메뉴 건너뛰기




Volumn 44, Issue 9, 2016, Pages 926-935

Randomised clinical trial: the effects of a multispecies probiotic vs. placebo on innate immune function, bacterial translocation and gut permeability in patients with cirrhosis

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTOXIN; NEOPTERIN; PLACEBO; PROBIOTIC AGENT;

EID: 84991080789     PISSN: 02692813     EISSN: 13652036     Source Type: Journal    
DOI: 10.1111/apt.13788     Document Type: Article
Times cited : (97)

References (43)
  • 1
    • 84880874176 scopus 로고    scopus 로고
    • Measuring the global burden of disease
    • Murray CJ, Lopez AD. Measuring the global burden of disease. N Engl J Med 2013; 369: 448–57.
    • (2013) N Engl J Med , vol.369 , pp. 448-457
    • Murray, C.J.1    Lopez, A.D.2
  • 3
    • 54449098017 scopus 로고    scopus 로고
    • Ammonia impairs neutrophil phagocytic function in liver disease
    • Shawcross DL, Wright GA, Stadlbauer V, et al. Ammonia impairs neutrophil phagocytic function in liver disease. Hepatology 2008; 48: 1202–12.
    • (2008) Hepatology , vol.48 , pp. 1202-1212
    • Shawcross, D.L.1    Wright, G.A.2    Stadlbauer, V.3
  • 4
    • 84874492266 scopus 로고    scopus 로고
    • Circulating neutrophil dysfunction in acute liver failure
    • Taylor NJ, Nishtala A, Manakkat Vijay GK, et al. Circulating neutrophil dysfunction in acute liver failure. Hepatology 2013; 57: 1142–52.
    • (2013) Hepatology , vol.57 , pp. 1142-1152
    • Taylor, N.J.1    Nishtala, A.2    Manakkat Vijay, G.K.3
  • 5
    • 84860388878 scopus 로고    scopus 로고
    • Evidence of neutrophil functional defect despite inflammation in stable cirrhosis
    • Tritto G, Bechlis Z, Stadlbauer V, et al. Evidence of neutrophil functional defect despite inflammation in stable cirrhosis. J Hepatol 2011; 55: 574–81.
    • (2011) J Hepatol , vol.55 , pp. 574-581
    • Tritto, G.1    Bechlis, Z.2    Stadlbauer, V.3
  • 6
    • 84946083743 scopus 로고    scopus 로고
    • Impaired innate immune response of leukocytes from ascitic fluid of patients with spontaneous bacterial peritonitis
    • Nieto JC, Sanchez E, Romero C, et al. Impaired innate immune response of leukocytes from ascitic fluid of patients with spontaneous bacterial peritonitis. J Leukocyte Biol 2015; 98: 819–25.
    • (2015) J Leukocyte Biol , vol.98 , pp. 819-825
    • Nieto, J.C.1    Sanchez, E.2    Romero, C.3
  • 7
    • 58249104043 scopus 로고    scopus 로고
    • Role of toll-like receptors 2, 4, and 9 in mediating neutrophil dysfunction in alcoholic hepatitis
    • Stadlbauer V, Mookerjee RP, Wright GA, et al. Role of toll-like receptors 2, 4, and 9 in mediating neutrophil dysfunction in alcoholic hepatitis. Am J Physiol Gastrointest Liver Physiol 2009; 296: G15–22.
    • (2009) Am J Physiol Gastrointest Liver Physiol , vol.296 , pp. G15-22
    • Stadlbauer, V.1    Mookerjee, R.P.2    Wright, G.A.3
  • 8
    • 34548706468 scopus 로고    scopus 로고
    • Neutrophil dysfunction in alcoholic hepatitis superimposed on cirrhosis is reversible and predicts the outcome
    • Mookerjee RP, Stadlbauer V, Lidder S, et al. Neutrophil dysfunction in alcoholic hepatitis superimposed on cirrhosis is reversible and predicts the outcome. Hepatology 2007; 46: 831–40.
