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Volumn 125, Issue 6, 2015, Pages 2445-2457

Lineage fate of ductular reactions in liver injury and carcinogenesis

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; NOTCH RECEPTOR; TAMOXIFEN; WNT PROTEIN;

EID: 84930393054     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI78585     Document Type: Article
Times cited : (132)

References (59)
  • 1
    • 80055051680 scopus 로고    scopus 로고
    • Ductular reactions in human liver: Diversity at the interface
    • Gouw AS, Clouston AD, Theise ND. Ductular reactions in human liver: Diversity at the interface. Hepatology. 2011;54(5): 1853-1863.
    • (2011) Hepatology , vol.54 , Issue.5 , pp. 1853-1863
    • Gouw, A.S.1    Clouston, A.D.2    Theise, N.D.3
  • 2
    • 79954447824 scopus 로고    scopus 로고
    • Ductal plates in hepatic ductular reactions. Hypothesis and implications. I. Types of ductular reaction reconsidered
    • Desmet VJ. Ductal plates in hepatic ductular reactions. Hypothesis and implications. I. Types of ductular reaction reconsidered. Virchows Arch. 2011;458(3): 251-259.
    • (2011) Virchows Arch , vol.458 , Issue.3 , pp. 251-259
    • Desmet, V.J.1
  • 3
    • 2542595537 scopus 로고    scopus 로고
    • Nomenclature of the finer branches of the biliary tree: Canals, ductules, and ductular reactions in human livers
    • Roskams TA, et al. Nomenclature of the finer branches of the biliary tree: Canals, ductules, and ductular reactions in human livers. Hepatology. 2004;39(6): 1739-1745.
    • (2004) Hepatology , vol.39 , Issue.6 , pp. 1739-1745
    • Roskams, T.A.1
  • 4
    • 80053610191 scopus 로고    scopus 로고
    • Embryonic ductal plate cells give rise to cholangiocytes, periportal hepatocytes and adult liver progenitor cells
    • Carpentier R, et al. Embryonic ductal plate cells give rise to cholangiocytes, periportal hepatocytes and adult liver progenitor cells. Gastroenterology. 2011;141(4): 1432-1438.
    • (2011) Gastroenterology , vol.141 , Issue.4 , pp. 1432-1438
    • Carpentier, R.1
  • 5
    • 14244252656 scopus 로고    scopus 로고
    • Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury
    • Michalopoulos GK, Barua L, Bowen WC. Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury. Hepatology. 2005;41(3): 535-544.
    • (2005) Hepatology , vol.41 , Issue.3 , pp. 535-544
    • Michalopoulos, G.K.1    Barua, L.2    Bowen, W.C.3
  • 6
    • 84876278823 scopus 로고    scopus 로고
    • Robust cellular reprogramming occurs spontaneously during liver regeneration
    • Yanger K, et al. Robust cellular reprogramming occurs spontaneously during liver regeneration. Genes Dev. 2013;27(7): 719-724.
    • (2013) Genes Dev , vol.27 , Issue.7 , pp. 719-724
    • Yanger, K.1
  • 7
    • 84879073587 scopus 로고    scopus 로고
    • Canonical Notch2 signaling determines biliary cell fates of embryonic hepatoblasts and adult hepatocytes independent of Hes1
    • Jeliazkova P, et al. Canonical Notch2 signaling determines biliary cell fates of embryonic hepatoblasts and adult hepatocytes independent of Hes1. Hepatology. 2013;57(6): 2469-2479.
    • (2013) Hepatology , vol.57 , Issue.6 , pp. 2469-2479
    • Jeliazkova, P.1
  • 8
    • 84922750939 scopus 로고    scopus 로고
    • Bipotential adult liver progenitors are derived from chronically injured mature hepatocytes
    • Tarlow BD, et al. Bipotential adult liver progenitors are derived from chronically injured mature hepatocytes. Cell Stem Cell. 2014;15(5): 605-618.
    • (2014) Cell Stem Cell , vol.15 , Issue.5 , pp. 605-618
    • Tarlow, B.D.1
  • 9
    • 84899505830 scopus 로고    scopus 로고
    • Hepatocytes, rather than cholangiocytes, can be the major source of primitive ductules in the chronically injured mouse liver
    • Sekiya S, Suzuki A. Hepatocytes, rather than cholangiocytes, can be the major source of primitive ductules in the chronically injured mouse liver. Am J Pathol. 2014;184(5): 1468-1478.
