-
1
-
-
84877155002
-
Placing a disrupted degradation motif at the C terminus of proteasome substrates attenuates degradation without impairing ubiquitylation
-
Alfassy, O.S., Cohen, I., Reiss, Y., Tirosh, B., Ravid, T., Placing a disrupted degradation motif at the C terminus of proteasome substrates attenuates degradation without impairing ubiquitylation. J. Biol. Chem. 288 (2013), 12645–12653.
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 12645-12653
-
-
Alfassy, O.S.1
Cohen, I.2
Reiss, Y.3
Tirosh, B.4
Ravid, T.5
-
2
-
-
84890204277
-
Protein quality control and elimination of protein waste: the role of the ubiquitin-proteasome system
-
Amm, I., Sommer, T., Wolf, D.H., Protein quality control and elimination of protein waste: the role of the ubiquitin-proteasome system. Biochim. Biophys. Acta 1843 (2014), 182–196.
-
(2014)
Biochim. Biophys. Acta
, vol.1843
, pp. 182-196
-
-
Amm, I.1
Sommer, T.2
Wolf, D.H.3
-
3
-
-
33746658984
-
An amphipathic helix targets serum and glucocorticoid-induced kinase 1 to the endoplasmic reticulum-associated ubiquitin-conjugation machinery
-
Arteaga, M.F., Wang, L., Ravid, T., Hochstrasser, M., Canessa, C.M., An amphipathic helix targets serum and glucocorticoid-induced kinase 1 to the endoplasmic reticulum-associated ubiquitin-conjugation machinery. Proc. Natl. Acad. Sci. USA 103 (2006), 11178–11183.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 11178-11183
-
-
Arteaga, M.F.1
Wang, L.2
Ravid, T.3
Hochstrasser, M.4
Canessa, C.M.5
-
4
-
-
81055139468
-
Structural insights into anaphase-promoting complex function and mechanism
-
Barford, D., Structural insights into anaphase-promoting complex function and mechanism. Philos. Trans. R. Soc. Lond. B Biol. Sci. 366 (2011), 3605–3624.
-
(2011)
Philos. Trans. R. Soc. Lond. B Biol. Sci.
, vol.366
, pp. 3605-3624
-
-
Barford, D.1
-
5
-
-
33748377124
-
Quantification of protein half-lives in the budding yeast proteome
-
Belle, A., Tanay, A., Bitincka, L., Shamir, R., O'Shea, E.K., Quantification of protein half-lives in the budding yeast proteome. Proc. Natl. Acad. Sci. USA 103 (2006), 13004–13009.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 13004-13009
-
-
Belle, A.1
Tanay, A.2
Bitincka, L.3
Shamir, R.4
O'Shea, E.K.5
-
6
-
-
0021668558
-
A positive selection for mutants lacking orotidine-5′-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance
-
Boeke, J.D., LaCroute, F., Fink, G.R., A positive selection for mutants lacking orotidine-5′-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance. Mol. Gen. Genet. 197 (1984), 345–346.
-
(1984)
Mol. Gen. Genet.
, vol.197
, pp. 345-346
-
-
Boeke, J.D.1
LaCroute, F.2
Fink, G.R.3
-
7
-
-
84941145210
-
The BioGRID interaction database: 2015 update
-
Chatr-Aryamontri, A., Breitkreutz, B.-J., Oughtred, R., Boucher, L., Heinicke, S., Chen, D., Stark, C., Breitkreutz, A., Kolas, N., O'Donnell, L., et al. The BioGRID interaction database: 2015 update. Nucleic Acids Res. 43 (2015), D470–D478.
-
(2015)
Nucleic Acids Res.
, vol.43
, pp. D470-D478
-
-
Chatr-Aryamontri, A.1
Breitkreutz, B.-J.2
Oughtred, R.3
Boucher, L.4
Heinicke, S.5
Chen, D.6
Stark, C.7
Breitkreutz, A.8
Kolas, N.9
O'Donnell, L.10
-
8
-
-
0027198563
-
Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MAT alpha 2 repressor
-
Chen, P., Johnson, P., Sommer, T., Jentsch, S., Hochstrasser, M., Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MAT alpha 2 repressor. Cell 74 (1993), 357–369.
