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Volumn 5, Issue , 2014, Pages

Optical control of insulin release using a photoswitchable sulfonylurea

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; INSULIN; JB 253; SULFONYLUREA; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT; SULFONYLUREA DERIVATIVE;

EID: 84925348891     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms6116     Document Type: Article
Times cited : (104)

References (60)
  • 1
    • 68449094325 scopus 로고    scopus 로고
    • The influence of glucose-lowering therapies on cancer risk in type 2 diabetes
    • Currie, C. J., Poole, C. D. & Gale, E. A. The influence of glucose-lowering therapies on cancer risk in type 2 diabetes. Diabetologia 52, 1766-1777 (2009).
    • (2009) Diabetologia , vol.52 , pp. 1766-1777
    • Currie, C.J.1    Poole, C.D.2    Gale, E.A.3
  • 2
    • 77958124842 scopus 로고    scopus 로고
    • AGEs and diabetic retinopathy
    • Stitt, A. W. AGEs and diabetic retinopathy. Invest. Ophthalmol. Vis. Sci. 51, 4867-4874 (2010).
    • (2010) Invest. Ophthalmol. Vis. Sci. , vol.51 , pp. 4867-4874
    • Stitt, A.W.1
  • 3
    • 33745863033 scopus 로고    scopus 로고
    • Islet beta cell failure in type 2 diabetes
    • Prentki, M. & Nolan, C. J. Islet beta cell failure in type 2 diabetes. J. Clin. Invest. 116, 1802-1812 (2006).
    • (2006) J. Clin. Invest. , vol.116 , pp. 1802-1812
    • Prentki, M.1    Nolan, C.J.2
  • 4
    • 0032983666 scopus 로고    scopus 로고
    • Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: Progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group
    • Turner, R. C., Cull, C. A., Frighi, V. & Holman, R. R. Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group. JAMA 281, 2005-2012 (1999).
    • (1999) JAMA , vol.281 , pp. 2005-2012
    • Turner, R.C.1    Cull, C.A.2    Frighi, V.3    Holman, R.R.4
  • 5
    • 0037850667 scopus 로고    scopus 로고
    • Effect on glycemic control of exenatide (synthetic exendin-4) additive to existing metformin and/or sulfonylurea treatment in patients with type 2 diabetes
    • Fineman, M. S. et al. Effect on glycemic control of exenatide (synthetic exendin-4) additive to existing metformin and/or sulfonylurea treatment in patients with type 2 diabetes. Diabetes Care 26, 2370-2377 (2003).
    • (2003) Diabetes Care , vol.26 , pp. 2370-2377
    • Fineman, M.S.1
  • 6
    • 84866268783 scopus 로고    scopus 로고
    • Management of hyperglycemia in type 2 diabetes: A patient-centered approach: Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
    • Inzucchi, S. E. et al. Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care 35, 1364-1379 (2012).
    • (2012) Diabetes Care , vol.35 , pp. 1364-1379
    • Inzucchi, S.E.1
  • 7
    • 0032124812 scopus 로고    scopus 로고
    • Correlating structure and function in ATP-sensitive K+ channels
    • Ashcroft, F. M. & Gribble, F. M. Correlating structure and function in ATP-sensitive K+ channels. Trends Neurosci. 21, 288-294 (1998).
    • (1998) Trends Neurosci. , vol.21 , pp. 288-294
    • Ashcroft, F.M.1    Gribble, F.M.2
  • 8
    • 0031917466 scopus 로고    scopus 로고
    • Toward understanding the assembly and structure of KATP channels
    • Aguilar-Bryan, L. et al. Toward understanding the assembly and structure of KATP channels. Physiol. Rev. 78, 227-245 (1998).
    • (1998) Physiol. Rev. , vol.78 , pp. 227-245
    • Aguilar-Bryan, L.1
  • 9
    • 0032933339 scopus 로고    scopus 로고
    • The structure and function of the ATP-sensitive K+ channel in insulin-secreting pancreatic beta-cells
    • Miki, T., Nagashima, K. & Seino, S. The structure and function of the ATP-sensitive K+ channel in insulin-secreting pancreatic beta-cells. J. Mol. Endocrinol. 22, 113-123 (1999).