    • (2007) Hepatology , vol.46 , pp. 831-840
    • Mookerjee, R.P.1    Stadlbauer, V.2    Lidder, S.3
  • 9
    • 84906220081 scopus 로고    scopus 로고
    • The severity of circulating neutrophil dysfunction in patients with cirrhosis is associated with 90-day and 1-year mortality
    • Taylor NJ, Manakkat Vijay GK, Abeles RD, et al. The severity of circulating neutrophil dysfunction in patients with cirrhosis is associated with 90-day and 1-year mortality. Aliment Pharmacol Ther 2014; 40: 705–15.
    • (2014) Aliment Pharmacol Ther , vol.40 , pp. 705-715
    • Taylor, N.J.1    Manakkat Vijay, G.K.2    Abeles, R.D.3
  • 10
    • 14244252178 scopus 로고    scopus 로고
    • Bacterial translocation (BT) in cirrhosis
    • Wiest R, Garcia-Tsao G. Bacterial translocation (BT) in cirrhosis. Hepatology 2005; 41: 422–33.
    • (2005) Hepatology , vol.41 , pp. 422-433
    • Wiest, R.1    Garcia-Tsao, G.2
  • 11
    • 84859510524 scopus 로고    scopus 로고
    • Endotoxin priming of neutrophils requires endocytosis and NADPH oxidase-dependent endosomal reactive oxygen species
    • Lamb FS, Hook JS, Hilkin BM, Huber JN, Volk AP, Moreland JG. Endotoxin priming of neutrophils requires endocytosis and NADPH oxidase-dependent endosomal reactive oxygen species. J Biol Chem 2012; 287: 12395–404.
    • (2012) J Biol Chem , vol.287 , pp. 12395-12404
    • Lamb, F.S.1    Hook, J.S.2    Hilkin, B.M.3    Huber, J.N.4    Volk, A.P.5    Moreland, J.G.6
  • 12
    • 84901331442 scopus 로고    scopus 로고
    • The liver may act as a firewall mediating mutualism between the host and its gut commensal microbiota
    • Balmer ML, Slack E, deGottardi A, et al. The liver may act as a firewall mediating mutualism between the host and its gut commensal microbiota. Science Transl Med 2014; 6: 237ra66.
    • (2014) Science Transl Med , vol.6 , pp. 237ra66
    • Balmer, M.L.1    Slack, E.2    de Gottardi, A.3
  • 13
    • 80054098741 scopus 로고    scopus 로고
    • Recommendations for probiotic use-2011 update
    • Floch MH, Walker WA, Madsen K, et al. Recommendations for probiotic use-2011 update. J Clin Gastroenterol 2011; 45(Suppl.): S168–71.
    • (2011) J Clin Gastroenterol , vol.45 , pp. S168-S171
    • Floch, M.H.1    Walker, W.A.2    Madsen, K.3
  • 14
    • 2342580955 scopus 로고    scopus 로고
    • Synbiotic modulation of gut flora: effect on minimal hepatic encephalopathy in patients with cirrhosis
    • Liu Q, Duan ZP, Ha DK, Bengmark S, Kurtovic J, Riordan SM. Synbiotic modulation of gut flora: effect on minimal hepatic encephalopathy in patients with cirrhosis. Hepatology 2004; 39: 1441–9.
    • (2004) Hepatology , vol.39 , pp. 1441-1449
    • Liu, Q.1    Duan, Z.P.2    Ha, D.K.3    Bengmark, S.4    Kurtovic, J.5    Riordan, S.M.6
  • 15
    • 36249031636 scopus 로고    scopus 로고
    • The effect of probiotics on gut flora, level of endotoxin and Child-Pugh score in cirrhotic patients: results of a double-blind randomized study
    • Lata J, Novotny I, Pribramska V, et al. The effect of probiotics on gut flora, level of endotoxin and Child-Pugh score in cirrhotic patients: results of a double-blind randomized study. Eur J Gastroenterol Hepatol 2007; 19: 1111–3.
