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Volumn 85, Issue 22, 2011, Pages 11791-11799

Structural studies of adeno-associated virus serotype 8 capsid transitions associated with endosomal trafficking

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; GREEN FLUORESCENT PROTEIN; MONOMER; PHOSPHOLIPASE A2;

EID: 80655142508     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.05305-11     Document Type: Article
Times cited : (81)

References (53)
  • 1
    • 33748945422 scopus 로고    scopus 로고
    • The 37/67-kilodalton laminin receptor is a receptor for adeno-associated virus serotypes 8, 2, 3, and 9
    • Akache, B., et al. 2006. The 37/67-kilodalton laminin receptor is a receptor for adeno-associated virus serotypes 8, 2, 3, and 9. J. Virol. 80:9831-9836.
    • (2006) J. Virol. , vol.80 , pp. 9831-9836
    • Akache, B.1
  • 2
    • 33846324384 scopus 로고    scopus 로고
    • A two-hybrid screen identifies cathepsins B and L as uncoating factors for adeno-associated virus 2 and 8
    • Akache, B., et al. 2007. A two-hybrid screen identifies cathepsins B and L as uncoating factors for adeno-associated virus 2 and 8. Mol. Ther. 15:330-339.
    • (2007) Mol. Ther. , vol.15 , pp. 330-339
    • Akache, B.1
  • 3
    • 0033998692 scopus 로고    scopus 로고
    • Infectious entry pathway of adeno-associated virus and adeno-associated virus vectors
    • Bartlett, J. S., R. Wilcher, and R. J. Samulski. 2000. Infectious entry pathway of adeno-associated virus and adeno-associated virus vectors. J. Virol. 74: 2777-2785.
    • (2000) J. Virol. , vol.74 , pp. 2777-2785
    • Bartlett, J.S.1    Wilcher, R.2    Samulski, R.J.3
  • 4
    • 0042028511 scopus 로고    scopus 로고
    • Geometry of interaction of the histidine ring with other planar and basic residues
    • Bhattacharyya, R., R. P. Saha, U. Samanta, and P. Chakrabarti. 2003. Geometry of interaction of the histidine ring with other planar and basic residues. J. Proteome Res. 2:255-263.
    • (2003) J. Proteome Res. , vol.2 , pp. 255-263
    • Bhattacharyya, R.1    Saha, R.P.2    Samanta, U.3    Chakrabarti, P.4
  • 5
    • 13444310872 scopus 로고    scopus 로고
    • Mutational analysis of narrow pores at the fivefold symmetry axes of adeno-associated virus type 2 capsids reveals a dual role in genome packaging and activation of phospholipase A2 activity
    • Bleker, S., F. Sonntag, and J. A. Kleinschmidt. 2005. Mutational analysis of narrow pores at the fivefold symmetry axes of adeno-associated virus type 2 capsids reveals a dual role in genome packaging and activation of phospholipase A2 activity. J. Virol. 79:2528-2540.
    • (2005) J. Virol. , vol.79 , pp. 2528-2540
    • Bleker, S.1    Sonntag, F.2    Kleinschmidt, J.A.3
  • 6
    • 3543012707 scopus 로고    scopus 로고
    • Crystallography & NMR System: a new software suite for macromolecular structure determination
    • Brunger, A. T., et al. 1998. Crystallography & NMR System: a new software suite for macromolecular structure determination. Acta Crystallogr. D Biol. Crystallogr. 54:905-921.
    • (1998) Acta Crystallogr. D Biol. Crystallogr. , vol.54 , pp. 905-921
    • Brunger, A.T.1
  • 7
    • 19644368252 scopus 로고    scopus 로고
    • Adeno-associated virus vectors in clinical trials
    • Carter, B. J. 2005. Adeno-associated virus vectors in clinical trials. Hum. Gene Ther. 16:541-550.
    • (2005) Hum. Gene Ther. , vol.16 , pp. 541-550
    • Carter, B.J.1
  • 8
    • 0032577550 scopus 로고    scopus 로고
    • HIV entry and its inhibition
    • Chan, D. C., and P. S. Kim. 1998. HIV entry and its inhibition. Cell 93:681-684.
