메뉴 건너뛰기




Volumn 45, Issue 1, 2016, Pages 145-158

Interleukin-13 Activates Distinct Cellular Pathways Leading to Ductular Reaction, Steatosis, and Fibrosis

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CRE RECOMBINASE; EPITHELIAL CELL ADHESION MOLECULE; GENOMIC DNA; INTERLEUKIN 13; INTERLEUKIN 13 RECEPTOR ALPHA2; INTERLEUKIN 33; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR ALPHA; MESSENGER RNA; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; TRIACYLGLYCEROL; BILE ACID;

EID: 84990859074     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2016.06.009     Document Type: Article
Times cited : (99)

References (53)
  • 1
    • 28544438991 scopus 로고    scopus 로고
    • Liver cancer: the role of stem cells
    • Alison, M.R., Lovell, M.J., Liver cancer: the role of stem cells. Cell Prolif. 38 (2005), 407–421.
    • (2005) Cell Prolif. , vol.38 , pp. 407-421
    • Alison, M.R.1    Lovell, M.J.2
  • 4
    • 84941182925 scopus 로고    scopus 로고
    • Efficacy and safety of tralokinumab in patients with severe uncontrolled asthma: a randomised, double-blind, placebo-controlled, phase 2b trial
    • Brightling, C.E., Chanez, P., Leigh, R., O'Byrne, P.M., Korn, S., She, D., May, R.D., Streicher, K., Ranade, K., Piper, E., Efficacy and safety of tralokinumab in patients with severe uncontrolled asthma: a randomised, double-blind, placebo-controlled, phase 2b trial. Lancet Respir. Med. 3 (2015), 692–701.
    • (2015) Lancet Respir. Med. , vol.3 , pp. 692-701
    • Brightling, C.E.1    Chanez, P.2    Leigh, R.3    O'Byrne, P.M.4    Korn, S.5    She, D.6    May, R.D.7    Streicher, K.8    Ranade, K.9    Piper, E.10
  • 7
    • 0032697042 scopus 로고    scopus 로고
    • An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response
    • Chiaramonte, M.G., Donaldson, D.D., Cheever, A.W., Wynn, T.A., An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response. J. Clin. Invest. 104 (1999), 777–785.
    • (1999) J. Clin. Invest. , vol.104 , pp. 777-785
    • Chiaramonte, M.G.1    Donaldson, D.D.2    Cheever, A.W.3    Wynn, T.A.4
  • 10
    • 16244416190 scopus 로고    scopus 로고
    • Fibrosis correlates with a ductular reaction in hepatitis C: roles of impaired replication, progenitor cells and steatosis
    • Clouston, A.D., Powell, E.E., Walsh, M.J., Richardson, M.M., Demetris, A.J., Jonsson, J.R., Fibrosis correlates with a ductular reaction in hepatitis C: roles of impaired replication, progenitor cells and steatosis. Hepatology 41 (2005), 809–818.
    • (2005) Hepatology , vol.41 , pp. 809-818
    • Clouston, A.D.1    Powell, E.E.2    Walsh, M.J.3    Richardson, M.M.4    Demetris, A.J.5    Jonsson, J.R.6
  • 12
    • 84961012817 scopus 로고
    • Similarities in the sequence of early histological changes induced in the liver of the rat by ethionine, 2-acetylamino-fluorene, and 3′-methyl-4-dimethylaminoazobenzene
    • Farber, E., Similarities in the sequence of early histological changes induced in the liver of the rat by ethionine, 2-acetylamino-fluorene, and 3′-methyl-4-dimethylaminoazobenzene. Cancer Res. 16 (1956), 142–148.
    • (1956) Cancer Res. , vol.16 , pp. 142-148
    • Farber, E.1
  • 17
    • 23244455992 scopus 로고    scopus 로고
    • Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution
    • Heller, F., Florian, P., Bojarski, C., Richter, J., Christ, M., Hillenbrand, B., Mankertz, J., Gitter, A.H., Bürgel, N., Fromm, M., et al. Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution. Gastroenterology 129 (2005), 550–564.
    • (2005) Gastroenterology , vol.129 , pp. 550-564
    • Heller, F.1    Florian, P.2    Bojarski, C.3    Richter, J.4    Christ, M.5    Hillenbrand, B.6    Mankertz, J.7    Gitter, A.H.8    Bürgel, N.9    Fromm, M.10
