PNIPAM nanoparticles for targeted and enhanced nose-to-brain delivery of curcuminoids: UPLC/ESI-Q-ToF-MS/MS-based pharmacokinetics and pharmacodynamic evaluation in cerebral ischemia model

Drug Delivery

Volumn 23, Issue 7, 2016, Pages 2095-2114

  Ahmad, Niyaz ^a   Ahmad, Iqbal ^a   Umar, Sadiq ^b   Iqbal, Zeenat ^a   Samim, Mohd ^b   Ahmad, Farhan Jalees ^a  

^a HAMDARD UNIVERSITY   (India)

^b HAMDARD UNIVERSITY   (India)

Author keywords

Bisdemethoxycurcumin; brain drug targeting potential; brain targeting efficiency; curcumin; demethoxycurcumin; intranasal

Indexed keywords

CURCUMIN; DEMETHOXYCURCUMIN; DIDEMETHOXYCURCUMIN; INTERLEUKIN 1BETA; NANOPARTICLE; POLY(N ISOPROPYLACRYLAMIDE); TUMOR NECROSIS FACTOR; ACRYLIC ACID RESIN; BIS(4-HYDROXYCINNAMOYL)METHANE; POLY-N-ISOPROPYLACRYLAMIDE;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BIOAVAILABILITY; BRAIN ISCHEMIA; CHEMICAL PARAMETERS; COGNITION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG HALF LIFE; DRUG RELEASE; DRUG SAFETY; DRUG TARGETING; ELECTROSPRAY IONIZATION QUADRUPOLE TIME OF FLIGHT MASS SPECTROSCOPY BASED BIOANALYTICAL METHOD; ELIMINATION RATE CONSTANT; ENTRAPMENT EFFICIENCY; GRIP STRENGTH; IN VITRO STUDY; LOADING CAPACITY; LOCOMOTION; MAXIMUM PLASMA CONCENTRATION; MEMBRANE TRANSPORT; NONHUMAN; NOSE TO BRAIN DRUG DELIVERY; PARTICLE SIZE; PHARMACODYNAMICS; POLYMERIZATION; PRIORITY JOURNAL; RAT; SYNTHESIS; TARGET ORGAN; TIME TO MAXIMUM PLASMA CONCENTRATION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; VALIDATION STUDY; ZETA POTENTIAL; ANALOGS AND DERIVATIVES; ANIMAL; BRAIN; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRANASAL DRUG ADMINISTRATION; METABOLISM; NOSE; PHYSIOLOGY; PROCEDURES; STROKE; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION; WISTAR RAT;

ACRYLIC RESINS; ADMINISTRATION, INTRANASAL; ANIMALS; BIOLOGICAL AVAILABILITY; BRAIN; BRAIN ISCHEMIA; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CURCUMIN; DRUG DELIVERY SYSTEMS; NANOPARTICLES; NOSE; PARTICLE SIZE; RATS; RATS, WISTAR; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STROKE; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION;

EID: 84991661274     PISSN: 10717544     EISSN: 15210464     Source Type: Journal    
DOI: 10.3109/10717544.2014.941076     Document Type: Article

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