Cellular Effects of Serotonin in the CNS

Handbook of Behavioral Neuroscience

Volumn 21, Issue C, 2010, Pages 219-231

  Andrade, Rodrigo ^a   Beck, Sheryl G ^b  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

5 HT1A; 5 HT2A; 5 HT3; 5 HT4; 5 HT7; cortex; GABAergic interneurons; hippocampus; pyramidal neurons; serotonin

Indexed keywords

EID: 84991552711     PISSN: 15697339     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1569-7339(10)70080-1     Document Type: Chapter

References (93)

1. G.K. Aghajanian G.J. Marek Serotonin induces excitatory postsynaptic potentials in apical dendrites of neocortical pyramidal cells Neuropharmacology 36 1997 589 599
2. G.K. Aghajanian G.J. Marek Serotonin, via 5-HT2A receptors, increases EPSCs in layer V pyramidal cells of prefrontal cortex by an asynchronous mode of glutamate release Brain Res. 825 1999 161 171
3. A.D. Ait L. Segu S. Naili M.C. Buhot Serotonin 1B receptor regulation after dorsal subiculum deafferentation Brain Res. Bull. 38 1995 17 23
4. 4-like receptors mediate the slow excitatory response to serotonin in the rat hippocampus J. Pharmacol. Exp. Ther. 257 1991 930 937
5. R. Andrade R.A. Nicoll Pharmacologically distinct actions of serotonin on single pyramidal neurones of the rat hippocampus recorded in vitro. J. Physiol. 394 1987 99 124
6. R. Araneda R. Andrade 5-Hydroxytryptamine2 and 5-hydroxytryptamine 1A receptors mediate opposing responses on membrane excitability in rat association cortex Neuroscience 40 1991 399 412
7. G.A. Ascoli L. Onso-Nanclares S.A. Anderson G. Barrionuevo R. Avides-Piccione A. Burkhalter G. Buzsaki B. Cauli J. Defelipe A. Fairen D. Feldmeyer G. Fishell Y. Fregnac T.F. Freund D. Gardner E.P. Gardner J.H. Goldberg M. Helmstaedter S. Hestrin F. Karube Z.F. Kisvarday B. Lambolez D.A. Lewis O. Marin H. Markram A. Munoz A. Packer C.C. Petersen K.S. Rockland J. Rossier B. Rudy P. Somogyi J.F. Staiger G. Tamas A.M. Thomson M. Toledo-Rodriguez Y. Wang D.C. West R. Yuste Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex Nat. Rev. Neurosci. 9 2008 557 568
8. A. Bacci J.R. Huguenard D.A. Prince Modulation of neocortical interneurons: extrinsic influences and exercises in self-control Trends Neurosci. 28 2005 602 610
9. J. Bachevalier K.A. Loveland The orbitofrontal-amygdala circuit and self-regulation of social-emotional behavior in autism Neurosci. Biobehav. Rev. 30 2006 97 117
10. W.L. Bacon S.G. Beck 5-Hydroxytryptamine(7) receptor activation decreases slow afterhyperpolarization amplitude in CA3 hippocampal pyramidal cells J. Pharmacol. Exp. Ther. 294 2000 672 679
11. 1A-mediated hyperpolarization in CA1 and CA3 hippocampal pyramidal cells J. Pharmacol. Exp. Ther. 263 1992 350 359
12. S.G. Beck W.P. Clarke J. Goldfarb Spiperone differentiates multiple 5-hydroxytryptamine responses in rat hippocampal slices in vitro. Eur. J. Pharmacol. 116 1985 195 197
13. J.C. Beique B. Campbell P. Perring M.W. Hamblin P. Walker L. Mladenovic R. Andrade Serotonergic regulation of membrane potential in developing rat prefrontal cortex: coordinated expression of 5-hydroxytryptamine (5-HT)1A, 5-HT2A, and 5-HT7 receptors J. Neurosci. 24 2004 4807 4817
14. J.C. Beique E.M. Chapin-Penick L. Mladenovic R. Andrade Serotonergic facilitation of synaptic activity in the developing rat prefrontal cortex J. Physiol. 556 2004 739 754
