Single-cell RNA sequencing reveals T helper cells synthesizing steroids De Novo to contribute to immune homeostasis

Cell Reports

Volumn 7, Issue 4, 2014, Pages 1130-1142

  Mahata, Bidesh ^a,b,c   Zhang, Xiuwei ^a   Kolodziejczyk, Aleksandra A ^c   Proserpio, Valentina ^a,b,c   Haim Vilmovsky, Liora ^a,b,c   Taylor, Angela E ^d   Hebenstreit, Daniel ^b,e   Dingler, Felix A ^b   Moignard, Victoria ^f   Göttgens, Berthold ^f   Arlt, Wiebke ^d   McKenzie, Andrew N J ^b   Teichmann, Sarah A ^a,c  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Italy)

^b MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^d UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^e UNIVERSITY OF WARWICK   (United Kingdom)

^f University of Cambridge   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); LYMPHOSTEROID; PREGNENOLONE; STEROID; UNCLASSIFIED DRUG; RNA; TRANSCRIPTOME;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR IMMUNITY; CHOLESTEROL SIDE CHAIN CLEAVAGE; CONTROLLED STUDY; DISEASE MODEL; GENE REARRANGEMENT; HELMINTHIASIS; HOMEOSTASIS; IMMUNE DEFICIENCY; IMMUNE HOMEOSTASIS; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RNA SEQUENCE; SINGLE CELL ANALYSIS; STEROIDOGENESIS; TH2 CELL; ENZYME ACTIVITY; IMMUNOREGULATION; LYMPHOCYTE DIFFERENTIATION; QUANTITATIVE ANALYSIS; SINGLE CELL RNA SEQUENCING; T LYMPHOCYTE SUBPOPULATION; UPREGULATION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; PROCEDURES; SEQUENCE ANALYSIS; TH1 CELL;

VERMES;

ANIMALS; HOMEOSTASIS; HUMANS; MICE; MICE, INBRED C57BL; PREGNENOLONE; RNA; SEQUENCE ANALYSIS, RNA; SINGLE-CELL ANALYSIS; TH1 CELLS; TH2 CELLS; TRANSCRIPTOME;

EID: 84901188210     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2014.04.011     Document Type: Article

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