A novel hemoglobin-based blood substitute protects against myocardial reperfusion injury

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 288, Issue 4 57-4, 2005, Pages

  Caswell, John E ^a   Strange, Micah B ^a   Rimmer III, David M ^b   Gibson, Michael F ^b   Cole, Phillip ^a   Lefer, David J ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b Louisiana State University Health Sciences Center   (United States)

Author keywords

Contractility; Infarction; Ischemia; Neutrophils

Indexed keywords

BLOOD SUBSTITUTE; CREATINE KINASE MB; DRUG VEHICLE; POLYMERIZED HEMOGLOBIN; RADIOACTIVE MICROSPHERE; TROPONIN I;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; BLOOD VOLUME; DOG; DRUG EFFECT; FEMALE; HEART MUSCLE BLOOD FLOW; HEART MUSCLE ISCHEMIA; HEMODYNAMICS; HISTOPATHOLOGY; MALE; MYOCARDITIS; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY; VISCOSITY;

ANIMALS; BLOOD PRESSURE; BLOOD SUBSTITUTES; CORONARY CIRCULATION; CREATINE KINASE; CREATINE KINASE, MB FORM; DOGS; FEMALE; HEART RATE; HEMOGLOBINS; ISOENZYMES; LEUKOCYTE COUNT; MALE; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; NEUTROPHILS; PLATELET COUNT; VENTRICULAR PRESSURE;

EID: 15744399176     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.00905.2004     Document Type: Article

References (23)

1. Abassi Z, Kotob S, Pieruzzi F, Abouassali M, Keiser HR, Fratantoni JC, and Alayash AI. Effects of polymerization on the hypertensive action of diaspirin cross-linked hemoglobin in rats. J Lab Clin Med 129: 603-610, 1997.
2. Chang TMS. Future prospects for artificial blood. Trends Biotechnol 17: 61-67, 1999.
3. Cohn SM. The current status of haemoglobin-based blood substitutes. Ann Med 29: 371-376, 1997.
4. Cohn SM. Is blood obsolete? J Trauma 42: 730-732, 1997.
5. Cole DJ, Drummond JC, Patel PM, and Reynolds LR. Hypervolemic- hemodilution during cerebral ischemia in rats: effect of diaspirin cross-linked hemoglobin (DCLHb) on neurologic outcome and infarct volume. J Neurosurg Anesthesiol 9: 44-50, 1997.
6. Conover CD, Linberg R, Shum KL, and Shorr RGL. The ability of polyethylene glycol conjugated bovine hemoglobin (PEG-Hb) to adequately deliver oxygen in both exchange transfusion and top-loaded rat models. Artif Cells Blood Substit Immobil Biotechnol 27: 93-107, 1999.
7. Engler RL. Free radical and granulocyte-mediated injury during myocardial ischemia and reperfusion. Am J Cardiol 63: 19E-23E, 1989.
8. Frietsch T, Lenz C, and Waschke KF. Artificial oxygen carriers. Eur J Anaesthesiol 15: 571-584, 1998.
9. Gould SA, Moore EE, Hoyt DB, Burch JM, Haenel JB, Garcia J, DeWoskin R, and Moss GS. The first randomized trial of human polymerized hemoglobin as a blood substitute in acute trauma and emergent surgery. J Am Coll Surg 187: 113-122, 1998.
10. Heneka MT, Loschmann PA, and Osswald H. Polymerized hemoglobin restores cardiovascular and kidney function in endotoxin-induced shock in the rat. J Clin Invest 99: 47-54, 1997.
11. Horn EP, Standl T, Wilhelm S, Jacobs EE, Freitag U, Freitag M, and Schulte am Esch J. Bovine hemoglobin increases skeletal muscle oxygenation during 95% artificial arterial stenosis. Surgery 121: 411-418, 1996.
12. Hughes GS, Francom SF, Antal EJ, Adams WJ, Locker PK, Yancey EP, and Jacobs EE. Hematologic effects of a novel hemoglobin-based oxygen carrier in normal male and female subjects. J Lab Clin Med 126: 444-451, 1995.
13. Johnson JL, Moore EE, Offner PJ, Haenel JB, Hides GA, and Tamura DY. Resuscitation of the injured patient with polymerized stroma-free hemoglobin does not produce systemic or pulmonary hypertension. Am J Surg 176: 612-617, 1998.
14. Lefer DJ, Flynn DM, and Buda AJ. Effects of a monoclonal antibody directed against P-selectin after myocardial ischemia and reperfusion. Am J Physiol Heart Circ Physiol 270: H88-H98, 1996.
15. McCord JM. Oxygen-derived free radicals in postischemic injury. N Engl J Med 312: 1713-1719, 1985.
16. Michael LH, Entman ML, Hartley CJ, Youker KA, Zhu J, Hall R, Hawkins HK, Berens K, and Ballantyne CM. Myocardial ischemia and reperfusion: a murine model. Am J Physiol Heart Circ Physiol 269: H2147-H2154, 1995.
17. Nose Y. Oxygen-carrying macromolecules: therapeutic agents for the treatment of hypoxia. Artif Organs 22: 618-622, 1998.
18. Polanczyk CA, Johnson PA, Cook EF, and Lee TH. A proposed strategy for utilization of creatine kinase-mb and troponin I in the evaluation of acute chest pain. Am J Cardiol 83: 1175-1179, 1999.
19. Puius YA, Zou M, Ho NT, Ho C, and Almo SC. Novel water-mediated hydrogen bonds as the structural basis for the low oxygen affinity of the blood substitute candidate rHb(a96Val-Trp). Biochemistry 37: 9258-9265, 1998.
20. Schreiber GB, Busch MP, Kleinman SH, and Korelitz JJ. The risk of transfusion-transmitted viral infections. N Engl J Med 334: 1685-1690, 1996.
21. Standl TG, Reeker W, Redmann G, Kochs E, Werner C, and Schulte am Esch J. Haemodynamic changes and skeletal muscle oxygen tension during complete blood exchange with ultrapurified polymerized bovine haemoglobin. Intensive Care Med 23: 865-872, 1997.
22. Van Iterson M, Sinaasappel M, Burhop K, Trouwborst A, and Ince C. Low-volume resuscitation with a hemoglobin-based oxygen carrier after hemorrhage improves gut microvascular oxygenation in swine. J Lab Clin Med 132: 421-431, 1998.
23. Vlahakes GJ, Lee R, Jacobs EE, LaRaia PJ, and Austen WG. Hemodynamic effects and oxygen transport properties of a new blood substitute in a model of massive blood replacement. J Thorac Cardiovasc Surg 100: 379-388, 1990.