    • (1999) J. Mol. Endocrinol. , vol.22 , pp. 113-123
    • Miki, T.1    Nagashima, K.2    Seino, S.3
  • 10
    • 0032787462 scopus 로고    scopus 로고
    • ATP-sensitive K+ channels and insulin secretion: Their role in health and disease
    • Ashcroft, F. M. & Gribble, F. M. ATP-sensitive K+ channels and insulin secretion: their role in health and disease. Diabetologia 42, 903-919 (1999).
    • (1999) Diabetologia , vol.42 , pp. 903-919
    • Ashcroft, F.M.1    Gribble, F.M.2
  • 11
    • 0037306308 scopus 로고    scopus 로고
    • Physiological and pathophysiological roles of ATP-sensitive K+ channels
    • Seino, S. & Miki, T. Physiological and pathophysiological roles of ATP-sensitive K+ channels. Prog. Biophys. Mol. Biol. 81, 133-176 (2003).
    • (2003) Prog. Biophys. Mol. Biol. , vol.81 , pp. 133-176
    • Seino, S.1    Miki, T.2
  • 12
    • 0035570732 scopus 로고    scopus 로고
    • Nutrient-secretion coupling in the pancreatic islet beta-cell: Recent advances
    • Rutter, G. A. Nutrient-secretion coupling in the pancreatic islet beta-cell: recent advances. Mol. Aspects Med. 22, 247-284 (2001).
    • (2001) Mol. Aspects Med. , vol.22 , pp. 247-284
    • Rutter, G.A.1
  • 13
    • 84858288206 scopus 로고    scopus 로고
    • Regulation of calcium in pancreatic alpha- and beta-cells in health and disease
    • Rorsman, P., Braun, M. & Zhang, Q. Regulation of calcium in pancreatic alpha- and beta-cells in health and disease. Cell Calcium 51, 300-308 (2012).
    • (2012) Cell Calcium , vol.51 , pp. 300-308
    • Rorsman, P.1    Braun, M.2    Zhang, Q.3
  • 14
    • 64149126546 scopus 로고    scopus 로고
    • Regulation of insulin secretion: A matter of phase control and amplitude modulation
    • Henquin, J. C. Regulation of insulin secretion: a matter of phase control and amplitude modulation. Diabetologia 52, 739-751 (2009).
    • (2009) Diabetologia , vol.52 , pp. 739-751
    • Henquin, J.C.1
  • 15
    • 0037380131 scopus 로고    scopus 로고
    • Multiple forms of 'kiss-and-run' exocytosis revealed by evanescent wave microscopy
    • Tsuboi, T. & Rutter, G. A. Multiple forms of 'kiss-and-run' exocytosis revealed by evanescent wave microscopy. Curr. Biol. 13, 563-567 (2003).
    • (2003) Curr. Biol. , vol.13 , pp. 563-567
    • Tsuboi, T.1    Rutter, G.A.2
  • 16
    • 0028904053 scopus 로고
    • Insulin action and the insulin signaling network
    • Cheatham, B. & Kahn, C. R. Insulin action and the insulin signaling network. Endocr. Rev. 16, 117-142 (1995).
    • (1995) Endocr. Rev. , vol.16 , pp. 117-142
    • Cheatham, B.1    Kahn, C.R.2
  • 17
    • 0024515411 scopus 로고
    • Symptomatic hypoglycemia in NIDDM patients treated with oral hypoglycemic agents
    • Jennings, A. M., Wilson, R. M. & Ward, J. D. Symptomatic hypoglycemia in NIDDM patients treated with oral hypoglycemic agents. Diabetes Care 12, 203-208 (1989).
    • (1989) Diabetes Care , vol.12 , pp. 203-208
    • Jennings, A.M.1    Wilson, R.M.2    Ward, J.D.3
  • 18
    • 33646422782 scopus 로고    scopus 로고
    • Risk of mortality and adverse cardiovascular outcomes in type 2 diabetes: A comparison of patients treated with sulfonylureas and metformin
    • Evans, J. M., Ogston, S. A., Emslie-Smith, A. & Morris, A. D. Risk of mortality and adverse cardiovascular outcomes in type 2 diabetes: a comparison of patients treated with sulfonylureas and metformin. Diabetologia 49, 930-936 (2006).
