Ginsenoside Rg1 protects mouse liver against ischemia-reperfusion injury through anti-inflammatory and anti-apoptosis properties

Journal of Surgical Research

Volumn 191, Issue 1, 2014, Pages 231-238

  Tao, Tianzhu ^a   Chen, Feng ^a   Bo, Lulong ^a   Xie, Qun ^a   Yi, Wenjing ^a   Zou, Yun ^a   Hu, Baoji ^a   Li, Jinbao ^a   Deng, Xiaoming ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Ginsenoside Rg1; Inflammation; Liver ischemia reperfusion injury

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GINSENOSIDE RG 1; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIVER PROTECTIVE AGENT; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; ANTIINFLAMMATORY AGENT; CELL ADHESION MOLECULE; CYTOKINE; GINSENOSIDE; HERBACEOUS AGENT;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIAPOPTOTIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; HEPATIC ARTERY; HISTOPATHOLOGY; LIVER CELL; LIVER CELL DAMAGE; LIVER INJURY; LIVER ISCHEMIA; LIVER NECROSIS; LIVER PROTECTION; MALE; MOUSE; NICK END LABELING; NONHUMAN; PORTAL VEIN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; REPERFUSION; REPERFUSION INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; CYTOLOGY; DISEASE MODEL; DOWN REGULATION; DRUG EFFECTS; HEPATITIS; HISTOCOMPATIBILITY; IMMUNOLOGY; ISCHEMIA; METABOLISM; NECROSIS; PATHOLOGY; PERITONEUM MACROPHAGE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; APOPTOSIS; CELL ADHESION MOLECULES; CYTOKINES; DISEASE MODELS, ANIMAL; DOWN-REGULATION; DRUGS, CHINESE HERBAL; GINSENOSIDES; HEPATITIS; MACROPHAGES, PERITONEAL; MALE; MICE, INBRED C57BL; NECROSIS; REPERFUSION INJURY; TRANSPLANTATION IMMUNOLOGY; WARM ISCHEMIA;

EID: 84906226030     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2014.03.067     Document Type: Article

References (27)

