Large-scale microfluidics providing high-resolution and high-throughput screening of Caenorhabditis elegans poly-glutamine aggregation model

Nature Communications

Volumn 7, Issue , 2016, Pages

  Mondal, Sudip ^a   Hegarty, Evan ^a   Martin, Chris ^a   Gökçe, Sertan Kutal ^a   Ghorashian, Navid ^a   Ben Yakar, Adela ^a,b  

^a The University of Texas at Austin   (United States)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEMATODAL AGENT; BENDROFLUMETHIAZIDE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BUSPIRONE; CELASTROL; DRONEDARONE; GELDANAMYCIN; IMIPRAMINE; POLYGLUTAMINE; RADICICOL; TANESPIMYCIN; PEPTIDE; PROTEIN AGGREGATE;

AGGREGATION; BIOASSAY; DRUG; IMAGE RESOLUTION; NEMATODE; OPTIMIZATION; PHENOTYPE;

ADULT; ALGORITHM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOMATION; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DOSE RESPONSE; FOOD AND DRUG ADMINISTRATION; HIGH THROUGHPUT SCREENING; IMAGE ANALYSIS; IMAGE PROCESSING; LARVAL STAGE; MICROFLUIDICS; NEMATODIASIS; NONHUMAN; PILOT STUDY; PROTEIN AGGREGATION; PROTEIN HOMEOSTASIS; WORM; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; DISEASE MODEL; DRUG APPROVAL; METABOLISM; PRECLINICAL STUDY; PROCEDURES; REPRODUCIBILITY; THREE DIMENSIONAL IMAGING; UNITED STATES;

ANIMALIA; CAENORHABDITIS ELEGANS;

ANIMALS; AUTOMATION; CAENORHABDITIS ELEGANS; DISEASE MODELS, ANIMAL; DRUG APPROVAL; DRUG EVALUATION, PRECLINICAL; HIGH-THROUGHPUT SCREENING ASSAYS; IMAGING, THREE-DIMENSIONAL; MICROFLUIDICS; MODELS, BIOLOGICAL; PEPTIDES; PROTEIN AGGREGATES; REPRODUCIBILITY OF RESULTS; UNITED STATES; UNITED STATES FOOD AND DRUG ADMINISTRATION;

EID: 84991404839     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms13023     Document Type: Article

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