    • (2006) Diabetologia , vol.49 , pp. 930-936
    • Evans, J.M.1    Ogston, S.A.2    Emslie-Smith, A.3    Morris, A.D.4
  • 19
    • 33746588255 scopus 로고    scopus 로고
    • Management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes
    • Nathan, D. M. et al. Management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 29, 1963-1972 (2006).
    • (2006) Diabetes Care , vol.29 , pp. 1963-1972
    • Nathan, D.M.1
  • 20
    • 77950524984 scopus 로고    scopus 로고
    • Neuronal regulation of homeostasis by nutrient sensing
    • Lam, T. K. Neuronal regulation of homeostasis by nutrient sensing. Nat. Med. 16, 392-395 (2010).
    • (2010) Nat. Med. , vol.16 , pp. 392-395
    • Lam, T.K.1
  • 21
    • 0035853122 scopus 로고    scopus 로고
    • Mice transgenically overexpressing sulfonylurea receptor 1 in forebrain resist seizure induction and excitotoxic neuron death
    • Hernandez-Sanchez, C. et al. Mice transgenically overexpressing sulfonylurea receptor 1 in forebrain resist seizure induction and excitotoxic neuron death. Proc. Natl Acad. Sci. USA 98, 3549-3554 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 3549-3554
    • Hernandez-Sanchez, C.1
  • 22
    • 0029662012 scopus 로고    scopus 로고
    • Sulfonylurea KATP blockade in type II diabetes and preconditioning in cardiovascular disease. Time for reconsideration
    • Engler, R. L. & Yellon, D. M. Sulfonylurea KATP blockade in type II diabetes and preconditioning in cardiovascular disease. Time for reconsideration. Circulation 94, 2297-2301 (1996).
    • (1996) Circulation , vol.94 , pp. 2297-2301
    • Engler, R.L.1    Yellon, D.M.2
  • 23
    • 0030772859 scopus 로고    scopus 로고
    • ATP-sensitive and inwardly rectifying potassium channels in smooth muscle
    • Quayle, J. M., Nelson, M. T. & Standen, N. B. ATP-sensitive and inwardly rectifying potassium channels in smooth muscle. Physiol. Rev. 77, 1165-1232 (1997).
    • (1997) Physiol. Rev. , vol.77 , pp. 1165-1232
    • Quayle, J.M.1    Nelson, M.T.2    Standen, N.B.3
  • 24
    • 41449113929 scopus 로고    scopus 로고
    • Photochemical control of endogenous ion channels and cellular excitability
    • Fortin, D. L. et al. Photochemical control of endogenous ion channels and cellular excitability. Nat. Methods 5, 331-338 (2008).
    • (2008) Nat. Methods , vol.5 , pp. 331-338
    • Fortin, D.L.1
  • 26
    • 0032542255 scopus 로고    scopus 로고
    • Repaglinide and related hypoglycemic benzoic acid derivatives
    • Grell, W. et al. Repaglinide and related hypoglycemic benzoic acid derivatives. J. Med. Chem. 41, 5219-5246 (1998).
    • (1998) J. Med. Chem. , vol.41 , pp. 5219-5246
    • Grell, W.1
  • 27
    • 84886737102 scopus 로고    scopus 로고
    • Antidiabetic sulfonylureas and cAMP cooperatively activate Epac2A
    • Takahashi, T. et al. Antidiabetic sulfonylureas and cAMP cooperatively activate Epac2A. Sci. Signal 6, ra94 (2013).
    • (2013) Sci. Signal , vol.6 , pp. ra94
    • Takahashi, T.1
  • 28
    • 68149136367 scopus 로고    scopus 로고
    • The cAMP sensor Epac2 is a direct target of antidiabetic sulfonylurea drugs
    • Zhang, C. L. et al. The cAMP sensor Epac2 is a direct target of antidiabetic sulfonylurea drugs. Science 325, 607-610 (2009).
