Unmasking stemspecific neutralizing epitopes by abolishing N-linked glycosylation sites of influenza virus hemagglutinin proteins for vaccine design

Journal of Virology

Volumn 90, Issue 19, 2016, Pages 8496-8508

  Liu, Wen Chun ^a   Jan, Jia Tsrong ^b   Huang, Yun Ju ^a   Chen, Ting Hsuan ^a   Wu, Suh Chin ^a  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b GENOMICS RESEARCH CENTER   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; INFLUENZA VIRUS HEMAGGLUTININ; INFLUENZA VACCINE; NEUTRALIZING ANTIBODY; RECOMBINANT PROTEIN; RECOMBINANT VACCINE; VIRUS ANTIBODY;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ANTIBODY TITER; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GLYCOSYLATION; INFLUENZA VIRUS; MOUSE; NONHUMAN; OPTICAL DENSITY; PRIORITY JOURNAL; PROTEIN DEPLETION; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; SURVIVAL RATE; VIRUS NEUTRALIZATION; VIRUS STRAIN; ANIMAL; BAGG ALBINO MOUSE; BLOOD; CHEMISTRY; DISEASE MODEL; DRUG DESIGN; GENETICS; IMMUNOLOGY; INFLUENZA A VIRUS (H1N1); INFLUENZA A VIRUS (H5N1); ORTHOMYXOVIRIDAE INFECTIONS; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; DISEASE MODELS, ANIMAL; DRUG DESIGN; EPITOPES; GLYCOSYLATION; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA VACCINES; MICE, INBRED BALB C; ORTHOMYXOVIRIDAE INFECTIONS; RECOMBINANT PROTEINS; SURVIVAL ANALYSIS; TREATMENT OUTCOME; VACCINES, SYNTHETIC;

EID: 84990225283     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00880-16     Document Type: Article

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