The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver

Nature Communications

Volumn 5, Issue , 2014, Pages

  Patel, Kashyap ^a   Foretz, Marc ^b,c   Marion, Allison ^b,c   Campbell, David G ^a   Gourlay, Robert ^a   Boudaba, Nadia ^b,c   Tournier, Emilie ^b,c   Titchenell, Paul ^d   Peggie, Mark ^a   Deak, Maria ^a   Wan, Min ^d   Kaestner, Klaus H ^d   Göransson, Olga ^e   Viollet, Benoit ^b,c   Gray, Nathanael S ^f   Birnbaum, Morris J ^d   Sutherland, Calum ^g   Sakamoto, Kei ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b INSTITUT COCHIN   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e LUND UNIVERSITY   (Sweden)

^f DANA FARBER CANCER INSTITUTE   (United States)

^g UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE KINASE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLUCAGON; GLUCOSE; HISTONE DEACETYLASE 4; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE LKB1; SALT INDUCIBLE KINASE 1; SALT INDUCIBLE KINASE 2; UNCLASSIFIED DRUG; CARBANILAMIDE DERIVATIVE; CRTC2 PROTEIN, MOUSE; CRTC3 PROTEIN, MOUSE; HG-9-91-01; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; PYRIMIDINE DERIVATIVE; SALT-INDUCIBLE KINASE-2, MOUSE; SIK1 PROTEIN, MOUSE; SIK3 PROTEIN, MOUSE; STK11 PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

BIOCHEMISTRY; CYTOLOGY; ENZYME ACTIVITY; FUNCTIONAL ROLE; GENE EXPRESSION; GLUCOSE; PHYSIOLOGY; RODENT;

ALLELE; ANIMAL CELL; ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE EXPRESSION; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; LIVER; LIVER CELL; MOUSE; NONHUMAN; PROTEIN DEPHOSPHORYLATION; ANIMAL; DEFICIENCY; DIET RESTRICTION; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HYPERGLYCEMIA; KNOCKOUT MOUSE; MALE; METABOLISM; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; FASTING; GENE EXPRESSION REGULATION; GLUCAGON; GLUCONEOGENESIS; GLUCOSE; HEPATOCYTES; HYPERGLYCEMIA; INSULIN; LIVER; MALE; MICE; MICE, KNOCKOUT; PHENYLUREA COMPOUNDS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PYRIMIDINES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 84905457029     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms5535     Document Type: Article

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