    • (2007) Eur J Gastroenterol Hepatol , vol.19 , pp. 1111-1113
    • Lata, J.1    Novotny, I.2    Pribramska, V.3
  • 16
    • 84913553798 scopus 로고    scopus 로고
    • Probiotic VSL#3 reduces liver disease severity and hospitalization in patients with cirrhosis: a randomized, controlled trial
    • Dhiman RK, Rana B, Agrawal S, et al. Probiotic VSL#3 reduces liver disease severity and hospitalization in patients with cirrhosis: a randomized, controlled trial. Gastroenterology 2014; 147: 1327–37.e3.
    • (2014) Gastroenterology , vol.147 , pp. 1327-1337
    • Dhiman, R.K.1    Rana, B.2    Agrawal, S.3
  • 17
    • 56349169101 scopus 로고    scopus 로고
    • Probiotics restore bowel flora and improve liver enzymes in human alcohol-induced liver injury: a pilot study
    • Kirpich IA, Solovieva NV, Leikhter SN, et al. Probiotics restore bowel flora and improve liver enzymes in human alcohol-induced liver injury: a pilot study. Alcohol 2008; 42: 675–82.
    • (2008) Alcohol , vol.42 , pp. 675-682
    • Kirpich, I.A.1    Solovieva, N.V.2    Leikhter, S.N.3
  • 18
    • 43049181923 scopus 로고    scopus 로고
    • Effect of probiotic treatment on deranged neutrophil function and cytokine responses in patients with compensated alcoholic cirrhosis
    • Stadlbauer V, Mookerjee RP, Hodges S, Wright GA, Davies NA, Jalan R. Effect of probiotic treatment on deranged neutrophil function and cytokine responses in patients with compensated alcoholic cirrhosis. J Hepatol 2008; 48: 945–51.
    • (2008) J Hepatol , vol.48 , pp. 945-951
    • Stadlbauer, V.1    Mookerjee, R.P.2    Hodges, S.3    Wright, G.A.4    Davies, N.A.5    Jalan, R.6
  • 19
    • 84991060863 scopus 로고    scopus 로고
    • ® BARRIER on parameters of intestinal barrier function
    • ® BARRIER on parameters of intestinal barrier function. Food Nutr Sci 2014; 5: 1739–45.
    • (2014) Food Nutr Sci , vol.5 , pp. 1739-1745
    • Van Hemert, S.1    Ormel, G.2
  • 20
    • 1642634548 scopus 로고    scopus 로고
    • Influence of neopterin on generation of reactive species by myeloperoxidase in human neutrophils
    • Razumovitch JA, Fuchs D, Semenkova GN, Cherenkevich SN. Influence of neopterin on generation of reactive species by myeloperoxidase in human neutrophils. Biochim Biophys Acta 2004; 1672: 46–50.
    • (2004) Biochim Biophys Acta , vol.1672 , pp. 46-50
    • Razumovitch, J.A.1    Fuchs, D.2    Semenkova, G.N.3    Cherenkevich, S.N.4
  • 21
    • 84942107018 scopus 로고    scopus 로고
    • Rapid killing of Capnocytophaga canimorsus and Capnocytophaga cynodegmi by human whole blood and serum is mediated via the complement system
    • Zangenah S, Bergman P. Rapid killing of Capnocytophaga canimorsus and Capnocytophaga cynodegmi by human whole blood and serum is mediated via the complement system. SpringerPlus 2015; 4: 517.
    • (2015) SpringerPlus , vol.4 , pp. 517
    • Zangenah, S.1    Bergman, P.2
  • 22
    • 0031008871 scopus 로고    scopus 로고
    • Acquired C3 deficiency in patients with alcoholic cirrhosis predisposes to infection and increased mortality
    • Homann C, Varming K, Hogasen K, et al. Acquired C3 deficiency in patients with alcoholic cirrhosis predisposes to infection and increased mortality. Gut 1997; 40: 544–9.
    • (1997) Gut , vol.40 , pp. 544-549
    • Homann, C.1    Varming, K.2    Hogasen, K.3
  • 23
    • 85010886615 scopus 로고    scopus 로고
    • Novel strategies in the prevention and treatment of urinary tract infections
    • Luthje P, Brauner A. Novel strategies in the prevention and treatment of urinary tract infections. Pathogens 2016; 5: doi: 10.3390/pathogens5010013.