    • (2014) Am J Pathol , vol.184 , Issue.5 , pp. 1468-1478
    • Sekiya, S.1    Suzuki, A.2
  • 10
    • 84859614232 scopus 로고    scopus 로고
    • Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease
    • Boulter L, et al. Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease. Nat Med. 2012;18(4): 572-579.
    • (2012) Nat Med , vol.18 , Issue.4 , pp. 572-579
    • Boulter, L.1
  • 11
    • 77149158796 scopus 로고    scopus 로고
    • Characterisation of the liver progenitor cell niche in liver diseases: Potential involvement of Wnt and Notch signalling
    • Spee B, et al. Characterisation of the liver progenitor cell niche in liver diseases: Potential involvement of Wnt and Notch signalling. Gut. 2010;59(2): 247-257.
    • (2010) Gut , vol.59 , Issue.2 , pp. 247-257
    • Spee, B.1
  • 12
    • 84920997369 scopus 로고    scopus 로고
    • Emerging roles of Notch signaling in liver disease
    • Geisler F, Strazzabosco M. Emerging roles of Notch signaling in liver disease. Hepatology. 2015;61(1): 382-392.
    • (2015) Hepatology , vol.61 , Issue.1 , pp. 382-392
    • Geisler, F.1    Strazzabosco, M.2
  • 13
    • 58149386485 scopus 로고    scopus 로고
    • Flow cytometric isolation and clonal identification of self-renewing bipotent hepatic progenitor cells in adult mouse liver
    • Suzuki A, et al. Flow cytometric isolation and clonal identification of self-renewing bipotent hepatic progenitor cells in adult mouse liver. Hepatology. 2008;48(6): 1964-1978.
    • (2008) Hepatology , vol.48 , Issue.6 , pp. 1964-1978
    • Suzuki, A.1
  • 14
    • 79958051227 scopus 로고    scopus 로고
    • Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice
    • Dorrell C, et al. Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice. Genes Dev. 2011;25(11): 1193-1203.
    • (2011) Genes Dev , vol.25 , Issue.11 , pp. 1193-1203
    • Dorrell, C.1
  • 15
    • 84873712443 scopus 로고    scopus 로고
    • In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration
    • Huch M, et al. In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. Nature. 2013;494(7436): 247-250.
    • (2013) Nature , vol.494 , Issue.7436 , pp. 247-250
    • Huch, M.1
  • 16
    • 68349094342 scopus 로고    scopus 로고
    • Potential hepatic stem cells reside in EpCAM+ cells of normal and injured mouse liver
    • Okabe M, et al. Potential hepatic stem cells reside in EpCAM+ cells of normal and injured mouse liver. Development. 2009;136(11): 1951-1960.
    • (2009) Development , vol.136 , Issue.11 , pp. 1951-1960
    • Okabe, M.1
  • 17
    • 84055199890 scopus 로고    scopus 로고
    • Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration
    • Malato Y, et al. Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration. J Clin Invest. 2011;121(12): 4850-4860.
    • (2011) J Clin Invest , vol.121 , Issue.12 , pp. 4850-4860
    • Malato, Y.1
  • 18
    • 78651228289 scopus 로고    scopus 로고
    • Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine
    • Furuyama K, et al. Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine. Nat Genet. 2010;43(1): 34-41.
    • (2010) Nat Genet , vol.43 , Issue.1 , pp. 34-41
    • Furuyama, K.1
  • 19
    • 84869751765 scopus 로고    scopus 로고
    • Liver progenitor cells yield functional hepatocytes in response to chronic liver injury in mice
    • Espanol-Suner R, et al. Liver progenitor cells yield functional hepatocytes in response to chronic liver injury in mice. Gastroenterology. 2012;143(6): 1564-1575.
    • (2012) Gastroenterology , vol.143 , Issue.6 , pp. 1564-1575
    • Espanol-Suner, R.1
  • 20
    • 84903279458 scopus 로고    scopus 로고
    • Clonal tracing of Sox9(+) liver progenitors in mouse oval cell injury
    • Tarlow BD, Finegold MJ, Grompe M. Clonal tracing of Sox9(+) liver progenitors in mouse oval cell injury. Hepatology. 2014;60(1): 278-289.