    • (2009) Science , vol.325 , pp. 607-610
    • Zhang, C.L.1
  • 29
    • 79951816217 scopus 로고    scopus 로고
    • Direct activation of Epac by sulfonylurea is isoform selective
    • Herbst, K. J., Coltharp, C., Amzel, L. M. & Zhang, J. Direct activation of Epac by sulfonylurea is isoform selective. Chem. Biol. 18, 243-251 (2011).
    • (2011) Chem. Biol. , vol.18 , pp. 243-251
    • Herbst, K.J.1    Coltharp, C.2    Amzel, L.M.3    Zhang, J.4
  • 30
    • 84885047941 scopus 로고    scopus 로고
    • Lipotoxicity disrupts incretin-regulated human beta cell connectivity
    • Hodson, D. J. et al. Lipotoxicity disrupts incretin-regulated human beta cell connectivity. J. Clin. Invest. 123, 4182-4194 (2013).
    • (2013) J. Clin. Invest. , vol.123 , pp. 4182-4194
    • Hodson, D.J.1
  • 31
    • 84888371075 scopus 로고    scopus 로고
    • Minireview: Intraislet regulation of insulin secretion in humans
    • Rutter, G. A. & Hodson, D. J. Minireview: intraislet regulation of insulin secretion in humans. Mol. Endocrinol. 27, 1984-1995 (2013).
    • (2013) Mol. Endocrinol. , vol.27 , pp. 1984-1995
    • Rutter, G.A.1    Hodson, D.J.2
  • 32
    • 0033499813 scopus 로고    scopus 로고
    • Different effects of tolbutamide and diazoxide in alpha, beta-, and delta-cells within intact islets of Langerhans
    • Quesada, I., Nadal, A. & Soria, B. Different effects of tolbutamide and diazoxide in alpha, beta-, and delta-cells within intact islets of Langerhans. Diabetes 48, 2390-2397 (1999).
    • (1999) Diabetes , vol.48 , pp. 2390-2397
    • Quesada, I.1    Nadal, A.2    Soria, B.3
  • 33
    • 0025869913 scopus 로고
    • Widespread synchronous [Ca2+ ]i oscillations due to bursting electrical activity in single pancreatic islets
    • Santos, R. M. et al. Widespread synchronous [Ca2+ ]i oscillations due to bursting electrical activity in single pancreatic islets. Pflugers Arch. 418, 417-422 (1991).
    • (1991) Pflugers Arch. , vol.418 , pp. 417-422
    • Santos, R.M.1
  • 34
    • 84863197999 scopus 로고    scopus 로고
    • Connexin-36 gap junctions regulate in vivo first- and second-phase insulin secretion dynamics and glucose tolerance in the conscious mouse
    • Head, W. S. et al. Connexin-36 gap junctions regulate in vivo first- and second-phase insulin secretion dynamics and glucose tolerance in the conscious mouse. Diabetes 61, 1700-1707 (2012).
    • (2012) Diabetes , vol.61 , pp. 1700-1707
    • Head, W.S.1
  • 35
    • 0034957915 scopus 로고    scopus 로고
    • Tolbutamide stimulation of pancreatic beta-cells involves both cell recruitment and increase in the individual Ca(2+) response
    • Jonkers, F. C., Guiot, Y., Rahier, J. & Henquin, J. C. Tolbutamide stimulation of pancreatic beta-cells involves both cell recruitment and increase in the individual Ca(2+) response. Br. J. Pharmacol. 133, 575-585 (2001).
    • (2001) Br. J. Pharmacol. , vol.133 , pp. 575-585
    • Jonkers, F.C.1    Guiot, Y.2    Rahier, J.3    Henquin, J.C.4
  • 36
    • 54249091226 scopus 로고    scopus 로고
    • Optical switches for remote and noninvasive control of cell signaling
    • Gorostiza, P. & Isacoff, E. Y. Optical switches for remote and noninvasive control of cell signaling. Science 322, 395-399 (2008).
    • (2008) Science , vol.322 , pp. 395-399
    • Gorostiza, P.1    Isacoff, E.Y.2
  • 37
    • 84894129042 scopus 로고    scopus 로고
    • Photopharmacology: Beyond proof of principle
    • Velema, W. A., Szymanski, W. & Feringa, B. L. Photopharmacology: beyond proof of principle. J. Am. Chem. Soc. 136, 2178-2191 (2014).