-
(1993)
Cell
, vol.74
, pp. 357-369
-
-
Chen, P.1
Johnson, P.2
Sommer, T.3
Jentsch, S.4
Hochstrasser, M.5
-
9
-
-
37249026703
-
Intracellular protein degradation from a vague idea through the lysosome and the ubiquitin-proteasome system and on to human diseases and drug targeting: Nobel Lecture, December 8, 2004
-
Ciechanover, A., Intracellular protein degradation from a vague idea through the lysosome and the ubiquitin-proteasome system and on to human diseases and drug targeting: Nobel Lecture, December 8, 2004. Ann. N Y Acad. Sci. 1116 (2007), 1–28.
-
(2007)
Ann. N Y Acad. Sci.
, vol.1116
, pp. 1-28
-
-
Ciechanover, A.1
-
10
-
-
84911414802
-
Reporter-based growth assay for systematic analysis of protein degradation
-
Cohen, I., Geffen, Y., Ravid, G., Ravid, T., Reporter-based growth assay for systematic analysis of protein degradation. J. Vis. Exp., 93, 2014, e52021.
-
(2014)
J. Vis. Exp.
, vol.93
, pp. e52021
-
-
Cohen, I.1
Geffen, Y.2
Ravid, G.3
Ravid, T.4
-
11
-
-
33947517558
-
AGGRESCAN: a server for the prediction and evaluation of “hot spots” of aggregation in polypeptides
-
Conchillo-Solé, O., de Groot, N.S., Avilés, F.X., Vendrell, J., Daura, X., Ventura, S., AGGRESCAN: a server for the prediction and evaluation of “hot spots” of aggregation in polypeptides. BMC Bioinformatics, 8, 2007, 65.
-
(2007)
BMC Bioinformatics
, vol.8
, pp. 65
-
-
Conchillo-Solé, O.1
de Groot, N.S.2
Avilés, F.X.3
Vendrell, J.4
Daura, X.5
Ventura, S.6
-
12
-
-
3042618914
-
Sir Antagonist 1 (San1) is a ubiquitin ligase
-
Dasgupta, A., Ramsey, K.L., Smith, J.S., Auble, D.T., Sir Antagonist 1 (San1) is a ubiquitin ligase. J. Biol. Chem. 279 (2004), 26830–26838.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 26830-26838
-
-
Dasgupta, A.1
Ramsey, K.L.2
Smith, J.S.3
Auble, D.T.4
-
13
-
-
84979854249
-
JPred4: a protein secondary structure prediction server
-
Drozdetskiy, A., Cole, C., Procter, J., Barton, G.J., JPred4: a protein secondary structure prediction server. Nucleic Acids Res. 43:W1 (2015), W389–W394.
-
(2015)
Nucleic Acids Res.
, vol.43
, Issue.W1
, pp. W389-W394
-
-
Drozdetskiy, A.1
Cole, C.2
Procter, J.3
Barton, G.J.4
-
14
-
-
57049182407
-
Degradation of misfolded protein in the cytoplasm is mediated by the ubiquitin ligase Ubr1
-
Eisele, F., Wolf, D.H., Degradation of misfolded protein in the cytoplasm is mediated by the ubiquitin ligase Ubr1. FEBS Lett. 582 (2008), 4143–4146.
-
(2008)
FEBS Lett.
, vol.582
, pp. 4143-4146
-
-
Eisele, F.1
Wolf, D.H.2
-
15
-
-
84863723691
-
Selective destruction of abnormal proteins by ubiquitin-mediated protein quality control degradation
-
Fredrickson, E.K., Gardner, R.G., Selective destruction of abnormal proteins by ubiquitin-mediated protein quality control degradation. Semin. Cell Dev. Biol. 23 (2012), 530–537.
-
(2012)
Semin. Cell Dev. Biol.
, vol.23
, pp. 530-537
-
-
Fredrickson, E.K.1
Gardner, R.G.2
-
16
-
-
84055200360
-
Exposure of bipartite hydrophobic signal triggers nuclear quality control of Ndc10 at the endoplasmic reticulum/nuclear envelope
-
Furth, N., Gertman, O., Shiber, A., Alfassy, O.S., Cohen, I., Rosenberg, M.M., Doron, N.K., Friedler, A., Ravid, T., Exposure of bipartite hydrophobic signal triggers nuclear quality control of Ndc10 at the endoplasmic reticulum/nuclear envelope. Mol. Biol. Cell 22 (2011), 4726–4739.