    • (2014) Hepatology , vol.60 , Issue.1 , pp. 278-289
    • Tarlow, B.D.1    Finegold, M.J.2    Grompe, M.3
  • 21
    • 84927782108 scopus 로고    scopus 로고
    • The biliary epithelium gives rise to liver progenitor cells
    • Rodrigo-Torres D, et al. The biliary epithelium gives rise to liver progenitor cells. Hepatology. 2014;60(4): 1367-1377.
    • (2014) Hepatology , vol.60 , Issue.4 , pp. 1367-1377
    • Rodrigo-Torres, D.1
  • 22
    • 84908355955 scopus 로고    scopus 로고
    • Evidence against a stem cell origin of new hepatocytes in a common mouse model of chronic liver injury
    • Schaub JR, Malato Y, Gormond C, Willenbring H. Evidence against a stem cell origin of new hepatocytes in a common mouse model of chronic liver injury. Cell Rep. 2014;8(4): 933-939.
    • (2014) Cell Rep , vol.8 , Issue.4 , pp. 933-939
    • Schaub, J.R.1    Malato, Y.2    Gormond, C.3    Willenbring, H.4
  • 23
    • 84925092021 scopus 로고    scopus 로고
    • Adult hepatocytes are generated by self-duplication rather than stem cell differentiation
    • Yanger K, et al. Adult hepatocytes are generated by self-duplication rather than stem cell differentiation. Cell Stem Cell. 2014;15(3): 340-349.
    • (2014) Cell Stem Cell , vol.15 , Issue.3 , pp. 340-349
    • Yanger, K.1
  • 24
    • 84255168800 scopus 로고    scopus 로고
    • Stem cells in liver diseases and cancer: Recent advances on the path to new therapies
    • Rountree CB, Mishra L, Willenbring H. Stem cells in liver diseases and cancer: Recent advances on the path to new therapies. Hepatology. 2012;55(1): 298-306.
    • (2012) Hepatology , vol.55 , Issue.1 , pp. 298-306
    • Rountree, C.B.1    Mishra, L.2    Willenbring, H.3
  • 25
    • 84877156945 scopus 로고    scopus 로고
    • Cancer stem cells in the development of liver cancer
    • Yamashita T, Wang XW. Cancer stem cells in the development of liver cancer. J Clin Invest. 2013;123(5): 1911-1918.
    • (2013) J Clin Invest , vol.123 , Issue.5 , pp. 1911-1918
    • Yamashita, T.1    Wang, X.W.2
  • 26
    • 73949140059 scopus 로고    scopus 로고
    • A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
    • Madisen L, et al. A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat Neurosci. 2010; 13(1): 133-140.
    • (2010) Nat Neurosci , vol.13 , Issue.1 , pp. 133-140
    • Madisen, L.1
  • 27
    • 84866995256 scopus 로고    scopus 로고
    • The NF-kappaB subunit RelA/p65 is dispensable for successful liver regeneration after partial hepatectomy in mice
    • Ringelhan M, Schmid RM, Geisler F. The NF-kappaB subunit RelA/p65 is dispensable for successful liver regeneration after partial hepatectomy in mice. PLoS One. 2012;7(10): E46469.
    • (2012) PLoS One , vol.7 , Issue.10 , pp. e46469
    • Ringelhan, M.1    Schmid, R.M.2    Geisler, F.3
  • 28
    • 69249083298 scopus 로고    scopus 로고
    • Enrichment and clonal culture of progenitor cells during mouse postnatal liver development in mice
    • Kamiya A, Kakinuma S, Yamazaki Y, Nakauchi H. Enrichment and clonal culture of progenitor cells during mouse postnatal liver development in mice. Gastroenterology. 2009;137(3): 1114-1126.
    • (2009) Gastroenterology , vol.137 , Issue.3 , pp. 1114-1126
    • Kamiya, A.1    Kakinuma, S.2    Yamazaki, Y.3    Nakauchi, H.4
  • 29
    • 79960726270 scopus 로고    scopus 로고
    • Contributions of new hepatocyte lineages to liver growth, maintenance, and regeneration in mice
    • Iverson SV, Comstock KM, Kundert JA, Schmidt EE. Contributions of new hepatocyte lineages to liver growth, maintenance, and regeneration in mice. Hepatology. 2011;54(2): 655-663.
    • (2011) Hepatology , vol.54 , Issue.2 , pp. 655-663
    • Iverson, S.V.1    Comstock, K.M.2    Kundert, J.A.3    Schmidt, E.E.4
  • 30
    • 79951539242 scopus 로고    scopus 로고
    • Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas
    • Kopp JL, et al. Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas. Development. 2011;138(4): 653-665.
