Age-Associated Sirtuin 1 Reduction in Vascular Smooth Muscle Links Vascular Senescence and Inflammation to Abdominal Aortic Aneurysm

Circulation Research

Volumn 119, Issue 10, 2016, Pages 1076-1088

  Chen, Hou Zao ^a   Wang, Fang ^a,c   Gao, Peng ^a,d   Pei, Jian Fei ^a   Liu, Yue ^a   Xu, Ting Ting ^a   Tang, Xiaoqiang ^a   Fu, Wen Yan ^a   Lu, Jie ^a   Yan, Yun Fei ^a   Wang, Xiao Man ^a   Han, Lei ^a   Zhang, Zhu Qin ^a   Zhang, Ran ^a   Zou, Ming Hui ^b,e   Liu, De Pei ^a  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^c CHINA JAPAN FRIENDSHIP HOSPITAL   (China)

^d THIRD MILITARY MEDICAL UNIVERSITY   (China)

^e GEORGIA STATE UNIVERSITY   (United States)

Author keywords

aging; angiotensin II; aortic aneurysm, abdominal; inflammation; SIRT1 protein, human

Indexed keywords

3 NITROTYROSINE; 8 HYDROXYDEOXYGUANOSINE; ANGIOTENSIN II; APOLIPOPROTEIN E; CALCIUM CHLORIDE; CD45 ANTIGEN; GELATINASE A; HISTONE DEACETYLASE 3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN P21; PROTEIN P53; SIRTUIN 1; CCL2 PROTEIN, MOUSE; SIRT1 PROTEIN, HUMAN; SIRT1 PROTEIN, MOUSE;

ABDOMINAL AORTA ANEURYSM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; RNA INTERFERENCE; SENESCENCE; TRANSCRIPTION INITIATION; UPREGULATION; VASCULAR SMOOTH MUSCLE CELL; VASCULITIS; AGING; ANEURYSM, RUPTURED; ANIMAL; AORTIC ANEURYSM, ABDOMINAL; AORTITIS; BIOSYNTHESIS; C57BL MOUSE; CHEMICALLY INDUCED; DEFICIENCY; DISEASE MODEL; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE; VASCULAR SMOOTH MUSCLE;

AGING; ANEURYSM, RUPTURED; ANGIOTENSIN II; ANIMALS; AORTIC ANEURYSM, ABDOMINAL; AORTITIS; APOLIPOPROTEINS E; CALCIUM CHLORIDE; CHEMOKINE CCL2; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MUSCLE, SMOOTH, VASCULAR; NF-KAPPA B; SIRTUIN 1;

EID: 84991508697     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.116.308895     Document Type: Article

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