-
(2011)
Mol. Biol. Cell
, vol.22
, pp. 4726-4739
-
-
Furth, N.1
Gertman, O.2
Shiber, A.3
Alfassy, O.S.4
Cohen, I.5
Rosenberg, M.M.6
Doron, N.K.7
Friedler, A.8
Ravid, T.9
-
17
-
-
17644396667
-
Degradation-mediated protein quality control in the nucleus
-
Gardner, R.G., Nelson, Z.W., Gottschling, D.E., Degradation-mediated protein quality control in the nucleus. Cell 120 (2005), 803–815.
-
(2005)
Cell
, vol.120
, pp. 803-815
-
-
Gardner, R.G.1
Nelson, Z.W.2
Gottschling, D.E.3
-
18
-
-
0032525130
-
Degradation signals for ubiquitin system proteolysis in Saccharomyces cerevisiae
-
Gilon, T., Chomsky, O., Kulka, R.G., Degradation signals for ubiquitin system proteolysis in Saccharomyces cerevisiae. EMBO J. 17 (1998), 2759–2766.
-
(1998)
EMBO J.
, vol.17
, pp. 2759-2766
-
-
Gilon, T.1
Chomsky, O.2
Kulka, R.G.3
-
19
-
-
0033834458
-
Degradation signals recognized by the Ubc6p-Ubc7p ubiquitin-conjugating enzyme pair
-
Gilon, T., Chomsky, O., Kulka, R.G., Degradation signals recognized by the Ubc6p-Ubc7p ubiquitin-conjugating enzyme pair. Mol. Cell. Biol. 20 (2000), 7214–7219.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 7214-7219
-
-
Gilon, T.1
Chomsky, O.2
Kulka, R.G.3
-
20
-
-
0016017019
-
Intracellular protein degradation in mammalian and bacterial cells
-
Goldberg, A.L., Dice, J.F., Intracellular protein degradation in mammalian and bacterial cells. Annu. Rev. Biochem. 43 (1974), 835–869.
-
(1974)
Annu. Rev. Biochem.
, vol.43
, pp. 835-869
-
-
Goldberg, A.L.1
Dice, J.F.2
-
21
-
-
84880053272
-
Hsp70 targets a cytoplasmic quality control substrate to the San1p ubiquitin ligase
-
Guerriero, C.J., Weiberth, K.F., Brodsky, J.L., Hsp70 targets a cytoplasmic quality control substrate to the San1p ubiquitin ligase. J. Biol. Chem. 288 (2013), 18506–18520.
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 18506-18520
-
-
Guerriero, C.J.1
Weiberth, K.F.2
Brodsky, J.L.3
-
22
-
-
84954288558
-
Tripartite degrons confer diversity and specificity on regulated protein degradation in the ubiquitin-proteasome system
-
Guharoy, M., Bhowmick, P., Sallam, M., Tompa, P., Tripartite degrons confer diversity and specificity on regulated protein degradation in the ubiquitin-proteasome system. Nat. Commun., 7, 2016, 10239.
-
(2016)
Nat. Commun.
, vol.7
, pp. 10239
-
-
Guharoy, M.1
Bhowmick, P.2
Sallam, M.3
Tompa, P.4
-
23
-
-
75749101057
-
Cytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1
-
Heck, J.W., Cheung, S.K., Hampton, R.Y., Cytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1. Proc. Natl. Acad. Sci. USA 107 (2010), 1106–1111.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 1106-1111
-
-
Heck, J.W.1
Cheung, S.K.2
Hampton, R.Y.3
-
25
-
-
0030457014
-
Ubiquitin-dependent protein degradation
-
Hochstrasser, M., Ubiquitin-dependent protein degradation. Annu. Rev. Genet. 30 (1996), 405–439.
-
(1996)
Annu. Rev. Genet.
, vol.30
, pp. 405-439
-
-
Hochstrasser, M.1
-
26
-
-
0032563319
-
Degradation signal masking by heterodimerization of MATalpha2 and MATa1 blocks their mutual destruction by the ubiquitin-proteasome pathway
-
Johnson, P.R., Swanson, R., Rakhilina, L., Hochstrasser, M., Degradation signal masking by heterodimerization of MATalpha2 and MATa1 blocks their mutual destruction by the ubiquitin-proteasome pathway. Cell 94 (1998), 217–227.
