Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells

Cell Stem Cell

Volumn 19, Issue 2, 2016, Pages 217-231

  Mou, Hongmei ^a,b,c   Vinarsky, Vladimir ^a,b,c   Tata, Purushothama Rao ^a,b   Brazauskas, Karissa ^a,c   Choi, Soon H ^d   Crooke, Adrianne K ^d   Zhang, Bing ^e   Solomon, George M ^f,i   Turner, Brett ^g   Bihler, Hermann ^j   Harrington, Jan ^j   Lapey, Allen ^c   Channick, Colleen ^c   Keyes, Colleen ^c   Freund, Adam ^k   Artandi, Steven ^k   Mense, Martin ^j   Rowe, Steven ^f,g,h,i   Engelhardt, John F ^d   Hsu, Ya Chieh ^e   Rajagopal, Jayaraj ^a,b,c,l   more..

^a MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

^b HARVARD STEM CELL INSTITUTE   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d UNIVERSITY OF IOWA   (United States)

^e HARVARD UNIVERSITY   (United States)

^f University of Alabama at Birmingham   (United States)

^g University of Alabama at Birmingham   (United States)

^h UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

ⁱ UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^j Cystic Fibrosis Foundation Therapeutics   (United States)

^k STANFORD UNIVERSITY   (United States)

^l Departments of Otology and Laryngology   (United States)

more..

Author keywords

dedifferentiation; differentiation; dual SMAD signaling inhibition; epithelial basal and stems cells; p63+ basal cells; replicative exhaustion; senescence; stemness; telomeres; TGF BMP4 SMAD signaling

Indexed keywords

BONE MORPHOGENETIC PROTEIN; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; PROTEIN P63; SMAD PROTEIN; SMAD1 PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL HYPERPLASIA; CONTROLLED STUDY; EPITHELIUM BASAL CELL; GERM LAYER; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; KERATINOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM; SENESCENCE; STEM CELL EXPANSION; ANIMAL; C57BL MOUSE; CELL AGING; CELL PROLIFERATION; CELL SELF-RENEWAL; CILIUM; CYTOLOGY; EPITHELIUM; EPITHELIUM CELL; LUNG; METABOLISM; MUCUS; SIGNAL TRANSDUCTION; TELOMERE;

ANIMALS; CELL AGING; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SELF RENEWAL; CILIA; EPITHELIAL CELLS; EPITHELIUM; HUMANS; KERATINOCYTES; LUNG; MICE, INBRED C57BL; MUCUS; SIGNAL TRANSDUCTION; SMAD PROTEINS; TELOMERE;

EID: 84990922590     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2016.05.012     Document Type: Article

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