Rapid killing of Capnocytophaga canimorsus and Capnocytophaga cynodegmi by human whole blood and serum is mediated via the complement system

SpringerPlus

Volumn 4, Issue 1, 2015, Pages

  Zangenah, Salah ^a   Bergman, Peter ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Alternative pathway; Capnocytophaga canimorsus; Capnocytophaga cynodegmi; Classical pathway; Complement system; Mannose binding lectin deficiency; Serum killing assay; Whole blood killing assay

Indexed keywords

EID: 84942107018     PISSN: None     EISSN: 21931801     Source Type: Journal    
DOI: 10.1186/s40064-015-1308-9     Document Type: Article

References (27)

1. Abdullah M, Nepluev I, Afonina G, Ram S, Rice P, Cade W, Elkins C (2005) Killing of dsrA mutants of Haemophilus ducreyi by normal human serum occurs via the classical complement pathway and is initiated by immunoglobulin M binding. Infect Immun 73(6):3431–3439
2. Bergman P, Norlin AC, Hansen S, Rekha RS, Agerberth B, Björkhem-Bergman L, Ekström L, Lindh JD, Andersson J (2012) Vitamin D3 supplementation in patients with frequent respiratory tract infections: a randomised and double-blind intervention study. BMJ Open 2(6):e001663
3. Bobo RA, Newton EJ (1976) A previously undescribed gram-negative bacillus causing septicemia and meningitis. Am J Clin Pathol 65(4):564–569
4. Brenner DJ, Hollis DG, Fanning GR, Weaver RE (1989) Capnocytophaga canimorsus sp. nov. (formerly CDC group DF-2), a cause of septicemia following dog bite, and C. cynodegmi sp. nov., a cause of localized wound infection following dog bite. J Clin Microbiol 27(2):231–235
5. Butler T (2015) Capnocytophaga canimorsus: an emerging cause of sepsis, meningitis, and post-splenectomy infection after dog bites. Eur J Clin Microbiol Infect Dis Off Publ Eur Soc Clin Microbiol 34(7):1271–1280
6. Butler T, Johnston KH, Gutierrez Y, Aikawa M, Cardaman R (1985) Enhancement of experimental bacteremia and endocarditis caused by dysgonic fermenter (DF-2) bacterium after treatment with methylprednisolone and after splenectomy. Infect Immun 47(1):294–300
7. Clas F, Loos M (1980) Killing of the S and Re forms of Salmonella minnesota via the classical pathway of complement activation in guinea-pig and human sera. Immunology 40(4):547–556
8. Davis SD, Wedgwood RJ (1965) Kinetics of the Bactericidal Action of Normal Serum on Gram-Negative Bacteria. J Immunol 95:75–79
9. Gasch O, Fernandez N, Armisen A, Verdaguer R, Fernandez P (2009) Community-acquired Capnocytophaga canimorsus meningitis in adults: report of one case with a subacute course and deafness, and literature review. Enferm Infecc Microbiol Clin 27(1):33–36
10. Hicklin H, Verghese A, Alvarez S (1987) Dysgonic fermenter 2 septicemia. Rev Infect Dis 9(5):884–890
11. Khawari AA, Myers JW, Ferguson DA Jr, Moorman JP (2005) Sepsis and meningitis due to Capnocytophaga cynodegmi after splenectomy. Clin Infect Dis Off Publ Infect Dis Soc Am 40(11):1709–1710
12. Kochi SK, Johnson RC (1988) Role of immunoglobulin G in killing of Borrelia burgdorferi by the classical complement pathway. Infect Immun 56(2):314–321
13. Kristian SA, Timmer AM, Liu GY, Lauth X, Sal-Man N, Rosenfeld Y, Shai Y, Gallo RL, Nizet V (2007) Impairment of innate immune killing mechanisms by bacteriostatic antibiotics. FASEB J Off Publ Fed Am Soc Exp Biol 21(4):1107–1116
14. Lewis K (2007) Persister cells, dormancy and infectious disease. Nat Rev Microbiol 5(1):48–56
15. Lion C, Escande F, Burdin JC (1996) Capnocytophaga canimorsus infections in human: review of the literature and cases report. Eur J Epidemiol 12(5):521–533
16. Oehler RL, Velez AP, Mizrachi M, Lamarche J, Gompf S (2009) Bite-related and septic syndromes caused by cats and dogs. Lancet Infect Dis 9(7):439–447
17. Olling S (1977) Sensitivity of gram-negative bacilli to the serum bactericidal activity: a marker of the host-parasite relationship in acute and persisting infections. Scand J Infect Dis Suppl 10:1–40
18. Renzi F, Manfredi P, Mally M, Moes S, Jeno P, Cornelis GR (2011) The N-glycan glycoprotein deglycosylation complex (Gpd) from Capnocytophaga canimorsus deglycosylates human IgG. PLoS Pathog 7(6):e1002118
19. Roantree RJ, Kuo TT, MacPhee DG (1977) The effect of defined lipopolysaccharide core defects upon antibiotic resistances of Salmonella typhimurium. J Gen Microbiol 103(2):223–234
20. Sarma PS, Mohanty S (2001) Capnocytophaga cynodegmi cellulitis, bacteremia, and pneumonitis in a diabetic man. J Clin Microbiol 39(5):2028–2029
21. Schreiber RD, Morrison DC, Podack ER, Muller-Eberhard HJ (1979) Bactericidal activity of the alternative complement pathway generated from 11 isolated plasma proteins. J Exp Med 149(4):870–882
22. Shahani L, Khardori N (2014) Overwhelming Capnocytophaga canimorsus infection in a patient with asplenia. BMJ Case Rep 2014:bcr2013202768. doi:10.1136/bcr-2013-202768
23. Shin H, Mally M, Kuhn M, Paroz C, Cornelis GR (2007) Escape from immune surveillance by Capnocytophaga canimorsus. J Infect Dis 195(3):375–386
24. Shin H, Mally M, Meyer S, Fiechter C, Paroz C, Zaehringer U, Cornelis GR (2009) Resistance of Capnocytophaga canimorsus to killing by human complement and polymorphonuclear leukocytes. Infect Immun 77(6):2262–2271
25. Suzuki M, Kimura M, Imaoka K, Yamada A (2010) Prevalence of Capnocytophaga canimorsus and Capnocytophaga cynodegmi in dogs and cats determined by using a newly established species-specific PCR. Vet Microbiol 144(1–2):172–176
26. Ugai T, Sugihara H, Nishida Y, Yamakura M, Takeuchi M, Matsue K (2014) Capnocytophaga canimorsus sepsis following BMT in a patient with AML: possible association with functional asplenia. Bone Marrow Transpl 49(1):153–154
27. Zangenah S, Ozenci V, Borang S, Bergman P (2012) Identification of blood and wound isolates of C. canimorsus and C. cynodegmi using VITEK2 and MALDI-TOF. Eur J Clin Microbiol Infect Dis Off Publ Eur Soc Clin Microbiol 31(10):2631–2637