    • (1998) Cell , vol.93 , pp. 681-684
    • Chan, D.C.1    Kim, P.S.2
  • 9
    • 85145134354 scopus 로고    scopus 로고
    • Atomic structure of viral particles
    • J. R. Kerr, S. F. Cotmore, M. E. Bloom, R. M. Linden, and C. R. Parrish (ed. ), Edward Arnold, Ltd., New York, NY
    • Chapman, M. S., and M. Agbandje-McKenna. 2006. Atomic structure of viral particles, p. 107-123. In J. R. Kerr, S. F. Cotmore, M. E. Bloom, R. M. Linden, and C. R. Parrish (ed.), Parvoviruses. Edward Arnold, Ltd., New York, NY.
    • (2006) Parvoviruses , pp. 107-123
    • Chapman, M.S.1    Agbandje-McKenna, M.2
  • 10
    • 34548250956 scopus 로고    scopus 로고
    • Parvoviral host range and cell entry mechanisms
    • Cotmore, S. F., and P. Tattersall. 2007. Parvoviral host range and cell entry mechanisms. Adv. Virus Res. 70:183-232.
    • (2007) Adv. Virus Res. , vol.70 , pp. 183-232
    • Cotmore, S.F.1    Tattersall, P.2
  • 11
    • 36749033228 scopus 로고    scopus 로고
    • The state of the art of adenoassociated virus-based vectors in gene therapy
    • Coura Rdos, S., and N. B. Nardi. 2007. The state of the art of adenoassociated virus-based vectors in gene therapy. Virol. J. 4:99.
    • (2007) Virol. J. , vol.4 , pp. 99
    • Coura Rdos, S.1    Nardi, N.B.2
  • 12
    • 54249126862 scopus 로고    scopus 로고
    • Gene therapy using adeno-associated virus vectors
    • Daya, S., and K. I. Berns. 2008. Gene therapy using adeno-associated virus vectors. Clin. Microbiol. Rev. 21:583-593.
    • (2008) Clin. Microbiol. Rev. , vol.21 , pp. 583-593
    • Daya, S.1    Berns, K.I.2
  • 14
    • 0035138205 scopus 로고    scopus 로고
    • Intracellular trafficking of adeno-associated virus vectors: routing to the late endosomal compartment and proteasome degradation
    • Douar, A. M., K. Poulard, D. Stockholm, and O. Danos. 2001. Intracellular trafficking of adeno-associated virus vectors: routing to the late endosomal compartment and proteasome degradation. J. Virol. 75:1824-1833.
    • (2001) J. Virol. , vol.75 , pp. 1824-1833
    • Douar, A.M.1    Poulard, K.2    Stockholm, D.3    Danos, O.4
  • 15
    • 0034924823 scopus 로고    scopus 로고
    • Mechanisms of viral membrane fusion and its inhibition
    • Eckert, D. M., and P. S. Kim. 2001. Mechanisms of viral membrane fusion and its inhibition. Annu. Rev. Biochem. 70:777-810.
    • (2001) Annu. Rev. Biochem. , vol.70 , pp. 777-810
    • Eckert, D.M.1    Kim, P.S.2
  • 17
    • 0029151404 scopus 로고
    • Adeno-associated virus vectors for gene therapy
    • Flotte, T. R., and B. J. Carter. 1995. Adeno-associated virus vectors for gene therapy. Gene Ther. 2:357-362.
    • (1995) Gene Ther , vol.2 , pp. 357-362
    • Flotte, T.R.1    Carter, B.J.2
  • 18
    • 0037015049 scopus 로고    scopus 로고
    • Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy
    • Gao, G. P., et al. 2002. Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy. Proc. Natl. Acad. Sci. U. S. A. 99:11854-11859.
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 11854-11859
    • Gao, G.P.1
  • 19
    • 0036246727 scopus 로고    scopus 로고
    • The VP1 capsid protein of adeno-associated virus type 2 is carrying a phospholipase A2 domain required for virus infectivity
    • Girod, A., et al. 2002. The VP1 capsid protein of adeno-associated virus type 2 is carrying a phospholipase A2 domain required for virus infectivity. J. Gen. Virol. 83:973-978.
