Zinc deficiency worsens and supplementation prevents high-fat diet induced vascular inflammation, oxidative stress, and pathological remodeling

Toxicological Sciences

Volumn 153, Issue 1, 2016, Pages 124-136

  Chen, Jun ^a,b,c   Wang, Shudong ^c,d   Luo, Manyu ^c,e   Zhang, Zhiguo ^d   Dai, Xiaozhen ^c,f   Kong, Maiying ^g   Cai, Lu ^b,c   Wang, Yuehui ^d   Shi, Bingyin ^a   Tan, Yi ^b,c  

^a THE FIRST AFFILIATED HOSPITAL OF XI AN JIAOTONG UNIVERSITY   (China)

^b WENZHOU MEDICAL UNIVERSITY   (China)

^c University of Louisville School of Medicine   (United States)

^d THE FIRST HOSPITAL OF JILIN UNIVERSITY   (China)

^e THE SECOND HOSPITAL OF JILIN UNIVERSITY   (China)

^f CHENGDU MEDICAL COLLEGE   (China)

^g UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

Antioxidant; High fat diet; Inflammation; Vascular disease; Zinc

Indexed keywords

3 NITROTYROSINE; 4 HYDROXYNONENAL; ANTIOXIDANT; CATALASE; CYTOKINE; METALLOTHIONEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE 1); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; ZINC;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTERIAL WALL THICKENING; ARTERIAL WALL THICKNESS; ARTICLE; BLOOD VESSEL WALL; CELL PROLIFERATION; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG EFFECT; DRUG MECHANISM; GENE EXPRESSION; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LIPID DIET; MALE; MOUSE; NONHUMAN; OBESITY; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; TUNICA MEDIA; VASCULAR FIBROSIS; VASCULAR REMODELING; WESTERN BLOTTING; ZINC DEFICIENCY; ANIMAL; C57BL MOUSE; DEFICIENCY; DRUG EFFECTS; VASCULITIS;

ANIMALS; BLOTTING, WESTERN; DIET, HIGH-FAT; MALE; MICE; MICE, INBRED C57BL; OXIDATIVE STRESS; REAL-TIME POLYMERASE CHAIN REACTION; VASCULAR REMODELING; VASCULITIS; ZINC;

EID: 84991037469     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfw110     Document Type: Article

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