15. J.C. Beique M. Imad L. Mladenovic J.A. Gingrich R. Andrade Mechanism of the 5-hydroxytryptamine 2A receptor-mediated facilitation of synaptic activity in prefrontal cortex Proc. Natl Acad. Sci. USA 104 2007 9870 9875
16. P.H. Boeijinga H.W. Boddeke Serotonergic modulation of neurotransmission in the rat subicular cortex in vitro: a role for 5-HT1B receptors Naunyn Schmiedebergs Arch. Pharmacol. 348 1993 553 557
17. P.H. Boeijinga H.W. Boddeke Activation of 5-HT1B receptors suppresses low but not high frequency synaptic transmission in the rat subicular cortex in vitro. Brain Res. 721 1996 59 65
18. A. Bonnin W. Peng W. Hewlett P. Levitt Expression mapping of 5-HT1 serotonin receptor subtypes during fetal and early postnatal mouse forebrain development Neuroscience 141 2006 781 794
19. A. Bonnin M. Torii L. Wang P. Rakic P. Levitt Serotonin modulates the response of embryonic thalamocortical axons to netrin-1 Nat. Neurosci. 10 2007 588 597
20. R.L. Buckner J.R. Andrews-Hanna D.L. Schacter The brain's default network: anatomy, function, and relevance to disease Ann. NY Acad. Sci. 1124 2008 1 38
21. S.Y. Choi J. Chang B. Jiang G.H. Seol S.S. Min J.S. Han H.S. Shin M. Gallagher A. Kirkwood Multiple receptors coupled to phospholipase C gate long-term depression in visual cortex J. Neurosci. 25 2005 11433 11443
22. S.W. Clay J. Allen T. Parran A review of addiction Postgrad. Med. 120 2008 E01 E07
23. A. Colino J.V. Halliwell Differential modulation of three separate K-conductances in hippocampal CA1 neurons by serotonin Nature 328 1987 73 77
24. A. Dahlstrom K. Fuxe Evidence for the existence of monoamine-containing neurons in the central nervous system: I. Demonstration of monoamines in cell bodies of brain neurons Acta Physiol. Scand. Suppl 232 1964 1 55
25. A.J. de Almeida G. Mengod Quantitative analysis of glutamatergic and GABAergic neurons expressing 5-HT(2A) receptors in human and monkey prefrontal cortex J. Neurochem. 103 2007 475 486
26. de Almeida, A.J. and Mengod, G. (2008). Serotonin 1A receptors in human and monkey prefrontal cortex are mainly expressed in pyramidal neurons and in a GABAergic interneuron subpopulation: implications for schizophrenia and its treatment. J. Neurochem., in press.
27. L.S. del Burgo R. Cortes G. Mengod J. Zarate E. Echevarria J. Salles Distribution and neurochemical characterization of neurons expressing GIRK channels in the rat brain J. Comp Neurol. 510 2008 581 606
28. D.R. Deng S. Djalali M. Holtje G. Grosse T. Stroh I. Voigt H. Kusserow F. Theuring G. Ahnert-Hilger H. Hortnagl Embryonic and postnatal development of the serotonergic raphe system and its target regions in 5-HT1A receptor deletion or overexpressing mouse mutants Neuroscience 147 2007 388 402
29. R.C. Foehring J.F. van Brederode G.A. Kinney W.J. Spain Serotonergic modulation of supragranular neurons in rat sensorimotor cortex J. Neurosci. 22 2002 8238 8250
30. T.F. Freund Interneuron Diversity series: rhythm and mood in perisomatic inhibition Trends Neurosci. 26 2003 489 495
31. T.F. Freund A.I. Gulyas L. Acsady T. Gorcs K. Toth Serotonergic control of the hippocampus via local inhibitory interneurons Proc. Natl Acad. Sci. USA 87 1990 8501 8505
32. T.F. Freund I. Katona Perisomatic inhibition Neuron 56 2007 33 42
33. C. Gross X. Zhuang K. Stark S. Ramboz R. Oosting L. Kirby L. Santarelli S. Beck R. Hen Serotonin1A receptor acts during development to establish normal anxietylike behaviour in the adult Nature 416 2002 396 400
