-
-
Raffaï, R.L.1
Dong, L.-M.2
Farese Jr., R.V.3
-
35
-
-
36049034200
-
Sphingosine-1-phosphate analogue FTY720 causes lymphocyte redistribution and hypercholesterolemia in ApoE-deficient mice
-
Klingenberg R, Nofer JR, Rudling M, et al. Sphingosine-1-phosphate analogue FTY720 causes lymphocyte redistribution and hypercholesterolemia in ApoE-deficient mice. Arterioscler Thromb Vasc Biol. 2007;27: 2392-2399
-
(2007)
Arterioscler Thromb Vasc Biol
, vol.27
, pp. 2392-2399
-
-
Klingenberg, R.1
Nofer, J.R.2
Rudling, M.3
-
36
-
-
84862509411
-
Effect of sphingosine 1-phosphate (S1P) receptor agonists FTY720 and CYM5442 on atherosclerosis development in LDL receptor deficient (LDL-R(-)/(-)) mice
-
Poti F, Costa S, Bergonzini V, et al. Effect of sphingosine 1-phosphate (S1P) receptor agonists FTY720 and CYM5442 on atherosclerosis development in LDL receptor deficient (LDL-R(-)/(-)) mice. Vascul Pharmacol. 2012;57:56-64
-
(2012)
Vascul Pharmacol
, vol.57
, pp. 56-64
-
-
Poti, F.1
Costa, S.2
Bergonzini, V.3
-
37
-
-
77950323431
-
Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis
-
Panizzi P, Swirski FK, Figueiredo JL, et al. Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis. J Am Coll Cardiol. 2010;55:1629-1638
-
(2010)
J Am Coll Cardiol
, vol.55
, pp. 1629-1638
-
-
Panizzi, P.1
Swirski, F.K.2
Figueiredo, J.L.3
-
38
-
-
33845970192
-
Ly-6Chi monocytes dominate hypercholesterolemia-Associated monocytosis and give rise to macrophages in atheromata
-
Swirski FK, Libby P, Aikawa E, et al. Ly-6Chi monocytes dominate hypercholesterolemia-Associated monocytosis and give rise to macrophages in atheromata. J Clin Invest. 2007;117:195-205
-
(2007)
J Clin Invest
, vol.117
, pp. 195-205
-
-
Swirski, F.K.1
Libby, P.2
Aikawa, E.3
-
39
-
-
81155162494
-
Immunopathogenesis of ischemia/reperfusion-Associated tissue damage
-
Ioannou A, Dalle Lucca J, Tsokos GC. Immunopathogenesis of ischemia/reperfusion-Associated tissue damage. Clin Immunol. 2011; 141:3-14
-
(2011)
Clin Immunol
, vol.141
, pp. 3-14
-
-
Ioannou, A.1
Dalle Lucca, J.2
Tsokos, G.C.3
-
40
-
-
33750701819
-
Myocardial infarct-sparing effect of adenosine A2A receptor activation is due to its action on CD4+ T lymphocytes
-
Yang Z, Day YJ, Toufektsian MC, et al. Myocardial infarct-sparing effect of adenosine A2A receptor activation is due to its action on CD4+ T lymphocytes. Circulation. 2006;114:2056-2064
-
(2006)
Circulation
, vol.114
, pp. 2056-2064
-
-
Yang, Z.1
Day, Y.J.2
Toufektsian, M.C.3
-
41
-
-
0041832283
-
B cell deficiency confers protection from renal ischemia reperfusion injury
-
Burne-Taney MJ, Ascon DB, Daniels F, et al. B cell deficiency confers protection from renal ischemia reperfusion injury. J Immunol. 2003;171: 3210-3215
-
(2003)
J Immunol
, vol.171
, pp. 3210-3215
-
-
Burne-Taney, M.J.1
Ascon, D.B.2
Daniels, F.3
-
42
-
-
66249141312
-
Sphingolipid signaling and treatment during remodeling of the uninfarcted ventricular wall after myocardial infarction
-
Yeh CC, Li H, Malhotra D, et al. Sphingolipid signaling and treatment during remodeling of the uninfarcted ventricular wall after myocardial infarction. Am J Physiol Heart Circ Physiol. 2009;296:H1193-H1199
-
(2009)
Am J Physiol Heart Circ Physiol
, vol.296
-
-
Yeh, C.C.1
Li, H.2
Malhotra, D.3
-
43
-
-
74049164847
-
Regulatory T cells exert checks and balances on self tolerance and autoimmunity
-
Wing K, Sakaguchi S. Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat Immunol. 2010;11:7-13
-
(2010)
Nat Immunol
, vol.11
, pp. 7-13
-
-
Wing, K.1
Sakaguchi, S.2
-
44
-
-
84859432016
-
Activation of CD4+ T lymphocytes improves wound healing and survival after experimental myocardial infarction in mice
-
Hofmann U, Beyersdorf N, Weirather J, et al. Activation of CD4+ T lymphocytes improves wound healing and survival after experimental myocardial infarction in mice. Circulation. 2012;125:1652-1663
-
(2012)
Circulation
, vol.125
, pp. 1652-1663
-
-
Hofmann, U.1
Beyersdorf, N.2
Weirather, J.3
-
45
-
-
33846908988
-
FTY720 ameliorates Th1-mediated colitis in mice by directly affecting the functional activity of CD4+CD25+ regulatory T cells
-
Daniel C, Sartory N, Zahn N, et al. FTY720 ameliorates Th1-mediated colitis in mice by directly affecting the functional activity of CD4+CD25+ regulatory T cells. J Immunol. 2007;178:2458-2468
-
(2007)
J Immunol
, vol.178
, pp. 2458-2468
-
-
Daniel, C.1
Sartory, N.2
Zahn, N.3
-
46
-
-
84881023737
-
Inducible Apoe gene repair in hypomorphic ApoE mice deficient in the low-density lipoprotein receptor promotes atheroma stabilization with a human-like lipoprotein profile
-
Eberle D, Luk FS, Kim RY, et al. Inducible Apoe gene repair in hypomorphic ApoE mice deficient in the low-density lipoprotein receptor promotes atheroma stabilization with a human-like lipoprotein profile. Arterioscler Thromb Vasc Biol. 2013;33:1759-1767
-
(2013)
Arterioscler Thromb Vasc Biol
, vol.33
, pp. 1759-1767
-
-
Eberle, D.1
Luk, F.S.2
Kim, R.Y.3
|