Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3

Nature Communications

Volumn 7, Issue , 2016, Pages

  Yahara, Yasuhito ^a,b   Takemori, Hiroshi ^c   Okada, Minoru ^a   Kosai, Azuma ^a   Yamashita, Akihiro ^a   Kobayashi, Tomohito ^a   Fujita, Kaori ^a   Itoh, Yumi ^c   Nakamura, Masahiro ^a   Fuchino, Hiroyuki ^d   Kawahara, Nobuo ^d   Fukui, Naoshi ^e   Watanabe, Akira ^a   Kimura, Tomoatsu ^b   Tsumaki, Noriyuki ^a  

^a KYOTO UNIVERSITY   (Japan)

^b UNIVERSITY OF TOYAMA   (Japan)

^c NATIONAL INSTITUTE OF BIOMEDICAL INNOVATION   (Japan)

^d and Nutrition   (Japan)

^e UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOTRANSFERASE; PHOSPHOTRANSFERASE INHIBITOR; PTEROSIN B; SALT INDUCIBLE KINASE 3; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; INDAN DERIVATIVE; KIAA0999 PROTEIN, HUMAN; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; SIK3 PROTEIN, MOUSE;

ABNORMALITY; AMINO ACID; ENZYME ACTIVITY; GENE EXPRESSION; MUSCLE; OSTEOLOGY; RISK FACTOR; RODENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; DRUG INHIBITION; HUMAN; HUMAN CELL; HYPERTROPHY; MALE; MOUSE; NONHUMAN; OSTEOARTHRITIS; PTERIDIUM AQUILINUM; TREATMENT OUTCOME; AGED; ANIMAL; CELL CULTURE; CHONDROCYTE; DRUG EFFECTS; FEMALE; GENETICS; IMMUNOBLOTTING; KNEE OSTEOARTHRITIS; KNOCKOUT MOUSE; METABOLISM; MIDDLE AGED; ORGAN SIZE; PATHOLOGY; PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VERY ELDERLY; WESTERN BLOTTING;

MUS; PTERIDIUM AQUILINUM;

AGED; AGED, 80 AND OVER; ANIMALS; ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; CARTILAGE, ARTICULAR; CELLS, CULTURED; CHONDROCYTES; FEMALE; HUMANS; HYPERTROPHY; IMMUNOBLOTTING; INDANS; MALE; MICE; MICE, KNOCKOUT; MIDDLE AGED; ORGAN SIZE; OSTEOARTHRITIS, KNEE; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84961653939     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms10959     Document Type: Article

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