  • 21
    • 84877927781 scopus 로고    scopus 로고
    • The origin of biliary strictures after liver transplantation: is it the amount of epithelial injury or insufficient regeneration that counts?
    • Karimian, N., Op den Dries, S., Porte, R.J., The origin of biliary strictures after liver transplantation: is it the amount of epithelial injury or insufficient regeneration that counts?. J. Hepatol. 58 (2013), 1065–1067.
    • (2013) J. Hepatol. , vol.58 , pp. 1065-1067
    • Karimian, N.1    Op den Dries, S.2    Porte, R.J.3
  • 23
    • 84895868220 scopus 로고    scopus 로고
    • Differential serum levels of eosinophilic eotaxins in primary sclerosing cholangitis, primary biliary cirrhosis, and autoimmune hepatitis
    • Landi, A., Weismuller, T.J., Lankisch, T.O., Santer, D.M., Tyrrell, D.L.J., Manns, M.P., Houghton, M., Differential serum levels of eosinophilic eotaxins in primary sclerosing cholangitis, primary biliary cirrhosis, and autoimmune hepatitis. J. Interferon Cytokine Res. 34 (2014), 204–214.
    • (2014) J. Interferon Cytokine Res. , vol.34 , pp. 204-214
    • Landi, A.1    Weismuller, T.J.2    Lankisch, T.O.3    Santer, D.M.4    Tyrrell, D.L.J.5    Manns, M.P.6    Houghton, M.7
  • 26
    • 84859414410 scopus 로고    scopus 로고
    • Assessment of liver steatosis and fibrosis in rats using integrated coherent anti-Stokes Raman scattering and multiphoton imaging technique
    • Lin, J., Lu, F., Zheng, W., Xu, S., Tai, D., Yu, H., Huang, Z., Assessment of liver steatosis and fibrosis in rats using integrated coherent anti-Stokes Raman scattering and multiphoton imaging technique. J. Biomed. Opt., 16, 2011, 116024.
    • (2011) J. Biomed. Opt. , vol.16 , pp. 116024
    • Lin, J.1    Lu, F.2    Zheng, W.3    Xu, S.4    Tai, D.5    Yu, H.6    Huang, Z.7
  • 27
    • 0032805251 scopus 로고    scopus 로고
    • Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA
    • Liu, F., Song, Y., Liu, D., Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA. Gene Ther. 6 (1999), 1258–1266.
    • (1999) Gene Ther. , vol.6 , pp. 1258-1266
    • Liu, F.1    Song, Y.2    Liu, D.3
  • 28
    • 80052654374 scopus 로고    scopus 로고
    • IL-13 induces connective tissue growth factor in rat hepatic stellate cells via TGF-β-independent Smad signaling
    • Liu, Y., Meyer, C., Müller, A., Herweck, F., Li, Q., Müllenbach, R., Mertens, P.R., Dooley, S., Weng, H.L., IL-13 induces connective tissue growth factor in rat hepatic stellate cells via TGF-β-independent Smad signaling. J. Immunol. 187 (2011), 2814–2823.
    • (2011) J. Immunol. , vol.187 , pp. 2814-2823
    • Liu, Y.1    Meyer, C.2    Müller, A.3    Herweck, F.4    Li, Q.5    Müllenbach, R.6    Mertens, P.R.7    Dooley, S.8    Weng, H.L.9
  • 29
    • 0032964899 scopus 로고    scopus 로고
    • Oval cell numbers in human chronic liver diseases are directly related to disease severity
    • Lowes, K.N., Brennan, B.A., Yeoh, G.C., Olynyk, J.K., Oval cell numbers in human chronic liver diseases are directly related to disease severity. Am. J. Pathol. 154 (1999), 537–541.
    • (1999) Am. J. Pathol. , vol.154 , pp. 537-541
    • Lowes, K.N.1    Brennan, B.A.2    Yeoh, G.C.3    Olynyk, J.K.4
  • 31
    • 47549119127 scopus 로고    scopus 로고
    • A CK19(CreERT) knockin mouse line allows for conditional DNA recombination in epithelial cells in multiple endodermal organs
    • Means, A.L., Xu, Y., Zhao, A., Ray, K.C., Gu, G., A CK19(CreERT) knockin mouse line allows for conditional DNA recombination in epithelial cells in multiple endodermal organs. Genesis 46 (2008), 318–323.