    • (2002) J. Gen. Virol. , vol.83 , pp. 973-978
    • Girod, A.1
  • 20
    • 33751210120 scopus 로고    scopus 로고
    • Structurally mapping the diverse phenotype of adeno-associated virus serotype 4
    • Govindasamy, L., et al. 2006. Structurally mapping the diverse phenotype of adeno-associated virus serotype 4. J. Virol. 80:11556-11570.
    • (2006) J. Virol. , vol.80 , pp. 11556-11570
    • Govindasamy, L.1
  • 21
    • 34547117580 scopus 로고    scopus 로고
    • Surface-exposed adeno-associated virus Vp1-NLS capsid fusion protein rescues infectivity of noninfectious wild-type Vp2/Vp3 and Vp3-only capsids but not that of fivefold pore mutant virions
    • Grieger, J. C., J. S. Johnson, B. Gurda-Whitaker, M. Agbandje-McKenna, and R. J. Samulski. 2007. Surface-exposed adeno-associated virus Vp1-NLS capsid fusion protein rescues infectivity of noninfectious wild-type Vp2/Vp3 and Vp3-only capsids but not that of fivefold pore mutant virions. J. Virol. 81:7833-7843.
    • (2007) J. Virol. , vol.81 , pp. 7833-7843
    • Grieger, J.C.1    Johnson, J.S.2    Gurda-Whitaker, B.3    Agbandje-McKenna, M.4    Samulski, R.J.5
  • 22
    • 33745859044 scopus 로고    scopus 로고
    • Mechanisms of pathogen entry through the endosomal compartments
    • Gruenberg, J., and F. G. van der Goot. 2006. Mechanisms of pathogen entry through the endosomal compartments. Nat. Rev. Mol. Cell Biol. 7:495-504.
    • (2006) Nat. Rev. Mol. Cell Biol. , vol.7 , pp. 495-504
    • Gruenberg, J.1    van der Goot, F.G.2
  • 23
    • 0035043237 scopus 로고    scopus 로고
    • Adeno-associated virus type 2-mediated gene transfer: altered endocytic processing enhances transduction efficiency in murine fibroblasts
    • Hansen, J., K. Qing, and A. Srivastava. 2001. Adeno-associated virus type 2-mediated gene transfer: altered endocytic processing enhances transduction efficiency in murine fibroblasts. J. Virol. 75:4080-4090.
    • (2001) J. Virol. , vol.75 , pp. 4080-4090
    • Hansen, J.1    Qing, K.2    Srivastava, A.3
  • 24
    • 0037320191 scopus 로고    scopus 로고
    • Characterization of tissue tropism determinants of adeno-associated virus type 1
    • Hauck, B., and W. Xiao. 2003. Characterization of tissue tropism determinants of adeno-associated virus type 1. J. Virol. 77:2768-2774.
    • (2003) J. Virol. , vol.77 , pp. 2768-2774
    • Hauck, B.1    Xiao, W.2
  • 25
    • 33745606715 scopus 로고    scopus 로고
    • Multiyear therapeutic benefit of AAV serotypes 2, 6, and 8 delivering factor VIII to hemophilia A mice and dogs
    • Jiang, H., et al. 2006. Multiyear therapeutic benefit of AAV serotypes 2, 6, and 8 delivering factor VIII to hemophilia A mice and dogs. Blood 108:107-115.
    • (2006) Blood , vol.108 , pp. 107-115
    • Jiang, H.1
  • 26
    • 0141454787 scopus 로고    scopus 로고
    • Identification of a heparin-binding motif on adenoassociated virus type 2 capsids
    • Kern, A., et al. 2003. Identification of a heparin-binding motif on adenoassociated virus type 2 capsids. J. Virol. 77:072-11081.
    • (2003) J. Virol. , vol.77 , pp. 072-11081
    • Kern, A.1
  • 27
    • 28444473059 scopus 로고    scopus 로고
    • Successful production of pseudotyped rAAV vectors using a modified baculovirus expression system
    • Kohlbrenner, E., et al. 2005. Successful production of pseudotyped rAAV vectors using a modified baculovirus expression system. Mol. Ther. 12:1217-1225.
