The effect of probiotics on gut flora, level of endotoxin and Child-Pugh score in cirrhotic patients: Results of a double-blind randomized study

European Journal of Gastroenterology and Hepatology

Volumn 19, Issue 12, 2007, Pages 1111-1113

  Lata, Jan ^a   Novotný, Ivo ^a   Příbramská, Veronika ^a   Juránková, Jana ^a   Frič, Přemysl ^b   Kroupa, Radek ^a   Stibůrek, Oldřich ^a  

^a UNIVERSITY HOSPITAL BRNO   (Czech Republic)

^b Radiodiagnostic Department   (Czech Republic)

Author keywords

Endotoxin; Escherichia coli Nissle; Liver cirrhosis; Probiotics

Indexed keywords

ENDOTOXIN; ESCHERICHIA COLI NISSLE; MUTAFLOR; PLACEBO; PROBIOTIC AGENT; UNCLASSIFIED DRUG;

ARTICLE; BLOOD ANALYSIS; CHEMICAL ANALYSIS; CLINICAL ARTICLE; CLINICAL EXAMINATION; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; ENDOTOXEMIA; FECES ANALYSIS; FEMALE; HUMAN; HUMAN TISSUE; INTESTINE FLORA; LIVER BIOPSY; LIVER CIRRHOSIS; LIVER FUNCTION; MALE; MICROBIOLOGY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; STATISTICAL SIGNIFICANCE; THERAPY EFFECT;

ADULT; AGED; COLON; DOUBLE-BLIND METHOD; ENDOTOXEMIA; ENDOTOXINS; ESCHERICHIA COLI; FECES; FEMALE; HUMANS; LIVER; LIVER CIRRHOSIS; MALE; MIDDLE AGED; PROBIOTICS; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 36249031636     PISSN: 0954691X     EISSN: None     Source Type: Journal    
DOI: 10.1097/MEG.0b013e3282efa40e     Document Type: Article

References (16)

1. Bauer TM, Schwacha H, Steinbruckner B, Brinkmann PE, Ditzen AK, Aponte JJ, et al. Small intestinal bacterial overgrowth in human cirrhosis is associated with systemic endotoxemia. Am J Gastroenterol 2002; 97:2364-2370.
2. Murray P, Baron E, Phaller M. Manual of clinical microbiology. Washington, DC: American Society for Microbiology; 1999.
3. Metchnikoff E. Prolongation of life. New York: Putnam; 1908.
4. Döderlein A. The vaginal transsudate and its significance for childbed fever. Centralblatt für Bacteriologie 1892; 11:699-700.
5. Cahn DR. Bacilli of infant stools stainable according to Gram. Centralblatt für Bakteriologie I. Abteilung Originale 1901; 30:721-726.
6. Lilly DM, Stillwell RH. Probiotics: growth promoting factors produced by microorganisms. Science 1965; 147:747-748.
7. Fuller R. Probiotics in man and animals. J Appl Bacteriol 1989; 66:365-378.
8. Havenaar R, Ten Brink B, Huis in't Veld JHJ. Selection of strains for probiotic use. In: Fuller R, editor. Probiotics: the scientific basis. London: Chapman and Hall; 1992. pp. 209-224.
9. Sartor RB. Probiotic therapy of intestinal inflammation and infections. Curr Opin Gastroenterol 2005; 21:44-50.
10. Fooks LJ, Gibson GR. Probiotics as modulators of the gut flora. Br J Nutrition 2002; 88:S39-S49.
11. Thalheimer U, Triantos CK, Samonakis DN, Patch D, Burroughs AK. Recent advances in clinical practice: infection, coagulation and variceal bleeding in cirrhosis. Gut 2005; 54:556-563.
12. Lata J, Jurankova J, Husova L, Senkyrik M, Dite P, Dastych M, et al. Variceal bleeding in portal hypertension: bacterial infection and comparison of efficacy of intravenous and per-oral application of antibiotics - a randomized trial. Eur J Gastroenterol Hepatol 2005; 17:1105-1110.
13. Liu Q, Duan ZP, Ha DK, Bengmark S, Kurtovic J, Riordan SM. Synbiotic modulation of gut flora: effect on minimal hepatic encephalopathy in patients with cirrhosis. Hepatology 2004; 39:1441-1449.
14. Wu CD, Li MZ, Chen CL. Endotoxin-induced liver injury and plasma tumor necrosis factor alfa, interleukin 6 level changes in rabbits. Chin J Dig Dis 1995; 15:256-258.
15. Hai YZ, Hui JW, Zhi L, Shu ZX. Intestinal microflora in patients with liver cirrhosis. Chin J Dig Dis 2004; 5:64-67.
16. Loguericio C, Federico A, Tuccillo C, Terracciano F, D́Auria MV, De Simone C, Del Vecchio Blanco C. Beneficial effects of probiotic VSL#3 on parameters of liver dysfunction in chronic liver diseases. J Clin Gastroenterol 2005; 39:540-543.