Natural product screening reveals naphthoquinone complex i bypass factors

PLoS ONE

Volumn 11, Issue 9, 2016, Pages

  Vafai, Scott B ^a,b   Mevers, Emily ^c   Higgins, Kathleen W ^a,b   Fomina, Yevgenia ^a,b   Zhang, Jianming ^a   Mandinova, Anna ^a   Newman, David ^d   Shaw, Stanley Y ^a   Clardy, Jon ^c   Mootha, Vamsi K ^a,b,c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; 2 METHOXY 1,4 NAPHTHOQUINONE; 2 METHOXY 3 METHYL 1,4, NAPHTHOQUINONE; 3 CHLORO CHIMAPHILIN; 3 HYDROXY CHIMAPHILIN; ALPHA LAPACHONE; CHIMAPHILIN; DEHYDRO ALPHA LAPACHONE; DEHYDROISO LAPACHONE; LAPACHOL; MENADIONE; NATURAL PRODUCT; UNCLASSIFIED DRUG; BIOLOGICAL PRODUCT; NAPHTHOQUINONE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE);

ANIMAL CELL; ARTICLE; BIGNONIACEAE; BIOASSAY; CHIMAPHILA UMBELLATA; CONTROLLED STUDY; CRISPR CAS SYSTEM; HIGH THROUGHPUT SCREENING; LIMIT OF DETECTION; MOLECULAR LIBRARY; MOUSE; MYOBLAST; NONHUMAN; STEREOSPERMUM EUPHOROIDES; ANIMAL; CELL LINE; CHEMISTRY; DEFICIENCY; DRUG EFFECTS; ERICACEAE; GENE EDITING; GENE INACTIVATION; GENETICS; METABOLISM; OXIDATIVE PHOSPHORYLATION; PRECLINICAL STUDY; SMEGMAMORPHA;

ANIMALS; BIGNONIACEAE; BIOLOGICAL PRODUCTS; CELL LINE; CRISPR-CAS SYSTEMS; DRUG EVALUATION, PRECLINICAL; ELECTRON TRANSPORT COMPLEX I; ERICACEAE; GENE EDITING; GENE KNOCKOUT TECHNIQUES; HIGH-THROUGHPUT SCREENING ASSAYS; MICE; MYOBLASTS; NAPHTHOQUINONES; OXIDATIVE PHOSPHORYLATION; SMEGMAMORPHA;

EID: 84990990185     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0162686     Document Type: Article

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