34. Q. Gu W. Singer Involvement of serotonin in developmental plasticity of kitten visual cortex Eur. J. Neurosci. 7 1995 1146 1153
35. A.I. Gulyas L. Acsady T.F. Freund Structural basis of the cholinergic and serotonergic modulation of GABAergic neurons in the hippocampus Neurochem. Int. 34 1999 359 372
36. E.L. Gustafson M.M. Durkin J.A. Bard J. Zgombick T.A. Branchek A receptor autoradiographic and in situ hybridization analysis of the distribution of the 5-ht7 receptor in rat brain Br. J. Pharmacol. 117 1996 657 666
37. R.M. Harris-Warrick E. Marder Modulation of neural networks for behavior Annu. Rev. Neurosci. 14 1991 39 57
38. L.K. Heisler H.M. Chu T.J. Brennan J.A. Danao P. Bajwa L.H. Parsons L.H. Tecott Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice Proc. Natl Acad. Sci. USA 95 1998 15049 15054
39. M.H. Higgs S.J. Slee W.J. Spain Diversity of gain modulation by noise in neocortical neurons: regulation by the slow afterhyperpolarization conductance J. Neurosci. 26 2006 8787 8799
40. B.L. Jacobs E.C. Azmitia Structure and function of the brain serotonin system Physiol. Rev. 72 1992 165 229
41. B.L. Jacobs C.A. Fornal Activity of serotonergic neurons in behaving animals Neuropsychopharmacology 21 1999 9S 15S
42. B.L. Jacobs F.J. Martin-Cora C.A. Fornal Activity of medullary serotonergic neurons in freely moving animals Brain Res. Brain Res. Rev. 40 2002 45 52
43. R.L. Jakab P.S. Goldman-Rakic Segregation of serotonin 5-HT2A and 5-HT3 receptors in inhibitory circuits of the primate cerebral cortex J. Comp. Neurol. 417 2000 337 348
44. T. Klausberger P.J. Magill L.F. Marton J.D. Roberts P.M. Cobden G. Buzsaki P. Somogyi Brain-state- and cell-type-specific firing of hippocampal interneurons in vivo. Nature 421 2003 844 848
45. T. Klausberger P. Somogyi Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operations Science 321 2008 53 57
46. L. Kojic R.H. Dyck Q. Gu R.M. Douglas J. Matsubara M.S. Cynader Columnar distribution of serotonin-dependent plasticity within kitten striate cortex Proc. Natl. Acad. Sci. USA 97 2000 1841 1844
47. L. Kojic Q. Gu R.M. Douglas M.S. Cynader Serotonin facilitates synaptic plasticity in kitten visual cortex: an in vitro study Brain Res. Dev. Brain Res. 101 1997 299 304
48. E.K. Lambe G.K. Aghajanian The role of Kv1.2-containing potassium channels in serotonin-induced glutamate release from thalamocortical terminals in rat frontal cortex J. Neurosci. 21 2001 9955 9963
49. A. Laurent J.M. Goaillard O. Cases C. Lebrand P. Gaspar N. Ropert Activity-dependent presynaptic effect of serotonin 1B receptors on the somatosensory thalamocortical transmission in neonatal mice J. Neurosci. 22 2002 886 900
50. D.P. Leone K. Srinivasan B. Chen E. Alcamo S.K. McConnell The determination of projection neuron identity in the developing cerebral cortex Curr. Opin. Neurobiol. 18 2008 28 35
51. H.G. Lidov R. Grzanna M.E. Molliver The serotonin innervation of the cerebral cortex in the rat – an immunohistochemical analysis Neuroscience 5 1980 207 227
52. S. Liu M.J. Bubar M.F. Lanfranco G.R. Hillman K.A. Cunningham Serotonin2C receptor localization in GABA neurons of the rat medial prefrontal cortex: implications for understanding the neurobiology of addiction Neuroscience 146 2007 1677 1688
