Glycosylations in the globular head of the hemagglutinin protein modulate the virulence and antigenic properties of the H1N1 influenza viruses

Science Translational Medicine

Volumn 5, Issue 187, 2013, Pages

  Medina, Rafael A ^a,b   Stertz, Silke ^a,c   Manicassamy, Balaji ^a,d   Zimmermann, Petra ^c   Sun, Xiangjie ^e   Albrecht, Randy A ^a   Uusi Kerttula, Hanni ^b   Zagordi, Osvaldo ^c   Belshe, Robert B ^f   Frey, Sharon E ^f   Tumpey, Terrence M ^e   García Sastre, Adolfo ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^c UNIVERSITY OF ZURICH   (Switzerland)

^d UNIVERSITY OF CHICAGO   (United States)

^e NATIONAL CENTER FOR IMMUNIZATION AND RESPIRATORY DISEASES   (United States)

^f SAINT LOUIS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEMAGGLUTININ; POLYCLONAL ANTIBODY;

2009 H1N1 INFLUENZA; ADULT; AGED; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ANTIGENIC VARIATION; ANTIGENICITY; ARTICLE; CONTROLLED STUDY; FEMALE; FERRET; GLYCOSYLATION; HUMAN; IMMUNE RESPONSE; INFLUENZA A (H1N1); INFLUENZA A (H3N2); INFLUENZA VIRUS A H1N1; MOUSE; MUTATIONAL ANALYSIS; NETHERLANDS; NONHUMAN; NUCLEOTIDE SEQUENCE; PANDEMIC INFLUENZA; PATHOGENICITY; PRIORITY JOURNAL; SEASONAL INFLUENZA; UNINDEXED SEQUENCE; VIRUS STRAIN; VIRUS VIRULENCE; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, VIRAL; GLYCOSYLATION; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; SEQUENCE HOMOLOGY, AMINO ACID; VIRULENCE;

EID: 84880558705     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3005996     Document Type: Article

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