Concurrent and robust regulation of feeding behaviors and metabolism by orexin neurons

Neuropharmacology

Volumn 85, Issue , 2014, Pages 451-460

  Inutsuka, Ayumu ^a   Inui, Azusa ^a   Tabuchi, Sawako ^a   Tsunematsu, Tomomi ^a   Lazarus, Michael ^b   Yamanaka, Akihiro ^a  

^a NAGOYA UNIVERSITY   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Feeding; Hypothalamus; Metabolism; Orexin; Pharmacogenetics

Indexed keywords

CELL PROTEIN; CLOZAPINE N OXIDE; CRE RECOMBINASE; DIPHTHERIA TOXIN; DIPHTHERIA TOXIN A; G PROTEIN COUPLED RECEPTOR; GLUCOSE; HM3DQ PROTEIN; OREXIN; PARVOVIRUS VECTOR; UNCLASSIFIED DRUG; DRINKING WATER; GLUCOSE BLOOD LEVEL; NEUROPEPTIDE; OREXINS; SIGNAL PEPTIDE;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR CHANGE; BEHAVIOR CONTROL; CELL ACTIVATION; CONTROLLED STUDY; FEEDING BEHAVIOR; FLUID INTAKE; FOOD INTAKE; GLUCOSE BLOOD LEVEL; LOCOMOTION; MALE; METABOLIC REGULATION; MOUSE; NERVE CELL; NERVE CELL STIMULATION; NONHUMAN; PHARMACOGENETICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RESPIRATORY EXCHANGE RATIO; RESPIRATORY TRACT PARAMETERS; WAKEFULNESS; ANIMAL; DEPENDOPARVOVIRUS; DRINKING; EATING; GENE VECTOR; GENETICS; METABOLISM; MOTOR ACTIVITY; PHYSIOLOGY;

ANIMALS; BLOOD GLUCOSE; DEPENDOVIRUS; DRINKING; DRINKING WATER; EATING; FEEDING BEHAVIOR; GENETIC VECTORS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MOTOR ACTIVITY; NEURONS; NEUROPEPTIDES;

EID: 84903518549     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2014.06.015     Document Type: Article

References (40)

