Mitochondria-Targeted Peptide Reverses Mitochondrial Dysfunction and Cognitive Deficits in Sepsis-Associated Encephalopathy

Molecular Neurobiology

Volumn 52, Issue 1, 2015, Pages 783-791

  Wu, Jing ^a,b   Zhang, Mingqiang ^b   Hao, Shuangying ^a   Jia, Ming ^b   Ji, Muhuo ^b   Qiu, Lili ^b   Sun, Xiaoyan ^a   Yang, Jianjun ^b   Li, Kuanyu ^a  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^b NANJING UNIVERSITY   (China)

Author keywords

Cognitive deficits; Hippocampus; Mitochondrial function; Sepsis associated encephalopathy; SS 31

Indexed keywords

ANTIOXIDANT; CRYOPYRIN; CYTOCHROME C; INTERLEUKIN 1BETA; PEPTIDE SS 31; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); UBIQUINOL CYTOCHROME C REDUCTASE; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATE; CARRIER PROTEIN; CIAS1 PROTEIN, MOUSE; PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; BRAIN MITOCHONDRION; CECAL LIGATION AND PUNCTURE-INDUCED SEPSIS; COGNITIVE DEFECT; CONTROLLED STUDY; EXPERIMENTAL BEHAVIORAL TEST; FEAR CONDITIONING TEST; HIPPOCAMPUS; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY; MORTALITY; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; OPEN FIELD TEST; SEPSIS ASSOCIATED ENCEPHALOPATHY; SURVIVAL RATE; ANIMAL; ANIMAL BEHAVIOR; C57BL MOUSE; CATALEPSY; CECUM; COGNITION DISORDERS; COMPLICATION; DRUG EFFECTS; ELECTRON TRANSPORT; FEAR; INFLAMMATION; LIGATION; METABOLISM; MITOCHONDRION; NERVE CELL; PATHOLOGY; PUNCTURE; SEPSIS-ASSOCIATED ENCEPHALOPATHY; SURVIVAL ANALYSIS;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; BEHAVIOR, ANIMAL; CARRIER PROTEINS; CECUM; COGNITION DISORDERS; ELECTRON TRANSPORT; FEAR; FREEZING REACTION, CATALEPTIC; HIPPOCAMPUS; INFLAMMATION; INTERLEUKIN-1BETA; LIGATION; MALE; MICE, INBRED C57BL; MITOCHONDRIA; NEURONS; PEPTIDES; PUNCTURES; REACTIVE OXYGEN SPECIES; SEPSIS-ASSOCIATED ENCEPHALOPATHY; SURVIVAL ANALYSIS;

EID: 84937969543     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-014-8918-z     Document Type: Article

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