Ginsenoside Rg1 protects against sepsis-associated encephalopathy through beclin 1–independent autophagy in mice

Journal of Surgical Research

Volumn 207, Issue , 2017, Pages 181-189

  Li, Yinjiao ^a   Wang, Fang ^b   Luo, Yan ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Autophagy; Cognitive impairment; Ginsenoside Rg1; Inflammation; Sepsis associated encephalopathy

Indexed keywords

BECLIN 1; CASPASE 3; GINSENOSIDE RG 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; TUMOR NECROSIS FACTOR; BIOLOGICAL MARKER; GINSENOSIDE; NEUROPROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HEART PERFUSION; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; MICROGLIA; MORRIS WATER MAZE TEST; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; SEPSIS ASSOCIATED ENCEPHALOPATHY; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; COMPLICATION; DRUG EFFECTS; METABOLISM; PHYSIOLOGY; RANDOMIZATION; SEPSIS; SEPSIS-ASSOCIATED ENCEPHALOPATHY; TREATMENT OUTCOME;

ANIMALS; APOPTOSIS; AUTOPHAGY; BECLIN-1; BIOMARKERS; BLOTTING, WESTERN; ENZYME-LINKED IMMUNOSORBENT ASSAY; GINSENOSIDES; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED C57BL; NEUROPROTECTIVE AGENTS; RANDOM ALLOCATION; SEPSIS; SEPSIS-ASSOCIATED ENCEPHALOPATHY; TREATMENT OUTCOME;

EID: 84991439235     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2016.08.080     Document Type: Article

References (31)

