Defects of High-Density Lipoproteins in Coronary Artery Disease Caused by Low Sphingosine-1-Phosphate Content Correction by Sphingosine-1-Phosphate - Loading

Journal of the American College of Cardiology

Volumn 66, Issue 13, 2015, Pages 1470-1485

  Sattler, Katherine ^a   Gräler, Markus ^b   Keul, Petra ^a   Weske, Sarah ^a   Reimann, Christina Maria ^b   Jindrová, Helena ^a   Kleinbongard, Petra ^a   Sabbadini, Roger ^c   Bröcker Preuss, Martina ^d   Erbel, Raimund ^a   Heusch, Gerd ^a   Levkau, Bodo ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

^b JENA UNIVERSITY HOSPITAL   (Germany)

^c Lpath Inc   (United States)

^d UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

apolipoprotein M; dysfunction; lipids; lipoproteins; signaling; sphingolipids; vasodilation

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN M; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HIGH DENSITY LIPOPROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN ANTIBODY; PROTEIN KINASE B; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; BIOLOGICAL MARKER; LYSOPHOSPHOLIPID; SPHINGOSINE; SPHINGOSINE 1-PHOSPHATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; ENDOTHELIUM CELL; ERYTHROCYTE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MAJOR CLINICAL STUDY; MOUSE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONTENT; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TANDEM MASS SPECTROMETRY; ULTRACENTRIFUGATION; UMBILICAL VEIN ENDOTHELIAL CELL; VASODILATATION; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; CHO CELL LINE; CRICETULUS; DRUG EFFECTS; HAMSTER; METABOLISM;

ANIMALS; BIOMARKERS; CHO CELLS; CORONARY ARTERY DISEASE; CRICETINAE; CRICETULUS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; LIPOPROTEINS, HDL; LYSOPHOSPHOLIPIDS; MICE; SPHINGOSINE;

EID: 84942156134     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2015.07.057     Document Type: Article

References (30)