    • (2011) Development , vol.138 , Issue.4 , pp. 653-665
    • Kopp, J.L.1
  • 31
    • 68549115658 scopus 로고    scopus 로고
    • Notch signaling controls liver development by regulating biliary differentiation
    • Zong Y, et al. Notch signaling controls liver development by regulating biliary differentiation. Development. 2009;136(10): 1727-1739.
    • (2009) Development , vol.136 , Issue.10 , pp. 1727-1739
    • Zong, Y.1
  • 32
    • 0022318864 scopus 로고
    • The streaming liver
    • Zajicek G, Oren R, Weinreb M Jr. The streaming liver. Liver. 1985;5(6): 293-300.
    • (1985) Liver , vol.5 , Issue.6 , pp. 293-300
    • Zajicek, G.1    Oren, R.2    Weinreb, M.3
  • 33
    • 84929607251 scopus 로고    scopus 로고
    • Determining the fate of hepatic cells by lineage tracing: Facts and pitfalls [published online ahead of print December 12, 2014]
    • Lemaigre FP. Determining the fate of hepatic cells by lineage tracing: Facts and pitfalls [published online ahead of print December 12, 2014]. Hepatology. doi: 10.1002/hep.27659.
    • Hepatology.
    • Lemaigre, F.P.1
  • 34
    • 84879601648 scopus 로고    scopus 로고
    • Non-parallel recombination limits Cre-LoxP-based reporters as precise indicators of conditional genetic manipulation
    • Liu J, Willet SG, Bankaitis ED, Xu Y, Wright CV, Gu G. Non-parallel recombination limits Cre-LoxP-based reporters as precise indicators of conditional genetic manipulation. Genesis. 2013;51(6): 436-442.
    • (2013) Genesis , vol.51 , Issue.6 , pp. 436-442
    • Liu, J.1    Willet, S.G.2    Bankaitis, E.D.3    Xu, Y.4    Wright, C.V.5    Gu, G.6
  • 35
    • 33645742425 scopus 로고    scopus 로고
    • A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells
    • Lee JS, et al. A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells. Nat Med. 2006;12(4): 410-416.
    • (2006) Nat Med , vol.12 , Issue.4 , pp. 410-416
    • Lee, J.S.1
  • 36
    • 0036210375 scopus 로고    scopus 로고
    • Generation and characterization of p53 null transformed hepatic progenitor cells: Oval cells give rise to hepatocellular carcinoma
    • Dumble ML, Croager EJ, Yeoh GC, Quail EA. Generation and characterization of p53 null transformed hepatic progenitor cells: Oval cells give rise to hepatocellular carcinoma. Carcinogenesis. 2002;23(3): 435-445.
    • (2002) Carcinogenesis , vol.23 , Issue.3 , pp. 435-445
    • Dumble, M.L.1    Croager, E.J.2    Yeoh, G.C.3    Quail, E.A.4
  • 37
    • 84879494478 scopus 로고    scopus 로고
    • Modeling pathogenesis of primary liver cancer in lineage-specific mouse cell types
    • Holczbauer A, et al. Modeling pathogenesis of primary liver cancer in lineage-specific mouse cell types. Gastroenterology. 2013;145(1): 221-231.
    • (2013) Gastroenterology , vol.145 , Issue.1 , pp. 221-231
    • Holczbauer, A.1
  • 38
    • 4644324186 scopus 로고    scopus 로고
    • NF-?B functions as a tumour promoter in inflammation-Associated cancer
    • Pikarsky E, et al. NF-?B functions as a tumour promoter in inflammation-Associated cancer. Nature. 2004;431(7007): 461-466.
    • (2004) Nature , vol.431 , Issue.7007 , pp. 461-466
    • Pikarsky, E.1
  • 39
    • 84879577931 scopus 로고    scopus 로고
    • Receptor for advanced glycation endproducts (RAGE) is a key regulator of oval cell activation and inflammation-Associated liver carcinogenesis in mice
    • Pusterla T, et al. Receptor for advanced glycation endproducts (RAGE) is a key regulator of oval cell activation and inflammation-Associated liver carcinogenesis in mice. Hepatology. 2013;58(1): 363-373.
    • (2013) Hepatology , vol.58 , Issue.1 , pp. 363-373
    • Pusterla, T.1
  • 40
    • 84864773126 scopus 로고    scopus 로고
    • Cholangiocarcinomas can originate from hepatocytes in mice
    • Fan B, et al. Cholangiocarcinomas can originate from hepatocytes in mice. J Clin Invest. 2012;122(8): 2911-2915.