1. 1 Fein, A.M., Calalang-Colucci, M.G., Acute lung injury and acute respiratory distress syndrome in sepsis and septic shock. Crit Care Clin 16 (2000), 289–317.
2. 2 Bleck, T.P., Smith, M.C., Pierre-Louis, S.J., et al. Neurologic complications of critical medical illnesses. Crit Care Med 21 (1993), 98–103.
3. 3 Page, V.J., Navarange, S., Gama, S., et al. Routine delirium monitoring in a UK critical care unit. Crit Care, 13, 2009, R16.
4. 4 Hough, C.L., Curtis, J.R., Long-term sequelae of critical illness: memories and health-related quality of life. Crit Care 9 (2005), 145–146.
5. 5 Hopkins, R.O., Weaver, L.K., Chan, K.J., et al. Quality of life, emotional, and cognitive function following acute respiratory distress syndrome. J Int Neuropsychol Soc 10 (2004), 1005–1017.
6. 6 Taccone, F.S., Su, F., Pierrakos, C., et al. Cerebral microcirculation is impaired during sepsis: an experimental study. Crit Care, 14, 2010, R140.
7. 7 Jacob, A., Brorson, J.R., Alexander, J.J., Septic encephalopathy: inflammation in man and mouse. Neurochem Int 58 (2011), 472–476.
8. 8 Azevedo, L.C., Mitochondrial dysfunction during sepsis. Endocr Metab Immune Disord Drug Targets 10 (2010), 214–223.
9. 9 Alirezaei, M., Kiosses, W.B., Flynn, C.T., et al. Disruption of neuronal autophagy by infected microglia results in neurodegeneration. PLoS One, 3, 2008, e2906.
10. 10 van Gool, W.A., van de Beek, D., Eikelenboom, P., Systemic infection and delirium: when cytokines and acetylcholine collide. Lancet 375 (2010), 773–775.
11. 11 Cunningham, C., Systemic inflammation and delirium: important co-factors in the progression of dementia. Biochem Soc Trans 39 (2011), 945–953.
12. 12 Zong, Y., Ai, Q.L., Zhong, L.M., et al. Ginsenoside Rg1 attenuates lipopolysaccharide-induced inflammatory responses via the phospholipase C-gamma1 signaling pathway in murine BV-2 microglial cells. Curr Med Chem 19 (2012), 770–779.
13. 13 Tao, T., Chen, F., Bo, L., et al. Ginsenoside Rg1 protects mouse liver against ischemia-reperfusion injury through anti-inflammatory and anti-apoptosis properties. J Surg Res 191 (2014), 231–238.
14. 14 Heng, Y., Zhang, Q.S., Mu, Z., et al. Ginsenoside Rg1 attenuates motor impairment and neuroinflammation in the MPTP-probenecid-induced parkinsonism mouse model by targeting alpha-synuclein abnormalities in the substantia nigra. Toxicol Lett 243 (2016), 7–21.
15. 15 Bao, S., Zou, Y., Wang, B., et al. Ginsenoside Rg1 improves lipopolysaccharide-induced acute lung injury by inhibiting inflammatory responses and modulating infiltration of M2 macrophages. Int Immunopharmacol 28 (2015), 429–434.
16. 16 Zhang, Y., Zhou, Y., Lou, J., et al. PD-L1 blockade improves survival in experimental sepsis by inhibiting lymphocyte apoptosis and reversing monocyte dysfunction. Crit Care, 14, 2010, R220.
17. 17 Wu, J., Zhang, M., Hao, S., et al. Mitochondria-targeted peptide reverses mitochondrial dysfunction and cognitive deficits in sepsis-associated encephalopathy. Mol Neurobiol 52 (2015), 783–791.
18. 18 Gofton, T.E., Young, G.B., Sepsis-associated encephalopathy. Nat Rev Neurol 8 (2012), 557–566.
19. 19 Michels, M., Vieira, A.S., Vuolo, F., et al. The role of microglia activation in the development of sepsis-induced long-term cognitive impairment. Brain Behav Immun 43 (2015), 54–59.
20. 20 Sprung, C.L., Peduzzi, P.N., Shatney, C.H., et al. Impact of encephalopathy on mortality in the sepsis syndrome. The Veterans Administration Systemic Sepsis Cooperative Study Group. Crit Care Med 18 (1990), 801–806.
21. 21 Cunningham, C., Microglia and neurodegeneration: the role of systemic inflammation. Glia 61 (2013), 71–90.
22. 22 Ito, D., Imai, Y., Ohsawa, K., et al. Microglia-specific localisation of a novel calcium binding protein, Iba1. Brain Res Mol Brain Res 57 (1998), 1–9.
23. 23 Akao, Y., Nakagawa, Y., Maruyama, W., et al. Apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, is mediated by activation of caspase 3. Neurosci Lett 267 (1999), 153–156.
24. 24 Yamamoto, A., Yue, Z., Autophagy and its normal and pathogenic states in the brain. Annu Rev Neurosci 37 (2014), 55–78.
25. 25 Wirawan, E., Lippens, S., Vanden, B.T., et al. Beclin1: a role in membrane dynamics and beyond. Autophagy 8 (2012), 6–17.
26. 26 Komatsu, M., Ichimura, Y., Physiological significance of selective degradation of p62 by autophagy. FEBS Lett 584 (2010), 1374–1378.
27. 27 Pankiv, S., Clausen, T.H., Lamark, T., et al. P62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem 282 (2007), 24131–24145.
28. 28 Scarlatti, F., Maffei, R., Beau, I., et al. Non-canonical autophagy: an exception or an underestimated form of autophagy?. Autophagy 4 (2008), 1083–1085.
29. 29 Tian, S., Lin, J., Jun, Z.J., et al. Beclin 1-independent autophagy induced by a Bcl-XL/Bcl-2 targeting compound, Z18. Autophagy 6 (2010), 1032–1041.
30. 30 Flavin, M.P., Zhao, G., Ho, L.T., Microglial tissue plasminogen activator (tPA) triggers neuronal apoptosis in vitro. Glia 29 (2000), 347–354.
31. 31 Wang, Y., Liu, Y., Zhang, X.Y., et al. Ginsenoside Rg1 regulates innate immune responses in macrophages through differentially modulating the NF-kappaB and PI3K/Akt/mTOR pathways. Int Immunopharmacol 23 (2014), 77–84.