Evaluation of brain-targeting for the nasal delivery of estradiol by the microdialysis method

International Journal of Pharmaceutics

Volumn 317, Issue 1, 2006, Pages 40-46

  Wang, Xiaomei ^a   He, Haibing ^a   Leng, Wei ^a   Tang, Xing ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Estradiol; Intravenous administration; Microdialysis; Nasal delivery; Olfactory pathway

Indexed keywords

BETA CYCLODEXTRIN DERIVATIVE; ESTRADIOL;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CEREBROSPINAL FLUID; CONTROLLED STUDY; DRUG BRAIN LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG DELIVERY SYSTEM; DRUG DETERMINATION; DRUG INFUSION; DRUG TARGETING; DRUG TRANSPORT; DRUG UPTAKE; FLUORESCENCE ANALYSIS; MALE; METHYLATION; MICRODIALYSIS; NONHUMAN; NOSE CAVITY; OLFACTORY NERVE; PRIORITY JOURNAL; RANDOMIZATION; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ADMINISTRATION, INTRANASAL; ANIMALS; BRAIN; ESTRADIOL; INJECTIONS, INTRAVENOUS; MALE; MICRODIALYSIS; NASAL CAVITY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 33744967949     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.02.055     Document Type: Article

References (38)

1. Amy J.J., Balmer J.A., Baumarten K., et al. A randomized study to compare the effectiveness, tolerability and acceptability of two different transderma; estradiol replacement therapies: the transdermal HRT Investigators Group. Int. J. Fertil. Menopausal. Stud. 38 (1993) 5-11
2. Anand Kumar T.C., David G.F.X., Umberkoman B., and Saini K.D. Uptake of radioactivity by body fluids and tissues in rhesus monkeys after intravenous injection or intranasal spray of tritium-labelled oestradiol and progesterone. Curr. Sci. 43 (1974) 435-439
3. Asko J., Granander M., Laine T., et al. Effect of dose on the absorption of estradiol from a transdermal gel. Maturitas 35 (2000) 51-56
4. Asko J., Bäckström A.-C., Elfström C., et al. Comparative absorption and variability in absorption of estradiol from a transdermal gel and a novel matrix-type transdermal patch. Maturitas 38 (2001) 189-196
5. Bito L., Davson H., Levin E., Murray M., and Snider N. The concentrations of free amino acids and other electrolytes in cerebrospinal fluid, in vivo dialysate of brain, and blood plasma of the dog. J. Neurochem. 13 (1966) 1057-1067
6. Chetkowski R.J., Meldrum D.R., Steingold K.A., et al. Biologic effects of transdermal estradiol. N. Engl. J. Med. 314 (1986) 1615-1620
7. Chou K.J., and Donovan M.D. Distribution of antihistamines into the CSF following intranasal delivery. Biopharm. Drug Dispos. 18 (1997) 335-346
8. Chou K.J., and Donovan M.D. Lidocaine distribution into the CNS following nasal and arterial delivery: a comparison of local sampling and microdialysis techniques. Int. J. Pharm. 171 (1998) 53-61
9. Chou R.C., and Levy G. Effect of heparin or salicylate infusion on serum protein binding and on concentrations of phenytoin in serum, brain and cerebrospinal fluid of rats. J. Pharmacol. Exp. Ther. 219 (1981) 42-48
10. Chow H.H.S., Chen Z., and Matsuura G.T. Direct transport of cocaine from the nasal cavity to the brain following intranasal cocaine administration in rats. J. Pharm. Sci. 88 (1999) 754-758
11. Chow H.H.S., Anavy N., and Villalobos A. Direct nose-brain transport of benzoylecgonine following intranasal administration in rats. J. Pharm. Sci. 90 (2001) 1729-1735
12. Dada O.A., Laumas V., Landgren B.-M., Cekan S.Z., and Diczfalusy E. Effect of graded oral doses of oestradiol on circulating hormonal levels. Acta Endocrinol. 88 (1978) 754-767
13. Dahlin M., and Björk E. Nasal absorption of (S)-UH-301 and its transport into the cerebrospinal fluid of rats. Int. J. Pharm. 195 (2000) 197-205
14. De Lignieres B., Basdevant A., Thomas G., Thalabard J.C., Mercier-Bodard C., and Conard J. Biological effects of estradiol-17β in postmenopausal women: oral versus percutaneous administration. J. Clin. Endocrinol. Metab. 62 (1986) 536-541