    • (2005) Mol. Ther. , vol.12 , pp. 1217-1225
    • Kohlbrenner, E.1
  • 28
    • 17444405970 scopus 로고    scopus 로고
    • A conformational change in the adeno-associated virus type 2 capsid leads to the exposure of hidden VP1 N termini
    • Kronenberg, S., B. Bottcher, C. W. von der Lieth, S. Bleker, and J. A. Kleinschmidt. 2005. A conformational change in the adeno-associated virus type 2 capsid leads to the exposure of hidden VP1 N termini. J. Virol. 79:5296-5303.
    • (2005) J. Virol. , vol.79 , pp. 5296-5303
    • Kronenberg, S.1    Bottcher, B.2    von der Lieth, C.W.3    Bleker, S.4    Kleinschmidt, J.A.5
  • 29
    • 33744474585 scopus 로고    scopus 로고
    • Production, purification, crystallization and preliminary X-ray analysis of adeno-associated virus serotype 8
    • Lane, M. D., et al. 2005. Production, purification, crystallization and preliminary X-ray analysis of adeno-associated virus serotype 8. Acta Crystallogr. F 61:558-561.
    • (2005) Acta Crystallogr. F , vol.61 , pp. 558-561
    • Lane, M.D.1
  • 30
    • 6344275675 scopus 로고    scopus 로고
    • Gene therapy with novel adeno-associated virus vectors substantially diminishes atherosclerosis in a murine model of familial hypercholesterolemia
    • Lebherz, C., et al. 2004. Gene therapy with novel adeno-associated virus vectors substantially diminishes atherosclerosis in a murine model of familial hypercholesterolemia. J. Gene Med. 6:663-672.
    • (2004) J. Gene Med. , vol.6 , pp. 663-672
    • Lebherz, C.1
  • 31
    • 77953285729 scopus 로고    scopus 로고
    • The structure of adenoassociated virus serotype 3B (AAV-3B): insights into receptor binding and immune evasion
    • Lerch, T. F., Q. Xie, and M. S. Chapman. 2010. The structure of adenoassociated virus serotype 3B (AAV-3B): insights into receptor binding and immune evasion. Virology 403:26-36.
    • (2010) Virology , vol.403 , pp. 26-36
    • Lerch, T.F.1    Xie, Q.2    Chapman, M.S.3
  • 32
    • 59149090531 scopus 로고    scopus 로고
    • Heparin binding induces conformational changes in adeno-associated virus serotype 2
    • Levy, H. C., et al. 2009. Heparin binding induces conformational changes in adeno-associated virus serotype 2. J. Struct. Biol. 165:146-156.
    • (2009) J. Struct. Biol. , vol.165 , pp. 146-156
    • Levy, H.C.1
  • 33
    • 30344450073 scopus 로고    scopus 로고
    • Mutations on the external surfaces of adenoassociated virus type 2 capsids that affect transduction and neutralization
    • Lochrie, M. A., et al. 2006. Mutations on the external surfaces of adenoassociated virus type 2 capsids that affect transduction and neutralization. J. Virol. 80:821-834.
    • (2006) J. Virol. , vol.80 , pp. 821-834
    • Lochrie, M.A.1
  • 34
    • 9644265332 scopus 로고    scopus 로고
    • Two novel adenoassociated viruses from cynomolgus monkey: pseudotyping characterization of capsid protein
    • Mori, S., L. Wang, T. Takeuchi, and T. Kanda. 2004. Two novel adenoassociated viruses from cynomolgus monkey: pseudotyping characterization of capsid protein. Virology 330:375-383.
    • (2004) Virology , vol.330 , pp. 375-383
    • Mori, S.1    Wang, L.2    Takeuchi, T.3    Kanda, T.4
  • 35
    • 80655133135 scopus 로고    scopus 로고
    • Reference deleted
    • Reference deleted
  • 36
    • 36049020398 scopus 로고    scopus 로고
    • Structure of adeno-associated virus serotype 8, a gene therapy vector
    • Nam, H. J., et al. 2007. Structure of adeno-associated virus serotype 8, a gene therapy vector. J. Virol. 81:12260-12271.