-
(1998)
Cell
, vol.94
, pp. 217-227
-
-
Johnson, P.R.1
Swanson, R.2
Rakhilina, L.3
Hochstrasser, M.4
-
27
-
-
84884867393
-
High-throughput analysis of in vivo protein stability
-
Kim, I., Miller, C.R., Young, D.L., Fields, S., High-throughput analysis of in vivo protein stability. Mol. Cell. Proteomics 12 (2013), 3370–3378.
-
(2013)
Mol. Cell. Proteomics
, vol.12
, pp. 3370-3378
-
-
Kim, I.1
Miller, C.R.2
Young, D.L.3
Fields, S.4
-
28
-
-
84883575302
-
DRIMust: a web server for discovering rank imbalanced motifs using suffix trees
-
Leibovich, L., Paz, I., Yakhini, Z., Mandel-Gutfreund, Y., DRIMust: a web server for discovering rank imbalanced motifs using suffix trees. Nucleic Acids Res. 41 (2013), W174–W179.
-
(2013)
Nucleic Acids Res.
, vol.41
, pp. W174-W179
-
-
Leibovich, L.1
Paz, I.2
Yakhini, Z.3
Mandel-Gutfreund, Y.4
-
29
-
-
84964321113
-
On the dependency of cellular protein levels on mRNA abundance
-
Liu, Y., Beyer, A., Aebersold, R., On the dependency of cellular protein levels on mRNA abundance. Cell 165 (2016), 535–550.
-
(2016)
Cell
, vol.165
, pp. 535-550
-
-
Liu, Y.1
Beyer, A.2
Aebersold, R.3
-
30
-
-
84978413857
-
Degradation signals for ubiquitin-proteasome-dependent cytosolic protein quality control (CytoQC) in yeast
-
Maurer, M.J., Spear, E.D., Yu, A.T., Lee, E.J., Shahzad, S., Michaelis, S., Degradation signals for ubiquitin-proteasome-dependent cytosolic protein quality control (CytoQC) in yeast. G3 (Bethesda) 6 (2016), 1853–1866.
-
(2016)
G3 (Bethesda)
, vol.6
, pp. 1853-1866
-
-
Maurer, M.J.1
Spear, E.D.2
Yu, A.T.3
Lee, E.J.4
Shahzad, S.5
Michaelis, S.6
-
31
-
-
4444320698
-
A genomic screen identifies Dsk2p and Rad23p as essential components of ER-associated degradation
-
Medicherla, B., Kostova, Z., Schaefer, A., Wolf, D.H., A genomic screen identifies Dsk2p and Rad23p as essential components of ER-associated degradation. EMBO Rep. 5 (2004), 692–697.
-
(2004)
EMBO Rep.
, vol.5
, pp. 692-697
-
-
Medicherla, B.1
Kostova, Z.2
Schaefer, A.3
Wolf, D.H.4
-
32
-
-
77954178073
-
A nucleus-based quality control mechanism for cytosolic proteins
-
Prasad, R., Kawaguchi, S., Ng, D.T., A nucleus-based quality control mechanism for cytosolic proteins. Mol. Biol. Cell 21 (2010), 2117–2127.
-
(2010)
Mol. Biol. Cell
, vol.21
, pp. 2117-2127
-
-
Prasad, R.1
Kawaguchi, S.2
Ng, D.T.3
-
33
-
-
50149086108
-
Diversity of degradation signals in the ubiquitin-proteasome system
-
Ravid, T., Hochstrasser, M., Diversity of degradation signals in the ubiquitin-proteasome system. Nat. Rev. Mol. Cell Biol. 9 (2008), 679–690.
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 679-690
-
-
Ravid, T.1
Hochstrasser, M.2
-
34
-
-
78650731442
-
Disorder targets misorder in nuclear quality control degradation: a disordered ubiquitin ligase directly recognizes its misfolded substrates
-
Rosenbaum, J.C., Fredrickson, E.K., Oeser, M.L., Garrett-Engele, C.M., Locke, M.N., Richardson, L.A., Nelson, Z.W., Hetrick, E.D., Milac, T.I., Gottschling, D.E., Gardner, R.G., Disorder targets misorder in nuclear quality control degradation: a disordered ubiquitin ligase directly recognizes its misfolded substrates. Mol. Cell 41 (2011), 93–106.