1. C. Fondevila, R.W. Busuttil, and J.W. Kupiec-Weglinski Hepatic ischemia/reperfusion injury-a fresh look Exp Mol Pathol 74 2003 86
2. B. Vollmar, J. Glasz, R. Leiderer, S. Post, and M.D. Menger Hepatic microcirculatory perfusion failure is a determinant of liver dysfunction in warm ischemia-reperfusion Am J Pathol 145 1994 1421
3. F. Serracino-Inglott, N.A. Habib, and R.T. Mathie Hepatic ischemia-reperfusion injury Am J Surg 181 2001 160
4. M. Mendes-Braz, M. Elias-Miro, M.B. Jimenez-Castro, A. Casillas-Ramirez, F.S. Ramalho, and C. Peralta The current state of knowledge of hepatic ischemia-reperfusion injury based on its study in experimental models J Biomed Biotechnol 2012 2012 298657
5. M. Abu-Amara, S.Y. Yang, N. Tapuria, B. Fuller, B. Davidson, and A. Seifalian Liver ischemia/reperfusion injury: processes in inflammatory networks-a review Liver Transpl 16 2010 1016
6. H. de Groot, and U. Rauen Ischemia-reperfusion injury: processes in pathogenetic networks: a review Transpl Proc 39 2007 481
7. J. Du, B. Cheng, X. Zhu, and C. Ling Ginsenoside Rg1, a novel glucocorticoid receptor agonist of plant origin, maintains glucocorticoid efficacy with reduced side effects J Immunol 187 2011 942
8. J. Geng, W. Peng, Y. Huang, H. Fan, and S. Li Ginsenoside-Rg1 from Panax notoginseng prevents hepatic fibrosis induced by thioacetamide in rats Eur J Pharmacol 634 2010 162
9. S.J. Kim, H.D. Yuan, and S.H. Chung Ginsenoside Rg1 suppresses hepatic glucose production via AMP-activated protein kinase in HepG2 cells Biol Pharm Bull 33 2010 325
10. H. Yin, Z. Liu, and F. Li et al. Ginsenoside-Rg1 enhances angiogenesis and ameliorates ventricular remodeling in a rat model of myocardial infarction J Mol Med (Berl) 89 2011 363
11. D. Zhu, L. Wu, and C.R. Li et al. Ginsenoside Rg1 protects rat cardiomyocyte from hypoxia/reoxygenation oxidative injury via antioxidant and intracellular calcium homeostasis J Cell Biochem 108 2009 117
12. Y. Zhai, X.D. Shen, and F. Gao et al. CXCL10 regulates liver innate immune response against ischemia and reperfusion injury Hepatology 47 2008 207
13. X.D. Shen, B. Ke, and Y. Zhai et al. CD154-CD40 T-cell costimulation pathway is required in the mechanism of hepatic ischemia/reperfusion injury, and its blockade facilitates and depends on heme oxygenase-1 mediated cytoprotection Transplantation 74 2002 315
14. H. Jiang, F. Meng, W. Li, L. Tong, H. Qiao, and X. Sun Splenectomy ameliorates acute multiple organ damage induced by liver warm ischemia reperfusion in rats Surgery 141 2007 32
15. L. Cao, Y. Zou, J. Zhu, X. Fan, and J. Li Ginsenoside Rg1 attenuates concanavalin A-induced hepatitis in mice through inhibition of cytokine secretion and lymphocyte infiltration Mol Cell Biochem 380 2013 203
16. Y. Zou, T. Tao, and Y. Tian et al. Ginsenoside Rg1 improves survival in a murine model of polymicrobial sepsis by suppressing the inflammatory response and apoptosis of lymphocytes J Surg Res 183 2013 760
17. K.K. Meldrum, D.R. Meldrum, K.L. Hile, A.L. Burnett, and A.H. Harken A novel model of ischemia in renal tubular cells which closely parallels in vivo injury J Surg Res 99 2001 288
18. J.D. Joo, M. Kim, V.D. D'Agati, and H.T. Lee Ischemic preconditioning provides both acute and delayed protection against renal ischemia and reperfusion injury in mice J Am Soc Nephrol 17 2006 3115
19. D. Takeuchi, H. Yoshidome, and H. Kurosawa et al. Interleukin-18 exacerbates pulmonary injury after hepatic ischemia/reperfusion in mice J Surg Res 158 2010 87
20. M. Behrends, R. Hirose, and Y.H. Park et al. Remote renal injury following partial hepatic ischemia/reperfusion injury in rats J Gastrointest Surg 12 2008 490
21. A.B. Lentsch, A. Kato, H. Yoshidome, K.M. McMasters, and M.J. Edwards Inflammatory mechanisms and therapeutic strategies for warm hepatic ischemia/reperfusion injury Hepatology 32 2000 169
22. N. Selzner, H. Rudiger, R. Graf, and P.A. Clavien Protective strategies against ischemic injury of the liver Gastroenterology 125 2003 917
23. C. Peralta, L. Fernandez, and J. Panes et al. Preconditioning protects against systemic disorders associated with hepatic ischemia-reperfusion through blockade of tumor necrosis factor-induced P-selectin up-regulation in the rat Hepatology 33 2001 100
24. B. Krishnadasan, B.V. Naidu, K. Byrne, C. Fraga, E.D. Verrier, and M.S. Mulligan The role of proinflammatory cytokines in lung ischemia-reperfusion injury J Thorac Cardiovasc Surg 125 2003 261
25. Y. Takahashi, R.W. Ganster, and A. Gambotto et al. Role of NF-kappa B on liver cold ischemia-reperfusion injury Am J Physiol Gastrointest Liver Physiol 283 2002 G1175
26. M.A. Daemen, C. van 't Veer, and G. Denecker et al. Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation J Clin Invest 104 1999 541
27. N.C. Hoglen, D.M. Anselmo, and M. Katori et al. A caspase inhibitor, IDN-6556, ameliorates early hepatic injury in an ex vivo rat model of warm and cold ischemia Liver Transpl 13 2007 361