    • (2008) Genesis , vol.46 , pp. 318-323
    • Means, A.L.1    Xu, Y.2    Zhao, A.3    Ray, K.C.4    Gu, G.5
  • 34
    • 33847387209 scopus 로고    scopus 로고
    • Ductular reaction is helpful in defining early stromal invasion, small hepatocellular carcinomas, and dysplastic nodules
    • Park, Y.N., Kojiro, M., Di Tommaso, L., Dhillon, A.P., Kondo, F., Nakano, M., Sakamoto, M., Theise, N.D., Roncalli, M., Ductular reaction is helpful in defining early stromal invasion, small hepatocellular carcinomas, and dysplastic nodules. Cancer 109 (2007), 915–923.
    • (2007) Cancer , vol.109 , pp. 915-923
    • Park, Y.N.1    Kojiro, M.2    Di Tommaso, L.3    Dhillon, A.P.4    Kondo, F.5    Nakano, M.6    Sakamoto, M.7    Theise, N.D.8    Roncalli, M.9
  • 35
    • 0036636093 scopus 로고    scopus 로고
    • The immunobiology of schistosomiasis
    • Pearce, E.J., MacDonald, A.S., The immunobiology of schistosomiasis. Nat. Rev. Immunol. 2 (2002), 499–511.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 499-511
    • Pearce, E.J.1    MacDonald, A.S.2
  • 40
    • 33745533559 scopus 로고    scopus 로고
    • Liver stem cells and their implication in hepatocellular and cholangiocarcinoma
    • Roskams, T., Liver stem cells and their implication in hepatocellular and cholangiocarcinoma. Oncogene 25 (2006), 3818–3822.
    • (2006) Oncogene , vol.25 , pp. 3818-3822
    • Roskams, T.1
  • 43
    • 65449177586 scopus 로고    scopus 로고
    • High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis
    • Schaap, F.G., van der Gaag, N.A., Gouma, D.J., Jansen, P.L., High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis. Hepatology 49 (2009), 1228–1235.
    • (2009) Hepatology , vol.49 , pp. 1228-1235
    • Schaap, F.G.1    van der Gaag, N.A.2    Gouma, D.J.3    Jansen, P.L.4
  • 45
    • 58149306389 scopus 로고    scopus 로고
    • Novel role of IL-13 in fibrosis induced by nonalcoholic steatohepatitis and its amelioration by IL-13R-directed cytotoxin in a rat model
    • Shimamura, T., Fujisawa, T., Husain, S.R., Kioi, M., Nakajima, A., Puri, R.K., Novel role of IL-13 in fibrosis induced by nonalcoholic steatohepatitis and its amelioration by IL-13R-directed cytotoxin in a rat model. J. Immunol. 181 (2008), 4656–4665.
    • (2008) J. Immunol. , vol.181 , pp. 4656-4665
    • Shimamura, T.1    Fujisawa, T.2    Husain, S.R.3    Kioi, M.4    Nakajima, A.5    Puri, R.K.6
  • 47
    • 77950609317 scopus 로고    scopus 로고
    • Notch signaling regulates formation of the three-dimensional architecture of intrahepatic bile ducts in mice
    • Sparks, E.E., Huppert, K.A., Brown, M.A., Washington, M.K., Huppert, S.S., Notch signaling regulates formation of the three-dimensional architecture of intrahepatic bile ducts in mice. Hepatology 51 (2010), 1391–1400.
    • (2010) Hepatology , vol.51 , pp. 1391-1400
    • Sparks, E.E.1    Huppert, K.A.2    Brown, M.A.3    Washington, M.K.4    Huppert, S.S.5
  • 50
    • 84939490816 scopus 로고    scopus 로고
    • Self-renewing diploid Axin2(+) cells fuel homeostatic renewal of the liver
    • Wang, B., Zhao, L., Fish, M., Logan, C.Y., Nusse, R., Self-renewing diploid Axin2(+) cells fuel homeostatic renewal of the liver. Nature 524 (2015), 180–185.
    • (2015) Nature , vol.524 , pp. 180-185
    • Wang, B.1    Zhao, L.2    Fish, M.3    Logan, C.Y.4    Nusse, R.5
  • 52
    • 84928583743 scopus 로고    scopus 로고
    • Type 2 cytokines: mechanisms and therapeutic strategies
    • Wynn, T.A., Type 2 cytokines: mechanisms and therapeutic strategies. Nat. Rev. Immunol. 15 (2015), 271–282.
    • (2015) Nat. Rev. Immunol. , vol.15 , pp. 271-282
    • Wynn, T.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.