    • (2012) J Clin Invest , vol.122 , Issue.8 , pp. 2911-2915
    • Fan, B.1
  • 41
    • 4043062056 scopus 로고    scopus 로고
    • Efficient temporally controlled targeted somatic mutagenesis in hepatocytes of the mouse
    • Schuler M, Dierich A, Chambon P, Metzger D. Efficient temporally controlled targeted somatic mutagenesis in hepatocytes of the mouse. Genesis. 2004;39(3): 167-172.
    • (2004) Genesis , vol.39 , Issue.3 , pp. 167-172
    • Schuler, M.1    Dierich, A.2    Chambon, P.3    Metzger, D.4
  • 42
    • 0023442448 scopus 로고
    • A precursor-product relationship exists between oval cells and hepatocytes in rat liver
    • Evarts RP, Nagy P, Marsden E, Thorgeirsson SS. A precursor-product relationship exists between oval cells and hepatocytes in rat liver. Carcinogenesis. 1987;8(11): 1737-1740.
    • (1987) Carcinogenesis , vol.8 , Issue.11 , pp. 1737-1740
    • Evarts, R.P.1    Nagy, P.2    Marsden, E.3    Thorgeirsson, S.S.4
  • 43
  • 44
    • 79952298241 scopus 로고    scopus 로고
    • Liver stem/progenitor cells: Their characteristics and regulatory mechanisms
    • Tanaka M, Itoh T, Tanimizu N, Miyajima A. Liver stem/progenitor cells: Their characteristics and regulatory mechanisms. J Biochem. 2011;149(3): 231-239.
    • (2011) J Biochem , vol.149 , Issue.3 , pp. 231-239
    • Tanaka, M.1    Itoh, T.2    Tanimizu, N.3    Miyajima, A.4
  • 45
    • 84899729602 scopus 로고    scopus 로고
    • Stem/progenitor cells in liver development, homeostasis, regeneration, and reprogramming
    • Miyajima A, Tanaka M, Itoh T. Stem/progenitor cells in liver development, homeostasis, regeneration, and reprogramming. Cell Stem Cell. 2014;14(5): 561-574.
    • (2014) Cell Stem Cell , vol.14 , Issue.5 , pp. 561-574
    • Miyajima, A.1    Tanaka, M.2    Itoh, T.3
  • 46
    • 78049513759 scopus 로고    scopus 로고
    • Age dependence of oval cell responses and bile duct carcinomas in male fischer 344 rats fed a cyclic choline-deficient, ethionine-supplemented diet
    • Guest I, Ilic Z, Sell S. Age dependence of oval cell responses and bile duct carcinomas in male fischer 344 rats fed a cyclic choline-deficient, ethionine-supplemented diet. Hepatology. 2010;52(5): 1750-1757.
    • (2010) Hepatology , vol.52 , Issue.5 , pp. 1750-1757
    • Guest, I.1    Ilic, Z.2    Sell, S.3
  • 47
    • 84888102117 scopus 로고    scopus 로고
    • Hepatic biliary epithelial cells acquire epithelial integrity but lose plasticity to differentiate into hepatocytes in vitro during development
    • Tanimizu N, Nakamura Y, Ichinohe N, Mizuguchi T, Hirata K, Mitaka T. Hepatic biliary epithelial cells acquire epithelial integrity but lose plasticity to differentiate into hepatocytes in vitro during development. J Cell Sci. 2013; 126(pt 22): 5239-5246.
    • (2013) J Cell Sci , vol.126 , pp. 5239-5246
    • Tanimizu, N.1    Nakamura, Y.2    Ichinohe, N.3    Mizuguchi, T.4    Hirata, K.5    Mitaka, T.6
  • 48
    • 84879174086 scopus 로고    scopus 로고
    • Notch signaling regulates tubular morphogenesis during repair from biliary damage in mice
    • Fiorotto R, et al. Notch signaling regulates tubular morphogenesis during repair from biliary damage in mice. J Hepatol. 2013;59(1): 124-130.
