Novel human IgG1 and IgG4 Fc-engineered antibodies with completely abolished immune effector functions

Protein Engineering, Design and Selection

Volumn 29, Issue 10, 2016, Pages 457-466

  Schlothauer, Tilman ^a   Herter, Sylvia ^b   Koller, Claudia Ferrara ^b   Grau Richards, Sandra ^b   Steinhart, Virginie ^b   Spick, Christian ^a   Kubbies, Manfred ^a   Klein, Christian ^b   Umaña, Pablo ^b   Mössner, Ekkehard ^b  

^a ROCHE INNOVATION CENTER MUNICH   (Germany)

^b Roche Innovation Center Zurich   (Switzerland)

Author keywords

ADCC; CDC; effector silent Fc; Fc Gamma Receptors

Indexed keywords

MAMMALS; RECOMBINANT PROTEINS;

ADCC; EFFECTOR SILENT FC; FC GAMMA RECEPTORS; HUMAN IGG; IMMUNE EFFECTORS; THERAPEUTIC APPLICATION;

ANTIBODIES;

CD9 ANTIGEN; COMPLEMENT COMPONENT C1Q; DRUG ANTIBODY; EPIDERMAL GROWTH FACTOR RECEPTOR; FC RECEPTOR; HUMAN IMMUNOGLOBULIN G ANTIBODY; HUMAN IMMUNOGLOBULIN G4; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G4; PROLINE; UNCLASSIFIED DRUG; COMPLEMENT 1Q RECEPTOR; COMPLEMENT RECEPTOR; FC RECEPTOR IIB; FCGR3A PROTEIN, HUMAN; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G; MEMBRANE PROTEIN;

ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ARTICLE; CONTROLLED STUDY; CYTOLYSIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; BINDING SITE; CELL LINE; CHEMISTRY; CONSERVED SEQUENCE; DRUG EFFECTS; GENETIC POLYMORPHISM; GENETICS; GLYCOSYLATION; IMMUNOLOGY; METABOLISM; MOLECULAR MODEL; MUTATION; PROTEIN ENGINEERING; PROTEIN SECONDARY STRUCTURE; THROMBOCYTE AGGREGATION;

BINDING SITES; CELL LINE; CONSERVED SEQUENCE; GLYCOSYLATION; HUMANS; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOGLOBULIN G; MEMBRANE GLYCOPROTEINS; MODELS, MOLECULAR; MUTATION; PLATELET AGGREGATION; POLYMORPHISM, GENETIC; PROTEIN ENGINEERING; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, COMPLEMENT; RECEPTORS, IGG;

EID: 84990942559     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzw040     Document Type: Article

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