    • (2007) J. Virol. , vol.81 , pp. 12260-12271
    • Nam, H.J.1
  • 37
    • 78649402995 scopus 로고    scopus 로고
    • Structural characterization of the dual glycan binding adeno-associated virus serotype 6
    • Ng, R., et al. 2010. Structural characterization of the dual glycan binding adeno-associated virus serotype 6. J. Virol. 84:12945-12957.
    • (2010) J. Virol. , vol.84 , pp. 12945-12957
    • Ng, R.1
  • 38
    • 0038618725 scopus 로고    scopus 로고
    • Identification of amino acid residues in the capsid proteins of adeno-associated virus type 2 that contribute to heparan sulfate proteoglycan binding
    • Opie, S. R., K. H. J. Warrington, M. Agbandje-McKenna, S. Zolotukhin, and N. Muzyczka. 2003. Identification of amino acid residues in the capsid proteins of adeno-associated virus type 2 that contribute to heparan sulfate proteoglycan binding. J. Virol. 77:6995-7006.
    • (2003) J. Virol. , vol.77 , pp. 6995-7006
    • Opie, S.R.1    Warrington, K.H.J.2    Agbandje-McKenna, M.3    Zolotukhin, S.4    Muzyczka, N.5
  • 39
    • 0031059866 scopus 로고    scopus 로고
    • Processing of X-ray diffraction data collected in oscillation mode
    • Otwinowski, Z., and W. Minor. 1997. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 296:307-326.
    • (1997) Methods Enzymol , vol.296 , pp. 307-326
    • Otwinowski, Z.1    Minor, W.2
  • 40
    • 20144387791 scopus 로고    scopus 로고
    • Structure of adeno-associated virus type 4
    • Padron, E., et al. 2005. Structure of adeno-associated virus type 4. J. Virol. 79:5047-5058.
    • (2005) J. Virol. , vol.79 , pp. 5047-5058
    • Padron, E.1
  • 41
    • 0035194351 scopus 로고    scopus 로고
    • Virus Particle Explorer (VIPER), a website for virus capsid structures and their computational analyses
    • Reddy, V. S., et al. 2001. Virus Particle Explorer (VIPER), a website for virus capsid structures and their computational analyses. J. Virol. 75:11943-11947.
    • (2001) J. Virol. , vol.75 , pp. 11943-11947
    • Reddy, V.S.1
  • 42
    • 0842264039 scopus 로고    scopus 로고
    • Total correction of hemophilia A mice with canine FVIII using an AAV 8 serotype
    • Sarkar, R., et al. 2004. Total correction of hemophilia A mice with canine FVIII using an AAV 8 serotype. Blood 103:1253-1260.
    • (2004) Blood , vol.103 , pp. 1253-1260
    • Sarkar, R.1
  • 43
    • 35548955563 scopus 로고    scopus 로고
    • Characterization of the relationship of AAV capsid domain swapping to liver transduction efficiency
    • Shen, X., T. Storm, and M. A. Kay. 2007. Characterization of the relationship of AAV capsid domain swapping to liver transduction efficiency. Mol. Ther. 15:1955-1962.
    • (2007) Mol. Ther. , vol.15 , pp. 1955-1962
    • Shen, X.1    Storm, T.2    Kay, M.A.3
  • 44
    • 0033783032 scopus 로고    scopus 로고
    • Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin
    • Skehel, J. J., and D. C. Wiley. 2000. Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin. Annu. Rev. Biochem. 69:531-569.
    • (2000) Annu. Rev. Biochem. , vol.69 , pp. 531-569
    • Skehel, J.J.1    Wiley, D.C.2
  • 45
    • 33750712806 scopus 로고    scopus 로고
    • Adeno-associated virus type 2 capsids with externalized VP1/VP2 trafficking domains are generated prior to passage through the cytoplasm and are maintained until uncoating occurs in the nucleus
    • Sonntag, F., S. Bleker, B. Leuchs, R. Fischer, and J. A. Kleinschmidt. 2006. Adeno-associated virus type 2 capsids with externalized VP1/VP2 trafficking domains are generated prior to passage through the cytoplasm and are maintained until uncoating occurs in the nucleus. J. Virol. 80:11040-11054.
