Carbon Monoxide-Saturated Hemoglobin-Based Oxygen Carriers Attenuate High-Altitude-Induced Cardiac Injury by Amelioration of the Inflammation Response and Mitochondrial Oxidative Damage

Cardiology (Switzerland)

Volumn 136, Issue 3, 2017, Pages 180-191

  Wang, Qingshu ^a   Hu, Ling ^a   Hu, Yu ^c   Gong, Gu ^a   Tan, Hua ^a   Deng, Li ^a   Sun, Xiaoqin ^a   Yi, Xiaobo ^a   Sun, Yangyang ^a   Wu, Wei ^a   Li, Tao ^b  

^a General Hospital of Chengdu Military Area Command   (China)

^b SICHUAN UNIVERSITY   (China)

^c 452 Hospital of Chinese PLA   (China)

Author keywords

Carbon monoxide; Cardiac pharmacology; Free radicals; High altitude medicine and physiology; Mitochondria

Indexed keywords

CARBOXYHEMOGLOBIN; CASPASE 3; CYTOCHROME C OXIDASE; GAMMA INTERFERON; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLYCOGEN SYNTHASE KINASE 3BETA; HEART ENZYME; HEMOGLOBIN; HYDROGEN PEROXIDE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; JANUS KINASE; MALONALDEHYDE; OXYHEMOGLOBIN; PROTEIN KINASE B; STAT3 PROTEIN; SUCCINATE DEHYDROGENASE; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR; CARBON MONOXIDE; OXYGEN;

ALTITUDE; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME RELEASE; HEART FUNCTION; HEART HEMODYNAMICS; HEART INJURY; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE NECROSIS; HEART PERFORMANCE; HISTOPATHOLOGY; HYPOXIA; INFLAMMATION; MALE; MEMBRANE DAMAGE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TUNEL ASSAY; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; DRUG EFFECT; HEART MITOCHONDRION; HEART VENTRICLE; NECROSIS; PATHOLOGY; PATHOPHYSIOLOGY; RANDOMIZATION;

ALTITUDE; ANIMALS; APOPTOSIS; CARBON MONOXIDE; HEART VENTRICLES; HEMOGLOBINS; HYPOXIA; INFLAMMATION; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA, HEART; NECROSIS; OXIDATIVE STRESS; OXYGEN; RANDOM ALLOCATION; VENTRICULAR FUNCTION, LEFT;

EID: 84991200108     PISSN: 00086312     EISSN: 14219751     Source Type: Journal    
DOI: 10.1159/000448652     Document Type: Article

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