    • (2016) Pathogens , vol.5
    • Luthje, P.1    Brauner, A.2
  • 24
    • 84878643958 scopus 로고    scopus 로고
    • Altered functionality of anti-bacterial antibodies in patients with chronic hepatitis C virus infection
    • Lamontagne A, Long RE, Comunale MA, et al. Altered functionality of anti-bacterial antibodies in patients with chronic hepatitis C virus infection. PLoS ONE 2013; 8: e64992.
    • (2013) PLoS ONE , vol.8
    • Lamontagne, A.1    Long, R.E.2    Comunale, M.A.3
  • 25
    • 0042162960 scopus 로고    scopus 로고
    • Potential role of immune system activation-associated production of neopterin derivatives in humans
    • Hoffmann G, Wirleitner B, Fuchs D. Potential role of immune system activation-associated production of neopterin derivatives in humans. Inflamm Res 2003; 52: 313–21.
    • (2003) Inflamm Res , vol.52 , pp. 313-321
    • Hoffmann, G.1    Wirleitner, B.2    Fuchs, D.3
  • 26
    • 0033064752 scopus 로고    scopus 로고
    • Neopterin: a review
    • Hamerlinck FFV. Neopterin: a review. Exp Dermatol 1999; 8: 167–76.
    • (1999) Exp Dermatol , vol.8 , pp. 167-176
    • Hamerlinck, F.F.V.1
  • 28
    • 40149099357 scopus 로고    scopus 로고
    • Bacterial infections, sepsis, and multiorgan failure in cirrhosis
    • Tandon P, Garcia-Tsao G. Bacterial infections, sepsis, and multiorgan failure in cirrhosis. Semin Liver Dis 2008; 28: 26–42.
    • (2008) Semin Liver Dis , vol.28 , pp. 26-42
    • Tandon, P.1    Garcia-Tsao, G.2
  • 30
    • 84901193937 scopus 로고    scopus 로고
    • Bacterial infections in cirrhosis: a position statement based on the EASL Special Conference 2013
    • Jalan R, Fernandez J, Wiest R, et al. Bacterial infections in cirrhosis: a position statement based on the EASL Special Conference 2013. J Hepatol 2014; 60: 1310–24.
    • (2014) J Hepatol , vol.60 , pp. 1310-1324
    • Jalan, R.1    Fernandez, J.2    Wiest, R.3
  • 31
    • 11844284850 scopus 로고    scopus 로고
    • Supply of pre- and probiotics reduces bacterial infection rates after liver transplantation–a randomized, double-blind trial
    • Rayes N, Seehofer D, Theruvath T, et al. Supply of pre- and probiotics reduces bacterial infection rates after liver transplantation–a randomized, double-blind trial. Am J Transplant 2005; 5: 125–30.
    • (2005) Am J Transplant , vol.5 , pp. 125-130
    • Rayes, N.1    Seehofer, D.2    Theruvath, T.3
  • 32
    • 0035133561 scopus 로고    scopus 로고
    • Bacterial translocation of enteric organisms in patients with cirrhosis
    • Cirera I, Bauer TM, Navasa M, et al. Bacterial translocation of enteric organisms in patients with cirrhosis. J Hepatol 2001; 34: 32–7.
    • (2001) J Hepatol , vol.34 , pp. 32-37
    • Cirera, I.1    Bauer, T.M.2    Navasa, M.3
  • 33
    • 84922630906 scopus 로고    scopus 로고
    • Supplementation of saturated long-chain fatty acids maintains intestinal eubiosis and reduces ethanol-induced liver injury in mice
    • Chen P, Torralba M, Tan J, et al. Supplementation of saturated long-chain fatty acids maintains intestinal eubiosis and reduces ethanol-induced liver injury in mice. Gastroenterology 2015; 148: 203–14 e16.