1. E.E. Abrahamson, R.K. Leak, and R.Y. Moore The suprachiasmatic nucleus projects to posterior hypothalamic arousal systems Neuroreport 12 2001 435 440 (Pubitemid 32114393)
2. A.R. Adamantidis, F. Zhang, A.M. Aravanis, K. Deisseroth, and L. De Lecea Neural substrates of awakening probed with optogenetic control of hypocretin neurons Nature 450 2007 420 424 (Pubitemid 350126754)
3. G.M. Alexander, S.C. Rogan, A.I. Abbas, B.N. Armbruster, Y. Pei, J.A. Allen, R.J. Nonneman, J. Hartmann, S.S. Moy, M.A. Nicolelis, J.O. Mcnamara, and B.L. Roth Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors Neuron 63 2009 27 39
4. B.N. Armbruster, X. Li, M.H. Pausch, S. Herlitze, and B.L. Roth Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand Proc. Natl. Acad. Sci. U. S. A. 104 2007 5163 5168 (Pubitemid 47186193)
5. D. Atasoy, Y. Aponte, H.H. Su, and S.M. Sternson A FLEX switch targets Channelrhodopsin-2 to multiple cell types for imaging and long-range circuit mapping J. Neurosci. 28 2008 7025 7030
6. K. Beppu, T. Sasaki, K.F. Tanaka, A. Yamanaka, Y. Fukazawa, R. Shigemoto, and K. Matsui Optogenetic countering of glial acidosis suppresses glial glutamate release and ischemic brain damage Neuron 81 2014 314 320
7. M.E. Carter, J. Brill, P. Bonnavion, J.R. Huguenard, R. Huerta, and L. De Lecea Mechanism for Hypocretin-mediated sleep-to-wake transitions Proc. Natl. Acad. Sci. U. S. A. 109 2012 E2635 E2644
8. R.M. Chemelli, J.T. Willie, C.M. Sinton, J.K. Elmquist, T. Scammell, C. Lee, J.A. Richardson, S.C. Williams, Y. Xiong, Y. Kisanuki, T.E. Fitch, M. Nakazato, R.E. Hammer, C.B. Saper, and M. Yanagisawa Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation Cell 98 1999 437 451 (Pubitemid 29402482)
9. T.C. Chou, C.E. Lee, J. Lu, J.K. Elmquist, J. Hara, J.T. Willie, C.T. Beuckmann, R.M. Chemelli, T. Sakurai, M. Yanagisawa, C.B. Saper, and T.E. Scammell Orexin (hypocretin) neurons contain dynorphin J. Neurosci 21 2001 RC168
10. L. De Lecea, and R. Huerta Hypocretin (orexin) regulation of sleep-to-wake transitions Front. Pharmacol. 5 2014 16
11. L. De Lecea, T.S. Kilduff, C. Peyron, X. Gao, P.E. Foye, P.E. Danielson, C. Fukuhara, E.L. Battenberg, V.T. Gautvik, F.S. Bartlett 2nd, W.N. Frankel, A.N. Van Den Pol, F.E. Bloom, K.M. Gautvik, and J.G. Sutcliffe The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity Proc. Natl. Acad. Sci. U. S. A. 95 1998 322 327 (Pubitemid 28103952)
12. I.V. Estabrooke, M.T. Mccarthy, E. Ko, T.C. Chou, R.M. Chemelli, M. Yanagisawa, C.B. Saper, and T.E. Scammell Fos expression in orexin neurons varies with behavioral state J. Neurosci. 21 2001 1656 1662 (Pubitemid 32182206)
13. A. Fisahn, F.G. Pike, E.H. Buhl, and O. Paulsen Cholinergic induction of network oscillations at 40 Hz in the hippocampus in vitro Nature 394 1998 186 189 (Pubitemid 28325972)
14. J.M. Guettier, D. Gautam, M. Scarselli, I. Ruiz De Azua, J.H. Li, E. Rosemond, X. Ma, F.J. Gonzalez, B.N. Armbruster, H. Lu, B.L. Roth, and J. Wess A chemical-genetic approach to study G protein regulation of beta cell function in vivo Proc. Natl. Acad. Sci. U. S. A. 106 2009 19197 19202
15. J. Hara, C.T. Beuckmann, T. Nambu, J.T. Willie, R.M. Chemelli, C.M. Sinton, F. Sugiyama, K. Yagami, K. Goto, M. Yanagisawa, and T. Sakurai Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity Neuron 30 2001 345 354 (Pubitemid 32530580)
16. A. Inutsuka, and A. Yamanaka The physiological role of orexin/hypocretin neurons in the regulation of sleep/wakefulness and neuroendocrine functions Front. Endocrinol. (Lausanne) 4 2013 18
17. M.J. Krashes, B.P. Shah, S. Koda, and B.B. Lowell Rapid versus delayed stimulation of feeding by the endogenously released AgRP neuron mediators GABA, NPY, and AgRP Cell Metab. 18 2013 588 595
18. K. Kunii, A. Yamanaka, T. Nambu, I. Matsuzaki, K. Goto, and T. Sakurai Orexins/hypocretins regulate drinking behaviour Brain Res. 842 1999 256 261 (Pubitemid 29447879)
19. A.E. Lang, and A.M. Lozano Parkinson's disease. First of two parts N. Engl. J. Med. 339 1998 1044 1053 (Pubitemid 28457867)
20. M. Lazarus, H.Y. Shen, Y. Cherasse, W.M. Qu, Z.L. Huang, C.E. Bass, R. Winsky-Sommerer, K. Semba, B.B. Fredholm, D. Boison, O. Hayaishi, Y. Urade, and J.F. Chen Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens J. Neurosci. 31 2011 10067 10075