15. Elisabeth S., Westlund P., Landgren B.-M., et al. Bioavailability of norethisterone acetate alone and in combination with estradiol administered in single or multiple oral doses to postmenopausal women. Maturitas 33 (1999) 59-69
16. Elmquist W.F., and Sawchuk R.J. Application of microdialysis in pharmacokinetic studies. Pharm. Res. 14 (1997) 267-288
17. Frenkel Y., Kopernik G., Lazer S., et al. Acceptability and skin reactions to transdermal estrogen replacement therapy in relation to climate. Maturitas 20 (1994) 31-36
18. Grebe S.K., Adams J.D., and Feek C.M. Systemic sensitization to ethanol by transdermal estrogen patches. Arch. Dermatol. 129 (1993) 379-380
19. Hansen D.K., Davies M.I., Lunte S.M., and Lunte C.E. Pharmacokinetic and metabolism studies using microdialysis sampling. J. Pharm. Sci. 88 (1999) 14-27
20. Hermens W.A.J.J., Deurloo M.J.M., Romeijn S.G., Verhoef J.C., and Merkus F.W.H.M. Nasal absorption enhancement of 17-b-oestradiol by dimethyl-β-cyclodextrin in rabbits and rats. Pharm. Res. 7 (1990) 500-503
21. Hirai S., Yashiki T., Matsuzawa T., and Mima H. Absorption of drugs from the nasal mucosa. Int. J. Pharm. 7 (1981) 317-325
22. Huang C.H., Kimura R., Bawarshi-Nassar R., and Hussain A. Mechanism of nasal absorption of drugs. I. Physicochemical parameters influencing the rate of in situ nasal absorption of drugs in rats. J. Pharm. Sci. 74 (1985) 608-611
23. Hussain M.A., Rakestraw D., Rowe S., and Aungst B.J. Nasal administration of a cognition enhancer provides improved bioavailability but not enhanced brain delivery. J. Pharm. Sci. 79 (1990) 771-772
24. Illum L. Transport of drugs from the nasal cavity to the central nervous system. Eur. J. Pharm. Sci. 11 (2000) 1-18
25. Kornhuber M.E., Kornhuber J., and Cimniak U. A method for repeated CSF sampling in the freely moving rat. J. Neurosci. Meth. 17 (1986) 63-68
26. Kupperman H.S., Blatt M.H.G., Wiesbader H., and Filler W. Comparative clinical evaluation of estrogenic preparations by the manopausal and amenorrheal indices. J. Clin. Endocrinol. 13 (1953) 688-703
27. Lonnroth P., Jansson P.A., and Smith U. A microdialysis method allowing characterization of intercellular water space in humans. Am. J. Physiol. 253 (1987) 228-231
28. Lyrenäs S., Carlström K., Bäckström T., and von Schoultz B. A comparison of serum oestrogen levels after percutaneous and oral administration of oestradiol-17b. Br. J. Obstet. Gynecol. 88 (1981) 181-187
29. Mascha P., van den Berg J., Coos Verhoef, Romeijn S.G., et al. Uptake of estradiol or progesterone into the CSF following intranasal and intravenous delivery in rats. Eur. J. Pharm. Biopharm. 58 (2004) 131-135
30. Mathison S., Nagilla R., and Kompella U.B. Nasal route for direct delivery of solutes to the central nervous system: fact or fiction?. J. Drug Target. 5 (1998) 415-441
31. O'Connel M.B. Pharmacokinetic and pharmacologic variation between different estrogen products. J. Clin. Pharmacol. 35 (1995) 18-24
32. Sarna G.S., Hutson P.H., Tricklebank M.D., and Curzon G. Determination of brain 5-hydroxytryptamine turnover in freely moving rats using repeated sampling of cerebrospinal fluid. J. Neurochem. 40 (1983) 383-388
33. Stanczyk F.Z., Shoupe D., Nunez V., Macias-Gonzales P., Vijod M.A., and Lobo R.A. A randomized comparison of nonoral estradiol delivery in postmenopausal women. Am. J. Obstet. Gynecol. 159 (1988) 1540-1546
34. Steingold K.A., Laufer L., Chetkowski J., et al. Treatment of hot flushes with transdermal estradiol administration. J. Clin. Endocrinol. Metab. 61 (1985) 627-632
35. ®. Maturitas 34 (2000) 57-64
36. Waynforth H.B., and Flecknell P.A. Cisternal puncture and Intracisternal Injection (1980), Academic Press, London pp. 59-61
37. Westergren I., and Johansson B.B. Changes in physiological parameters of rat cerebrospinal fluid during chronic sampling: evaluation of two sampling methods. Brain Res. Bull. 27 (1991) 283-286
38. Westerink B.H. Brain microdialysis and its application for the study of animal behaviour. Behav. Brain Res. 70 (1995) 103-124