    • (2013) J Hepatol , vol.59 , Issue.1 , pp. 124-130
    • Fiorotto, R.1
  • 49
    • 84894291020 scopus 로고    scopus 로고
    • Regeneration of liver after extreme hepatocyte loss occurs mainly via biliary transdifferentiation in zebrafish
    • He J, Lu H, Zou Q, Luo L. Regeneration of liver after extreme hepatocyte loss occurs mainly via biliary transdifferentiation in zebrafish. Gastroenterology. 2014;146(3): 789-800.e8.
    • (2014) Gastroenterology , vol.146 , Issue.3 , pp. 789-800e8
    • He, J.1    Lu, H.2    Zou, Q.3    Luo, L.4
  • 50
    • 84894330173 scopus 로고    scopus 로고
    • Extensive conversion of hepatic biliary epithelial cells to hepatocytes after near total loss of hepatocytes in zebrafish
    • Choi TY, Ninov N, Stainier DY, Shin D. Extensive conversion of hepatic biliary epithelial cells to hepatocytes after near total loss of hepatocytes in zebrafish. Gastroenterology. 2014;146(3): 776-788.
    • (2014) Gastroenterology , vol.146 , Issue.3 , pp. 776-788
    • Choi, T.Y.1    Ninov, N.2    Stainier, D.Y.3    Shin, D.4
  • 51
    • 84876737263 scopus 로고    scopus 로고
    • Aneuploidy, polyploidy and ploidy reversal in the liver
    • Duncan AW. Aneuploidy, polyploidy and ploidy reversal in the liver. Semin Cell Dev Biol. 2013;24(4): 347-356.
    • (2013) Semin Cell Dev Biol , vol.24 , Issue.4 , pp. 347-356
    • Duncan, A.W.1
  • 52
    • 84879494430 scopus 로고    scopus 로고
    • Low hepatocyte repopulation from stem cells: A matter of hepatobiliary linkage not massive production
    • Theise ND, Dolle L, Kuwahara R. Low hepatocyte repopulation from stem cells: A matter of hepatobiliary linkage not massive production. Gastroenterology. 2013;145(1): 253-254.
    • (2013) Gastroenterology , vol.145 , Issue.1 , pp. 253-254
    • Theise, N.D.1    Dolle, L.2    Kuwahara, R.3
  • 53
    • 84920989984 scopus 로고    scopus 로고
    • Long-term culture of genomestable bipotent stem cells from adult human liver
    • Huch M, et al. Long-term culture of genomestable bipotent stem cells from adult human liver. Cell. 2015;160(1-2): 299-212.
    • (2015) Cell , vol.160 , Issue.1-2 , pp. 299-212
    • Huch, M.1
  • 54
    • 71649092364 scopus 로고    scopus 로고
    • Pancreatic exocrine duct cells give rise to insulin-producing β cells during embryogenesis but not after birth
    • Solar M, et al. Pancreatic exocrine duct cells give rise to insulin-producing β cells during embryogenesis but not after birth. Dev Cell. 2009;17(6): 849-860.
    • (2009) Dev Cell , vol.17 , Issue.6 , pp. 849-860
    • Solar, M.1
  • 55
    • 52449122255 scopus 로고    scopus 로고
    • Conditional ablation of Notch signaling in pancreatic development
    • Nakhai H, et al. Conditional ablation of Notch signaling in pancreatic development. Develop- ment. 2008;135(16): 2757-2765.
    • (2008) Develop- ment , vol.135 , Issue.16 , pp. 2757-2765
    • Nakhai, H.1
  • 56
    • 0033230616 scopus 로고    scopus 로고
    • Intestinal polyposis in mice with a dominant stable mutation of the β-catenin gene
    • Harada N, et al. Intestinal polyposis in mice with a dominant stable mutation of the β-catenin gene. EMBO J. 1999;18(21): 5931-5942.
    • (1999) EMBO J , vol.18 , Issue.21 , pp. 5931-5942
    • Harada, N.1
  • 57
    • 0027363563 scopus 로고
    • Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease
    • Smit JJ, et al. Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease. Cell. 1993;75(3): 451-462.
    • (1993) Cell , vol.75 , Issue.3 , pp. 451-462
    • Smit, J.J.1
  • 59
    • 0022831014 scopus 로고
    • Liver tumour promotion by chemicals: Models and mechanisms
    • Sarma DS, Rao PM, Rajalakshmi S. Liver tumour promotion by chemicals: Models and mechanisms. Cancer Surv. 1986;5(4): 781-798.
    • (1986) Cancer Surv , vol.5 , Issue.4 , pp. 781-798
    • Sarma, D.S.1    Rao, P.M.2    Rajalakshmi, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.