53. J.F. Lopez-Gimenez G. Mengod J.M. Palacios M.T. Vilaro Selective visualization of rat brain 5-HT2A receptors by autoradiography with [3H]MDL 100,907 Naunyn Schmiedebergs Arch. Pharmacol. 356 1997 446 454
54. Y. Ma H. Hu A.S. Berrebi P.H. Mathers A. Agmon Distinct subtypes of somatostatin-containing neocortical interneurons revealed in transgenic mice J. Neurosci. 26 2006 5069 5082
55. G.J. Marek G.K. Aghajanian 5-HT2A receptor or alpha 1-adrenoceptor activation induces excitatory postsynaptic currents in layer V pyramidal cells of the medial prefrontal cortex Eur. J. Pharmacol. 367 1999 197 206
56. R. Martin-Ruiz M.V. Puig P. Celada D.A. Shapiro B.L. Roth G. Mengod F. Artigas Control of serotonergic function in medial prefrontal cortex by serotonin-2A receptors through a glutamate-dependent mechanism J. Neurosci. 21 2001 9856 9866
57. J.F. Maya Vetencourt A. Sale A. Viegi L. Baroncelli P.R. De O.F. O'Leary E. Castren L. Maffei The antidepressant fluoxetine restores plasticity in the adult visual cortex Science 320 2008 385 388
58. L.L. McMahon J.A. Kauer Hippocampal interneurons are excited via serotonin-gated ion channels J. Neurophysiol. 78 1997 2493 2502
59. Z. Molnar A.F. Cheung Towards the classification of subpopulations of layer V pyramidal projection neurons Neurosci. Res. 55 2006 105 115
60. B.J. Molyneaux P. Arlotta J.R. Menezes J.D. Macklis Neuronal subtype specification in the cerebral cortex Nat. Rev. Neurosci. 8 2007 427 437
61. M. Morales C. Backman Coexistence of serotonin 3 (5-HT3) and CB1 cannabinoid receptors in interneurons of hippocampus and dentate gyrus Hippocampus 12 2002 756 764
62. T. Murakoshi S.Y. Song S. Konishi T. Tanabe Multiple G-protein-coupled receptors mediate presynaptic inhibition at single excitatory synapses in the rat visual cortex Neurosci. Lett. 309 2001 117 120
63. C.L. Parks P.S. Robinson E. Sibille T. Shenk M. Toth Increased anxiety of mice lacking the serotonin1A receptor Proc. Natl. Acad. Sci. USA 95 1998 10734 10739
64. P. Parra A.I. Gulyas R. Miles How many subtypes of inhibitory cells in the hippocampus? Neuron 20 1998 983 993
65. T.D. Patel F.C. Zhou Ontogeny of 5-HT1A receptor expression in the developing hippocampus Brain Res. Dev. Brain Res. 157 2005 42 57
66. P. Piguet M. Galvan Transient and long-lasting actions of 5-HT on rat dentate gyrus neurones in vitro. J Physiol. 481 Pt 3 1994 629 639
67. S. Ramboz R. Oosting D.A. Amara H.F. Kung P. Blier M. Mendelsohn J.J. Mann D. Brunner R. Hen Serotonin receptor 1A knockout: an animal model of anxiety-related disorder Proc. Natl. Acad. Sci. USA 95 1998 14476 14481
68. R.W. Rhoades C.A. Benett-Clarke M.Y. Shi R.D. Mooney Effects of 5-HT on thalamocortical synaptic transmission in the developing rat J. Neurophysiol. 72 1994 2438 2450
69. M. Segal The action of serotonin in the rat hippocampal slice preparation J. Physiol. 303 1980 423 439
70. G.H. Seol J. Ziburkus S. Huang L. Song I.T. Kim K. Takamiya R.L. Huganir H.K. Lee A. Kirkwood Neuromodulators control the polarity of spike-timing-dependent synaptic plasticity Neuron 55 2007 919 929
71. W.J. Spain Serotonin has different effects on two classes of Betz cells from the cat J. Neurophysiol. 72 1994 1925 1937
72. H.W. Steinbusch Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals Neuroscience 6 1981 557 618
73. K. Sugino C.M. Hempel M.N. Miller A.M. Hattox P. Shapiro C. Wu Z.J. Huang S.B. Nelson Molecular taxonomy of major neuronal classes in the adult mouse forebrain Nat. Neurosci. 9 2006 99 107