    • (2014) J. Am. Chem. Soc. , vol.136 , pp. 2178-2191
    • Velema, W.A.1    Szymanski, W.2    Feringa, B.L.3
  • 38
    • 84867569847 scopus 로고    scopus 로고
    • Azo-propofols: Photochromic potentiators of GABA(A) receptors
    • Stein, M. et al. Azo-propofols: photochromic potentiators of GABA(A) receptors. Angew. Chem. Int. Ed. 51, 10500-10504 (2012).
    • (2012) Angew. Chem. Int. Ed. , vol.51 , pp. 10500-10504
    • Stein, M.1
  • 39
    • 84856406430 scopus 로고    scopus 로고
    • Optochemical control of genetically engineered neuronal nicotinic acetylcholine receptors
    • Tochitsky, I. et al. Optochemical control of genetically engineered neuronal nicotinic acetylcholine receptors. Nat. Chem. 4, 105-111 (2012).
    • (2012) Nat. Chem. , vol.4 , pp. 105-111
    • Tochitsky, I.1
  • 40
    • 84862794890 scopus 로고    scopus 로고
    • Rapid optical control of nociception with an ion-channel photoswitch
    • Mourot, A. et al. Rapid optical control of nociception with an ion-channel photoswitch. Nat. Methods 9, 396-402 (2012).
    • (2012) Nat. Methods , vol.9 , pp. 396-402
    • Mourot, A.1
  • 41
    • 84890834989 scopus 로고    scopus 로고
    • Optical control of an ion channel gate
    • Lemoine, D. et al. Optical control of an ion channel gate. Proc. Natl Acad. Sci. USA 110, 20813-20818 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 20813-20818
    • Lemoine, D.1
  • 42
    • 84887654062 scopus 로고    scopus 로고
    • Optical control of antibacterial activity
    • Velema, W. A. et al. Optical control of antibacterial activity. Nat. Chem. 5, 924-928 (2013).
    • (2013) Nat. Chem. , vol.5 , pp. 924-928
    • Velema, W.A.1
  • 44
    • 0036894342 scopus 로고    scopus 로고
    • Sulfonylurea stimulation of insulin secretion
    • Proks, P., Reimann, F., Green, N., Gribble, F. & Ashcroft, F. Sulfonylurea stimulation of insulin secretion. Diabetes 51(Suppl 3): S368-S376 (2002).
    • (2002) Diabetes , vol.51 , pp. S368-S376
    • Proks, P.1    Reimann, F.2    Green, N.3    Gribble, F.4    Ashcroft, F.5
  • 46
    • 84901913372 scopus 로고    scopus 로고
    • Optogenetic control of insulin secretion in intact pancreatic islets with beta-cell- specific expression of Channelrhodopsin-2
    • Reinbothe, T. M., Safi, F., Axelsson, A. S., Mollet, I. G. & Rosengren, A. H. Optogenetic control of insulin secretion in intact pancreatic islets with beta-cell- specific expression of Channelrhodopsin-2. Islets 6 (2014).
    • (2014) Islets , vol.6
    • Reinbothe, T.M.1    Safi, F.2    Axelsson, A.S.3    Mollet, I.G.4    Rosengren, A.H.5
  • 47
    • 79959514813 scopus 로고    scopus 로고
    • A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice
    • Ye, H., Daoud-El Baba, M., Peng, R. W. & Fussenegger, M. A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice. Science 332, 1565-1568 (2011).
    • (2011) Science , vol.332 , pp. 1565-1568
    • Ye, H.1    Daoud-El Baba, M.2    Peng, R.W.3    Fussenegger, M.4
  • 48
    • 75149182370 scopus 로고    scopus 로고
    • GLP-1-based therapy for diabetes: What you do not know can hurt you
    • Butler, P. C., Dry, S. & Elashoff, R. GLP-1-based therapy for diabetes: what you do not know can hurt you. Diabetes Care 33, 453-455 (2010).
    • (2010) Diabetes Care , vol.33 , pp. 453-455
    • Butler, P.C.1    Dry, S.2    Elashoff, R.3
  • 49
    • 84891821223 scopus 로고    scopus 로고
    • Do GLP-1-based therapies increase cancer risk?