1. G. Assmann, H. Schulte, A. von Eckardstein, and Y. Huang High-density lipoprotein cholesterol as a predictor of coronary heart disease risk. The PROCAM experience and pathophysiological implications for reverse cholesterol transport Atherosclerosis 124 Suppl 1996 S11 S20
2. K.A. Rye, and P.J. Barter Cardioprotective functions of HDLs J Lipid Res 55 2014 168 179
3. K. Sattler, and B. Levkau Sphingosine-1-phosphate as a mediator of high-density lipoprotein effects in cardiovascular protection Cardiovasc Res 82 2009 201 211
4. A. Kontush, and M.J. Chapman Functionally defective high-density lipoprotein: a new therapeutic target at the crossroads of dyslipidemia, inflammation, and atherosclerosis Pharmacol Rev 58 2006 342 374
5. Y. Huang, J.A. DiDonato, B.S. Levison, and et al. An abundant dysfunctional apolipoprotein A1 in human atheroma Nat Med 20 2014 193 203
6. M. Riwanto, L. Rohrer, B. Roschitzki, and et al. Altered activation of endothelial anti- and proapoptotic pathways by high-density lipoprotein from patients with coronary artery disease: role of high-density lipoprotein-proteome remodeling Circulation 127 2013 891 904
7. K.M. Argraves, and W.S. Argraves HDL serves as a S1P signaling platform mediating a multitude of cardiovascular effects J Lipid Res 48 2007 2325 2333
8. T. Kimura, K. Sato, E. Malchinkhuu, and et al. High-density lipoprotein stimulates endothelial cell migration and survival through sphingosine 1-phosphate and its receptors Arterioscler Thromb Vasc Biol 23 2003 1283 1288
9. J.R. Nofer, M. van der Giet, M. Tolle, and et al. HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3 J Clin Invest 113 2004 569 581
10. R. Tao, H.E. Hoover, N. Honbo, and et al. High-density lipoprotein determines adult mouse cardiomyocyte fate after hypoxia-reoxygenation through lipoprotein-associated sphingosine 1-phosphate Am J Physiol Heart Circ Physiol 298 2010 H1022 H1028
11. C. Christoffersen, H. Obinata, S.B. Kumaraswamy, and et al. Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M Proc Natl Acad Sci U S A 108 2011 9613 9618
12. K.J. Sattler, S. Elbasan, P. Keul, and et al. Sphingosine 1-phosphate levels in plasma and HDL are altered in coronary artery disease Basic Res Cardiol 105 2010 821 832
13. N. O'Brien, S.T. Jones, D.G. Williams, and et al. Production and characterization of monoclonal anti-sphingosine-1-phosphate antibodies J Lipid Res 50 2009 2245 2257
14. R. Pappu, S.R. Schwab, I. Cornelissen, and et al. Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate Science 316 2007 295 298
15. C. Bode, S.C. Sensken, U. Peest, and et al. Erythrocytes serve as a reservoir for cellular and extracellular sphingosine 1-phosphate J Cell Biochem 109 2010 1232 1243
16. B.F. Asztalos, P.S. Roheim, R.L. Milani, and et al. Distribution of ApoA-I-containing HDL subpopulations in patients with coronary heart disease Arterioscler Thromb Vasc Biol 20 2000 2670 2676
17. D.Q. Shih, M. Bussen, E. Sehayek, and et al. Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism Nat Genet 27 2001 375 382
18. S. Richter, D.Q. Shih, E.R. Pearson, and et al. Regulation of apolipoprotein M gene expression by MODY3 gene hepatocyte nuclear factor-1alpha: haploinsufficiency is associated with reduced serum apolipoprotein M levels Diabetes 52 2003 2989 2995
19. C. Besler, K. Heinrich, L. Rohrer, and et al. Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease J Clin Invest 121 2011 2693 2708
20. T. Vaisar, S. Pennathur, P.S. Green, and et al. Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDL J Clin Invest 117 2007 746 756
21. G. Theilmeier, C. Schmidt, J. Herrmann, and et al. High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptor Circulation 114 2006 1403 1409
22. T. Kimura, K. Sato, A. Kuwabara, and et al. Sphingosine 1-phosphate may be a major component of plasma lipoproteins responsible for the cytoprotective actions in human umbilical vein endothelial cells J Biol Chem 276 2001 31780 31785
23. R. Karuna, R. Park, A. Othman, and et al. Plasma levels of sphingosine-1-phosphate and apolipoprotein M in patients with monogenic disorders of HDL metabolism Atherosclerosis 219 2011 855 863
24. A. Kontush, P. Therond, A. Zerrad, and et al. Preferential sphingosine-1-phosphate enrichment and sphingomyelin depletion are key features of small dense HDL3 particles: relevance to antiapoptotic and antioxidative activities Arterioscler Thromb Vasc Biol 27 2007 1843 1849
25. I. Sutter, R. Park, A. Othman, and et al. Apolipoprotein M modulates erythrocyte efflux and tubular reabsorption of sphingosine-1-phosphate J Lipid Res 55 2014 1730 1737
26. X.P. Li, S.P. Zhao, X.Y. Zhang, L. Liu, M. Gao, and Q.C. Zhou Protective effect of high density lipoprotein on endothelium-dependent vasodilatation Int J Cardiol 73 2000 231 236
27. L.E. Spieker, I. Sudano, D. Hurlimann, and et al. High-density lipoprotein restores endothelial function in hypercholesterolemic men Circulation 105 2002 1399 1402
28. X. Tong, P. Lv, A.V. Mathew, and et al. The compensatory enrichment of sphingosine-1-phosphate harbored on glycated high-density lipoprotein restores endothelial protective function in type 2 diabetes mellitus Cardiovasc Diabetol 13 2014 82
29. S. Selim, M. Sunkara, A.K. Salous, and et al. Plasma levels of sphingosine 1-phosphate are strongly correlated with haematocrit, but variably restored by red blood cell transfusions Clin Sci (Lond) 121 2011 565 572
30. K. Sattler, I. Lehmann, M. Graler, and et al. HDL-bound sphingosine 1-phosphate (S1P) predicts the severity of coronary artery atherosclerosis Cell Physiol Biochem 34 2014 172 184