    • (2006) J. Virol. , vol.80 , pp. 11040-11054
    • Sonntag, F.1    Bleker, S.2    Leuchs, B.3    Fischer, R.4    Kleinschmidt, J.A.5
  • 46
    • 10944239670 scopus 로고    scopus 로고
    • Efficacy of an adeno-associated virus 8-pseudotyped vector in glycogen storage disease type II
    • Sun, B., et al. 2005. Efficacy of an adeno-associated virus 8-pseudotyped vector in glycogen storage disease type II. Mol. Ther. 11:57-65.
    • (2005) Mol. Ther. , vol.11 , pp. 57-65
    • Sun, B.1
  • 47
    • 1542347741 scopus 로고    scopus 로고
    • Rapid uncoating of vector genomes is the key to efficient liver transduction with pseudotyped adeno-associated virus vectors
    • Thomas, C. E., T. A. Storm, Z. Huang, and M. A. Kay. 2004. Rapid uncoating of vector genomes is the key to efficient liver transduction with pseudotyped adeno-associated virus vectors. J. Virol. 78:3110-3122.
    • (2004) J. Virol. , vol.78 , pp. 3110-3122
    • Thomas, C.E.1    Storm, T.A.2    Huang, Z.3    Kay, M.A.4
  • 48
    • 0033808531 scopus 로고    scopus 로고
    • Monoclonal antibodies against the adeno-associated virus type 2 (AAV-2) capsid: epitope mapping and identification of capsid domains involved in AAV-2-cell interaction and neutralization of AAV-2 infection
    • Wobus, C. E., et al. 2000. Monoclonal antibodies against the adeno-associated virus type 2 (AAV-2) capsid: epitope mapping and identification of capsid domains involved in AAV-2-cell interaction and neutralization of AAV-2 infection. J. Virol. 74:9281-9293.
    • (2000) J. Virol. , vol.74 , pp. 9281-9293
    • Wobus, C.E.1
  • 49
    • 0033851104 scopus 로고    scopus 로고
    • Mutational analysis of the adeno-associated virus type 2 (AAV2) capsid gene and construction of AAV2 vectors with altered tropism
    • Wu, P., et al. 2000. Mutational analysis of the adeno-associated virus type 2 (AAV2) capsid gene and construction of AAV2 vectors with altered tropism. J. Virol. 74:8635-8647.
    • (2000) J. Virol. , vol.74 , pp. 8635-8647
    • Wu, P.1
  • 50
    • 33750722840 scopus 로고    scopus 로고
    • Single amino acid changes can influence titer, heparin binding, and tissue tropism in different adeno-associated virus serotypes
    • Wu, Z., et al. 2006. Single amino acid changes can influence titer, heparin binding, and tissue tropism in different adeno-associated virus serotypes. J. Virol. 80:393-11397.
    • (2006) J. Virol. , vol.80 , pp. 393-11397
    • Wu, Z.1
  • 51
    • 0036678455 scopus 로고    scopus 로고
    • The atomic structure of adeno-associated virus (AAV-2), a vector for human gene therapy
    • Xie, Q., et al. 2002. The atomic structure of adeno-associated virus (AAV-2), a vector for human gene therapy. Proc. Natl. Acad. Sci. U. S. A. 99:10405-10410.
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 10405-10410
    • Xie, Q.1
  • 52
    • 54549096772 scopus 로고    scopus 로고
    • Tyrosine-phosphorylation of AAV2 vectors and its consequences on viral intracellular trafficking and transgene expression
    • Zhong, L., et al. 2008. Tyrosine-phosphorylation of AAV2 vectors and its consequences on viral intracellular trafficking and transgene expression. Virology 381:194-202.
    • (2008) Virology , vol.381 , pp. 194-202
    • Zhong, L.1
  • 53
    • 45549090635 scopus 로고    scopus 로고
    • Next generation of adeno-associated virus 2 vectors: point mutations in tyrosines lead to high-efficiency transduction at lower doses
    • Zhong, L., et al. 2008. Next generation of adeno-associated virus 2 vectors: point mutations in tyrosines lead to high-efficiency transduction at lower doses. Proc. Natl. Acad. Sci. U. S. A. 105:7827-7832.
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 7827-7832
    • Zhong, L.1


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