-
(2011)
Mol. Cell
, vol.41
, pp. 93-106
-
-
Rosenbaum, J.C.1
Fredrickson, E.K.2
Oeser, M.L.3
Garrett-Engele, C.M.4
Locke, M.N.5
Richardson, L.A.6
Nelson, Z.W.7
Hetrick, E.D.8
Milac, T.I.9
Gottschling, D.E.10
Gardner, R.G.11
-
35
-
-
57349123491
-
The N-terminal domain of MyoD is necessary and sufficient for its nuclear localization-dependent degradation by the ubiquitin system
-
Sadeh, R., Breitschopf, K., Bercovich, B., Zoabi, M., Kravtsova-Ivantsiv, Y., Kornitzer, D., Schwartz, A., Ciechanover, A., The N-terminal domain of MyoD is necessary and sufficient for its nuclear localization-dependent degradation by the ubiquitin system. Proc. Natl. Acad. Sci. USA 105 (2008), 15690–15695.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 15690-15695
-
-
Sadeh, R.1
Breitschopf, K.2
Bercovich, B.3
Zoabi, M.4
Kravtsova-Ivantsiv, Y.5
Kornitzer, D.6
Schwartz, A.7
Ciechanover, A.8
-
36
-
-
84901012110
-
How the nucleus copes with proteotoxic stress
-
Shibata, Y., Morimoto, R.I., How the nucleus copes with proteotoxic stress. Curr. Biol. 24 (2014), R463–R474.
-
(2014)
Curr. Biol.
, vol.24
, pp. R463-R474
-
-
Shibata, Y.1
Morimoto, R.I.2
-
37
-
-
84974622030
-
Cadmium and secondary structure-dependent function of a degron in the Pca1p cadmium exporter
-
Smith, N., Wei, W., Zhao, M., Qin, X., Seravalli, J., Kim, H., Lee, J., Cadmium and secondary structure-dependent function of a degron in the Pca1p cadmium exporter. J. Biol. Chem. 291 (2016), 12420–12431.
-
(2016)
J. Biol. Chem.
, vol.291
, pp. 12420-12431
-
-
Smith, N.1
Wei, W.2
Zhao, M.3
Qin, X.4
Seravalli, J.5
Kim, H.6
Lee, J.7
-
38
-
-
84892865694
-
Sorting out the trash: the spatial nature of eukaryotic protein quality control
-
Sontag, E.M., Vonk, W.I., Frydman, J., Sorting out the trash: the spatial nature of eukaryotic protein quality control. Curr. Opin. Cell Biol. 26 (2014), 139–146.
-
(2014)
Curr. Opin. Cell Biol.
, vol.26
, pp. 139-146
-
-
Sontag, E.M.1
Vonk, W.I.2
Frydman, J.3
-
39
-
-
0035887277
-
A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation
-
Swanson, R., Locher, M., Hochstrasser, M., A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation. Genes Dev. 15 (2001), 2660–2674.
-
(2001)
Genes Dev.
, vol.15
, pp. 2660-2674
-
-
Swanson, R.1
Locher, M.2
Hochstrasser, M.3
-
40
-
-
0026068805
-
Naming a targeting signal
-
Varshavsky, A., Naming a targeting signal. Cell 64 (1991), 13–15.
-
(1991)
Cell
, vol.64
, pp. 13-15
-
-
Varshavsky, A.1
-
41
-
-
0027964654
-
Chelation of serine 39 to Mg2+ latches a gate at the active site of enolase: structure of the bis(Mg2+) complex of yeast enolase and the intermediate analog phosphonoacetohydroxamate at 2.1-A resolution
-
Wedekind, J.E., Poyner, R.R., Reed, G.H., Rayment, I., Chelation of serine 39 to Mg2+ latches a gate at the active site of enolase: structure of the bis(Mg2+) complex of yeast enolase and the intermediate analog phosphonoacetohydroxamate at 2.1-A resolution. Biochemistry 33 (1994), 9333–9342.
-
(1994)
Biochemistry
, vol.33
, pp. 9333-9342
-
-
Wedekind, J.E.1
Poyner, R.R.2
Reed, G.H.3
Rayment, I.4
|