    • (2015) Gastroenterology , vol.148 , pp. 203-214
    • Chen, P.1    Torralba, M.2    Tan, J.3
  • 34
    • 84867116816 scopus 로고    scopus 로고
    • Probiotic supplementation affects markers of intestinal barrier, oxidation, and inflammation in trained men; a randomized, double-blinded, placebo-controlled trial
    • Lamprecht M, Bogner S, Schippinger G, et al. Probiotic supplementation affects markers of intestinal barrier, oxidation, and inflammation in trained men; a randomized, double-blinded, placebo-controlled trial. J Int Soc Sports Nutr 2012; 9: 45.
    • (2012) J Int Soc Sports Nutr , vol.9 , pp. 45
    • Lamprecht, M.1    Bogner, S.2    Schippinger, G.3
  • 35
    • 10744231191 scopus 로고    scopus 로고
    • Intestinal permeability is increased in patients with advanced cirrhosis
    • Pascual S, Such J, Esteban A, et al. Intestinal permeability is increased in patients with advanced cirrhosis. Hepatogastroenterology 2003; 50: 1482–6.
    • (2003) Hepatogastroenterology , vol.50 , pp. 1482-1486
    • Pascual, S.1    Such, J.2    Esteban, A.3
  • 36
    • 70349736175 scopus 로고    scopus 로고
    • Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2
    • Tripathi A, Lammers KM, Goldblum S, et al. Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2. Proc Natl Acad Sci USA 2009; 106: 16799–804.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 16799-16804
    • Tripathi, A.1    Lammers, K.M.2    Goldblum, S.3
  • 37
    • 84928953612 scopus 로고    scopus 로고
    • Gut-liver axis in liver cirrhosis: how to manage leaky gut and endotoxemia
    • Fukui H. Gut-liver axis in liver cirrhosis: how to manage leaky gut and endotoxemia. World J Hepatol 2015; 7: 425–42.
    • (2015) World J Hepatol , vol.7 , pp. 425-442
    • Fukui, H.1
  • 38
    • 20844440555 scopus 로고    scopus 로고
    • Beneficial effects of a probiotic VSL#3 on parameters of liver dysfunction in chronic liver diseases
    • Loguercio C, Federico A, Tuccillo C, et al. Beneficial effects of a probiotic VSL#3 on parameters of liver dysfunction in chronic liver diseases. J Clin Gastroenterol 2005; 39: 540–3.
    • (2005) J Clin Gastroenterol , vol.39 , pp. 540-543
    • Loguercio, C.1    Federico, A.2    Tuccillo, C.3
  • 39
    • 39449089584 scopus 로고    scopus 로고
    • Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial
    • Besselink MG, van Santvoort HC, Buskens E, et al. Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial. Lancet 2008; 371: 651–9.
    • (2008) Lancet , vol.371 , pp. 651-659
    • Besselink, M.G.1    van Santvoort, H.C.2    Buskens, E.3
  • 40
    • 84949755726 scopus 로고    scopus 로고
    • Immunosuppression and probiotics: are they effective and safe?
    • Stadlbauer V. Immunosuppression and probiotics: are they effective and safe? Beneficial Microbes 2015; 6: 823–8.
    • (2015) Beneficial Microbes , vol.6 , pp. 823-828
    • Stadlbauer, V.1
  • 41
    • 84922708862 scopus 로고    scopus 로고
    • Intestinal permeability – a new target for disease prevention and therapy
    • Bischoff SC, Barbara G, Buurman W, et al. Intestinal permeability – a new target for disease prevention and therapy. BMC Gastroenterol 2014; 14: 189.
    • (2014) BMC Gastroenterol , vol.14 , pp. 189
    • Bischoff, S.C.1    Barbara, G.2    Buurman, W.3
  • 42
    • 34848907434 scopus 로고    scopus 로고
    • Endotoxin measures in patients' sample: how valid are the results?
    • author reply 7-3
    • Stadlbauer V, Davies NA, Wright G, Jalan R. Endotoxin measures in patients' sample: how valid are the results? J Hepatol 2007; 47: 726–7; author reply 7-3.
    • (2007) J Hepatol , vol.47 , pp. 726-727
    • Stadlbauer, V.1    Davies, N.A.2    Wright, G.3    Jalan, R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.