    • Nauck, M. A. & Friedrich, N. Do GLP-1-based therapies increase cancer risk? Diabetes Care 36(Suppl 2): S245-S252 (2013).
    • (2013) Diabetes Care , vol.36 , pp. S245-S252
    • Nauck, M.A.1    Friedrich, N.2
  • 50
    • 84889260345 scopus 로고    scopus 로고
    • A closed-loop synthetic gene circuit for the treatment of diet-induced obesity in mice
    • Rossger, K., Charpin-El-Hamri, G. & Fussenegger, M. A closed-loop synthetic gene circuit for the treatment of diet-induced obesity in mice. Nat. Commun. 4, 2825 (2013).
    • (2013) Nat. Commun. , vol.4 , pp. 2825
    • Rossger, K.1    Charpin-El-Hamri, G.2    Fussenegger, M.3
  • 52
    • 78650902662 scopus 로고    scopus 로고
    • Optogenetics
    • Deisseroth, K. Optogenetics. Nat. Methods 8, 26-29 (2011).
    • (2011) Nat. Methods , vol.8 , pp. 26-29
    • Deisseroth, K.1
  • 53
    • 79751531412 scopus 로고    scopus 로고
    • Time-lapse imaging of disease progression in deep brain areas using fluorescence microendoscopy
    • Barretto, R. P. et al. Time-lapse imaging of disease progression in deep brain areas using fluorescence microendoscopy. Nat. Med. 17, 223-228 (2011).
    • (2011) Nat. Med. , vol.17 , pp. 223-228
    • Barretto, R.P.1
  • 54
    • 84876310253 scopus 로고    scopus 로고
    • Injectable, cellular-scale optoelectronics with applications for wireless optogenetics
    • Kim, T. I. et al. Injectable, cellular-scale optoelectronics with applications for wireless optogenetics. Science 340, 211-216 (2013).
    • (2013) Science , vol.340 , pp. 211-216
    • Kim, T.I.1
  • 55
    • 79957900616 scopus 로고    scopus 로고
    • Dynamics of insulin secretion and the clinical implications for obesity and diabetes
    • Seino, S., Shibasaki, T. & Minami, K. Dynamics of insulin secretion and the clinical implications for obesity and diabetes. J. Clin. Invest. 121, 2118-2125 (2011).
    • (2011) J. Clin. Invest. , vol.121 , pp. 2118-2125
    • Seino, S.1    Shibasaki, T.2    Minami, K.3
  • 56
    • 17844379717 scopus 로고    scopus 로고
    • Hypothalamic K(ATP) channels control hepatic glucose production
    • Pocai, A. et al. Hypothalamic K(ATP) channels control hepatic glucose production. Nature 434, 1026-1031 (2005).
    • (2005) Nature , vol.434 , pp. 1026-1031
    • Pocai, A.1
  • 57
    • 84872287315 scopus 로고    scopus 로고
    • Rapid determination of ionization constants (pK a) by UV spectroscopy using 96-well microtiter plates
    • Martinez, C. H. & Dardonville, C. Rapid determination of ionization constants (pK a) by UV spectroscopy using 96-well microtiter plates. ACS Med. Chem. Lett. 4, 142-145 (2013).
    • (2013) ACS Med. Chem. Lett. , vol.4 , pp. 142-145
    • Martinez, C.H.1    Dardonville, C.2
  • 58
    • 0242560405 scopus 로고    scopus 로고
    • SIR97: A new tool for crystal structure determination and refinement
    • Altomare, A. et al. SIR97: a new tool for crystal structure determination and refinement. J. Appl. Crystallogr. 32, 115-119 (1999).
    • (1999) J. Appl. Crystallogr. , vol.32 , pp. 115-119
    • Altomare, A.1
  • 60
    • 84906672321 scopus 로고    scopus 로고
    • ADCY5 couples glucose to insulin secretion in human islets
    • Hodson, D. J. et al. ADCY5 couples glucose to insulin secretion in human islets. Diabetes 63, 3009-3021 (2014).
    • (2014) Diabetes , vol.63 , pp. 3009-3021
    • Hodson, D.J.1


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