21. T. Moriguchi, T. Sakurai, S. Takahashi, K. Goto, and M. Yamamoto The human prepro-orexin gene regulatory region that activates gene expression in the lateral region and represses it in the medial regions of the hypothalamus J. Biol. Chem. 277 2002 16985 16992 (Pubitemid 34967727)
22. T. Nambu, T. Sakurai, K. Mizukami, Y. Hosoya, M. Yanagisawa, and K. Goto Distribution of orexin neurons in the adult rat brain Brain Res. 827 1999 243 260 (Pubitemid 29222929)
23. S. Nishino, B. Ripley, S. Overeem, G.J. Lammers, and E. Mignot Hypocretin (orexin) deficiency in human narcolepsy Lancet 355 2000 39 40 (Pubitemid 30072183)
24. N.J. Oppenheimer, and J.W. Bodley Diphtheria toxin. Site and configuration of ADP-ribosylation of diphthamide in elongation factor 2 J. Biol. Chem. 256 1981 8579 8581 (Pubitemid 12254806)
25. C. Peyron, J. Faraco, W. Rogers, B. Ripley, S. Overeem, Y. Charnay, S. Nevsimalova, M. Aldrich, D. Reynolds, R. Albin, R. Li, M. Hungs, M. Pedrazzoli, M. Padigaru, M. Kucherlapati, J. Fan, R. Maki, G.J. Lammers, C. Bouras, R. Kucherlapati, S. Nishino, and E. Mignot A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains Nat. Med. 6 2000 991 997
26. C. Peyron, D.K. Tighe, A.N. Van Den Pol, L. De Lecea, H.C. Heller, J.G. Sutcliffe, and T.S. Kilduff Neurons containing hypocretin (orexin) project to multiple neuronal systems J. Neurosci. 18 1998 9996 10015 (Pubitemid 28543775)
27. R.S. Ray, A.E. Corcoran, R.D. Brust, J.C. Kim, G.B. Richerson, E. Nattie, and S.M. Dymecki Impaired respiratory and body temperature control upon acute serotonergic neuron inhibition Science 333 2011 637 642
28. T. Sakurai The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness Nat. Rev. Neurosci. 8 2007 171 181 (Pubitemid 46294664)
29. T. Sakurai, A. Amemiya, M. Ishii, I. Matsuzaki, R.M. Chemelli, H. Tanaka, S.C. Williams, J.A. Richarson, G.P. Kozlowski, S. Wilson, J.R. Arch, R.E. Buckingham, A.C. Haynes, S.A. Carr, R.S. Annan, D.E. Mcnulty, W.S. Liu, J.A. Terrett, N.A. Elshourbagy, D.J. Bergsma, and M. Yanagisawa Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior Cell 92 1998 1 page following 696
30. T. Sakurai, T. Moriguchi, K. Furuya, N. Kajiwara, T. Nakamura, M. Yanagisawa, and K. Goto Structure and function of human prepro-orexin gene J. Biol. Chem. 274 1999 17771 17776
31. K. Sasaki, M. Suzuki, M. Mieda, N. Tsujino, B. Roth, and T. Sakurai Pharmacogenetic modulation of orexin neurons alters sleep/wakefulness states in mice PLoS One 6 2011 e20360
32. A.L. Szymczak, C.J. Workman, Y. Wang, K.M. Vignali, S. Dilioglou, E.F. Vanin, and D.A. Vignali Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide-based retroviral vector Nat. Biotechnol. 22 2004 589 594 (Pubitemid 38585911)
33. T.C. Thannickal, R.Y. Moore, R. Nienhuis, L. Ramanathan, S. Gulyani, M. Aldrich, M. Cornford, and J.M. Siegel Reduced number of hypocretin neurons in human narcolepsy Neuron 27 2000 469 474
34. N. Tsujino, A. Yamanaka, K. Ichiki, Y. Muraki, T.S. Kilduff, K. Yagami, S. Takahashi, K. Goto, and T. Sakurai Cholecystokinin activates orexin/hypocretin neurons through the cholecystokinin A receptor J. Neurosci. 25 2005 7459 7469 (Pubitemid 41129819)
35. T. Tsunematsu, T.S. Kilduff, E.S. Boyden, S. Takahashi, M. Tominaga, and A. Yamanaka Acute optogenetic silencing of orexin/hypocretin neurons induces slow-wave sleep in mice J. Neurosci. 31 2011 10529 10539
36. D. Tupone, C.J. Madden, G. Cano, and S.F. Morrison An orexinergic projection from perifornical hypothalamus to raphe pallidus increases rat brown adipose tissue thermogenesis J. Neurosci. 31 2011 15944 15955
37. M. Van Den Top, M.F. Nolan, K. Lee, P.J. Richardson, R.M. Buijs, C.H. Davies, and D. Spanswick Orexins induce increased excitability and synchronisation of rat sympathetic preganglionic neurones J. Physiol. 549 2003 809 821 (Pubitemid 36889771)
38. A. Yamanaka, T. Sakurai, T. Katsumoto, M. Yanagisawa, and K. Goto Chronic intracerebroventricular administration of orexin-A to rats increases food intake in daytime, but has no effect on body weight Brain Res. 849 1999 248 252
39. A. Yamanaka, S. Tabuchi, T. Tsunematsu, Y. Fukazawa, and M. Tominaga Orexin directly excites orexin neurons through orexin 2 receptor J. Neurosci. 30 2010 12642 12652
40. C.X. Yi, M.J. Serlie, M.T. Ackermans, E. Foppen, R.M. Buijs, H.P. Sauerwein, E. Fliers, and A. Kalsbeek A major role for perifornical orexin neurons in the control of glucose metabolism in rats Diabetes 58 2009 1998 2005