74. H.Y. Tan J.H. Callicott D.R. Weinberger Dysfunctional and compensatory prefrontal cortical systems, genes and the pathogenesis of schizophrenia Cereb. Cortex 17 Suppl. 1 2007 i171 i181
75. E. Tanaka R.A. North Actions of 5-hydroxytryptamine on neurons of the rat cingulate cortex J. Neurophysiol. 69 1993 1749 1757
76. J. Tanji E. Hoshi Role of the lateral prefrontal cortex in executive behavioral control Physiol. Rev. 88 2008 37 57
77. G.E. Torres I.L. Holt R. Andrade Antagonists of 5-HT4 receptor-mediated responses in adult hippocampal neurons J. Pharmacol. Exp. Ther. 271 1994 255 261
78. J.L. Torres-Escalante J.A. Barral M.D. Ibarra-Villa A. Perez-Burgos J.L. Gongora-Alfaro J.C. Pineda 5-HT1A, 5-HT2, and GABAB receptors interact to modulate neurotransmitter release probability in layer 2/3 somato-sensory rat cortex as evaluated by the paired pulse protocol J. Neurosci. Res. 78 2004 268 278
79. H.B. Uylings H.J. Groenewegen B. Kolb Do rats have a prefrontal cortex? Behav. Brain Res. 146 2003 3 17
80. C.G. van Eden H.B. Uylings Cytoarchitectonic development of the prefrontal cortex in the rat J. Comp. Neurol. 241 1985 253 267
81. C. Villalobos J.C. Beique J.A. Gingrich R. Andrade Serotonergic regulation of calcium-activated potassium currents in rodent prefrontal cortex Eur. J. Neurosci. 22 2005 1120 1126
82. M.L. Vizuete J.L. Venero E. Traiffort C. Vargas A. Machado J. Cano Expression of 5-HT7 receptor mRNA in rat brain during postnatal development Neurosci. Lett. 227 1997 53 56
83. A. Vysokanov J. Flores-Hernandez D.J. Surmeier mRNAs for clozapine-sensitive receptors co-localize in rat prefrontal cortex neurons Neurosci. Lett. 258 1998 179 182
84. C. Waeber M. Sebben A. Nieoullon J. Bockaert A. Dumuis Regional distribution and ontogeny of 5-HT4 binding sites in rodent brain Neuropharmacology 33 1994 527 541
85. D.L. Willins A.Y. Deutch B.L. Roth Serotonin 5-HT2A receptors are expressed on pyramidal cells and interneurons in the rat cortex Synapse 27 1997 79 82
86. Z. Xiang D.A. Prince Heterogeneous actions of serotonin on interneurons in rat visual cortex J. Neurophysiol. 89 2003 1278 1287
87. C.L. Young-Davies C.A. Benett-Clarke R.D. Lane R.W. Rhoades Selective facilitation of the serotonin(1B) receptor causes disorganization of thalamic afferents and barrels in somatosensory cortex of rat J. Comp. Neurol. 425 2000 130 138
88. Z.W. Zhang Serotonin induces tonic firing in layer V pyramidal neurons of rat prefrontal cortex during postnatal development J. Neurosci. 23 2003 3373 3384
89. Z.W. Zhang Canadian Association of Neurosciences review: postnatal development of the mammalian neocortex: role of activity revisited Can. J. Neurol. Sci. 33 2006 158 169
90. Z.W. Zhang D. Arsenault Gain modulation by serotonin in pyramidal neurones of the rat prefrontal cortex J. Physiol. 566 2005 379 394
91. F.M. Zhou J.J. Hablitz Activation of serotonin receptors modulates synaptic transmission in rat cerebral cortex J. Neurophysiol. 82 1999 2989 2999
92. P. Zhong W. Liu Z. Gu Z. Yan Serotonin facilitates long-term depression induction in prefrontal cortex via p38 MAPK/Rab5-mediated enhancement of AMPA receptor internalization J. Physiol. 586 2008 4465 4479
93. L. Kojic Q. Gu R.M. Douglas M.S. Cynader Laminar distribution of cholinergic- and serotonergic-dependent plasticity within kitten visual cortex Brain Res. Dev. Brain Res. 126 2001 157 162