Cryo-electron microscopy reconstruction and stability studies of the wild type and the R432A variant of adeno-associated virus type 2 reveal that capsid structural stability is a major factor in genome packaging

Journal of Virology

Volumn 90, Issue 19, 2016, Pages 8542-8551

  Drouin, Lauren M ^a   Lins, Bridget ^a   Janssen, Maria ^b   Bennett, Antonette ^a   Chipman, Paul ^a   McKenna, Robert ^a   Chen, Weijun ^a   Muzyczka, Nicholas ^a   Cardone, Giovanni ^b   Baker, Timothy S ^b   Agbandje McKenna, Mavis ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENO ASSOCIATED VIRUS 2; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; CRYOELECTRON MICROSCOPY; DIFFERENTIAL SCANNING CALORIMETRY; DNA FRAGMENTATION; HYDROGEN BOND; IMAGE RECONSTRUCTION; MORPHOLOGY; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN STABILITY; THERMOSTABILITY; VIRUS CAPSID; VIRUS GENOME; VIRUS REPLICATION; CHEMISTRY; DEPENDOPARVOVIRUS; GENETICS; METABOLISM; MOLECULAR MODEL; PHYSIOLOGY; PROTEIN ANALYSIS; RADIATION RESPONSE; THREE DIMENSIONAL IMAGING; ULTRASTRUCTURE; VIRION; VIRUS ASSEMBLY;

CAPSID PROTEIN; MUTANT PROTEIN; PROTEIN BINDING;

CAPSID PROTEINS; CRYOELECTRON MICROSCOPY; DEPENDOVIRUS; IMAGING, THREE-DIMENSIONAL; MODELS, MOLECULAR; MUTANT PROTEINS; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; VIRION; VIRUS ASSEMBLY;

EID: 84990214291     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00575-16     Document Type: Article

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